Mannitol and the mechanisms behind bronchoconstriction
Backer, V., okt. 2019, I: The Journal of allergy and clinical immunology. 144, 4, s. 931-932 2 s.
Publikation: Bidrag til tidsskrift › Leder › peer review
Backer, V., okt. 2019, I: The Journal of allergy and clinical immunology. 144, 4, s. 931-932 2 s.
Publikation: Bidrag til tidsskrift › Leder › peer review
Mortensen, L. Q., Andresen, K., Burcharth, J., Pommergaard, H-C. & Rosenberg, J., 2019, I: Frontiers in big data. 2, s. 4
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Sonesson, B., Dias, N., Abdulrasak, M. & Resch, T., jun. 2019, I: Journal of Vascular Surgery. 69, 6, s. 1664-1669 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Larsen, S. C. & Heitmann, B. L., 1 maj 2019, I: The Journal of Nutrition. 149, 5, s. 824-830 7 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
BACKGROUND: Few studies have examined the relationship between eating frequency and long-term change in body weight, and the results have been inconsistent.
OBJECTIVE: We examined the associations between eating frequency and 6-y changes in body mass index (BMI; in kg/m2), fat mass, fat-free mass, body fat percentage, and waist circumference.
METHODS: The study consisted of Danish men (n = 1080) and women (n = 1044) aged 35-67 y with repeated measures of eating frequency, adiposity, and covariates during 11 y. Multiple linear regression was used to assess the associations between baseline eating frequency and subsequent change in BMI, fat mass, fat-free mass, fat percentage, and waist circumference, as well as the association between initial change in eating frequency and subsequent change in the same outcomes.
RESULTS: Total baseline eating frequency was not associated with change in outcomes. However, when separately examining regular meals and snacks, each additional daily meal was associated with a subsequent 6-y change in BMI of -0.14 (95% CI: -0.27, -0.00). Similar tendencies of inverse associations were found for change in fat mass (P = 0.04), fat-free mass (P = 0.07), and waist circumference (P = 0.05). We found no association between initial change in total eating frequency and subsequent change in outcomes. However, each additional daily regular meal after 5 y was associated with a subsequent 6-y change in BMI of -0.16 (95% CI: -0.30, -0.01). Inverse associations were also seen for fat (P = 0.04) and fat-free mass (P = 0.05). In contrast, an increase in daily frequency of snacking was associated with an increase in fat mass (P = 0.04) and fat percentage (P = 0.02).
CONCLUSIONS: Our results indicate that total frequency of eating has little or no influence on adiposity among middle-aged Danish men and women. Consumption of regular meals, but not snack consumption, showed a weak inverse association with longitudinal gains in BMI.
Originalsprog | Engelsk |
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Tidsskrift | The Journal of Nutrition |
Vol/bind | 149 |
Udgave nummer | 5 |
Sider (fra-til) | 824-830 |
Antal sider | 7 |
ISSN | 0022-3166 |
DOI | |
Status | Udgivet - 1 maj 2019 |
Copyright © American Society for Nutrition 2019.
Bartels, E. M., Andersen, E. L., Olsen, J. K., Kristensen, L. E., Bliddal, H., Danneskiold-Samsøe, B. & Harrison, A. P., jun. 2019, I: Physiological Reports. 7, 11, s. e14109
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
The condition of active muscles determines an individual's ability to carry out daily activities and has implications for an athlete's performance. Multi-frequency bioimpedance (mfBIA) is a non-invasive, well-known, validated, and much used method to assess muscle condition. However, it is rarely used to its full potential. Our aim was to apply mfBIA fully in the assessment of an adult healthy population, to compare muscle condition in different functional rested muscle groups, with age, and between men and women, and establish a control data set. Fifty healthy subjects (25 men/25 women) aged 20-69 years, participated. mfBIA measurements at a frequency range of 4-1000 kHz were taken from muscles of the lower and the upper extremities, the upper back, and the hand. Data were analyzed using ImpediMed software, giving Impedance, Resistance, Reactance, Phase Angle, Center Frequency, external and internal Resistance, and Membrane Capacitance. Differences between means were tested for statistical significance. A P value >0.05 was considered nonsignificant. While no difference in the mfBIA parameters was seen with age, a highly significant gender difference was seen. At rest, women's muscles cf men's showed a significantly higher center frequency and intra- and extra-cellular resistance, while the membrane capacitance was lower. A set of values for mfBIA parameters for healthy adult individuals are given for some of the main muscles which are frequently part of muscle assessment. The documented gender difference in muscle condition at rest has important implications in work situations, during physical rehabilitation and when training for competitive sports.
