Published in 2014

KRONIK Fremdriftsreformen vil sikre middelmådighed

Fosbøl, E. L., Torp-Pedersen, C., Gislason, G. & Køber, L., jan. 2014, I: Ugeskrift for Laeger. 176, 1

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Længerevarende opioidbehandling kan påvirke den endokrine funktion

Sjøgren, P. & Lindholm, J., 14 apr. 2014, I: Ugeskrift for Laeger. 176, 8

Publikation: Bidrag til tidsskriftReviewpeer review

Magnetic resonance imaging (MRI) assessment of early response to certolizumab pegol in rheumatoid arthritis: a randomized, double-blind, placebo-controlled Phase IIIb study applying MRI at weeks 0, 1, 2, 4, 8, and 16.

Østergaard, M., Jacobsson, L., Schaufelberger, C., Hansen, M. S., Bijlsma, J., Dudek, A., Reel-Bakalarska, M., Staalens, F., Haake, R., Sundman-Engberg, B. & Bliddal, H., 2014, I: Scandinavian Journal of Rheumatology. 43, Suppl. 127, s. 14 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 43
Udgave nummer Suppl. 127
Sider (fra-til) 14
Antal sider 1
ISSN 0300-9742
Status Udgivet - 2014

Magnetic Resonance imaging-assessment of early response to certolizumab pegol in rheumatoid arthritis: A randomized, double-blind, placebo-controlled phase IIIB study applying magnetic resonance imaging at weeks 0, 1, 2, 4, 8 and 16.

Østergaard, M., Jacobsson, L., Schaufelberger, C., Hansen, M. S., Bijlsma, J., Dudek, A., Rell-Bakalarska, M., Staelens, F., Haake, R., Sundman-Engberg, E. & Bliddal, H., 2014, I: Annals of the Rheumatic Diseases. 73, Suppl. 2, s. 472 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 73
Udgave nummer Suppl. 2
Sider (fra-til) 472
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2014

Manglende evidens for medicinsk behandling af ammeinsufficiens

Axelsson, P. B., Bjerrum, F. & Løkkegaard, E. C. L., 24 feb. 2014, I: Ugeskrift for Laeger. 176, 9A, s. V06130415

Publikation: Bidrag til tidsskriftReviewpeer review

Murine solid tumours as a novel model to study bacterial biofilm formation in vivo

Pawar, V., Crull, K., Komor, U., Kasnitz, N., Frahm, M., Kocijancic, D., Westphal, K., Leschner, S., Wolf, K., Loessner, H., Rohde, M., Häussler, S. & Weiss, S., aug. 2014, I: Journal of Internal Medicine. 276, 2, s. 130-9 10 s.

Publikation: Bidrag til tidsskriftReviewpeer review

Nanoscaled biological gated field effect transistors for cytogenetic analysis

Kwasny, D., Dimaki, M., Andersen, K. B., Zulfiqar, A., Tumer, Z. & Svendsen, W. E., 23 sep. 2014, 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014. Institute of Electrical and Electronics Engineers Inc., s. 130-134 5 s. 6908775. (9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014).

Publikation: Bidrag til bog/antologi/rapportKonferencebidrag i proceedingsForskningpeer review

Neonatal hepatitis as first manifestation of hyperimmunoglobulinemia d syndrome

von Linstow, M-L. & Rosenfeldt, V., 2014, I: Case Reports in Pediatrics. 2014, s. 936890

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Novel circulating microRNA signature as a potential non-invasive multi-marker test in ER-positive early-stage breast cancer: a case control study

Kodahl, A. R., Lyng, M. B., Binder, H., Cold, S., Gravgaard, K., Knoop, A. S. & Ditzel, H. J., jul. 2014, I: Molecular Oncology. 8, 5, s. 874-83 10 s.

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One fourth of acutely admitted patients use over-the-counter-drugs 24 hours prior to hospitalization

Pedersen, M. & Brabrand, M., feb. 2014, I: Ugeskrift for Laeger. 176, 4, s. 345 1 s.

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review

Bliddal, H., Leeds, A. R. & Christensen, R., jul. 2014, I: Obesity reviews : an official journal of the International Association for the Study of Obesity. 15, 7, s. 578-86 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Obesity is widely acknowledged as a risk factor for both the incidence and progression of osteoarthritis, and has a negative influence on outcomes. Loss of at least 10% of body weight, coupled with exercise, is recognized as a cornerstone in the management of obese patients with osteoarthritis, and can lead to significant improvement in symptoms, pain relief, physical function and health-related quality of life. However, questions still remain surrounding optimal management. Given the significant health, social and economic burden of osteoarthritis, especially in obese patients, it is imperative to advance our knowledge of osteoarthritis and obesity, and apply this to improving care and outcomes. This paper overviews what is already known about osteoarthritis and obesity, discusses current key challenges and ongoing hypotheses arising from research in these areas, and finally, postulates what the future may hold in terms of new horizons for obese patients with osteoarthritis.

