Published in 1992

Eight stroke patients were examined serially in the acute phase and 1 week and 2-4 weeks after stroke with water-suppressed proton magnetic resonance spectroscopy. The time courses of lactate level and regional cerebral blood flow were studied. A high lactate level was found in the acute phase. The lactate content decreased to barely detectable levels during the following 3 weeks, while regional blood flow increased during this period. The inverse relationship between lactate level and cerebral blood flow suggests that lactate plays no substantial role in the vasodilatation underlying the hyperemia that follows reperfusion. The amount of lactate present in the acute phase reflects the severity of ischemia in the affected region. The lactate level was still above normal in the subacute phase with hyperemia, suggesting lactate production through aerobic glycolysis. Thus, the lactate level in the subacute phase probably does not reflect the degree of anaerobic glycolysis in hypoxic neuronal tissue.

Originalsprog Engelsk
Tidsskrift Journal of Magnetic Resonance Imaging
Udgivelsesdato 1 sep 1992
Vol/bind 2
Tidsskriftsnummer 5
Sider 511-517
Antal sider 7
ISSN 1053-1807
Status Udgivet

Comparison studies of HPV detection in areas at different risk for cervical cancer

Kjaer, S. K. & Jensen, O. M., 1992, I: IARC scientific publications. 119, s. 243-9 7 s.

Publikation: Bidrag til tidsskriftReviewpeer review

Consensus on fibromyalgia. Preliminary draft.

Kamper-Jørgensen, F., Jacobsen, S., Danneskiold-Samsøe, B. & Bartels, E. M., 1992, Consensus on fibromyalgia. Preliminary draft..

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Engelsk
Titel Consensus on fibromyalgia. Preliminary draft.
Publikationsdato 1992
Status Udgivet - 1992

Den alkoholmisbrugende operationspatient

Tønnesen, H., 1992, I: Månedsskrift for praktisk lægegerning.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Dansk
Tidsskrift Månedsskrift for praktisk lægegerning
ISSN 0373-2746
Status Udgivet - 1992

Development of lung function in relation to increased degree of bronchial responsiveness

Backer, V. & Ulrik, C. S., 1992, I: The Journal of asthma : official journal of the Association for the Care of Asthma. 29, 5, s. 331-41 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Distribution of serum IgE in children and adolescents aged 7 to 16 years in Copenhagen, in relation to factors of importance

Backer, V., Ulrik, C. S., Wendelboe, D., Bach-Mortensen, N., Hansen, K. K., Laursen, E. M. & Dirksen, A., okt. 1992, I: Allergy. 47, 5, s. 484-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Dynamic muscular endurance in primary fibromyalgia compared with chronic myofascial pain syndrome

Jacobsen, S. & Danneskiold-Samsøe, B., feb. 1992, I: Archives of Physical Medicine and Rehabilitation. 73, 2, s. 170-3 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The objective of the study was to quantify the voluntary dynamic muscular endurance (DME) in patients with primary fibromyalgia (PF) since easy fatigability of muscles is one of the major symptoms in this syndrome. Consecutive outpatients referred to a rheumatology clinic specializing in PF were investigated. Thirty-six patients with PF were compared with 18 patients with chronic myofascial pain (CMP) syndrome. Subjects were matched according to gender, age, height, weight, peak torque, and contractional work. The DME was defined as the number of repeated knee extensions necessary for the contractional work in two successive knee extensions to be equal to or below 70% of the initial value measured with an isokinetic dynamometer. A significantly lower DME was found in the PF group than in the CMP group: 11 (7-13) and 18 (11-25), respectively (median and quartiles), p less than .005. Patients with PF have a low voluntary muscular endurance compared to CMP patients.
Originalsprog Engelsk
Tidsskrift Archives of Physical Medicine and Rehabilitation
Vol/bind 73
Udgave nummer 2
Sider (fra-til) 170-3
Antal sider 4
ISSN 0003-9993
Status Udgivet - feb. 1992

BACKGROUND AND PURPOSE: The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy.

