Backer, V., Ulrik, C. S., Wendelboe, D., Bach-Mortensen, N., Hansen, K. K., Laursen, E. M. & Dirksen, A., okt. 1992, I: Allergy. 47, 5, s. 484-9 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Jacobsen, S. & Danneskiold-Samsøe, B., feb. 1992, I: Archives of Physical Medicine and Rehabilitation. 73, 2, s. 170-3 4 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Archives of Physical Medicine and Rehabilitation |
| Vol/bind | 73 |
| Udgave nummer | 2 |
| Sider (fra-til) | 170-3 |
| Antal sider | 4 |
| ISSN | 0003-9993 |
| Status | Udgivet - feb. 1992 |
Gideon, P., Henriksen, O., Sperling, B., Christiansen, P., Olsen, T. S., Jørgensen, H. S. & Arlien-Søborg, P. nov 1992 I : Stroke; a journal of cerebral circulation. 23, 11, s. 1566-72 7 s.
Publikation: Forskning - peer review › Tidsskriftartikel
BACKGROUND AND PURPOSE: The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy.
METHODS: Eight patients with acute stroke were studied serially in the acute phase, 1 week after, and 2-4 weeks after the onset of clinical symptoms. Ten healthy volunteers served as controls. A stimulated echo (STEAM) sequence was used for measurement of the brain metabolites in a volume of interest located within the infarcted area as visualized by magnetic resonance imaging. For quantification, the unsaturated water signal was used as the internal standard. Regional cerebral blood flow in the infarcted area was measured relative to a symmetrically located unaffected area by means of single-photon emission computed tomographic scanning, using 99mTc-labeled d,l-hexamethylenepropyleneamine oxime as the flow tracer.
RESULTS: Relative regional cerebral blood flow was considerably reduced in the infarcted area in the acute phase. After 1 week, hyperemia was seen in all but one patient. The N-acetylaspartate content was significantly reduced, with the loss appearing to occur between 6 and 24 hours after the stroke incident. The reduction in N-acetylaspartate content was greater in the central part than in the peripheral part of the infarcted area. Creatine and phosphocreatine were also reduced in the infarcted area, whereas no significant change was seen in the choline content.
CONCLUSIONS: Assuming that N-acetylaspartate content reflects neuronal survival or loss, our results may suggest that treatment procedures with restoration of blood flow to severely ischemic areas should be initiated within the first 6 hours after stroke onset.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Stroke; a journal of cerebral circulation |
| Udgivelsesdato | nov 1992 |
| Vol/bind | 23 |
| Tidsskriftsnummer | 11 |
| Sider | 1566-72 |
| Antal sider | 7 |
| ISSN | 0039-2499 |
| Status | Udgivet |
Gideon, P., Henriksen, O., Sperling, B., Christiansen, P., Olsen, T. S., Jørgensen, H. S. & Arlien-Søborg, P. nov 1992 I : Stroke. 23, 11, s. 1566-1572 7 s.
Publikation: Forskning - peer review › Tidsskriftartikel
BACKGROUND AND PURPOSE: The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy.
METHODS: Eight patients with acute stroke were studied serially in the acute phase, 1 week after, and 2-4 weeks after the onset of clinical symptoms. Ten healthy volunteers served as controls. A stimulated echo (STEAM) sequence was used for measurement of the brain metabolites in a volume of interest located within the infarcted area as visualized by magnetic resonance imaging. For quantification, the unsaturated water signal was used as the internal standard. Regional cerebral blood flow in the infarcted area was measured relative to a symmetrically located unaffected area by means of single-photon emission computed tomographic scanning, using 99mTc-labeled d,l-hexamethylenepropyleneamine oxime as the flow tracer.
RESULTS: Relative regional cerebral blood flow was considerably reduced in the infarcted area in the acute phase. After 1 week, hyperemia was seen in all but one patient. The N-acetylaspartate content was significantly reduced, with the loss appearing to occur between 6 and 24 hours after the stroke incident. The reduction in N-acetylaspartate content was greater in the central part than in the peripheral part of the infarcted area. Creatine and phosphocreatine were also reduced in the infarcted area, whereas no significant change was seen in the choline content.
