The Parker Institute

Published in 2014

Validity and reliability of 3D US for the detection of erosions in patients with rheumatoid arthritis using MRI as the gold standard

Ellegaard, K., Bliddal, H., Møller Døhn, U., Henriksen, M., Boesen, M., Bouert, R., Danneskiold-Samsøe, B. & Torp-Pedersen, S., apr. 2014, I: Ultraschall in der Medizin. 35, 2, s. 137-41 5 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

PURPOSE: To test the reliability and validity of a 3D US erosion score in RA using MRI as the gold standard.

MATERIALS AND METHODS: RA patients were examined with 3D US and 3 T MRI over the 2nd and 3rd metacarpophalangeal joints. 3D blocks were evaluated by two investigators. The erosions were estimated according to a semi-quantitative score (SQS) (0 - 3) and a quantitative score (QS) (mm²). MRI was evaluated according to the RAMRIS score. For the estimation of reliability, intra-class correlation coefficients (ICC) were used. Validity was tested using Spearman's rho (rs). The sensitivity and specificity were also calculated.

RESULTS: 28 patients with RA were included. The ICC for the inter-observer reliability in the QS was 0.41 and 0.13 for the metacarpal bone and phalangeal bone, respectively, and 0.86 and 0.16, respectively, in the SQS. The ICC for the intra-observer reliability in the QS was 0.75 and 0.48 for the metacarpal bone and phalangeal bone, respectively, and 0.83 and 0.60, respectively, in the SQS. The correlation with MRI for the metacarpal bone was significant, with values of 0.73 (p = 0.0001) (SQ) and 0.74 (p = 0.0001) (SQS). For the phalangeal bone, bad correlation was found: 0.28 (p = 0.145) (SQ) and 0.26 (p = 0.57) (SQS). The sensitivity and specificity for the metacarpal bone were 86 % and 85 % respectively. For the phalangeal bone they were 60 % and 97 %, respectively.

CONCLUSION: Good inter- and intra-observer reliability and correlation with MRI were seen in the assessment of erosions with 3D US in the metacarpal bone, while the results were low and insignificant for the phalangeal bone, indicating that 3D US still has room for improvement.

Originalsprog	Engelsk
Tidsskrift	Ultraschall in der Medizin
Vol/bind	35
Udgave nummer	2
Sider (fra-til)	137-41
Antal sider	5
ISSN	0172-4614
DOI	https://doi.org/10.1055/s-0032-1330348
Status	Udgivet - apr. 2014

Which factors influence radiographic progression during treatment with tumor necrosis factor inhibitors in clinical practice? Results from 930 patients with rheumatoid arthritis in the nationwide Danish DANBIO registry

Ørnbjerg, L. M., Østergaard, M., Bøyesen, P., Krogh, N. S., Thormann, A., Tarp, U., Poulsen, U. E., Espesen, J., Schlemmer, A., Graudal, N., Kollerup, G., Jensen, D. V., Madsen, O. R., Glintborg, B., Christensen, T., Lindegaard, H., Bøhme, W., Hansen, A., Andersen, A. R. & Hetland, M. L., dec. 2014, I: Journal of Rheumatology. 41, 12, s. 2352-60 9 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

OBJECTIVE: To investigate baseline characteristics associated with radiographic progression and the effect of disease activity, drug, switching, and withdrawal on radiographic progression in tumor necrosis factor (TNF) inhibitor-naive patients with rheumatoid arthritis (RA) followed for about 2 years after anti-TNF initiation in clinical practice.

METHODS: DANBIO-registered patients with RA who had available radiographs (anti-TNF initiation and ∼2 yrs followup) were included. Radiographs were scored, blinded to chronology with the Sharp/van der Heijde method and linked with DANBIO data. Baseline characteristics were investigated with univariate regression and significant variables included in a multivariable logistic regression analysis with ± radiographic progression [Δ total Sharp score (TSS) > 0] as dependent variable. Effect of time-averaged C-reactive protein (CRP), 28-joint Disease Activity Score with CRP (DAS28-CRP), and treatment status at followup were investigated with univariate regression analysis.

