Published in 2009

The Bath metrology index as assessed by a trained and an untrained rater in patients with spondylarthropathy: a study of intra- and inter-rater agreements

Madsen, O. R., Hansen, L. B., Rytter, A., Suetta, C. & Egsmose, C., jan. 2009, I: Clinical Rheumatology. 28, 1, s. 35-40 6 s.

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The Bath ankylosing spondylitis metrology index (BASMI; range 0-10) has gained widespread use in daily clinical practice as an objective measure of spinal stiffness not only in patients with ankylosing spondylitis (AS) but also in patients with other spondylarthropathies (SpA). We examined intra-rater and inter-rater reproducibility of BASMI scoring in 30 Danish patients with SpA (median age 40 years, range 22-56 years) fulfilling the European Spondylarthropathy Study Group criteria, 25 of them satisfying the modified New York Criteria for AS. Measurements were performed twice on two different days (median interval 7 days, range 4-11) by a trained physiotherapist (PT) and by an untrained nurse who had undergone a single 1-h training session with the PT. The median BASMI score obtained by the PT on the two test days was 3.5 (range 1-8) and 3.0 (range 1-8), respectively (NS). Test-retest BASMI scores from the PT were significantly correlated (r(s) = 0.95, p < 0.0001). The 95% likely range for the difference between a patient's BASMI scores from two tests was +/-1.4 corresponding to a minimal detectable difference of +/-2 in the individual patient as the scale consists of intervals of 1. Similar results were achieved by the nurse. BASMI scores obtained by the two raters were significantly inter-correlated (r(s) = 0.95, p < 0.0001). The mean difference between paired BASMI scores obtained by the nurse and the PT on test day 1 was -0.2 with a minimal detectable difference of +/-2. A similar result was found using data from test day 2. In conclusion, a change in BASMI less than 2 may be due solely to expected random measurement error. A single 1-h training session allowed an untrained nurse to obtain BASMI results almost identical to those of an experienced PT.

Originalsprog Engelsk
Tidsskrift Clinical Rheumatology
Vol/bind 28
Udgave nummer 1
Sider (fra-til) 35-40
Antal sider 6
ISSN 0770-3198
DOI
Status Udgivet - jan. 2009

The efficacy of a smoking cessation programme in patients undergoing elective surgery: a randomised clinical trial

Sadr Azodi, O., Lindström, D., Adami, J., Tønnesen, H., Nåsell, H., Gilljam, H. & Wladis, A., 2009, I: Anaesthesia. 64

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Originalsprog Engelsk
Tidsskrift Anaesthesia
Vol/bind 64
ISSN 0003-2409
Status Udgivet - 2009

Toxic hepatitis induced by infliximab in a patient with rheumatoid arthritis with no relapse after switching to etanercept

Carlsen, K. M., Riis, L. & Madsen, O. R., 1 aug. 2009, I: Clinical Rheumatology. 28, 8, s. 1001-3 3 s.

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We present a case of toxic hepatitis related to infliximab treatment in a 38-year-old woman with rheumatoid arthritis (RA). The patient had previously been treated with different disease-modifying drugs (DMARDs) alone or in combination but had never revealed signs of liver dysfunction. Due to high disease activity, treatment with infliximab (3 mg/kg i.v.) was initiated in combination with methotrexate (MTX) (25 mg/week) and folic acid (5 mg/week). The patient stopped MTX and folic acid on her own initiative after 3 weeks due to improvement of joint symptoms. After seven infusions, progressive elevations of the transaminases up to five times the upper normal limit were noted and treatment with infliximab was terminated. Serological tests for viral and autoimmune hepatitis and for ANA and anti-dsDNA were all negative. Specific infliximab antibodies could not be detected. Ultrasound of the liver was normal. Liver biopsy showed late signs of acute toxic hepatitis without MTX-related fibrosis. This is one the first cases that convincingly demonstrates that infliximab treatment may cause toxic hepatitis. Moreover, the case suggests a lack of hepatic cross-toxicity between infliximab and etanercept as the patient continued with etanercept without new episodes of liver dysfunction.
Originalsprog Engelsk
Tidsskrift Clinical Rheumatology
Vol/bind 28
Udgave nummer 8
Sider (fra-til) 1001-3
Antal sider 3
ISSN 0770-3198
DOI
Status Udgivet - 1 aug. 2009