CONCLUSIONS: Assuming that N-acetylaspartate content reflects neuronal survival or loss, our results may suggest that treatment procedures with restoration of blood flow to severely ischemic areas should be initiated within the first 6 hours after stroke onset.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Stroke |
| Udgivelsesdato | nov 1992 |
| Vol/bind | 23 |
| Tidsskriftsnummer | 11 |
| Sider | 1566-1572 |
| Antal sider | 7 |
| ISSN | 0039-2499 |
| Status | Udgivet |
Prescott, E., Nørrgård, J., Rotbøl Pedersen, L. & Danneskiold-Samsøe, B., 1992, I: Scandinavian Journal of Rheumatology. 21, 4, s. 206
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Scandinavian Journal of Rheumatology |
| Vol/bind | 21 |
| Udgave nummer | 4 |
| Sider (fra-til) | 206 |
| ISSN | 0300-9742 |
| Status | Udgivet - 1992 |
Felding, C., Jensen, L. M. & Tønnesen, H., 1992, I: American Journal of Obstetrics and Gynecology. 166
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | American Journal of Obstetrics and Gynecology |
| Vol/bind | 166 |
| ISSN | 0002-9378 |
| Status | Udgivet - 1992 |
Tønnesen, H., 1992, I: Acta Psychiatrica Scandinavica. 369
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Acta Psychiatrica Scandinavica |
| Vol/bind | 369 |
| ISSN | 0001-690X |
| Status | Udgivet - 1992 |
Ulrik, C. S., Backer, V. & Dirksen, A., 1992, I: The Journal of asthma : official journal of the Association for the Care of Asthma. 29, 1, s. 29-38 10 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Allen, P. D., Schmidt, T. A., Marsh, J. D. & Kjeldsen, K., 1992, I: Basic Research in Cardiology. 87 Suppl 1, s. 87-94 8 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Kjaer, S. K., aug. 1992, I: Current Opinion in Obstetrics & Gynecology. 4, 4, s. 586-93 8 s.
Publikation: Bidrag til tidsskrift › Review › peer review
Schmidt, T. A., Larsen, J. S. & Kjeldsen, K., dec. 1992, I: Journal of Neurochemistry. 59, 6, s. 2094-104 11 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Ulrik, C. S., Backer, V., Aldershvile, J. & Pietersen, A. H., jun. 1992, I: American Heart Journal. 123, 6, s. 1550-4 5 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Raben, A., Kiens, B., Richter, E. A., Rasmussen, L. B., Svenstrup, B., Micic, S. & Bennett, P., nov. 1992, I: Medicine and Science in Sports and Exercise. 24, 11, s. 1290-7 8 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Serum sex hormones and endurance performance after a lacto-ovo vegetarian and a mixed diet. Med. Sci. Sports Exerc., Vol. 24, No. 11, pp. 1290-1297, 1992. The effect of a lacto-ovo vegetarian (V) and a mixed, meat-rich (M) diet on the level of serum sex hormones, gonadotropins, and endurance performance of eight male endurance athletes was investigated in a 2 x 6 wk cross-over study. The energy contribution from carbohydrate, fat, and protein was 58%, 27%, and 15% on the V diet and 58%, 28%, and 14 E% on the M diet. For total fasting serum testosterone (T) there was a significant interaction between diet and time (P < 0.01). Thus, the V diet resulted in a lower total T level (13.7, 9.8-32.4 nmol.l-1) (median and range) compared with the M diet (17.4, 11.8-33.5 nmol.l-1). During exercise after 6 wk on the diets total T was also significantly lower on the V than on the M diet (P < 0.05). Serum free testosterone, however, did not differ significantly during the 6 wk dietary intervention periods and neither did serum concentrations of sex hormone binding globulin, dihydrotestosterone, dehydroepiandrosterone sulphate, 4-androstenedione, estrone, estradiol, estrone sulphate, or gonadotropins. Endurance performance time was higher for six and lower for two after the mixed diet compared with the vegetarian diet. This was not significant, however. In conclusion, 6 wk on a lacto-ovo vegetarian diet caused a minor decrease in total testosterone and no significant changes in physical performance in male endurance athletes compared with 6 wk on a mixed, meatrich diet.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Medicine and Science in Sports and Exercise |
| Vol/bind | 24 |
| Udgave nummer | 11 |
| Sider (fra-til) | 1290-7 |
| Antal sider | 8 |
| ISSN | 0195-9131 |
| Status | Udgivet - nov. 1992 |
Ahring, K. K., Ahring, J. P., Joyce, C. & Farid, N. R., aug. 1992, I: Diabetes Care. 15, 8, s. 971-5 5 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Sonne, N. M. & Tønnesen, H., 1992, I: British Journal of Neurosurgery. 6
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
| Originalsprog | Dansk |
|---|---|
| Tidsskrift | British Journal of Neurosurgery |
| Vol/bind | 6 |
| ISSN | 0268-8697 |
| Status | Udgivet - 1992 |
Backer, V., Nybo Jensen, B., Pedersen, C., Hertz, J. B. & Jensen, T. H., 1992, I: Scandinavian Journal of Infectious Diseases. 24, 1, s. 29-34 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Nielsen, H. W., Samuelsson, I. S., Kjaer, S. K., Christoffersen, M. H., Brix, P. & Hein, H. S., 22 apr. 1991, I: Ugeskrift for Laeger. 153, 17, s. 1189-93 5 s.
