Published in 1992

Time-related decrease in diffusion capacity in HIV-infected patients with impaired immune function

Backer, V., Nybo Jensen, B., Pedersen, C., Hertz, J. B. & Jensen, T. H., 1992, I: Scandinavian Journal of Infectious Diseases. 24, 1, s. 29-34 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Published in 1991

Alkohol-og narkotikabrug blandt danske unge i 1980'erne

Nielsen, H. W., Samuelsson, I. S., Kjaer, S. K., Christoffersen, M. H., Brix, P. & Hein, H. S., 22 apr. 1991, I: Ugeskrift for Laeger. 153, 17, s. 1189-93 5 s.

Publikation: Bidrag til tidsskriftReviewpeer review

Case-control study of risk factors for cervical neoplasia in Denmark. I: Role of the "male factor" in women with one lifetime sexual partner

Kjaer, S. K., de Villiers, E. M., Dahl, C., Engholm, G., Bock, J. E., Vestergaard, B. F., Lynge, E. & Jensen, O. M., 22 apr. 1991, I: International Journal of Cancer. 48, 1, s. 39-44 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Contraceptive use in random samples of Greenlandic and Danish women--changes from 1986 to 1988

Kjaer, S. K., Svare, E. I., Haugaard, B. J., Teisen, C., Christensen, R. B., Lynge, E. & Jensen, O. M., mar. 1991, I: Scandinavian journal of social medicine. 19, 1, s. 39-43 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The effects of dietary supplementation with ω‐3‐polyunsaturated fatty acids (ω‐3‐PUFA) on the proliferative response of PBMC and on the secretion of monokines and arachidonic acid metabolites from PBMC and monocytes (Mo) from healthy subjects and patients with recent‐onset insulin‐dependent diabetes mellitus (IDDM) were examined. Three groups of eight to nine healthy individuals were randomized to either 2.0 g/day or 4.0 g/day of ω‐3‐PUFA devoid of vitamins A and D, or an isocaloric amount of placebo. Furthermore, eight patients with recent‐onset IDDM received 4.0 g/day of ω‐3‐PUFA. IL‐lβ production and TNF‐α secretion was determined before and after 7 weeks of treatment, and 10 weeks after withdrawal of treatment. Significant increases in platelet and PBMC membrane eicosapentaenoic acid was found in ω‐3‐PUFA‐treated individuals. ω‐3‐PUFA treatment significantly reduced the content of IL‐Ib in lysates of PBMC, but did not affect PBMC or Mo secretion of IL‐1β, TNF‐α or prostaglandin E2 (PGE2) or PBMC leukotriene B4 (LTB4) secretion in healthy subjects or in IDDM patients. A significant inhibition of the PHA‐stimulated. but not the spontaneous or PPD‐stimulated, proliferative response of PBMC was observed in healthy and diabetic subjects treated with (o‐3‐PUFA. No correlation was found between PHA‐stimulated PBMC proliferation and PBMC secretion of TNF‐α and IL‐1β. There were no significant differences in the spontaneous or the PPD‐or PHA‐stimulated proliferative responses of PBMC between diabetic and healthy individuals at entry. We conclude that although dietary supplementation with 4.0 g/day of ω‐3‐PUFA inhibits the proliferation of PBMC and reduces IL‐I immunoreactivity in PBMC and Mo, it does not alter monokine, PGE2 or LTB4, secretion in healthy or IDDM subjects.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Immunology
Vol/bind 34
Udgave nummer 4
Sider (fra-til) 399-410
Antal sider 12
ISSN 0300-9475
DOI
Status Udgivet - 1 jan. 1991

Isokinetic and isometric muscle strength combined with transcutaneous electrical muscle stimulation in primary fibromyalgia syndrome

Jacobsen, S., Wildschiødtz, G. & Danneskiold-Samsøe, B., sep. 1991, I: Journal of Rheumatology. 18, 9, s. 1390-3 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Twenty women with primary fibromyalgia syndrome and 20 age matched healthy women were investigated. The subjects performed maximum voluntary isokinetic contractions of the right quadriceps in an isokinetic dynamometer. Maximum voluntary isometric contractions of the right quadriceps were performed with superimposed transcutaneous electrical stimulation. The examination protocol was repeated after 1 h of resting. Isokinetic and isometric muscle strength was found to be, respectively, 45% (p = 0.0001) and 44% (p = 0.0001) lower in the patient group compared to the healthy subjects. The frequency of superimposed twitches was 65% in the patient group and 15% in the control group (p = 0.003). Patients with primary fibromyalgia have a lower maximum voluntary muscle strength than expected. The increased presence of superimposed electrically elicited twitches during maximum voluntary contraction indicates submaximal force application in primary fibromyalgia syndrome.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 18
Udgave nummer 9
Sider (fra-til) 1390-3
Antal sider 4
ISSN 0315-162X
Status Udgivet - sep. 1991