RESULTS: The study included 930 patients. They were 75% women, 79% positive for IgM-rheumatoid factor (IgM-RF), median age was 57 yrs (range 19-88), disease duration 9 yrs (1-59), DAS28-CRP 5.0 (1.4-7.8), TSS median 15 [3-45 interquartile range (IQR)] and mean 31 (SD 40). Patients started treatment with infliximab (59%), etanercept (18%), or adalimumab (23%). At followup (median 526 days, IQR 392-735), 61% were treated with the initial anti-TNF, 29% had switched TNF inhibitor, and 10% had withdrawn. Twenty-seven percent of patients had progressed radiographically. ΔTSS was median 0.0 [0.0-0.5 IQR/mean 0.6 (SD 2.4)] units/year. Higher TSS, older age, positive IgM-RF, and concomitant prednisolone at baseline were associated with radiographic progression. Time-averaged DAS28-CRP and time-averaged CRP, but not type of TNF inhibitor, were associated with radiographic progression. Patients who stopped/switched during followup progressed more than patients who continued treatment.

CONCLUSION: High TSS, older age, IgM-RF positivity, and concomitant prednisolone were associated with radiographic progression during 2 years of followup of 930 anti-TNF-treated patients with RA in clinical practice. High disease activity and switching/stopping anti-TNF treatment were associated with radiographic progression.

Originalsprog	Engelsk
Tidsskrift	Journal of Rheumatology
Vol/bind	41
Udgave nummer	12
Sider (fra-til)	2352-60
Antal sider	9
ISSN	0315-162X
DOI	https://doi.org/10.3899/jrheum.131299
Status	Udgivet - dec. 2014

Acid-base transport in pancreas-new challenges

Novak, I., Haanes, K. A. & Wang, J., 2013, I: Frontiers in Physiology. 4 DEC, Article 380.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Adherence to methotrexate therapy among patients with rheumatoid arthritis in Denmark: A registry based cohort study

Bliddal, H., Christensen, R. D. K., Østergaard, M., Lorenzen, T., Hansen, M. S., Vestergaard, P. & Eriksen, S. A., 2013, I: Arthritis & Rheumatism. 65, Suppl. 10, s. S451 1 s.

Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning › peer review

Originalsprog	Engelsk
Tidsskrift	Arthritis & Rheumatism
Vol/bind	65
Udgave nummer	Suppl. 10
Sider (fra-til)	S451
Antal sider	1
ISSN	0004-3591
Status	Udgivet - 2013

Agreement between measures of ´walking related knee pain` in knee osteoarthritis: A cross-sectional study

Klokker, L., Christensen, R. D. K., Osborne, R., Aaboe, J., Bliddal, H. & Henriksen, M., 2013, I: OA Musculoskeletal Medicine. 1, 3, s. 1-22 22 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Originalsprog	Engelsk
Tidsskrift	OA Musculoskeletal Medicine
Vol/bind	1
Udgave nummer	3
Sider (fra-til)	1-22
Antal sider	22
Status	Udgivet - 2013

Altered Visual and Feet Proprioceptive Feedbacks during Quiet Standing Increase Postural Sway in Patients with Severe Knee Osteoarthritis

Hirata, R. P., Jørgensen, T. S., Rosager, S., Arendt-Nielsen, L., Bliddal, H., Henriksen, M. & Graven-Nielsen, T., 2013, I: P L o S One. 8, 8, s. e71253

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

The objective was to investigate how postural control in knee osteoarthritis (KOA) patients, with different structural severities and pain levels, is reorganized under different sensory conditions.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	8
Udgave nummer	8
Sider (fra-til)	e71253
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0071253
Status	Udgivet - 2013

Arthroscopic partial meniscectomy in middle-aged patients with mild or no knee osteoarthritis: a protocol for a double-blind, randomized sham-controlled multi-centre trial

