Stillesiddende adfærd i et folkesundhedsperspektiv
Aadahl, M., Said, M., Petersen, C. B. & Møller, T., 2015.
Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning
Aadahl, M., Said, M., Petersen, C. B. & Møller, T., 2015.
Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning
Keller, A. & Bucher Della Torre, S., aug. 2015, I: Childhood obesity (Print). 11, 4, s. 338-46 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
BACKGROUND: The prevalence of overweight and obesity among children and adolescents has increased worldwide and has reached alarming proportions. Currently, sugar-sweetened beverages (SSBs) are the primary source of added sugar in the diet of children and adolescents. Contradictive findings from studies and reviews have fueled an endless debate on the role of SSBs in the development of childhood obesity.
OBJECTIVES: The primary aim of the present review of reviews was to assess how review- and study-level methodological factors explain conflicting results across reviews and meta-analyses by providing an up-to-date synthesis of recent evidence regarding the association between SSB consumption and weight gain, overweight, and obesity in a population of 6-month-old to 19-year-old children and adolescents. The secondary aim was to assess the quality of included reviews using the Assessment of Multiple SysTemAtic Reviews (AMSTAR) measurement tool.
METHODS: Systematic literature reviews and meta-analyses were included. The literature search was performed through the platforms Pubmed/Medline, Cinahl, and Web of Knowledge.
RESULTS: Thirteen reviews and meta-analyses were included. Nine reviews concluded that there was a direct association between SSBs and obesity in children and adolescents and four others did not. The quality of the included reviews was low to moderate, and the two reviews with the highest quality scores showed discrepant results.
CONCLUSIONS: The majority of reviews concluded that there was a direct association between SSB consumption and weight gain, overweight, and obesity in children and adolescents. However, recent evidence from well-conducted meta-analyses shows discrepant results regarding the association between SSB and weight gain, overweight, and obesity among children and adolescents. Improving methodological quality of studies and reviews as well as ensuring responsible conduct of research and scientific integrity is essential for the provision of objective results.
Originalsprog | Engelsk |
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Tidsskrift | Childhood obesity (Print) |
Vol/bind | 11 |
Udgave nummer | 4 |
Sider (fra-til) | 338-46 |
Antal sider | 9 |
ISSN | 2153-2168 |
DOI | |
Status | Udgivet - aug. 2015 |
Jakobsen, A. K., Jacobsson, L. T. H., Patschan, O., Hopfgarten, T., Askling, J. & Kristensen, L. E., 21 sep. 2015, I: Scandinavian Journal of Urology. 49, 6, s. 1-6 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
OBJECTIVE: The aim of this study was to estimate rates and type of definitive surgical interventions for nephrolithiasis in Swedish patients with ankylosing spondylitis (AS) compared to the general population.
MATERIALS AND METHODS: This national prospective cohort study linked data from Swedish population and healthcare registries. Incidence rates and interventions for nephrolithiasis during follow-up in patients with AS were compared to general population comparator (GPC) subjects.
RESULTS: In total, 8572 AS patients were followed for 49,959 person-years and 39,639 matched GPCs were followed for 225,221 person-years. Mean age at study entry was 46 years [interquartile range (IQR) 36-56 years] and 65% were male. In AS patients with a diagnosis of nephrolithiasis during the study period, 29% (72/250) underwent similar intervention for nephrolithiasis compared to 24% (114/466) GPCs (p = 0.21). The incidence rate ratio (RR) in overall AS patients was 2.9 [95% confidence interval (CI) 2.1-3.8] during a median follow-up of 6.2 years (IQR 3.2-8.6 years). With prior diagnosis of nephrolithiasis, the RR for AS patients compared to GPCs was 3.7 (95% CI 1.8-7.7); without prior nephrolithiasis the RR was 2.1 (95% CI 1.5-3.0). Increasing age [odds ratio (OR) 1.02, 95% CI 1.01-1.03], prior nephrolithiasis diagnosis (OR 3.3, 95% CI 1.97-5.62) and atherosclerotic cardiac disease (OR 2.0, 95% CI 1.03-3.91) were identified as predictors of intervention for nephrolithiasis.
CONCLUSIONS: Patients with AS have an almost three-fold increased risk of surgical intervention for kidney stones, with similar management, compared to the general population.