On circadian rhythms in human epidermal cell proliferation

Frentz, G., Møller, U., Hölmich, P. & Christensen, I. J. 1991 I : Acta Dermato-Venereologica. 71, 1, s. 85-7 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The ascertainment of consistent diurnal variations in human epidermal cell proliferation may have important implications for the treatment of many skin diseases. For the evaluation of diurnal rhythms in the growth of human epidermis, skin biopsies were taken every 4th hour for 48 h from each of two persons under synchronized living conditions. The epidermal cell proliferation was assessed by the fraction of cells in S and in G2-M phase as determined by measurements of the DNA content in the individual cells in single-cell suspensions. The existence of diurnally consistent body functions in the test persons was verified by monitoring the excretion of cortisol by urine. The fraction of cells in G2-M phase indicated circadian rhythmicity for the first 32 h of the test period. No regular variation according to time of day could be established in the fraction of cells in S-phase.

Originalsprog Engelsk
Tidsskrift Acta Dermato-Venereologica
Vol/bind 71
Tidsskriftsnummer 1
Sider (fra-til) 85-7
Antal sider 3
ISSN 0001-5555
Status Udgivet - 1991

Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation

Jacobsen, S., Danneskiold-Samsøe, B. & Andersen, R. B., 1991, I: Scandinavian Journal of Rheumatology. 20, 4, s. 294-302 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

S-adenosylmethionine is a relatively new anti-inflammatory drug with analgesic and anti-depressant effects. Efficacy of 800 mg orally administered s-adenosylmethionine daily versus placebo for six weeks was investigated in 44 patients with primary fibromyalgia in double-blind settings. Tender point score, isokinetic muscle strength, disease activity, subjective symptoms (visual analog scale), mood parameters and side effects were evaluated. Improvements were seen for clinical disease activity (P = 0.04), pain experienced during the last week (P = 0.002), fatigue (P = 0.02), morning stiffness (P = 0.03) and mood evaluated by Face Scale (P = 0.006) in the actively treated group compared to placebo. The tender point score, isokinetic muscle strength, mood evaluated by Beck Depression Inventory and side effects did not differ in the two treatment groups. S-adenosylmethionine has some beneficial effects on primary fibromyalgia and could be an important option in the treatment hereof.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 20
Udgave nummer 4
Sider (fra-til) 294-302
Antal sider 9
ISSN 0300-9742
Status Udgivet - 1991

Radiologic manifestations of focal cerebral hyperemia in acute stroke

Olsen, T. S., Skriver, E. B. & Herning, M., mar. 1991, I: Acta Radiologica. 32, 2, s. 100-4 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In 16 acute stroke patients with focal cerebral hyperemia angiography and regional cerebral blood flow (rCBF) were studied 1 to 4 days post stroke. CT was performed twice with and without contrast enhancement 3 +/- 1 days and 16 +/- 4 days post stroke. Angiographic evidence of focal cerebral hyperemia was seen in 8 patients in the form of early filling veins. In 5 of these the hyperemic areas were located within infarcted areas and in 3 patients in areas which appeared normal on CT. In the remaining 8 patients the hyperemias were located perifocally around ischemic infarcts. Early filling veins were not seen in this type of hyperemia. The blood flow was higher and the transit time of the contrast medium was faster in the former type of hyperemia probably because of arteriovenous shunting. Contrast enhancement was not observed on the early CT but was typically seen in the infarcts on the late CT at a time when the hyperemic state is known to have vanished. It is concluded that focal cerebral hyperemia is not responsible for contrast enhancement on CT.