Hare, K. B., Lohmander, L. S., Christensen, R. & Roos, E. M., 2013, I: B M C Musculoskeletal Disorders. 14, s. 71

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Arthroscopic partial meniscectomy has been shown to be of no benefit to patients with concomitant knee osteoarthritis, but the optimal treatment of a degenerative meniscus tear in patients with mild or no knee osteoarthritis is unknown. This article describes the rationale and methodology of a randomized sham-controlled trial to assess the benefit of arthroscopic partial meniscectomy of a medial meniscus tear in patients with mild or no knee osteoarthritis. The objective of the study is to test whether the benefit from arthroscopic partial meniscectomy in patients with knee pain, medial meniscus lesion and mild/no knee osteoarthritis, is greater after arthroscopic partial meniscectomy than following sham surgery.

Originalsprog	Engelsk
Tidsskrift	B M C Musculoskeletal Disorders
Vol/bind	14
Sider (fra-til)	71
ISSN	1471-2474
DOI	https://doi.org/10.1186/1471-2474-14-71
Status	Udgivet - 2013

Assessment of pressure-pain thresholds and central sensitization of pain in lateral epicondylalgia

Jespersen, A., Amris, K., Graven-Nielsen, T., Arendt-Nielsen, L., Bartels, E. M., Torp-Pedersen, S., Bliddal, H. & Danneskiold-Samsoe, B., feb. 2013, I: Pain medicine (Malden, Mass.). 14, 2, s. 297-304 8 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

OBJECTIVE.: To assess pain sensitivity and spreading hyperalgesia in lateral epicondylalgia (LE). SUBJECTS.: Twenty-two women with LE, and 38 controls were included. OUTCOME MEASURES.: Computerized cuff pressure algometry was used for assessment of pressure-pain threshold and tolerance. The stimulus was applied using a single (stimulation-area: 241 cm(2) ) or double-chambered (stimulation-area: 482 cm(2) ) tourniquet on the arm and leg. Spatial summation was expressed as the ratio between pressure-pain thresholds to single and double cuff-chamber stimulation. During 10-minute constant pressure stimulation at intensity relative to the individual pain threshold, the pain intensity was continuously recorded using an electronic visual analogue scale (VAS), and from this the degree of temporal summation was estimated. For LE, a Doppler ultrasound examination of the elbow was made to identify inflammation. RESULTS.: In LE compared with controls the pressure-pain threshold and tolerance were on average reduced by respectively 31% (nonsignificant) and 18% (nonsignificant) on the lower arm and by 32% (P

Originalsprog	Engelsk
Tidsskrift	Pain medicine (Malden, Mass.)
Vol/bind	14
Udgave nummer	2
Sider (fra-til)	297-304
Antal sider	8
DOI	https://doi.org/10.1111/pme.12021
Status	Udgivet - feb. 2013

Association between the SVS/AAVS anatomical severity grading score and operative outcomes in fenestrated endovascular repair of juxtarenal aortic aneurysm

Kristmundsson, T., Sonesson, B., Dias, N., Malina, M. & Resch, T., jun. 2013, I: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists. 20, 3, s. 356-65 10 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Authors' response

Krogh, T. P., Fredberg, U., Stengaard-Pedersen, K., Christensen, R., Jensen, P. & Ellingsen, T., jul. 2013, I: The American journal of sports medicine. 41, 7, s. NP34-5

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Originalsprog	Engelsk
Tidsskrift	The American journal of sports medicine
Vol/bind	41
Udgave nummer	7
Sider (fra-til)	NP34-5
ISSN	0363-5465
Status	Udgivet - jul. 2013

Beyond access to medicines: Eliciting high-income country support for a new global health research and development paradigm

Regmi, S., Kaas-Hansen, B. S. & Iversen, J. H., dec. 2013, I: Journal of global health. 3, 2, s. 020303

Publikation: Bidrag til tidsskrift › Review › peer review

Body mass index and stroke: overweight and obesity less often associated with stroke recurrence

Andersen, K. K. & Olsen, T. S., nov. 2013, I: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 22, 8, s. e576-81

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Although obesity is associated with excess mortality and morbidity, mortality is lower in obese than in normal weight stroke patients (the obesity paradox). Studies now indicate that obesity is not associated with increased risk of recurrent stroke in the years after first stroke. We studied the association between body mass index (BMI) and stroke patient's risk of having a history of previous stroke (recurrent stroke).