Originalsprog | Engelsk |
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Tidsskrift | Scandinavian Journal of Urology |
Vol/bind | 49 |
Udgave nummer | 6 |
Sider (fra-til) | 1-6 |
Antal sider | 6 |
ISSN | 2168-1805 |
DOI | |
Status | Udgivet - 21 sep. 2015 |
Kristensen, A. K. B., Holler, J. G., Mikkelsen, S., Hallas, J. & Lassen, A., 9 apr. 2015, I: Critical care (London, England). 19, 1, s. 158
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Hansen, M., Bahne, E., Sonne, D. P., Rehfeld, J. F., Holst, J. J., Vilsboll, T. & Knop, F. K., sep. 2015, s. S110-S110. 1 s.
Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review
Keller, A., Rohde, J. F., Raymond, K. & Heitmann, B. L., 12 feb. 2015, I: Journal of Periodontology. s. 1-15 15 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Introduction: Periodontitis and obesity are among the most common chronic disorders affecting the world's populations, and recent reviews suggest a potential link between overweight/obesity and periodontitis. However, due to the scarcity of prospective evidence, previous reviews were primarily based on cross-sectional studies, with only few longitudinal or intervention studies included. The objective was to examine the time-dependent association between obesity and periodontitis and how weight-changes may affect the development of periodontitis in the general population. Therefore, longitudinal and experimental studies that assessed the association between overweight, obesity, weight gain, waist circumference and periodontitis were reviewed Method: Intervention and longitudinal studies with overweight or obesity as their exposure and periodontitis as their outcome were searched through the platforms Pubmed/Medline and Web of Knowledge. Results: Eight longitudinal and five intervention studies were included. Two of the longitudinal studies found a direct association between degree of overweight at baseline and subsequent risk of developing periodontitis, and further three studies found a direct association between obesity and development of periodontitis among adults. Two intervention studies on the influence of obesity on periodontal treatment effects found that the response to non-surgical periodontal treatment was better among lean than obese patients, the remaining three studies did not report treatment differences between obese and lean. Among the eight longitudinal studies, one study adjusted for CRP and biological markers of inflammation such as CRP, IL-6 and TNFα and inflammation markers were analyzed separately in three of the five intervention studies. Conclusion: This systematic review suggests that overweight, obesity, weight gain and increased waist circumference may be risk factors for development or worsening with regard to periodontal measures.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Periodontology |
Sider (fra-til) | 1-15 |
Antal sider | 15 |
ISSN | 0022-3492 |
DOI | |
Status | Udgivet - 12 feb. 2015 |
Ring, H. C., Riis Mikkelsen, P., Miller, I. M., Jenssen, H., Fuursted, K., Saunte, D. M. & Jemec, G. B. E., okt. 2015, I: Experimental Dermatology. 24, 10, s. 727-31 5 s.
Publikation: Bidrag til tidsskrift › Review › peer review
Knudsen, G. M., Jensen, P. S., Erritzoe, D., Baaré, W. F. C., Ettrup, A., Fisher, P. M., Gillings, N., Hansen, H. D., Hansen, L. K., Hasselbalch, S. G., Henningsson, S., Herth, M. M., Holst, K. K., Iversen, P., Kessing, L. V., Macoveanu, J., Madsen, K. S., Mortensen, E. L., Nielsen, F. Å., Paulson, O. B., Siebner, H. R., Stenbæk, D. S., Svarer, C., Jernigan, T. L., Strother, S. C. & Frokjaer, V. G. 17 apr 2015 I : NeuroImage.
Publikation: Forskning - peer review › Tidsskriftartikel
The Cimbi database and Cimbi biobank were formally established in 2008 with the purpose to store the wealth of Cimbi-acquired data in a highly structured and standardized manner in accordance with the regulations issued by the Danish Data Protection Agency as well as to provide a quality-controlled resource for future hypothesis-generating and hypothesis-driven studies.
The Cimbi database currently comprises a total of 1100 PET and 1000 structural and functional MRI scans and it holds a multitude of additional data, such as genetic and biochemical data, and scores from 17 self-reported questionnaires and from 11 neuropsychological paper/computer tests. The database associated Cimbi biobank currently contains blood and in some instances saliva samples from about 500 healthy volunteers and 300 patients with e.g., major depression, dementia, substance abuse, obesity, and impulsive aggression. Data continue to be added to the Cimbi database and biobank.
Originalsprog | Engelsk |
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Tidsskrift | NeuroImage |
Udgivelsesdato | 17 apr 2015 |
ISSN | 1053-8119 |
DOI | |
Status | In press |
Klokker, L., Osborne, R., Wæhrens, E. E., Norgaard, O., Bandak, E., Bliddal, H. & Henriksen, M., okt. 2015, I: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 24, 10, s. 2423-32 10 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
OBJECTIVE: To comprehensively identify components of the physical limitation concept in knee osteoarthritis (OA) and to rate the clinical importance of these using perspectives of both patients and health professionals.
