Published in 1995

Bronchial hyperresponsiveness in children and adolescents

Backer, V., nov. 1995, I: Danish Medical Journal. 42, 5, s. 397-409 13 s.

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Divergent human papillomavirus type 16 variants are serologically cross-reactive

Cheng, G., Icenogle, J. P., Kirnbauer, R., Hubbert, N. L., St Louis, M. E., Han, C., Svare, E. I., Kjaer, S. K., Lowy, D. R. & Schiller, J. T., dec. 1995, I: The Journal of infectious diseases. 172, 6, s. 1584-7 4 s.

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Falling incidence of penis cancer in an uncircumcised population (Denmark 1943-90)

Frisch, M., Friis, S., Kjaer, S. K. & Melbye, M., 2 dec. 1995, I: BMJ (Clinical research ed.). 311, 7018, s. 1471

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Naloxone-provoked vaso-vagal response to head-up tilt in men

Madsen, P., Olesen, H. L., Secher, N. H. & Klokker, M., mar. 1995, I: European Journal of Applied Physiology and Occupational Physiology. 70, 3, s. 246-251 6 s.

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Ojenskader ved hobbyarbejde med maskinelt håndvaerktøj

Hölmich, L. R., Hölmich, P. & Lohmann, M. 10 apr. 1995 I : Ugeskrift for laeger. 157, 15, s. 2131-4 4 s.

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Data from the EU-project EHLASS (European Home and Leisure Accident Surveillance System) collected from five Danish hospitals during the period 1989-1991 contained 185,551 accidents occurring at home and during leisure time. The population in the catchment area is approximately 700,000. Of these accidents, 9900 involved eye-injury, 2940 of these occurred during hobby-activities, and 1460 of these while the subject was using either drilling-, welding- or grinding-equipment. The incidence of eye-injuries occurring during the use of these machines has risen from 0.6/1000/year in 1989 to 0.7/1000/year in 1990 and to 0.8/1000/year in 1991. In 98% of the cases the patients were men, 30% were between 20 and 29 years of age. A common activity at the time of the accident was "car-repairing". Foreign-body-lesions were seen in 60% of the cases, and actinic conjunctivitis in 30%. None of the injuries were serious, but they were often very painful and demanding of resources. All the injuries could have been avoided by the use of proper eye protection.

Originalsprog Dansk
Tidsskrift Ugeskrift for laeger
Vol/bind 157
Tidsskriftsnummer 15
Sider (fra-til) 2131-4
Antal sider 4
ISSN 0041-5782
Status Udgivet - 10 apr. 1995

Persistent reduction in lung function after Pneumocystis carinii pneumonia in AIDS patients

Nelsing, S., Jensen, B. N. & Backer, V., 1995, I: Scandinavian Journal of Infectious Diseases. 27, 4, s. 351-5 5 s.

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Reaction Papters to Chapters 10 and 11

Jensen, R. H., Olesen, J., D. Mohl, N. & J. Gatchel, R., 1995, I: Progress in Pain Research and Management. s. 193-198 6 s.

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Sympathetic influence on cardiovascular responses to sustained head‐up tilt in humans

PEDERSEN, M., MADSEN, P., KLOKKER, M., OLESEN, H. L. & SECHER, N. H., dec. 1995, I: Acta Physiologica Scandinavica. 155, 4, s. 435-444 10 s.

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The twitch interpolation technique for study of fatigue of human quadriceps muscle

Bülow, P. M., Nørregaard, J., Mehlsen, J. & Danneskiold-Samsøe, B., 1 nov. 1995, I: Journal of Neuroscience Methods. 62, 1-2, s. 103-9 7 s.

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The aim of the study was to examine if the twitch interpolation technique could be used to objectively measure fatigue in the quadriceps muscle in subjects performing submaximally. The 'true' maximum isometric quadriceps torque was determined in 21 healthy subject using the twitch interpolation technique. Then an endurance test was performed in which the subjects made repeated isometric contractions at 50% of the 'true' maximum torque for 4 s, separated by 6 s rest periods. During the test, the force response to single electrical stimulation (twitch amplitude) was measured at 50% and 25% of the estimated maximum torque. In 10 subjects, the test was repeated 2-4 weeks later. Twitch amplitudes at 50% of maximum torque declined exponentially with time in 20 of 21 subjects. The distribution of the exponential rate constant was skewed with a mean of 4.6 h-1 and range of 0.3-21.5 h-1. After logarithmical transformation, the distribution of the exponential rate constant fitted closely to a normal distribution, and the inter-individual variation was SD = 1.15 compared to an intra-individual variation of 0.29. The coefficient of correlation for repeated determination was 0.91 (P <0.001, n = 10). In conclusion, the twitch technique can be used for objectively measuring fatigue of the quadriceps muscle.
Originalsprog Engelsk
Tidsskrift Journal of Neuroscience Methods
Vol/bind 62
Udgave nummer 1-2
Sider (fra-til) 103-9
Antal sider 7
ISSN 0165-0270
Status Udgivet - 1 nov. 1995

Thoracic electrical impedance and fluid balance during aortic surgery

Jónsson, F., Madsen, P., Jørgensen, L. G., Lunding, M. & Secher, N. H., maj 1995, I: Acta Anaesthesiologica Scandinavica. 39, 4, s. 513-517 5 s.