Originalsprog	Engelsk
Tidsskrift	Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Vol/bind	22
Udgave nummer	8
Sider (fra-til)	e576-81
ISSN	1052-3057
DOI	https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.06.031
Status	Udgivet - nov. 2013

Can hospitals and health services do more for public health?

Tønnesen, H., 2013, I: Clinical Health Promotion. 3, 1, s. 3

Publikation: Bidrag til tidsskrift › Leder › peer review

Originalsprog	Engelsk
Tidsskrift	Clinical Health Promotion
Vol/bind	3
Udgave nummer	1
Sider (fra-til)	3
Status	Udgivet - 2013

Case management in aftercare of involuntarily committed patients with substance abuse. A randomized trial

Lindahl, M. L., Berglund, M. & Tönnesen, H., jun. 2013, I: Nordic Journal of Psychiatry. 67, 3, s. 197-203 7 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Objective: Case management has since the 1970s been widely used to co-ordinate services for mental health patients. The methodology has expanded to support patients in many different types of conditions. This study is one of very few randomized trials on case management in a European setting. It examined the impact of case management on substance abuse and use of service after discharge from court-ordered institutional care. Methods: Court-ordered patients with substance abuse (n = 36) were randomly assigned to either strengths based case management or treatment-as-usual during 6 months in aftercare. Data was collected at intake, at conclusion of intervention and at 6 month's follow-up with a follow-up rate of 94%. Results: Case management interventions were well received by the patients with no drop-out during intervention. Patients with the support of a case manager seemed to sustain abstinence in a higher degree compared with treatment-as-usual but no differences were detected in regard to use of care. A subgroup analysis showed that patients with a continuous drug abuse did have access to care from both social welfare and hospital care systems. Conclusions: Case management may be useful in order to retain abstinence in aftercare following court-ordered treatment. The social welfare and hospital care systems seem to provide care irrespective of case manager intervention. The study design, interventions and assessments instruments were well received by patients but needs to be replicated with a larger population. Clinical implications: The 100% retention in the case management support group indicates that patients were satisfied with this type of intervention and the methodology seems to be useful in order to retain abstinence.

Originalsprog	Engelsk
Tidsskrift	Nordic Journal of Psychiatry
Vol/bind	67
Udgave nummer	3
Sider (fra-til)	197-203
Antal sider	7
ISSN	0803-9488
DOI	https://doi.org/10.3109/08039488.2012.704068
Status	Udgivet - jun. 2013

Cause-specific mortality after stroke: relation to age, sex, stroke severity, and risk factors in a 10-year follow-up study

Mogensen, U. B., Olsen, T. S., Andersen, K. K. & Gerds, T. A., okt. 2013, I: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 22, 7, s. e59-65

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

We investigated cause-specific mortality in relation to age, sex, stroke severity, and cardiovascular risk factor profile in the Copenhagen Stroke Study cohort with 10 years of follow-up. In a Copenhagen community, all patients admitted to the hospital with stroke during 1992-1993 (n = 988) were registered on admission. Evaluation included stroke severity, computed tomography scan, and a cardiovascular risk profile. Cause of death within 10 years according to death certificate information was classified as stroke, heart/arterial disease, or nonvascular disease. Competing-risks analyses were performed by cause-specific Cox regression after multiple imputation of missing data, assuming that values were missing at random. Death was due to stroke in 310 patients (31%), to heart/arterial disease in 209 patients (21%), and to nonvascular diseases in 289 patients (29%); 180 patients were still alive after 10 years (18%). Stroke was the dominant cause of death during first year, with an absolute risk of 20.2% versus 5.2% for heart/arterial disease and 6.5% for nonvascular disease. The subsequent absolute risk of death per year was 2.8% for stroke, 4.5% for heart/arterial disease, and 5.2% for nonvascular disease. Death after stroke was associated with older age, male sex, greater stroke severity, and diabetes regardless of the cause of death. Previous stroke and hemorrhagic stroke were associated with death by stroke, ischemic heart disease was associated with death by heart/arterial disease and atrial fibrillation was associated with death by cardiovascular disease (stroke or heart/arterial disease). Hypertension, smoking, and alcohol consumption were not associated with cause-specific death.