METHODS: Eight patients with acute stroke were studied serially in the acute phase, 1 week after, and 2-4 weeks after the onset of clinical symptoms. Ten healthy volunteers served as controls. A stimulated echo (STEAM) sequence was used for measurement of the brain metabolites in a volume of interest located within the infarcted area as visualized by magnetic resonance imaging. For quantification, the unsaturated water signal was used as the internal standard. Regional cerebral blood flow in the infarcted area was measured relative to a symmetrically located unaffected area by means of single-photon emission computed tomographic scanning, using 99mTc-labeled d,l-hexamethylenepropyleneamine oxime as the flow tracer.

RESULTS: Relative regional cerebral blood flow was considerably reduced in the infarcted area in the acute phase. After 1 week, hyperemia was seen in all but one patient. The N-acetylaspartate content was significantly reduced, with the loss appearing to occur between 6 and 24 hours after the stroke incident. The reduction in N-acetylaspartate content was greater in the central part than in the peripheral part of the infarcted area. Creatine and phosphocreatine were also reduced in the infarcted area, whereas no significant change was seen in the choline content.

CONCLUSIONS: Assuming that N-acetylaspartate content reflects neuronal survival or loss, our results may suggest that treatment procedures with restoration of blood flow to severely ischemic areas should be initiated within the first 6 hours after stroke onset.

Originalsprog Engelsk
Tidsskrift Stroke; a journal of cerebral circulation
Udgivelsesdato nov 1992
Vol/bind 23
Tidsskriftsnummer 11
Sider 1566-72
Antal sider 7
ISSN 0039-2499
Status Udgivet

BACKGROUND AND PURPOSE: The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy.

METHODS: Eight patients with acute stroke were studied serially in the acute phase, 1 week after, and 2-4 weeks after the onset of clinical symptoms. Ten healthy volunteers served as controls. A stimulated echo (STEAM) sequence was used for measurement of the brain metabolites in a volume of interest located within the infarcted area as visualized by magnetic resonance imaging. For quantification, the unsaturated water signal was used as the internal standard. Regional cerebral blood flow in the infarcted area was measured relative to a symmetrically located unaffected area by means of single-photon emission computed tomographic scanning, using 99mTc-labeled d,l-hexamethylenepropyleneamine oxime as the flow tracer.

RESULTS: Relative regional cerebral blood flow was considerably reduced in the infarcted area in the acute phase. After 1 week, hyperemia was seen in all but one patient. The N-acetylaspartate content was significantly reduced, with the loss appearing to occur between 6 and 24 hours after the stroke incident. The reduction in N-acetylaspartate content was greater in the central part than in the peripheral part of the infarcted area. Creatine and phosphocreatine were also reduced in the infarcted area, whereas no significant change was seen in the choline content.

CONCLUSIONS: Assuming that N-acetylaspartate content reflects neuronal survival or loss, our results may suggest that treatment procedures with restoration of blood flow to severely ischemic areas should be initiated within the first 6 hours after stroke onset.

Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato nov 1992
Vol/bind 23
Tidsskriftsnummer 11
Sider 1566-1572
Antal sider 7
ISSN 0039-2499
Status Udgivet

Fibromyalgia and magnesia

Prescott, E., Nørrgård, J., Rotbøl Pedersen, L. & Danneskiold-Samsøe, B., 1992, I: Scandinavian Journal of Rheumatology. 21, 4, s. 206

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 21
Udgave nummer 4
Sider (fra-til) 206
ISSN 0300-9742
Status Udgivet - 1992

Influence of alcohol abuse on postoperative morbidity after hysterectomy

Felding, C., Jensen, L. M. & Tønnesen, H., 1992, I: American Journal of Obstetrics and Gynecology. 166

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift American Journal of Obstetrics and Gynecology
Vol/bind 166
ISSN 0002-9378
Status Udgivet - 1992

Influence of alcohol on several physiological functions and its reversibility: a surgical view

Tønnesen, H., 1992, I: Acta Psychiatrica Scandinavica. 369

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Acta Psychiatrica Scandinavica
Vol/bind 369
ISSN 0001-690X
Status Udgivet - 1992

