Published in 2015

Increase in waist circumference over 6 years predicts subsequent cardiovascular disease and total mortality in nordic women

Klingberg, S., Mehlig, K., Lanfer, A., Björkelund, C., Heitmann, B. L. & Lissner, L., okt. 2015, I: Obesity (Silver Spring, Md.). 23, 10, s. 2123-30 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: Despite solid evidence of an association between centralized body fatness and subsequent disease risk, little is known about the consequences of changes in body fat distribution. Recently it was shown that large hip circumference (HC), measured once, was protective against total and cardiovascular disease (CVD) mortality in women but that gain or loss in HC was unrelated to these outcomes. This study examines whether a 6-year change in waist circumference (WC) predicts mortality and CVD in the same study sample.

METHODS: Baseline WC and 6-year change in WC as predictors of mortality and CVD were analyzed in 2,492 women from the Danish MONICA study and the Prospective Population Study of Women in Gothenburg, Sweden.

RESULTS: Increase in WC was significantly associated with increased subsequent mortality and CVD adjusting for BMI and other covariates, with some evidence of a J-shaped association. Associations between increase in WC and outcomes were restricted to women with normal weight at baseline and to ever-smokers.

CONCLUSIONS: In contrast to changes in HC which did not predict mortality and CVD, a 6-year increase in WC is strongly predictive, particularly among initially lean women and ever-smokers. This implies the importance of developing strategies to prevent central fat deposition.

Originalsprog Engelsk
Tidsskrift Obesity (Silver Spring, Md.)
Vol/bind 23
Udgave nummer 10
Sider (fra-til) 2123-30
Antal sider 8
ISSN 1930-7381
DOI
Status Udgivet - okt. 2015

Integration of health promotion in clinical hospital departments: standards fulfillment, documentation of needs and service delivery

Svane, J. K., Chiou, S-T., Chang, Y-L., Shen, S-H., Huang, C-H., Pan, C-Y., Lin, M-N., Shieh, Y-H., Wu, T., Wu, S-C., Chau, T-T., Hung, L-Y., Kan, Y-Y., Wang, C-J., Yuan, R-Y., Yu, H-I., Chuo, Y-H., Chen, M-S., Chan, H-T., Chou, Y-L., & 5 flerePei, D., Wang, NP., Tsai, T-C., Wu, H-C. & Tønnesen, H., 2015, I: Clinical Health Promotion. 5, 1, s. 11-17 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Clinical Health Promotion
Vol/bind 5
Udgave nummer 1
Sider (fra-til) 11-17
Antal sider 7
Status Udgivet - 2015

International Consensus for ultrasound lesions in gout: results of Delphi process and web-reliability exercise

Gutierrez, M., Schmidt, W. A., Thiele, R. G., Keen, H. I., Kaeley, G. S., Naredo, E., Iagnocco, A., Bruyn, G. A., Balint, P. V., Filippucci, E., Mandl, P., Kane, D., Pineda, C., Delle Sedie, A., Hammer, H. B., Christensen, R., D'Agostino, M. A., Terslev, L. & OMERACT Ultrasound Gout Task Force group, okt. 2015, I: Rheumatology (Oxford, England). 54, 10, s. 1797-805 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: To produce consensus-based definitions of the US elementary lesions in gout and to test their reliability in a web-based exercise.

METHODS: The process consisted of two steps. In the first step a written Delphi questionnaire was developed from a systematic literature review and expert international consensus. This collated information resulted in four statements defining US elementary lesions: double contour (DC), tophus, aggregates and erosion. The Delphi questionnaire was sent to 35 rheumatology experts in US, asking them to rate their level of agreement or disagreement with each statement. The second step tested the reliability by a web-exercise. US images of both normal and gouty elementary lesions were collected by the participants. A facilitator then constructed an electronic database of 110 images. The database was sent to the participants, who evaluated the presence/absence of US elementary lesions. A group of 20 images was displayed twice to evaluate intra-reader reliability.