Originalsprog Engelsk
Tidsskrift Obesity reviews : an official journal of the International Association for the Study of Obesity
Vol/bind 15
Udgave nummer 7
Sider (fra-til) 578-86
Antal sider 9
ISSN 1467-7881
DOI
Status Udgivet - jul. 2014

Outcomes of fenestrated endovascular repair of juxtarenal aortic aneurysm

Kristmundsson, T., Sonesson, B., Dias, N., Törnqvist, P., Malina, M. & Resch, T., jan. 2014, I: Journal of Vascular Surgery. 59, 1, s. 115-20 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Patients' preferences for subcutaneous trastuzumab versus conventional intravenous infusion for the adjuvant treatment of HER2-positive early breast cancer: final analysis of 488 patients in the international, randomized, two-cohort PrefHer study

Pivot, X., Gligorov, J., Müller, V., Curigliano, G., Knoop, A., Verma, S., Jenkins, V., Scotto, N., Osborne, S., Fallowfield, L. & PrefHer Study Group, okt. 2014, I: Annals of Oncology. 25, 10, s. 1979-1987 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Pneumococcal disease seasonality: incidence, severity and the role of influenza activity

Weinberger, D. M., Harboe, Z. B., Viboud, C., Krause, T. G., Miller, M., Mølbak, K. & Konradsen, H. B., mar. 2014, I: European Respiratory Journal. Supplement. 43, 3, s. 833-41 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort

Bank, S., Skytt Andersen, P., Burisch, J., Pedersen, N., Roug, S., Galsgaard, J., Turino, S. Y., Broder Brodersen, J., Rashid, S., Kaiser Rasmussen, B., Avlund, S., Bastholm Olesen, T., Jürgen Hoffmann, H., Kragh Thomsen, M., Ostergaard Thomsen, V., Frydenberg, M., Andersen Nexø, B., Sode, J., Vogel, U. & Andersen, V., 2014, I: P L o S One. 9, 6, s. e98815

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), result from the combined effects of susceptibility genes and environmental factors. Polymorphisms in genes regulating inflammation may explain part of the genetic heritage.

METHODS: Using a candidate gene approach, 39 mainly functional single nucleotide polymorphisms (SNPs) in 26 genes regulating inflammation were assessed in a clinical homogeneous group of severely diseased patients consisting of 624 patients with CD, 411 patients with UC and 795 controls. The results were analysed using logistic regression.

RESULTS: Sixteen polymorphisms in 13 genes involved in regulation of inflammation were associated with risk of CD and/or UC (p≤0.05). The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC. When including all patients (IBD) the polymorphisms TLR2 (rs4696480 and rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs187084), TNFRSF1A (rs4149570), IL6R (rs4537545), IL10 (rs3024505), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk. After Bonferroni correction for multiple testing, both the homozygous and the heterozygous variant genotypes of IL23R G>A(rs11209026) (ORCD,adj: 0.38, 95% CI: 0.21-0.67, p = 0.03; ORIBD,adj 0.43, 95% CI: 0.28-0.67, p = 0.007) and PTPN22 1858 G>A(rs2476601) (ORCD,unadj 0.54, 95% CI: 0.41-0.72, p = 7*10-4; ORIBD,unadj: 0.61, 95% CI: 0.48-0.77, p = 0.001) were associated with reduced risk of CD.

CONCLUSION: The biological effects of the studied polymorphisms suggest that genetically determined high inflammatory response was associated with increased risk of CD. The many SNPs found in TLRs suggest that the host microbial composition or environmental factors in the gut are involved in risk of IBD in genetically susceptible individuals.

Originalsprog Engelsk
Tidsskrift P L o S One
Vol/bind 9
Udgave nummer 6
Sider (fra-til) e98815
ISSN 1932-6203
DOI
Status Udgivet - 2014

Postoperative effects of neuromuscular exercise prior to hip or knee arthroplasty: a randomised controlled trial

Villadsen, A., Overgaard, S., Holsgaard-Larsen, A., Christensen, R. & Roos, E. M., jun. 2014, I: Annals of the Rheumatic Diseases. 73, 6, s. 1130-7 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: To investigate the postoperative efficacy of a supervised programme of neuromuscular exercise prior to hip or knee arthroplasty.