Mortality and decline in lung function in 213 adults with bronchial asthma: a ten-year follow up

Ulrik, C. S., Backer, V. & Dirksen, A., 1992, I: The Journal of asthma : official journal of the Association for the Care of Asthma. 29, 1, s. 29-38 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Na,K-ATPase expression in normal and failing human left ventricle

Allen, P. D., Schmidt, T. A., Marsh, J. D. & Kjeldsen, K., 1992, I: Basic Research in Cardiology. 87 Suppl 1, s. 87-94 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Pathology of the cervix

Kjaer, S. K., aug. 1992, I: Current Opinion in Obstetrics & Gynecology. 4, 4, s. 586-93 8 s.

Publikation: Bidrag til tidsskriftReviewpeer review

Quantification of rat cerebral cortex Na+,K(+)-ATPase: effect of age and potassium depletion

Schmidt, T. A., Larsen, J. S. & Kjeldsen, K., dec. 1992, I: Journal of Neurochemistry. 59, 6, s. 2094-104 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Serial pulmonary function tests in patients treated with low-dose amiodarone

Ulrik, C. S., Backer, V., Aldershvile, J. & Pietersen, A. H., jun. 1992, I: American Heart Journal. 123, 6, s. 1550-4 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Serum sex hormones and endurance performance after a lacto-ovo vegetarian and a mixed diet

Raben, A., Kiens, B., Richter, E. A., Rasmussen, L. B., Svenstrup, B., Micic, S. & Bennett, P., nov. 1992, I: Medicine and Science in Sports and Exercise. 24, 11, s. 1290-7 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Serum sex hormones and endurance performance after a lacto-ovo vegetarian and a mixed diet. Med. Sci. Sports Exerc., Vol. 24, No. 11, pp. 1290-1297, 1992. The effect of a lacto-ovo vegetarian (V) and a mixed, meat-rich (M) diet on the level of serum sex hormones, gonadotropins, and endurance performance of eight male endurance athletes was investigated in a 2 x 6 wk cross-over study. The energy contribution from carbohydrate, fat, and protein was 58%, 27%, and 15% on the V diet and 58%, 28%, and 14 E% on the M diet. For total fasting serum testosterone (T) there was a significant interaction between diet and time (P < 0.01). Thus, the V diet resulted in a lower total T level (13.7, 9.8-32.4 nmol.l-1) (median and range) compared with the M diet (17.4, 11.8-33.5 nmol.l-1). During exercise after 6 wk on the diets total T was also significantly lower on the V than on the M diet (P < 0.05). Serum free testosterone, however, did not differ significantly during the 6 wk dietary intervention periods and neither did serum concentrations of sex hormone binding globulin, dihydrotestosterone, dehydroepiandrosterone sulphate, 4-androstenedione, estrone, estradiol, estrone sulphate, or gonadotropins. Endurance performance time was higher for six and lower for two after the mixed diet compared with the vegetarian diet. This was not significant, however. In conclusion, 6 wk on a lacto-ovo vegetarian diet caused a minor decrease in total testosterone and no significant changes in physical performance in male endurance athletes compared with 6 wk on a mixed, meatrich diet.

Originalsprog Engelsk
Tidsskrift Medicine and Science in Sports and Exercise
Vol/bind 24
Udgave nummer 11
Sider (fra-til) 1290-7
Antal sider 8
ISSN 0195-9131
Status Udgivet - nov. 1992

Telephone modem access improves diabetes control in those with insulin-requiring diabetes

Ahring, K. K., Ahring, J. P., Joyce, C. & Farid, N. R., aug. 1992, I: Diabetes Care. 15, 8, s. 971-5 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The influence of alcoholism on outcome after evacuation of subdural haematoma

Sonne, N. M. & Tønnesen, H., 1992, I: British Journal of Neurosurgery. 6

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Originalsprog Dansk
Tidsskrift British Journal of Neurosurgery
Vol/bind 6
ISSN 0268-8697
Status Udgivet - 1992

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