Published in 2015

Safety of Etoricoxib, Celecoxib, and Nonselective Nonsteroidal Antiinflammatory Drugs in Ankylosing Spondylitis and Other Spondyloarthritis Patients: A Swedish National Population-Based Cohort Study

Kristensen, L. E., Jakobsen, A. K., Askling, J., Nilsson, F. & Jacobsson, L. T. H., aug. 2015, I: Arthritis Care & Research. 67, 8, s. 1137-49 13 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

OBJECTIVE: Safety data regarding the use of etoricoxib and other nonsteroidal antiinflammatory drugs (NSAIDs) in ankylosing spondylitis (AS) and other spondyloarthritis (SpA) patients are rather limited. Our objective was to estimate and compare rates of gastrointestinal, renovascular, and cardiovascular adverse events in patients exposed to etoricoxib, celecoxib, or nonselective NSAIDs or totally unexposed to NSAIDs.

METHODS: We performed a national register-based cohort study on patients with AS or SpA (n = 21,872) identified in the Swedish national patient register from 1987-2009. Treatment exposure was assessed time dependently based on the prescription drug register from 2006-2009, adjusting for sociodemographics and comorbidities derived from national population-based registers.

RESULTS: Exposure to etoricoxib, celecoxib, and nonselective NSAIDs was 7.6%, 3.9%, and 71.2%, respectively. No major risk differences for serious cardiovascular, gastrointestinal, or renal adverse events were seen among the 3 exposure groups. Patients unexposed to NSAIDs had more baseline comorbidities and an increased relative risk for congestive heart failure events during the study period (2.0, 95% confidence interval [95% CI] 1.3-3.2). The relative risk for atherosclerotic events was nonsignificant when compared to the nonselective NSAID group (1.0, 95% CI 0.7-1.5), while the relative risk for gastrointestinal events was lower for unexposed patients (0.5, 95% CI 0.4-0.7).

CONCLUSION: Overall, serious adverse events related to nonselective NSAIDs, etoricoxib, and celecoxib were similar and in the range of what would be expected in a group of SpA patients. Patients unexposed to NSAIDs had considerably more baseline comorbidities and increased risk for congestive heart failure, reflecting a selection of patients being prescribed NSAIDs in clinical practice.

Originalsprog Engelsk
Tidsskrift Arthritis Care & Research
Vol/bind 67
Udgave nummer 8
Sider (fra-til) 1137-49
Antal sider 13
ISSN 2151-464X
DOI
Status Udgivet - aug. 2015

Samtidig volvulus i sigmoideum og caecum

Berg, A. K. & Perdawood, S. K., 21 sep. 2015, I: Ugeskrift for Laeger. 177, 39, s. V04150346

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Satisfaction with daily occupations amongst asylum seekers in Denmark

Morville, A-L., Erlandsson, L-K., Danneskiold-Samsøe, B., Amris, K. & Eklund, M., maj 2015, I: Scandinavian Journal of Occupational Therapy. 22, 3, s. 207-15 9 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

AIM: The aim of this study was to describe asylum seekers' satisfaction with daily occupations and activity level while in a Danish asylum centre, and whether this changed over time. Another aim was to describe whether exposure to torture, self-rated health measures, and ADL ability were related to their satisfaction with daily occupations and activity level.

METHODS: A total of 43 asylum seekers at baseline and 17 at follow-up were included. The questionnaires Satisfaction with Daily Occupations, Major Depression Inventory, WHO-5 Wellbeing, Pain Detect, a questionnaire covering torture, and basic social information were used as well as Assessment of Motor and Process Skills.

RESULTS: The results showed a low level of satisfaction with daily occupations at both baseline and follow-up. There was no statistically significant change in satisfaction or activity level between baseline and the follow-up. Associations between AMPS process skills--education, worst pain and activity level--were present at baseline, as was a relationship between AMPS process skills and satisfaction. At follow-up, associations between WHO-5 and satisfaction and activity level and between MDI scores and activity level were found.