RESULTS: A total of 32 participants responded to the questionnaires. Good agreement (>80%) was obtained for US definitions on DC, tophus, aggregates and erosion in the Delphi exercise after three rounds. The reliability on images showed inter-reader κ values for DC, tophus, aggregates, erosion findings of 0.98, 0.71, 0.54 and 0.85, respectively. The mean intra-reader κ values were also acceptable: 0.93, 0.78, 0.65 and 0.78, respectively.

CONCLUSION: This, the first consensus-based US definition of elementary lesions in gout, demonstrated good reliability overall. It constitutes an essential step in developing a core outcome measurement that permits a higher degree of homogeneity and comparability between multicentre studies.

Originalsprog Engelsk
Tidsskrift Rheumatology (Oxford, England)
Vol/bind 54
Udgave nummer 10
Sider (fra-til) 1797-805
Antal sider 9
ISSN 1462-0324
DOI
Status Udgivet - okt. 2015

Investing in clinical health promotion

Tønnesen, H., 2015, I: Clinical Health Promotion. 5, s. 65-66 2 s.

Publikation: Bidrag til tidsskriftLeder

Originalsprog Engelsk
Tidsskrift Clinical Health Promotion
Vol/bind 5
Sider (fra-til) 65-66
Antal sider 2
Status Udgivet - 2015

K(V)7.4 channels participate in the control of rodent renal vascular resting tone

Salomonsson, M., Brasen, J. C., Braunstein, T. H., Hagelqvist, P., Holstein-Rathlou, N.-H. & Sorensen, C. M., jul. 2015, I: Acta physiologica (Oxford, England). 214, 3, s. 402-14 13 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Klinisk neurologi og neurokirurgi

Paulson, O. B., Gjerris, F. & Soelberg Sørensen, P., 2015, 6. udgave udg. Kbh: FADL's Forlag. 791 s.

Publikation: Bog/antologi/afhandling/rapportBogForskningpeer review

Lactate level, aetiology and mortality of adult patients in an emergency department: a cohort study

Pedersen, M., Brandt, V. S., Holler, J. G. & Lassen, A. T., sep. 2015, I: Emergency medicine journal : EMJ. 32, 9, s. 678-84 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Long-term incidence of vitrectomy and associated risk factors in young Danish patients with Type 1 diabetes: the Danish Cohort of Paediatric Diabetes 1987

Broe, R., Rasmussen, M. L., Frydkjaer-Olsen, U., Olsen, B. S., Mortensen, H. B., Peto, T. & Grauslund, J., apr. 2015, I: Diabetic Medicine. 32, 4, s. 542-545 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

AIMS: To examine the long-term incidence of vitrectomy in young people with Type 1 diabetes.

METHODS: We prospectively studied 324 people with Type 1 diabetes who participated in baseline examinations in 1995. Surgical history was obtained from the Danish National Patient Registry in April 2012.

RESULTS: During the 17-year study period, 39 people (12.0%) underwent vitrectomy at least once. The mean age and diabetes duration at first vitrectomy were 29.8 and 22.9 years, respectively, and 64.1% of the participants were men. In multivariable Cox regression analysis, baseline age (hazard ratio 0.81 per 1 year increase), BMI (hazard ratio 1.21 per 1 kg/m(2) increase), HbA1c (hazard ratio 1.72 per 1% increase) and diabetic retinopathy (hazard ratio 2.85 and 6.07 for mild and moderate/severe diabetic retinopathy vs none, respectively) were independent predictors of vitrectomy (P < 0.05 for all variables).

CONCLUSIONS: Vitrectomy is a relatively common procedure in young people with Type 1 diabetes, with poor glycaemic control being the strongest modifiable risk factor.