OBJECTIVE: Colour Doppler ultrasound (CDU) displays blood flow in the tissues and is able to detect hyperaemia. Because hyperaemia is part of the inflammatory response, the amount of CDU activity in the inflamed synovium may be used to quantify the inflammatory activity in RA. It has never been investigated if the amount of CDU activity in a single joint can be used to quantify disease activity in RA.

METHODS: A total of 109 patients with RA and affection of the wrist joint underwent a standardized CDU examination assessing three positions in their most affected wrist at start up in biological treatment. On the same day the following measures of disease activity were collected: assessment of the number of tender and swollen joints, CRP, ESR and 28-joint disease activity score (DAS28). The amount of CDU activity was quantified by measuring the percentage of colour in the synovium--the colour fraction (CF). Correlation between CF and other measures of disease activity was calculated.

RESULTS: There was a significant correlation between CF and DAS28 (r = 0.29; P < 0.001), swollen joint count (r = 0.35; P < 0.001), CRP (r = 0.5; P < 0.001) and ESR (r = 0.5; P < 0.001). No other significant correlations were found.

CONCLUSION: A standardized ultrasound examination of a single affected wrist joint in patients with RA may be used as a measure of disease activity. More studies are needed to identify the number of joints needed to examine by CDU to obtain the best validity of Doppler measurements.

Originalsprog Engelsk
Tidsskrift Rheumatology
Vol/bind 48
Udgave nummer 3
Sider (fra-til) 254-7
Antal sider 4
ISSN 1462-0324
DOI
Status Udgivet - 2009

Published in 2008

Acute energy restriction triggers Wallerian degeneration in mouse

Alvarez, S., Moldovan, M. & Krarup, C., jul. 2008, I: Experimental Neurology. 212, 1, s. 166-78 13 s.

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Airway responses to eucapnic hyperpnea, exercise, and methacholine in elite swimmers

Pedersen, L., Winther, S., Backer, V., Anderson, S. D. & Larsen, K. R., sep. 2008, I: Medicine and Science in Sports and Exercise. 40, 9, s. 1567-72 6 s.

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Airway responsiveness and inflammation in adolescent elite swimmers

Pedersen, L., Lund, T. K., Barnes, P. J., Kharitonov, S. A. & Backer, V., aug. 2008, I: The Journal of allergy and clinical immunology. 122, 2, s. 322-7, 327.e1

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Anterior cervical discectomy with or without fusion with ray titanium cage: a prospective randomized clinical study

Hauerberg, J., Kosteljanetz, M., Bøge-Rasmussen, T., Dons, K., Gideon, P., Springborg, J. B. & Wagner, A., 1 mar. 2008, I: Spine. 33, 5, s. 458-64 7 s.

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Arvelig Parkinsons sygdom. Dansk Selskab for Bevaegeforstyrrelser

Hjermind, L. E., Nielsen, J. E. & Dansk Selskab for Bevaegeforstyrrelser, 17 mar. 2008, I: Ugeskrift for Laeger. 170, 12, s. 1016

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Basale journaloplysninger om risikofaktorer. Underernaering, overvaegt, fysisk inaktivitet, rygning og alkohol

Tønnesen, H., Roswall, N., Odgaard, M. D., Pedersen, K. M., Larsen, K. L., Mathiassen, B., Farlie, R., Elbirk, A., Hüttel, M., Danborg, L., Vestermark, V., Petri, A. L., Ebbehøj, N., Frederiksen, M. & Hejgaard, T., 12 maj 2008, I: Ugeskrift for Laeger. 170, 20, s. 1747-52 6 s.