CONCLUSION: Asylum seekers experience a low level of satisfaction with daily occupations, both at arrival and after 10 months in an asylum centre. There is a need for further research and development of occupation-focused rehabilitation methods for the asylum seeker population.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Occupational Therapy
Vol/bind 22
Udgave nummer 3
Sider (fra-til) 207-15
Antal sider 9
ISSN 1103-8128
DOI
Status Udgivet - maj 2015

Self-reported health-related quality of life predicts 5-year mortality and hospital readmissions in patients with ischaemic heart disease

Hansen, T. B., Thygesen, L. C., Zwisler, A. D., Helmark, L., Hoogwegt, M., Versteeg, H., Höfer, S. & Oldridge, N., jul. 2015, I: European Journal of Preventive Cardiology. 22, 7, s. 882-9 8 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Single-dose colesevelam has no effect on postprandial GLP-1 levels, but increases CCK levels and decreases gallbladder refilling and gastric emptying in type 2 diabetes

Bahne, E., Hansen, M., Sonne, D. P., Rehfeld, J. F., Holst, J. J., Vilsboll, T. & Knop, F. K., sep. 2015, s. S343-S343. 1 s.

Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

Smoking and mental illness

Tønnesen, H., 2015, I: Clinical Health Promotion. 5, s. 33-34 2 s.

Publikation: Bidrag til tidsskrift › Leder

Originalsprog Engelsk
Tidsskrift Clinical Health Promotion
Vol/bind 5
Sider (fra-til) 33-34
Antal sider 2
Status Udgivet - 2015

Sonoelectrochemical mineralization of perfluorooctanoic acid using Ti/PbO2 anode assessed by response surface methodology

Bonyadinejad, G., Khosravi, M., Ebrahimi, A., Nateghi, R., Taghavi-Shahri, S. M. & Mohammadi, H., 14 nov. 2015, I: Journal of Environmental Health Science and Engineering. 13, 1, 77.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Stillesiddende adfærd i et folkesundhedsperspektiv

Aadahl, M., Said, M., Petersen, C. B. & Møller, T., 2015.

Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning

Sugar-Sweetened Beverages and Obesity among Children and Adolescents: A Review of Systematic Literature Reviews

Keller, A. & Bucher Della Torre, S., aug. 2015, I: Childhood obesity (Print). 11, 4, s. 338-46 9 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

BACKGROUND: The prevalence of overweight and obesity among children and adolescents has increased worldwide and has reached alarming proportions. Currently, sugar-sweetened beverages (SSBs) are the primary source of added sugar in the diet of children and adolescents. Contradictive findings from studies and reviews have fueled an endless debate on the role of SSBs in the development of childhood obesity.

OBJECTIVES: The primary aim of the present review of reviews was to assess how review- and study-level methodological factors explain conflicting results across reviews and meta-analyses by providing an up-to-date synthesis of recent evidence regarding the association between SSB consumption and weight gain, overweight, and obesity in a population of 6-month-old to 19-year-old children and adolescents. The secondary aim was to assess the quality of included reviews using the Assessment of Multiple SysTemAtic Reviews (AMSTAR) measurement tool.

METHODS: Systematic literature reviews and meta-analyses were included. The literature search was performed through the platforms Pubmed/Medline, Cinahl, and Web of Knowledge.

RESULTS: Thirteen reviews and meta-analyses were included. Nine reviews concluded that there was a direct association between SSBs and obesity in children and adolescents and four others did not. The quality of the included reviews was low to moderate, and the two reviews with the highest quality scores showed discrepant results.

CONCLUSIONS: The majority of reviews concluded that there was a direct association between SSB consumption and weight gain, overweight, and obesity in children and adolescents. However, recent evidence from well-conducted meta-analyses shows discrepant results regarding the association between SSB and weight gain, overweight, and obesity among children and adolescents. Improving methodological quality of studies and reviews as well as ensuring responsible conduct of research and scientific integrity is essential for the provision of objective results.

Originalsprog Engelsk
Tidsskrift Childhood obesity (Print)
Vol/bind 11
Udgave nummer 4
Sider (fra-til) 338-46
Antal sider 9
ISSN 2153-2168
DOI
Status Udgivet - aug. 2015

Surgical interventions for nephrolithiasis in ankylosing spondylitis and the general population

Jakobsen, A. K., Jacobsson, L. T. H., Patschan, O., Hopfgarten, T., Askling, J. & Kristensen, L. E., 21 sep. 2015, I: Scandinavian Journal of Urology. 49, 6, s. 1-6 6 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

OBJECTIVE: The aim of this study was to estimate rates and type of definitive surgical interventions for nephrolithiasis in Swedish patients with ankylosing spondylitis (AS) compared to the general population.