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Published in 1994

Absence of vasoactive peptide release from brain to cerebral circulation during onset of migraine with aura

Friberg, L., Olesen, J., Olsen, T. S., Karle, A., Ekman, R. & Fahrenkrug, J., feb. 1994, I: Cephalalgia. 14, 1, s. 47-54 8 s.

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In eight patients carotid angiography was required for evaluation of transient neurological attacks. Cerebral blood flow results, angiography and clinical observations subsequently suggested the diagnosis of migraine. We measured plasma concentrations of substance P(SP), neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) in repeated blood samples obtained from the carotid artery and the internal jugular vein in conjunction with cerebral angiography followed by 4 to 6 repeated recordings of regional cerebral blood flow (rCBF) with the intracarotid Xenon-133 injection technique. This technique is known to induce attacks of migraine with aura in many sufferers. Four patients developed aura symptoms. In three this was succeeded by throbbing headache. Typical, migraine-related, focal hypoperfusion occurred in conjunction with the aura symptoms. The remaining four patients had no symptoms or rCBF changes. There were no systematic or statistically significant changes over time in arterial-venous plasma concentrations or in the release rates of any of the peptides. All migraineurs had an overall elevated mean CGRP value compared to control values from the literature. The overall plasma levels of the potent vasoconstrictor NPY were higher (p <0.10) in the group that developed symptoms and rCBF changes (136 pmol/l) than in the non-symptomatic group (97 pmol/l). The difference in NPY levels could perhaps be associated with the focal rCBF decrease seen in the attack group.
Originalsprog Engelsk
Tidsskrift Cephalalgia
Vol/bind 14
Udgave nummer 1
Sider (fra-til) 47-54
Antal sider 8
ISSN 0333-1024
Status Udgivet - feb. 1994

An 8-year follow-up study of pulmonary function in patients with rheumatoid arthritis

Linstow, M., Ulrik, C. S., Kriegbaum, N. J., Backer, V. & Oxholm, P., 1994, I: Rheumatology International. 14, 3, s. 115-8 4 s.

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Biochemical changes in relation to a maximal exercise test in patients with fibromyalgia

Nørregaard, J., Bülow, P. M., Mehlsen, J. & Danneskiold-Samsøe, B., 1 mar. 1994, I: Clinical Physiology and Functional Imaging. 14, 2, s. 159-67 9 s.

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Patients with fibromyalgia often complain of fatigue and pain during exercise and of worsening of pain days after exercise. The aim of the study described here was to determine if abnormal changes in potassium or lactate could be observed during an exercise test in fibromyalgia. Whether an abnormal incline in plasma creatine kinase or myoglobin could be observed days after the test was studied also. Fifteen female fibromyalgia patients and 15 age- and sex-matched controls performed a stepwise incremental maximal bicycle-ergometer test. Blood samples were collected from a catheter in a cubital vein. The changes in heart rate, potassium levels, and haematocrit during the exercise test were similar in the two groups. The maximal obtained lactate concentration was 4.2 mmol l-1 (3.5-5.6) in the patients as compared to 4.9 mmol l-1 (3.9-5.9) in the controls (NS). The estimated anaerobic threshold of 2 mmol l-1 was reached at a heart rate of 124 min-1 in the patients with fibromyalgia as compared to 140 min-1 in the controls (P = 0.02). In relation to workload, the patients scored higher on a Borg scale for perceived exertion during exercise, but if the Borg score was related to lactate no significant difference was found. The patients reported 86% and 79% of maximal pain in the thighs on the visual analogue scale 1 and 2 days after the test, but the creatine kinase and myoglobin concentrations were not increased.
Originalsprog Engelsk
Tidsskrift Clinical Physiology and Functional Imaging
Vol/bind 14
Udgave nummer 2
Sider (fra-til) 159-67
Antal sider 9
ISSN 1475-0961
Status Udgivet - 1 mar. 1994

Bronchial responsiveness in children and adolescents: a comparison between previously asthmatic, currently asthmatic, and normal subjects

Hansen, K. K., Laursen, E. M., Backer, V., Bach-Mortensen, N., Prahl, P. & Koch, C., 1994, I: The Journal of asthma : official journal of the Association for the Care of Asthma. 31, 2, s. 99-107 9 s.