Originalsprog	Engelsk
Tidsskrift	Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Vol/bind	22
Udgave nummer	7
Sider (fra-til)	e59-65
ISSN	1052-3057
DOI	https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.04.006
Status	Udgivet - okt. 2013

Changes in bone marrow lesions in response to weight-loss in obese knee osteoarthritis patients: a prospective cohort study

Gudbergsen, H., Boesen, M., Christensen, R., Bartels, E. M., Henriksen, M., Danneskiold-Samsøe, B. & Bliddal, H., 2013, I: B M C Musculoskeletal Disorders. 14, s. 106

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Patients are susceptible for knee osteoarthritis (KOA) with increasing age and obesity and KOA is expected to become a major disabling disease in the future. An important feature of KOA on magnetic resonance imaging (MRI) is changes in the subchondral bone, bone marrow lesions (BMLs), which are related to the future degeneration of the knee joint as well as prevalent clinical symptoms. The aim of this study was to investigate the changes in BMLs after a 16-week weight-loss period in obese subjects with KOA and relate changes in BMLs to the effects of weight-loss on clinical symptoms.

Originalsprog	Engelsk
Tidsskrift	B M C Musculoskeletal Disorders
Vol/bind	14
Sider (fra-til)	106
ISSN	1471-2474
DOI	https://doi.org/10.1186/1471-2474-14-106
Status	Udgivet - 2013

Clinical response, drug survival and predictors thereof in 432 ankylosing spondylitis patients after switching tumour necrosis factor α inhibitor therapy: results from the Danish nationwide DANBIO registry

Glintborg, B., Østergaard, M., Krogh, N. S., Tarp, U., Manilo, N., Loft, A. G. R., Hansen, A., Schlemmer, A., Fana, V., Lindegaard, H. M., Nordin, H., Rasmussen, C., Ejstrup, L., Jensen, D. V., Petersen, P. M. & Hetland, M. L., 2013, I: Annals of the Rheumatic Diseases. 72, s. 1149-1155

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

OBJECTIVE: To investigate frequencies and reasons for switching, treatment responses and drug survival in patients with ankylosing spondylitis (AS) switching tumour-necrosis-factor-α inhibitor (TNFi) treatment in routine clinical care. METHODS: AS patients were identified in the Danish nationwide DANBIO registry. Disease activity, treatment responses (50% or 20 mm reduction in Bath AS Disease Activity Index (BASDAI)), duration and rates of drug survival and predictors thereof were studied in patients receiving ≥2 different biological drugs. RESULTS: Of 1436 AS patients starting TNFi treatment, 432 patients (30%) switched to a second and 137 (10%) to a third biological drug. Compared with non-switchers, switchers were more frequently women (33%/22%), had shorter disease duration (3 years/5 years) and higher BASDAI (62(52-76) mm/56(43-69) mm (median(interquartile-range))), Bath AS Functional Index (BASFI) (54(39-71) mm/47(31-65) mm) and visual-analogue-scale (VAS) global, pain and fatigue scores when they started the first TNFi (all p

Originalsprog	Engelsk
Tidsskrift	Annals of the Rheumatic Diseases
Vol/bind	72
Sider (fra-til)	1149-1155
ISSN	0003-4967
DOI	https://doi.org/10.1136/annrheumdis-2012-201933
Status	Udgivet - 2013

Comparative effectiveness of injection therapies in lateral epicondylitis: a systematic review and network meta-analysis of randomized controlled trials

Krogh, T. P., Bartels, E. M., Ellingsen, T. J., Stengaard-Pedersen, K., Buchbinder, R., Fredberg, U., Bliddal, H. & Christensen, R., jun. 2013, I: The American journal of sports medicine. 41, 6, s. 1435-46 12 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Injection therapy with glucocorticoids has been used since the 1950s as a treatment strategy for lateral epicondylitis (tennis elbow). Lately, several novel injection therapies have become available.