Originalsprog Engelsk
Tidsskrift Acta Radiologica
Vol/bind 32
Udgave nummer 2
Sider (fra-til) 100-4
Antal sider 5
ISSN 0284-1851
Status Udgivet - mar. 1991

Sensitivity and specificity of the histamine challenge test for the diagnosis of asthma in an unselected sample of children and adolescents

Backer, V., Groth, S., Dirksen, A., Bach-Mortensen, N., Hansen, K. K., Laursen, E. M. & Wendelboe, D., okt. 1991, I: European Respiratory Journal. Supplement. 4, 9, s. 1093-100 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Single cell morphology of muscle in patients with chronic muscle pain

Jacobsen, S., Bartels, E. M. & Danneskiold-Samsøe, B., 1991, I: Scandinavian Journal of Rheumatology. 20, 5, s. 336-43 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In 119 patients referred with suspected fibromyalgia, biopsies from the quadriceps muscle were analyzed for "rubber band" morphology, and isokinetic quadriceps strength was measured. Eighty-four fulfilled the criteria for fibromyalgia, 26 had chronic myofascial pain (CMP) and 9 had other diseases including 5 with concomitant fibromyalgia. Twenty-four CMP patients and 48 fibromyalgia patients were randomly selected to match with regard to sex, age, smoking and drinking habits. "Rubber band" morphology was blindly graded on a biopsy score scale from 0 to 2. A statistically significant difference in biopsy score was found between the two matched groups (P = 0.003); median biopsy score in fibromyalgia was 0.42 and 0.25 in CMP. A cut-off value at 0.33 gave a specificity of 71% and a sensitivity of 63%. Isokinetic muscle strength did not differ in the fibromyalgia and CMP groups and was not related to the biopsy score. "Rubber band" morphology is seen more often in fibromyalgia patients than in CMP patients. The exact genesis of this phenomenon is still unknown but theories connected with the possible pathogenesis of the syndrome are presented.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 20
Udgave nummer 5
Sider (fra-til) 336-43
Antal sider 8
ISSN 0300-9742
Status Udgivet - 1991

Spontaneous changes in bronchial responsiveness in children and adolescents: an 18-month follow-up

Backer, V., Groth, S. & Dirksen, A., 1991, I: Pediatric Pulmonology. 11, 1, s. 22-8 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The distribution of bronchial responsiveness to histamine and exercise in 527 children and adolescents

Backer, V., Dirksen, A., Bach-Mortensen, N., Hansen, K. K., Laursen, E. M. & Wendelboe, D., jul. 1991, I: The Journal of allergy and clinical immunology. 88, 1, s. 68-76 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Valg af kontraception i relation til seksuel aktivitet blandt yngre kvinder i Nuuk/Godthåb (Grønland) og i Nykøbing Falster (Danmark). En populationsbaseret tvaersnitsundersøgelse blandt 1,247 kvinder

Kjaer, S. K., Teisen-Simony, M. L., Haugaard, B. J., Christensen, R. B., Lynge, E. & Jensen, O. M., 21 jan. 1991, I: Ugeskrift for Laeger. 153, 4, s. 278-81 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Published in 1990

A follow-up study of pulmonary function in patients with primary Sjögren's syndrome

Linstow, M., Kriegbaum, N. J., Backer, V., Ulrik, C. & Oxholm, P., 1990, I: Rheumatology International. 10, 2, s. 47-9 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abnormal Papanicolaou smear. A population-based study of risk factors in Greenlandic and Danish women

Kjaer, S. K., Poll, P., Jensen, H., Engholm, G., Haugaard, B. J., Teisen, C., Christensen, R. B., Möller, K. A., Vestergaard, B. F. & de Villiers, E. M., 1990, I: Acta Obstetricia et Gynecologica Scandinavica. 69, 1, s. 79-86 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Advances in Pain research and Therapy Volume 17

Andersen, R. B., Jacobsen, S., Danneskiold-Samsøe, B. & Bartels, E. M., 1990, Advances in Pain research and Therapy Volume 17. Bind 296-76.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

Originalsprog Engelsk
Titel Advances in Pain research and Therapy Volume 17
Vol/bind 296-76
Publikationsdato 1990
Status Udgivet - 1990

Lymphopenia in heavy drinkers - reversibility and relation to the duration of drinking episodes

Tønnesen, H., Andersen, J. R., Pedersen, A. E. & Kaiser, A. H., 1990, I: Annals of Medicine.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Annals of Medicine
ISSN 0785-3890
Status Udgivet - 1990

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