Originalsprog Engelsk
Tidsskrift Diabetic Medicine
Vol/bind 32
Udgave nummer 4
Sider (fra-til) 542-545
Antal sider 4
ISSN 0742-3071
DOI
Status Udgivet - apr. 2015

Low Prevalence of Parvovirus 4 in HIV-infected Children in Denmark

Rosenfeldt, V., Norja, P., Lindberg, E., Jensen, L., Hedman, L., Väisänen, E., Li, X., Hedman, K. & von Linstow, M-L., jul. 2015, I: The Pediatric infectious disease journal. 34, 7, s. 761-2 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Magnetic resonance imaging in rheumatoid arthritis

Østergaard, M., Axelsen, M. B. & Boesen, M., 2015, Atlas of Rheumatoid Arthritis. Springer Healthcare

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

Originalsprog Engelsk
Titel Atlas of Rheumatoid Arthritis
Forlag Springer Healthcare
Publikationsdato 2015
Status Udgivet - 2015

Managing chronic pain in survivors of torture

Amris, K. & Williams, A. C. D. C., jan. 2015, I: Pain Management. 5, 1, s. 5-12 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

All generalist and specialist clinicians are likely to encounter torture survivors among refugees and asylum seekers. A minority of people survive torture and a smaller minority reach a developed country; those who do tend to be the more resilient and resourceful. They have many health, social and welfare problems; persistent pain in the musculoskeletal system is one of the most common. There is little specific evidence on pain in survivors of torture; the guidelines on interdisciplinary specialist management are applicable. Most of the literature on refugee survivors of torture has an exclusive focus on psychological disorders, with particularly poor understanding of pain problems. This article summarizes the current status of assessment and treatment of pain problems in the torture survivor.

Originalsprog Engelsk
Tidsskrift Pain Management
Vol/bind 5
Udgave nummer 1
Sider (fra-til) 5-12
Antal sider 8
ISSN 1758-1869
DOI
Status Udgivet - jan. 2015

Matrix metalloproteinase 14 is required for fibrous tissue expansion

Yeung, C.-Y. C., 21 sep. 2015, I: eLife. https://doi.org/10.7554/eLife.09345.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: To determine if variations in trial eligibility criteria and patient baseline characteristics could be considered effect modifiers of the treatment response when testing targeted therapies (biological agents and targeted synthetic disease modifying antirheumatic drugs (DMARDs)) for rheumatoid arthritis (RA).

METHODS: We conducted a meta-epidemiological study of all trials evaluating a targeted therapy approved by regulatory authorities for treating RA. The database search was completed on December 11th 2013. Eligible trials reported ACR20 data at months 3-6 and used an add-on design. Odds ratios (ORs) were calculated from the response rates and compared among the trial eligibility criteria/patient baseline characteristics of interest. Comparisons are presented as the Ratio of Odds Ratios (ROR).

RESULTS: Sixty-two trials (19,923 RA patients) were included in the primary analyses using ACR20 response. Overall, targeted therapies constituted an effective treatment (OR 3.96 95% confidence interval (CI) 3.41 to 4.60). The majority of the trial eligibility criteria and patient baseline characteristics did not modify treatment effect. The added benefit of targeted therapies was lower in trials including "DMARD-naïve" patients compared with trials including "DMARD inadequate responders" (ROR = 0.45, 95%CI 0.31 to 0.66) and trials including "targeted therapy inadequate responders" (0.50, 95%CI 0.29 to 0.87), test for interaction: p = 0.0002. Longer mean disease duration was associated with a higher likelihood of responding to treatment (β = 1.05, 95%CI 1.00 to 1.11 OR's per year; p = 0.03). Analyses conducted using DAS28-remission as the outcome supported the above-mentioned findings.

CONCLUSION: Our results suggest that a highly selective inclusion is not associated with greater treatment effect, as might otherwise be expected. The added benefit of a targeted therapy was lower in trials including patients who were DMARD-naïve and trials including patients with shorter disease durations.

Originalsprog Engelsk
Tidsskrift P L o S One
Vol/bind 10
Udgave nummer 9
Sider (fra-til) e0136982
ISSN 1932-6203
DOI
Status Udgivet - 2015

MRI assessment of early response to certolizumab pegol in rheumatoid arthritis: a randomised, double-blind, placebo-controlled phase IIIb study applying MRI at weeks 0, 1, 2, 4, 8 and 16

Østergaard, M., Jacobsson, L. T. H., Schaufelberger, C., Hansen, M. S., Bijlsma, J. W. J., Dudek, A., Rell-Bakalarska, M., Staelens, F., Haake, R., Sundman-Engberg, B. & Bliddal, H., 2015, I: Annals of the Rheumatic Diseases. 74, s. 1156-1163 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVES: To identify the first time point of an MRI-verified response to certolizumab pegol (CZP) therapy in patients with rheumatoid arthritis (RA).