DESIGN: Concept mapping, a structured group process, was used to identify and organize data in focus groups (patients) and via a global web-based survey (professionals). Ideas were elicited through a nominal group technique and then organized using multidimensional scaling, cluster analysis, participant validation, rating of clinical importance, and thematic analyses to generate a conceptual model of physical limitations in knee OA.
RESULTS: Fifteen Danish patients and 200 international professionals contributed to generating the conceptual model. Five clusters emerged: 'Limitations/physical deficits'; 'Everyday hurdles'; 'You're not the person you used to be'; 'Need to adjust way of living'; and 'External limitations,' each with sub-clusters. Patients generally found their limitations more important than the professionals did.
CONCLUSION: Patients and professionals agreed largely on the physical limitation concept in knee OA. Some limitations of high importance to patients were lower rated by the professionals, highlighting the importance of including patients when conceptualizing patient outcomes. These data offer new knowledge to guide selection of clinically relevant outcomes and development of outcome measures in knee OA.
Originalsprog | Engelsk |
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Tidsskrift | Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation |
Vol/bind | 24 |
Udgave nummer | 10 |
Sider (fra-til) | 2423-32 |
Antal sider | 10 |
ISSN | 0962-9343 |
DOI | |
Status | Udgivet - okt. 2015 |
Branci, S., Thorborg, K., Bech, B. H., Boesen, M., Magnussen, E., Court-Payen, M., Nielsen, M. B. & Hölmich, P., 2015, I: British Journal of Sports Medicine. 49, 10, s. 692-9
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
BACKGROUND: There is currently no standardised MRI evaluation protocol for athletes who present with symptoms that may relate to the pubic symphysis, the pubic bones, and the adductor muscle insertions. We outline the protocol and reliability data.
MATERIAL AND METHODS: Three musculoskeletal radiologists developed an 11-element MRI evaluation protocol defined according to precise criteria and illustrated in a pictorial atlas. Eighty-six male athletes (soccer players and non-soccer players) underwent standardised 3 Tesla MRI of the pelvis. Two external musculoskeletal radiologists were trained to use the protocol and pictorial atlas during two sessions of 2-4 h each. Each radiologist rated all 86 MRI independently. One radiologist evaluated the scans once, the other twice 2 months apart. Cohen κ statistics were used to determine intraobserver and interobserver agreement.
RESULTS: The main findings were (1) substantial intraobserver (κ range 0.65-0.67) and moderate interobserver (κ range 0.45-0.52) agreement in rating pubic bone marrow oedema, (2) substantial to moderate intraobserver (κ range 0.49-0.72) and moderate-to-fair interobserver (κ range 0.21-0.52) agreement in rating most other MRI findings, (3) slight intraobserver and interobserver (κ range -0.06-0.05) agreement in rating adductor longus tendinopathy.
CONCLUSIONS: The Copenhagen Standardised MRI protocol demonstrated moderate-to-substantial reliability in rating bone marrow oedema, and varied from fair-to-substantial agreement for the majority of MRI features, but showed only slight agreement in rating adductor longus tendinopathy. This rigorous investigation also confirms that while MRI evaluation seems to provide reasonable reliability in rating pubic bone marrow oedema, the evaluation of adductor tendinopathy in a clinical and research setting needs further resolution by continued development and testing of MRI acquisition protocols.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Sports Medicine |
Vol/bind | 49 |
Udgave nummer | 10 |
Sider (fra-til) | 692-9 |
ISSN | 0306-3674 |
DOI | |
Status | Udgivet - 2015 |
Jørgensen, T. S., Henriksen, M., Rosager, S., Klokker, L., Ellegaard, K., Danneskiold-Samsøe, B., Bliddal, H. & Graven-Nielsen, T., 2015, I: Scandinavian Journal of Pain. 6, s. 43 49 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Originalsprog | Engelsk |
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Tidsskrift | Scandinavian Journal of Pain |
Vol/bind | 6 |
Sider (fra-til) | 43 |
Antal sider | 49 |
ISSN | 1877-8860 |
Status | Udgivet - 2015 |
Nørgaard, O., Furstrand, D., Klokker, L., Karnoe, A., Batterham, R., Kayser, L. & Osborne, R. H., 2015, I: Knowledge Management & E-Learning: An International Journal. 7, 4, s. 522 540 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Originalsprog | Engelsk |
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Tidsskrift | Knowledge Management & E-Learning: An International Journal |
Vol/bind | 7 |
Udgave nummer | 4 |
Sider (fra-til) | 522 |
Antal sider | 540 |
ISSN | 2073-7904 |
Status | Udgivet - 2015 |
Lie, E., Kristensen, L. E., Forsblad-d'Elia, H., Zverkova-Sandström, T., Askling, J., Jacobsson, L. T. & ARTIS Study Group, jun. 2015, I: Annals of the Rheumatic Diseases. 74, 6, s. 970-8 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
OBJECTIVE: To assess the effect of comedication with conventional synthetic disease modifying antirheumatic drugs (csDMARDs) on retention to tumour necrosis factor inhibitor (TNFi) therapy in patients with ankylosing spondylitis (AS) and undifferentiated spondyloarthritis (uSpA).