Publikation: Bidrag til tidsskrift › Review › peer review
Kjaer, S. K., de Villiers, E. M., Dahl, C., Engholm, G., Bock, J. E., Vestergaard, B. F., Lynge, E. & Jensen, O. M., 22 apr. 1991, I: International Journal of Cancer. 48, 1, s. 39-44 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Kjaer, S. K., Svare, E. I., Haugaard, B. J., Teisen, C., Christensen, R. B., Lynge, E. & Jensen, O. M., mar. 1991, I: Scandinavian journal of social medicine. 19, 1, s. 39-43 5 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
MØLVIG, J., POCIOT, F., WORSAAE, H., WOGENSEN, L. D., BAEK, L., CHRISTENSEN, P., MANDRUP‐POULSEN, T., ANDERSEN, K., MADSEN, P., DYERBERG, J. & NERUP, J., 1 jan. 1991, I: Scandinavian Journal of Immunology. 34, 4, s. 399-410 12 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
The effects of dietary supplementation with ω‐3‐polyunsaturated fatty acids (ω‐3‐PUFA) on the proliferative response of PBMC and on the secretion of monokines and arachidonic acid metabolites from PBMC and monocytes (Mo) from healthy subjects and patients with recent‐onset insulin‐dependent diabetes mellitus (IDDM) were examined. Three groups of eight to nine healthy individuals were randomized to either 2.0 g/day or 4.0 g/day of ω‐3‐PUFA devoid of vitamins A and D, or an isocaloric amount of placebo. Furthermore, eight patients with recent‐onset IDDM received 4.0 g/day of ω‐3‐PUFA. IL‐lβ production and TNF‐α secretion was determined before and after 7 weeks of treatment, and 10 weeks after withdrawal of treatment. Significant increases in platelet and PBMC membrane eicosapentaenoic acid was found in ω‐3‐PUFA‐treated individuals. ω‐3‐PUFA treatment significantly reduced the content of IL‐Ib in lysates of PBMC, but did not affect PBMC or Mo secretion of IL‐1β, TNF‐α or prostaglandin E2 (PGE2) or PBMC leukotriene B4 (LTB4) secretion in healthy subjects or in IDDM patients. A significant inhibition of the PHA‐stimulated. but not the spontaneous or PPD‐stimulated, proliferative response of PBMC was observed in healthy and diabetic subjects treated with (o‐3‐PUFA. No correlation was found between PHA‐stimulated PBMC proliferation and PBMC secretion of TNF‐α and IL‐1β. There were no significant differences in the spontaneous or the PPD‐or PHA‐stimulated proliferative responses of PBMC between diabetic and healthy individuals at entry. We conclude that although dietary supplementation with 4.0 g/day of ω‐3‐PUFA inhibits the proliferation of PBMC and reduces IL‐I immunoreactivity in PBMC and Mo, it does not alter monokine, PGE2 or LTB4, secretion in healthy or IDDM subjects.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Scandinavian Journal of Immunology |
| Vol/bind | 34 |
| Udgave nummer | 4 |
| Sider (fra-til) | 399-410 |
| Antal sider | 12 |
| ISSN | 0300-9475 |
| DOI | |
| Status | Udgivet - 1 jan. 1991 |