METHODS: Forty-one patients with active RA despite disease-modifying antirheumatic drug therapy were randomised 2:1 to CZP (CZP loading dose 400 mg every 2 weeks at weeks 0-4; CZP 200 mg every 2 weeks at weeks 6-16) or placebo→CZP (placebo at weeks 0-2; CZP loading dose at weeks 2-6; CZP 200 mg every 2 weeks at weeks 8-16). Contrast-enhanced MRI of one hand and wrist was acquired at baseline (week 0) and weeks 1, 2, 4, 8 and 16. All six time points were read simultaneously, blinded to time, using the Outcome Measures in Rheumatology Clinical Trials RA MRI scoring system. Primary outcome was change in synovitis score in the CZP group; secondary outcomes were change in bone oedema (osteitis) and erosion scores and clinical outcome measures.

RESULTS: Forty patients were treated (27 CZP, 13 placebo→CZP), and 36 (24 CZP, 12 placebo→CZP) completed week 16. In the CZP group, there were significant reductions from baseline synovitis (Hodges-Lehmann estimate of median change, -1.5, p=0.049) and osteitis scores (-2.5, p=0.031) at week 16. Numerical, but statistically insignificant, MRI inflammation reductions were observed at weeks 1-2 in the CZP group. No significant change was seen in bone erosion score. Improvements across all clinical outcomes were seen in the CZP group.

CONCLUSIONS: CZP reduced MRI synovitis and osteitis scores at week 16, despite small sample size and the technical challenge of reading six time points simultaneously. This study provides essential information on optimal MRI timing for subsequent trials.

TRIAL REGISTRATION NUMBER: ClinicalTrials.gov, NCT01235598.

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Udgave nummer 74
Sider (fra-til) 1156-1163
Antal sider 8
ISSN 0003-4967
DOI
Status Udgivet - 2015

BACKGROUND: Soccer players are commonly affected by long-standing adductor-related groin pain (ARGP), but the clinical significance of MRI findings in these athletes is largely unknown. Our aims were (1) to evaluate whether MRI findings are associated with long-standing ARGP in soccer players, (2) to assess MRI findings in asymptomatic soccer players and non-soccer playing controls.

METHODS: This cross-sectional study included 28 male soccer players with long-standing ARGP, 17 male asymptomatic soccer players and 20 male asymptomatic non-soccer playing athletes of matching age and athletic exposure. Participants underwent identical standardised and reliable clinical examination, and MRI scans (3 T) of the pelvis performed by a blinded observer. Images were consensus rated by three blinded radiologists according to a standardised MRI evaluation protocol. The associations between clinical adductor-related findings and pathological MRI findings were investigated with χ(2) statistics and OR.

RESULTS: Central disc protrusion (p=0.027) and higher grades of pubic bone marrow oedema (BMO; p=0.027) were significantly more present in symptomatic players than asymptomatic players. However, up to 71% of asymptomatic soccer players displayed different positive MRI findings, and asymptomatic soccer players had significantly higher odds (OR ranging from 6.3 to 13.3) for BMO, adductor tendinopathy and degenerative changes than non-soccer players.

CONCLUSIONS: ARGP in soccer players was associated with central disc protrusion and higher grades of pubic BMO. Moreover, positive MRI findings were significantly more frequent in soccer players compared with non-soccer players irrespective of symptoms, suggesting that these MRI changes may be associated with soccer play itself rather than clinical symptoms.