MATERIALS AND METHODS: This national prospective cohort study linked data from Swedish population and healthcare registries. Incidence rates and interventions for nephrolithiasis during follow-up in patients with AS were compared to general population comparator (GPC) subjects.

RESULTS: In total, 8572 AS patients were followed for 49,959 person-years and 39,639 matched GPCs were followed for 225,221 person-years. Mean age at study entry was 46 years [interquartile range (IQR) 36-56 years] and 65% were male. In AS patients with a diagnosis of nephrolithiasis during the study period, 29% (72/250) underwent similar intervention for nephrolithiasis compared to 24% (114/466) GPCs (p = 0.21). The incidence rate ratio (RR) in overall AS patients was 2.9 [95% confidence interval (CI) 2.1-3.8] during a median follow-up of 6.2 years (IQR 3.2-8.6 years). With prior diagnosis of nephrolithiasis, the RR for AS patients compared to GPCs was 3.7 (95% CI 1.8-7.7); without prior nephrolithiasis the RR was 2.1 (95% CI 1.5-3.0). Increasing age [odds ratio (OR) 1.02, 95% CI 1.01-1.03], prior nephrolithiasis diagnosis (OR 3.3, 95% CI 1.97-5.62) and atherosclerotic cardiac disease (OR 2.0, 95% CI 1.03-3.91) were identified as predictors of intervention for nephrolithiasis.

CONCLUSIONS: Patients with AS have an almost three-fold increased risk of surgical intervention for kidney stones, with similar management, compared to the general population.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Urology
Vol/bind 49
Udgave nummer 6
Sider (fra-til) 1-6
Antal sider 6
ISSN 2168-1805
DOI
Status Udgivet - 21 sep. 2015

Systolic blood pressure and short-term mortality in the emergency department and prehospital setting: a hospital-based cohort study

Kristensen, A. K. B., Holler, J. G., Mikkelsen, S., Hallas, J. & Lassen, A., 9 apr. 2015, I: Critical care (London, England). 19, 1, s. 158

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

The acute glucose-lowering effect of metfomin in patients with type 2 diabetes is partly glucagon-like peptide-1-dependent

Hansen, M., Bahne, E., Sonne, D. P., Rehfeld, J. F., Holst, J. J., Vilsboll, T. & Knop, F. K., sep. 2015, s. S110-S110. 1 s.

Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review

The Association Between Periodontal Disease and Overweight and Obesity: A Systematic Review

Keller, A., Rohde, J. F., Raymond, K. & Heitmann, B. L., 12 feb. 2015, I: Journal of Periodontology. s. 1-15 15 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Introduction: Periodontitis and obesity are among the most common chronic disorders affecting the world's populations, and recent reviews suggest a potential link between overweight/obesity and periodontitis. However, due to the scarcity of prospective evidence, previous reviews were primarily based on cross-sectional studies, with only few longitudinal or intervention studies included. The objective was to examine the time-dependent association between obesity and periodontitis and how weight-changes may affect the development of periodontitis in the general population. Therefore, longitudinal and experimental studies that assessed the association between overweight, obesity, weight gain, waist circumference and periodontitis were reviewed Method: Intervention and longitudinal studies with overweight or obesity as their exposure and periodontitis as their outcome were searched through the platforms Pubmed/Medline and Web of Knowledge. Results: Eight longitudinal and five intervention studies were included. Two of the longitudinal studies found a direct association between degree of overweight at baseline and subsequent risk of developing periodontitis, and further three studies found a direct association between obesity and development of periodontitis among adults. Two intervention studies on the influence of obesity on periodontal treatment effects found that the response to non-surgical periodontal treatment was better among lean than obese patients, the remaining three studies did not report treatment differences between obese and lean. Among the eight longitudinal studies, one study adjusted for CRP and biological markers of inflammation such as CRP, IL-6 and TNFα and inflammation markers were analyzed separately in three of the five intervention studies. Conclusion: This systematic review suggests that overweight, obesity, weight gain and increased waist circumference may be risk factors for development or worsening with regard to periodontal measures.