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Lifestyle factors are important for clinical outcome. Systematic and early identification of these factors is important in order to offer relevant lifestyle intervention programmes. The objective was to evaluate whether basic registration of risk factors was understandable, applicable and sufficient in the clinical workday.
Bidragets oversatte titel [Basic registration of risk factors in medical records. Malnutrition, overweight, physical inactivity, smoking and alcohol]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 170
Udgave nummer 20
Sider (fra-til) 1747-52
Antal sider 6
Status Udgivet - 12 maj 2008

Behandling af aquagen pruritus ved polycytaemia vera med paroxetin--en selektiv serotoningenoptagelseshaemmer

Kümler, T., Hedlund, D., Hast, R. & Hasselbalch, H. C., 15 sep. 2008, I: Ugeskrift for Laeger. 170, 38, s. 2981

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Costs and quality of life for prehabilitation and early rehabilitation after surgery of the lumbar spine

Nielsen, P. R., Andreasen, J. H., Asmussen, M. & Tønnesen, H., 1 jan. 2008, I: B M C Health Services Research. 8, s. 209

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During the recent years improved operation techniques and administrative procedures have been developed for early rehabilitation. At the same time preoperative lifestyle intervention (prehabilitation) has revealed a large potential for additional risk reduction. The aim was to assess the quality of life and to estimate the cost-effectiveness of standard care versus an integrated programme including prehabilitation and early rehabilitation.
Originalsprog Engelsk
Tidsskrift B M C Health Services Research
Vol/bind 8
Sider (fra-til) 209
ISSN 1472-6963
DOI
Status Udgivet - 1 jan. 2008

Dynamic adaptation of tendon and muscle connective tissue to mechanical loading

Mackey, A. L., Heinemeier, K. M., Koskinen, S. O. A. & Kjaer, M., 2008, I: Connective Tissue Research. 49, 3, s. 165-8 4 s.

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Early interim PET scan in Hodgkin lymphoma: where do we stand?

Gallamini, A., Hutchings, M., Avigdor, A. & Polliack, A., apr. 2008, I: Leukemia and Lymphoma. 49, 4, s. 659-62 4 s.

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Effects of a perioperative smoking cessation intervention on postoperative complications: a randomized trial

Lindström, D., Sadr Azodi, O., Wladis, A., Tønnesen, H., Linder, S., Nåsell, H., Ponzer, S. & Adami, J., 1 nov. 2008, I: Annals of Surgery. 248, 5, s. 739-45 7 s.

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To determine whether an intervention with smoking cessation starting 4 weeks before general and orthopedic surgery would reduce the frequency of postoperative complications.
Originalsprog Engelsk
Tidsskrift Annals of Surgery
Vol/bind 248
Udgave nummer 5
Sider (fra-til) 739-45
Antal sider 7
ISSN 0003-4932
DOI
Status Udgivet - 1 nov. 2008

Graft rejection after hematopoietic cell transplantation with nonmyeloablative conditioning

Masmas, T. N., Petersen, S. L., Madsen, H. O., Ryder, L. P., Kornblit, B., Svejgaard, A., Andersen, P., Dickmeiss, E. & Vindeløv, L. L., jul. 2008, I: American Journal of Hematology. 83, 7, s. 563-9 7 s.

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Health service interventions targeting relatives of heart patients: a review of the literature

Nissen, N. K., Madsen, M. & Olsen Zwisler, A-D., nov. 2008, I: Scandinavian Journal of Public Health. Supplement. 36, 8, s. 818-26 9 s.

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Hybrid recanalization of superior mesenteric artery occlusion in acute mesenteric ischemia

Sonesson, B., Hinchliffe, R. J., Dias, N. V., Resch, T. A., Malina, M. & Ivancev, K., feb. 2008, I: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists. 15, 1, s. 129-32 4 s.

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