METHODS: Data on patients with a clinical diagnosis of AS or uSpA starting treatment with adalimumab, etanercept or infliximab as their first TNFi during 2003-2010 were retrieved from the Swedish national biologics register and linked to national population based registers. Five-year drug survival was analysed by Cox regression with age, sex, baseline csDMARD comedication, TNFi type, prescription year and covariates representing frailty and socioeconomic status. AS and uSpA were analysed separately. Sensitivity analyses included models with csDMARD as a time-dependent covariate and adjustments for additional potential confounders.
RESULTS: 1365 patients with AS and 1155 patients with uSpA were included, of whom 40.8% versus 50.3% used csDMARD comedication at baseline. In the unadjusted analyses superior drug survival was observed for patients using versus not using csDMARD comedication among patients with AS (p<0.001) but not among patients with uSpA (p=0.175). In the multivariable Cox regression analyses comedication with csDMARD was associated with better retention to TNFi therapy both in AS (HR 0.71, p<0.001) and uSpA (HR 0.82, p=0.020). The results were similar with csDMARD comedication as a time-dependent covariate, and the associations were retained when adjusting for erythrocyte sedimentation rate, C-reactive protein, patient global, swollen joints, uveitis, psoriasis and inflammatory bowel disease.
CONCLUSIONS: In this large register study of patients with AS and uSpA, use of csDMARD comedication was associated with better 5-year retention to the first TNFi.
Originalsprog | Engelsk |
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Tidsskrift | Annals of the Rheumatic Diseases |
Vol/bind | 74 |
Udgave nummer | 6 |
Sider (fra-til) | 970-8 |
Antal sider | 9 |
ISSN | 0003-4967 |
DOI | |
Status | Udgivet - jun. 2015 |
Hansen, M., Sonne, D. P., Bahne, E., Rehfeld, J. F., Holst, J. J., Vilsboll, T. & Knop, F. K., jun. 2015, s. A305-A305. 1 s.
Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning › peer review
Esbensen, B., Thomsen, T., Hetland, M. L., Beyer, N., Midtgaard, J., Løppenthin, K., Jennum, P., Østergaard, M., Sørensen, J., Christensen, R. & Aadahl, M., 27 jan. 2015, I: Trials. 16, 1, s. 23
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
BackgroundSedentary behavior has been recognized as a distinct and independent risk factor for cardiovascular morbidity and mortality, independent of moderate and vigorous physical activity during leisure time. Sedentary behavior has become increasingly prevalent in modern society. Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease and premature death, partly caused by the chronic inflammatory rheumatic disease itself, but also due to physical inactivity. Recent research has shown that sedentary behavior can be reduced through behavioral intervention in elderly and in overweight study populations.BackgroundPatients with RA (Rheumatoid Arthritis) are more sedentary than the general population. Reduction of Sedentary Behaviour (SB) has been suggested as a mean for improvement of health in patients with chronic diseases and mobility problems. Short-term intervention studies have demonstrated that SB can be reduced by behavioural interventions in healthy populations. However, it remains unexplored whether it is valid for patients with RA also.Therefore, the aim of this trial is to investigate the efficacy of an individually tailored, theory-based motivational counseling intervention on reducing daily sitting time in sedentary patients with RA. Additionally, to explore whether a reduction in daily sitting time is associated with reduced pain and fatigue, self-reported physical function, self-efficacy, improved health-related quality of life (HRQoL) and cardiovascular biomarker levels, and finally to assess the cost-effectiveness of the intervention.Methods/DesignFor this parallel group randomized trial, 150 patients with RA and at least 5 hours of sitting time per day, will be recruited from a rheumatology outpatient clinic, and block-randomized to the intervention group or the control group receiving usual care. The intervention includes: 1) individual motivational counseling (in total 3 sessions) on reduction of daily sitting time in combination with 2) individual Short Text Message Service (SMS) reminders over a 16-week intervention period. Primary outcome is change in daily sitting time (minutes) from baseline to 16 weeks measured objectively using an ActivPAL® Activity Monitor. Secondary outcomes include fatigue, pain, physical function, HRQoL, self-efficacy, costs and cost-effectiveness. Furthermore, anthropometric measures will be included as well as measurement of blood pressure and serum lipids. All outcomes are assessed at baseline and repeated after 16 weeks. Follow-up assessments are made at 6 and 18 months post-intervention.DiscussionThe intervention is simple, non-invasive and may be implemented at low costs. If the study confirms the positive results expected, the intervention might be implemented in clinical practice and potentially transferred to other clinical populations.Trial registrationClinicalTrial.gov registration number: NCT01969604.Date of registration: 17 October 2013.