Originalsprog Engelsk
Tidsskrift Journal of Periodontology
Sider (fra-til) 1-15
Antal sider 15
ISSN 0022-3492
DOI
Status Udgivet - 12 feb. 2015

The bacteriology of hidradenitis suppurativa: a systematic review

Ring, H. C., Riis Mikkelsen, P., Miller, I. M., Jenssen, H., Fuursted, K., Saunte, D. M. & Jemec, G. B. E., okt. 2015, I: Experimental Dermatology. 24, 10, s. 727-31 5 s.

Publikation: Bidrag til tidsskrift › Review › peer review

We here describe a multimodality neuroimaging containing data from healthy volunteers and patients, acquired within the Lundbeck Foundation Center for Integrated Molecular Brain Imaging (Cimbi) in Copenhagen, Denmark. The data is of particular relevance for neurobiological research questions related to the serotonergic transmitter system with its normative data on the serotonergic subtype receptors 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4 and the 5-HT transporter (5-HTT), but can easily serve other purposes.

The Cimbi database and Cimbi biobank were formally established in 2008 with the purpose to store the wealth of Cimbi-acquired data in a highly structured and standardized manner in accordance with the regulations issued by the Danish Data Protection Agency as well as to provide a quality-controlled resource for future hypothesis-generating and hypothesis-driven studies.

The Cimbi database currently comprises a total of 1100 PET and 1000 structural and functional MRI scans and it holds a multitude of additional data, such as genetic and biochemical data, and scores from 17 self-reported questionnaires and from 11 neuropsychological paper/computer tests. The database associated Cimbi biobank currently contains blood and in some instances saliva samples from about 500 healthy volunteers and 300 patients with e.g., major depression, dementia, substance abuse, obesity, and impulsive aggression. Data continue to be added to the Cimbi database and biobank.

Originalsprog Engelsk
Tidsskrift NeuroImage
Udgivelsesdato 17 apr 2015
ISSN 1053-8119
DOI
Status In press

OBJECTIVE: To comprehensively identify components of the physical limitation concept in knee osteoarthritis (OA) and to rate the clinical importance of these using perspectives of both patients and health professionals.

DESIGN: Concept mapping, a structured group process, was used to identify and organize data in focus groups (patients) and via a global web-based survey (professionals). Ideas were elicited through a nominal group technique and then organized using multidimensional scaling, cluster analysis, participant validation, rating of clinical importance, and thematic analyses to generate a conceptual model of physical limitations in knee OA.

RESULTS: Fifteen Danish patients and 200 international professionals contributed to generating the conceptual model. Five clusters emerged: 'Limitations/physical deficits'; 'Everyday hurdles'; 'You're not the person you used to be'; 'Need to adjust way of living'; and 'External limitations,' each with sub-clusters. Patients generally found their limitations more important than the professionals did.

CONCLUSION: Patients and professionals agreed largely on the physical limitation concept in knee OA. Some limitations of high importance to patients were lower rated by the professionals, highlighting the importance of including patients when conceptualizing patient outcomes. These data offer new knowledge to guide selection of clinically relevant outcomes and development of outcome measures in knee OA.

Originalsprog Engelsk
Tidsskrift Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
Vol/bind 24
Udgave nummer 10
Sider (fra-til) 2423-32
Antal sider 10
ISSN 0962-9343
DOI
Status Udgivet - okt. 2015

BACKGROUND: There is currently no standardised MRI evaluation protocol for athletes who present with symptoms that may relate to the pubic symphysis, the pubic bones, and the adductor muscle insertions. We outline the protocol and reliability data.

MATERIAL AND METHODS: Three musculoskeletal radiologists developed an 11-element MRI evaluation protocol defined according to precise criteria and illustrated in a pictorial atlas. Eighty-six male athletes (soccer players and non-soccer players) underwent standardised 3 Tesla MRI of the pelvis. Two external musculoskeletal radiologists were trained to use the protocol and pictorial atlas during two sessions of 2-4 h each. Each radiologist rated all 86 MRI independently. One radiologist evaluated the scans once, the other twice 2 months apart. Cohen κ statistics were used to determine intraobserver and interobserver agreement.

RESULTS: The main findings were (1) substantial intraobserver (κ range 0.65-0.67) and moderate interobserver (κ range 0.45-0.52) agreement in rating pubic bone marrow oedema, (2) substantial to moderate intraobserver (κ range 0.49-0.72) and moderate-to-fair interobserver (κ range 0.21-0.52) agreement in rating most other MRI findings, (3) slight intraobserver and interobserver (κ range -0.06-0.05) agreement in rating adductor longus tendinopathy.