METHODS: In this assessor-blinded randomised controlled trial, we included 165 patients scheduled for hip or knee arthroplasty due to severe osteoarthritis (OA). An 8-week preoperative neuromuscular supervised exercise programme was delivered twice a week for 1 h as adjunct treatment to the standard arthroplasty procedure and compared with the standard arthroplasty procedure alone. The primary outcome was self-reported physical function measured on the activities of daily living (ADL) subscale in the Hip disability and Osteoarthritis Outcome Score (HOOS) and the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaires for patients with hip and knee OA, respectively. Primary endpoint was 3 months after surgery.

RESULTS: 165 patients randomised to the two groups were on average 67±8 years, 84 (51%) had hip OA and 92 (56%) were women. 153 patients (93%) underwent planned surgery and were evaluated postoperatively. There was no statistically significant difference in effects between hip or knee patients (p=0.7370). Three months postoperatively, no difference was found between groups for ADL (4.4, 95% CI -0.8 to 9.5) or pain (4.5, 95% CI -0.8 to 9.9). However, there was a statistically significant difference indicating an effect of exercise over the entire period (baseline to 3-months postoperatively) (p=0.0029).

CONCLUSIONS: Eight weeks of supervised neuromuscular exercise prior to total joint arthroplasty (TJA) of the hip or knee did not confer additional benefits 3 months postoperatively compared with TJA alone. However, the intervention group experienced a statistically significant short-term benefit in ADL and pain, suggesting an earlier onset of postoperative recovery.

TRIAL REGISTRATION: ClinicalTrials NCT01003756.

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 73
Udgave nummer 6
Sider (fra-til) 1130-7
Antal sider 8
ISSN 0003-4967
DOI
Status Udgivet - jun. 2014

Preferences of patients and health professionals for route and frequency of administration of biologic agents in the treatment of rheumatoid arthritis

Huynh, T. K., Ostergaard, A., Egsmose, C. & Madsen, O. R., 2014, I: Patient Preference and Adherence. 8, s. 93-9 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To examine the preferences of rheumatoid arthritis (RA) patients and health professionals (HPs) for the route and frequency of administration of biologic drugs.
Originalsprog Engelsk
Tidsskrift Patient Preference and Adherence
Vol/bind 8
Sider (fra-til) 93-9
Antal sider 7
ISSN 1177-889X
DOI
Status Udgivet - 2014

Psychometric evaluation of the Danish version of Satisfaction with Daily Occupations (SDO)

Eklund, M. & Morville, A-L., maj 2014, I: Scandinavian Journal of Occupational Therapy. 21, 3, s. 166-71 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

AIMS: The Satisfaction with Daily Occupations (SDO) scale assesses satisfaction within the domains of work, leisure, domestic tasks, and self-care. The aim was to investigate the psychometric properties of the Danish version of the SDO when used with asylum seekers.

METHODS: The participants were 93 Danes without known ill health and 43 asylum seekers. They completed the SDO and rated their perceived health, activity level, and general satisfaction with daily occupations. Translation into Danish and back-translation into Swedish was made by professional interpreters.

RESULTS: Internal consistency was α = 0.75 for the Danish sample and α = 0.79 for the asylum seekers. The SDO distinguished between asylum seekers and the Danish sample, suggesting criterion validity. Concurrent validity, analysed against general satisfaction with daily occupations, was indicated for both samples. Discriminant validity was indicated against self-rated health for both samples and against activity level for the Danish sample. There was, however, a correlation of 0.65 between the SDO satisfaction score and activity level for the asylum seekers.

CONCLUSION: The SDO exhibited satisfactory internal consistency and criterion and concurrent validity. The findings regarding discriminant validity were somewhat inconclusive. The Danish SDO may be regarded as psychometrically sound but further psychometric testing is needed.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Occupational Therapy
Vol/bind 21
Udgave nummer 3
Sider (fra-til) 166-71
Antal sider 6
ISSN 1103-8128
DOI
Status Udgivet - maj 2014

Quick diagnostic unit integrated in an emergency department setting reduces medical admissions – an observational study

Petersen, D. B. & Schmidt, T. A., 2014, I: Journal of Hospital administration. 3, 3, 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Response to Hitman. Insulin degludec: a new insulin for today?

Schmidt, T. A., mar. 2014, I: Diabetic medicine : a journal of the British Diabetic Association. 31, 3, s. 377-8 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

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