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Cancer morbidity in alcohol abusers

Tønnesen, H., Møller, H., Andersen, J. R., Juel, K. & Jensen, E., 1994, I: British Journal of Cancer. 69

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Originalsprog Dansk
Tidsskrift British Journal of Cancer
Vol/bind 69
ISSN 0007-0920
Status Udgivet - 1994

Cerebral oxygen extraction, oxygen consumption, and regional cerebral blood flow during the aura phase of migraine

Friberg, L., Olesen, J., Lassen, N. A., Olsen, T. S. & Karle, A. maj 1994 I : Stroke. 25, 5, s. 974-9 6 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The aura phase of migraine is associated with focal blood flow changes, but it has been largely unknown whether these changes are correlated to changes in the cerebral metabolism.
Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato maj 1994
Vol/bind 25
Tidsskriftsnummer 5
Sider 974-9
Antal sider 6
ISSN 0039-2499
Status Udgivet

Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists

Sjøgren, P., Jensen, N.-H. & Jensen, T. S., nov. 1994, I: Pain. 59, 2, s. 313-316 4 s.

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In 92 migraine patients and 44 healthy control subjects we recorded regional cerebral blood flow (rCBF) with single photon emission computerized tomography and (133) Xe inhalation or with i.v. (99m) Tc-HMPAO. Migraine patients were studied interictally. A quantitated analysis of right-left asymmetry indices in a fixed set of regions of interest was compared with the normal asymmetry indices in the healthy controls. An asymmetry index deviating more than ± 2.5 S.D.s in normals was defined as pathological asymmetry. By quantitated analysis 47% of images from patients with aura attacks and 48% of images from patients without aura attacks were established to contain higher rate of asymmetries, the difference being statistically significant (p < 0.05, Wilcoxon). A blinded visual analysis and scoring by a four level scale were done by four experienced observers. rCBF images from 18% of patients having attacks with aura and from 19% of patients without aura attacks was scored as containing abnormal right-left asymmetries by the visual analysis. Images from healthy controls were all scored to be normal. In 37% of the images (all from patients) there was lack of consensus among observers (κ = 0.28). There was no correlation between visual or quantitated abnormalities and age, duration of migraine, frequency of attacks or prophylactic medication. No correlation could be established between asymmetries and the usual side of headache or aura symptoms. Two conclusions emerged: (1) visual evaluation of interictal migraine rCBF images is insufficient to pick up abnormalities; (2) almost 50% of the migraine sufferers had abnormal rCBF/asymmetries. However, these are discrete compared with those typically seen during the aura phase of a migraine attack. One explanation to the patchy rCBF patterns might be that they reflect interictal cerebrovascular dysregulation which might to be a common feature in both types of migraine.

Originalsprog Engelsk
Tidsskrift European journal of neurology : the official journal of the European Federation of Neurological Societies
Udgivelsesdato sep 1994
Vol/bind 1
Tidsskriftsnummer 1
Sider 35-43
Antal sider 9
ISSN 1351-5101
DOI
Status Udgivet

Magnetisk resonans-spektroskopi ved fibromyalgi. En undersøgelse af fosfat-31 spektra fra skeletmuskulaturen i hvile, under og efter arbejde

Jacobsen, S., Jensen, K. E., Thomsen, C., Danneskiold-Samsøe, B. & Henriksen, O., 14 nov. 1994, I: Ugeskrift for Laeger. 156, 46, s. 6841-4 4 s.

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31phosphorus nuclear magnetic resonance (31P NMR) spectroscopy of painful calf muscle was performed in 12 patients with fibromyalgia and 7 healthy subjects during rest, aerobic and anaerobic exercising conditions, and postexercise recovery. Ratios of inorganic phosphate and creatine phosphate (Pi/PCr) and pH were calculated from the collected 31P NMR spectra. Resting values of Pi/PCr were normal in the patients. Patients only tolerated 49% of the workload tolerated by the controls (P = 0.005). Patients and controls had similar rates of Pi/PCr and pH changes during work and recovery. The controls were able to change their Pi/PCr and pH more than the patients, due to the greater workload reached. However, statistical significance was only reached for the anaerobic static exercise (P = 0.003). It was concluded that fibromyalgia patients have a reduced voluntary capacity for work, but with a biochemical response to work and recovery similar to healthy subjects.
Bidragets oversatte titel Magnetic resonance spectroscopy in fibromyalgia. A study of phosphate-31 spectra from skeletal muscles during rest and after exercise
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 156
Udgave nummer 46
Sider (fra-til) 6841-4
Antal sider 4
ISSN 0041-5782
Status Udgivet - 14 nov. 1994

Monoclonal IgA class-switch variants against bacterial surface antigens: molecular forms and transport into murine respiratory secretions

Steinmetz, I., Albrecht, F., Häussler, S. & Brenneke, B., nov. 1994, I: European Journal of Immunology. 24, 11, s. 2855-62 8 s.

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