Originalsprog | Engelsk |
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Tidsskrift | Trials |
Vol/bind | 16 |
Udgave nummer | 1 |
Sider (fra-til) | 23 |
ISSN | 1745-6215 |
DOI | |
Status | Udgivet - 27 jan. 2015 |
Flamand, M. K., Schroeder, T. V. & Tønnesen, H., 2015, I: International Journal of Environmental Research and Public Health. 12, 3, s. 2574-87 14 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
BACKGROUND: Tobacco smoking is more prevalent among the elderly than among the young, and the elderly also have the most frequent contact with the health care system. The aim of this study was to evaluate the effectiveness of the Gold Standard Program, which is an intensive six-week smoking cessation program, on continuous self-reported abstinence rates after six months, on participants over the age of 60 years in a real life setting.
METHODS: This was a retrospective cohort study from the national Danish smoking cessation database.
RESULTS: The database registered 7369 participants over the age of 60 years (range 60-82) and 24,294 below 60 years (range 15-59). Continuous abstinence rate after six months was 37% for the elderly compared to 35% for the younger (p < 0.05). The significant variables for continuous abstinence were: living with another adult (OR 1.10), prior professional recommendation for smoking cessation (OR 1.12), being compliant with program (OR 1.35) and being abstinent at end of course (OR 13.3).
CONCLUSIONS: Participants over the age of 60 years had significantly higher continuous abstinence rates after six months than the participants less than 60 years. It is never too late for health professionals to recommend and educate patients about smoking cessation programs even if they are over 60 years of age.
Originalsprog | Engelsk |
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Tidsskrift | International Journal of Environmental Research and Public Health |
Vol/bind | 12 |
Udgave nummer | 3 |
Sider (fra-til) | 2574-87 |
Antal sider | 14 |
ISSN | 1660-4601 |
DOI | |
Status | Udgivet - 2015 |
Poone, G. K., Hasseldam, H., Munkholm, N., Rasmussen, R. S., Grønberg, N. V. & Johansen, F. F., 15 maj 2015, I: Brain Sciences. 5, 2, s. 178-87 10 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Cox, T. R., Rumney, R. M. H., Schoof, E. M., Perryman, L., Høye, A. M., Agrawal, A., Bird, D., Latif, N. A., Forrest, H., Evans, H. R., Huggins, I. D., Lang, G., Linding, R., Gartland, A. & Erler, J. T., 1 maj 2015, I: Nature. 522, 7554, s. 106-110 5 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Gottlieb, A. B., Levin, A. A., Armstrong, A. W., Abernethy, A., Duffin, K. C., Bhushan, R., Garg, A., Merola, J. F., Maccarone, M. & Christensen, R., feb. 2015, I: Journal of the American Academy of Dermatology. 72, 2, s. 345-8 4 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
As quality standards are increasingly in demand throughout medicine, dermatology needs to establish outcome measures to quantify the effectiveness of treatments and providers. The International Dermatology Outcome Measures Group was established to address this need. Beginning with psoriasis, the group aims to create a tool considerate of patients and providers using the input of all relevant stakeholders in assessment of disease severity and response to treatment. Herein, we delineate the procedures through which consensus is being reached and the future directions of the project.
Originalsprog | Engelsk |
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Tidsskrift | Journal of the American Academy of Dermatology |
Vol/bind | 72 |
Udgave nummer | 2 |
Sider (fra-til) | 345-8 |
Antal sider | 4 |
ISSN | 0190-9622 |
DOI | |
Status | Udgivet - feb. 2015 |
Schmidt, T. A. & Yudkin, J. S., 1 mar. 2015, I: The Lancet Diabetes and Endocrinology. 3, 3, s. 168 1 s.
Publikation: Bidrag til tidsskrift › Letter