Originalsprog	Engelsk
Tidsskrift	The American journal of sports medicine
Vol/bind	41
Udgave nummer	6
Sider (fra-til)	1435-46
Antal sider	12
ISSN	0363-5465
DOI	https://doi.org/10.1177/0363546512458237
Status	Udgivet - jun. 2013

Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults

Christensen, P., Frederiksen, R., Bliddal, H., Riecke, B. F., Bartels, E. M., Henriksen, M., Juul-S Rensen, T., Gudbergsen, H., Winther, K., Astrup, A. & Christensen, R., okt. 2013, I: Obesity (Silver Spring, Md.). 21, 10, s. 1982-90 9 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk-factors, nutritional health, and body composition after 1-year weight-loss maintenance achieved by [D]diet, [E]knee-exercise, or [C]control, following weight loss by low-energy-diet.

Originalsprog	Engelsk
Tidsskrift	Obesity (Silver Spring, Md.)
Vol/bind	21
Udgave nummer	10
Sider (fra-til)	1982-90
Antal sider	9
ISSN	1930-7381
DOI	https://doi.org/10.1002/oby.20413
Status	Udgivet - okt. 2013

Complications to cerebrospinal fluid drainage and predictors of spinal cord ischemia in patients with aortic disease undergoing advanced endovascular therapy

Mehmedagic, I., Resch, T. & Acosta, S., aug. 2013, I: Vascular and Endovascular Surgery. 47, 6, s. 415-22 8 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Published in 2014

Validity and reliability of 3D US for the detection of erosions in patients with rheumatoid arthritis using MRI as the gold standard

Which factors influence radiographic progression during treatment with tumor necrosis factor inhibitors in clinical practice? Results from 930 patients with rheumatoid arthritis in the nationwide Danish DANBIO registry

Published in 2013

Acid-base transport in pancreas-new challenges

Adherence to methotrexate therapy among patients with rheumatoid arthritis in Denmark: A registry based cohort study

Agreement between measures of ´walking related knee pain` in knee osteoarthritis: A cross-sectional study

Altered Visual and Feet Proprioceptive Feedbacks during Quiet Standing Increase Postural Sway in Patients with Severe Knee Osteoarthritis

Arthroscopic partial meniscectomy in middle-aged patients with mild or no knee osteoarthritis: a protocol for a double-blind, randomized sham-controlled multi-centre trial

Assessment of pressure-pain thresholds and central sensitization of pain in lateral epicondylalgia

Association between the SVS/AAVS anatomical severity grading score and operative outcomes in fenestrated endovascular repair of juxtarenal aortic aneurysm

Authors' response

Beyond access to medicines: Eliciting high-income country support for a new global health research and development paradigm

Body mass index and stroke: overweight and obesity less often associated with stroke recurrence

Can hospitals and health services do more for public health?

Case management in aftercare of involuntarily committed patients with substance abuse. A randomized trial

Cause-specific mortality after stroke: relation to age, sex, stroke severity, and risk factors in a 10-year follow-up study

Changes in bone marrow lesions in response to weight-loss in obese knee osteoarthritis patients: a prospective cohort study

Clinical response, drug survival and predictors thereof in 432 ankylosing spondylitis patients after switching tumour necrosis factor α inhibitor therapy: results from the Danish nationwide DANBIO registry

Comparative effectiveness of injection therapies in lateral epicondylitis: a systematic review and network meta-analysis of randomized controlled trials

Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults

Complications to cerebrospinal fluid drainage and predictors of spinal cord ischemia in patients with aortic disease undergoing advanced endovascular therapy

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