CONCLUSIONS: The Copenhagen Standardised MRI protocol demonstrated moderate-to-substantial reliability in rating bone marrow oedema, and varied from fair-to-substantial agreement for the majority of MRI features, but showed only slight agreement in rating adductor longus tendinopathy. This rigorous investigation also confirms that while MRI evaluation seems to provide reasonable reliability in rating pubic bone marrow oedema, the evaluation of adductor tendinopathy in a clinical and research setting needs further resolution by continued development and testing of MRI acquisition protocols.

Originalsprog Engelsk
Tidsskrift British Journal of Sports Medicine
Vol/bind 49
Udgave nummer 10
Sider (fra-til) 692-9
ISSN 0306-3674
DOI
Status Udgivet - 2015

The Dynamics of the pain system is intact in patients with knee osteoarthritis: An exploratory study

Jørgensen, T. S., Henriksen, M., Rosager, S., Klokker, L., Ellegaard, K., Danneskiold-Samsøe, B., Bliddal, H. & Graven-Nielsen, T., 2015, I: Scandinavian Journal of Pain. 6, s. 43 49 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Pain
Vol/bind 6
Sider (fra-til) 43
Antal sider 49
ISSN 1877-8860
Status Udgivet - 2015

The e-health literacy framework: A conceptual framework for characterizing e-health users and their interaction wiht e-health systems

Nørgaard, O., Furstrand, D., Klokker, L., Karnoe, A., Batterham, R., Kayser, L. & Osborne, R. H., 2015, I: Knowledge Management & E-Learning: An International Journal. 7, 4, s. 522 540 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Originalsprog Engelsk
Tidsskrift Knowledge Management & E-Learning: An International Journal
Vol/bind 7
Udgave nummer 4
Sider (fra-til) 522
Antal sider 540
ISSN 2073-7904
Status Udgivet - 2015

The effect of comedication with conventional synthetic disease modifying antirheumatic drugs on TNF inhibitor drug survival in patients with ankylosing spondylitis and undifferentiated spondyloarthritis: results from a nationwide prospective study

Lie, E., Kristensen, L. E., Forsblad-d'Elia, H., Zverkova-Sandström, T., Askling, J., Jacobsson, L. T. & ARTIS Study Group, jun. 2015, I: Annals of the Rheumatic Diseases. 74, 6, s. 970-8 9 s.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

OBJECTIVE: To assess the effect of comedication with conventional synthetic disease modifying antirheumatic drugs (csDMARDs) on retention to tumour necrosis factor inhibitor (TNFi) therapy in patients with ankylosing spondylitis (AS) and undifferentiated spondyloarthritis (uSpA).

METHODS: Data on patients with a clinical diagnosis of AS or uSpA starting treatment with adalimumab, etanercept or infliximab as their first TNFi during 2003-2010 were retrieved from the Swedish national biologics register and linked to national population based registers. Five-year drug survival was analysed by Cox regression with age, sex, baseline csDMARD comedication, TNFi type, prescription year and covariates representing frailty and socioeconomic status. AS and uSpA were analysed separately. Sensitivity analyses included models with csDMARD as a time-dependent covariate and adjustments for additional potential confounders.

RESULTS: 1365 patients with AS and 1155 patients with uSpA were included, of whom 40.8% versus 50.3% used csDMARD comedication at baseline. In the unadjusted analyses superior drug survival was observed for patients using versus not using csDMARD comedication among patients with AS (p<0.001) but not among patients with uSpA (p=0.175). In the multivariable Cox regression analyses comedication with csDMARD was associated with better retention to TNFi therapy both in AS (HR 0.71, p<0.001) and uSpA (HR 0.82, p=0.020). The results were similar with csDMARD comedication as a time-dependent covariate, and the associations were retained when adjusting for erythrocyte sedimentation rate, C-reactive protein, patient global, swollen joints, uveitis, psoriasis and inflammatory bowel disease.

CONCLUSIONS: In this large register study of patients with AS and uSpA, use of csDMARD comedication was associated with better 5-year retention to the first TNFi.

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 74
Udgave nummer 6
Sider (fra-til) 970-8
Antal sider 9
ISSN 0003-4967
DOI
Status Udgivet - jun. 2015

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