Originalsprog Engelsk
Tidsskrift British Journal of Sports Medicine
Vol/bind 49
Sider (fra-til) 681-91
ISSN 0306-3674
DOI
Status Udgivet - 2015

Multi-frequency bioimpedance in equine muscle assessment

Harrison, A. P., Elbrønd, V. S., Riis-Olesen, K. & Bartels, E. M., mar. 2015, I: Physiological Measurement. 36, 3, s. 453-64 12 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Multi-frequency BIA (mfBIA) equipment has been shown to be a non-invasive and reliable method to assess a muscle as a whole or at fibre level. In the equine world this may be the future method of assessment of training condition or of muscle injury. The aim of this study was to test if mfBIA reliably can be used to assess the condition of a horse's muscles in connection with health assessment, injury and both training and re-training. mfBIA measurements was carried out on 10 'hobby' horses and 5 selected cases with known anamnesis. Impedance, resistance, reactance, phase angle, centre frequency, membrane capacitance and both extracellular and intracellular resistance were measured. Platinum electrodes in connection with a conductance paste were used to accommodate the typical BIA frequencies and to facilitate accurate measurements. Use of mfBIA data to look into the effects of myofascial release treatment was also demonstrated. Our findings indicate that mfBIA provides a non-invasive, easily measurable and very precise assessment of the state of muscles in horses. This study also shows the potential of mfBIA as a diagnostic tool as well as a tool to monitor effects of treatment e.g. myofascial release therapy and metabolic diseases, respectively.

Originalsprog Engelsk
Tidsskrift Physiological Measurement
Vol/bind 36
Udgave nummer 3
Sider (fra-til) 453-64
Antal sider 12
ISSN 0967-3334
DOI
Status Udgivet - mar. 2015

Multi-frequency bioimpedance in human muscle assessment

Bartels, E. M., Sørensen, E. R. & Harrison, A. P., apr. 2015, I: Physiological Reports. 3, 4, e12354.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Bioimpedance analysis (BIA) is a well-known and tested method for body mass and muscular health assessment. Multi-frequency BIA (mfBIA) equipment now makes it possible to assess a particular muscle as a whole, as well as looking at a muscle at the fiber level. The aim of this study was to test the hypothesis that mfBIA can be used to assess the anatomical, physiological, and metabolic state of skeletal muscles. mfBIA measurements focusing on impedance, resistance, reactance, phase angle, center frequency, membrane capacitance, and both extracellular and intracellular resistance were carried out. Eight healthy human control subjects and three selected cases were examined to demonstrate the extent to which this method may be used clinically, and in relation to training in sport. The electrode setup is shown to affect the mfBIA parameters recorded. Our recommendation is the use of noble metal electrodes in connection with a conductance paste to accommodate the typical BIA frequencies, and to facilitate accurate impedance and resistance measurements. The use of mfBIA parameters, often in conjunction with each other, can be used to reveal indications of contralateral muscle loss, extracellular fluid differences, contracted state, and cell transport/metabolic activity, which relate to muscle performance. Our findings indicate that mfBIA provides a noninvasive, easily measurable and very precise momentary assessment of skeletal muscles.

Originalsprog Engelsk
Artikelnummer e12354
Tidsskrift Physiological Reports
Vol/bind 3
Udgave nummer 4
DOI
Status Udgivet - apr. 2015

Multidrug-resistant tuberculosis in Europe, 2010-2011

TBNET, mar. 2015, I: Emerging Infectious Diseases . 21, 3, s. 409-16 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Muskelfremhævende paraffinolieinjektioner

Gyldenløve, M. & Hansen, D., dec. 2015, I: Ugerskrift for Læger. 2015, 2452.

Publikation: Bidrag til tidsskriftLetterpeer review

National klinisk retningslinje for øvre dysfagi - Opsporing, udredning og udvalgte indsatse

Læbo (Ginnerup-Nielsen), E. G., 2015, National klinisk retningslinje for øvre dysfagi - Opsporing, udredning og udvalgte indsatse. (National klinisk retningslinje).

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel National klinisk retningslinje for øvre dysfagi - Opsporing, udredning og udvalgte indsatse
Publikationsdato 2015
Status Udgivet - 2015
Navn National klinisk retningslinje

Pages