Originalsprog | Engelsk |
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Tidsskrift | Physiological Reports |
Vol/bind | 7 |
Udgave nummer | 11 |
Sider (fra-til) | e14109 |
ISSN | 2051-817X |
DOI | |
Status | Udgivet - jun. 2019 |
© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
Jensen, J. D., Tang, L. H., Zwisler, A-D. O., Houlind, K. C. & Skou, S. T., dec. 2019, I: Scandinavian cardiovascular journal : SCJ. 53, 6, s. 361-372 12 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Begtrup, L. M., Specht, I. O., Hammer, P. E. C., Flachs, E. M., Garde, A. H., Hansen, J., Hansen, Å. M., Kolstad, H. A., Larsen, A. D. & Bonde, J. P., 1 maj 2019, I: Occupational and Environmental Medicine. 76, 5, s. 302-308 7 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
OBJECTIVE: Observational studies indicate an association between working nights and miscarriage, but inaccurate exposure assessment precludes causal inference. Using payroll data with exact and prospective measurement of night work, the objective was to investigate whether working night shifts during pregnancy increases the risk of miscarriage.
METHODS: A cohort of 22 744 pregnant women was identified by linking the Danish Working Hour Database (DWHD), which holds payroll data on all Danish public hospital employees, with Danish national registers on births and admissions to hospitals (miscarriage). The risk of miscarriage during pregnancy weeks 4-22 according to measures of night work was analysed using Cox regression with time-varying exposure adjusted for a fixed set of potential confounders.
RESULTS: In total 377 896 pregnancy weeks (average 19.7) were available for follow-up. Women who had two or more night shifts the previous week had an increased risk of miscarriage after pregnancy week 8 (HR 1.32 (95% CI 1.07 to 1.62) compared with women, who did not work night shifts. The cumulated number of night shifts during pregnancy weeks 3-21 increased the risk of miscarriages in a dose-dependent pattern.
CONCLUSIONS: The study corroborates earlier findings that night work during pregnancy may confer an increased risk of miscarriage and indicates a lowest observed threshold level of two night shifts per week.
Originalsprog | Engelsk |
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Tidsskrift | Occupational and Environmental Medicine |
Vol/bind | 76 |
Udgave nummer | 5 |
Sider (fra-til) | 302-308 |
Antal sider | 7 |
ISSN | 1351-0711 |
DOI | |
Status | Udgivet - 1 maj 2019 |
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Hammer, P. E. C., Garde, A. H., Begtrup, L. M., Flachs, E. M., Hansen, J., Hansen, Å. M., Hougaard, K. S., Kolstad, H. A., Larsen, A. D., Pinborg, A. B., Specht, I. O. & Bonde, J. P., 1 mar. 2019, I: Occupational and Environmental Medicine. 76, 3, s. 163-168 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
OBJECTIVE: The aim of our study was to investigate the acute effect of night work during pregnancy on the risk of calling in sick the following day using register-based information and the workers as their own controls.
METHODS: Using the payroll-based national Danish Working Hour Database, including all public hospital employees in Denmark, we identified 9799 pregnant women with ≥1 day shift and ≥1 night shift and ≥1 day of sick leave during the first 32 pregnancy weeks from January 2007 to December 2013. We performed fixed effects logistic regression, that is, within-worker comparisons, of the risk of sick leave of any duration starting within 24 hours after night shifts of different length versus day shifts.
RESULTS: Most of the participants were nurses (64%) or physicians (16%). We found an increased relative risk of sick leave following night shifts compared with day shifts during all pregnancy trimesters. The risk was highest for night shifts lasting >12 hours (OR 1.37, 95% CI 1.15 to 1.63 for nurses; OR 1.87, 95% CI 1.69 to 2.08 for physicians) and among women aged >35 years (OR 1.42, 95% CI 1.24 to 1.63).
CONCLUSION: Among Danish public hospital employees night shifts during pregnancy, especially shifts longer than 12 hours, increased the risk of calling in sick the following day independent of personal factors and time-invariant confounders in all pregnancy trimesters.
Originalsprog | Engelsk |
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Tidsskrift | Occupational and Environmental Medicine |
Vol/bind | 76 |
Udgave nummer | 3 |
Sider (fra-til) | 163-168 |
Antal sider | 6 |
ISSN | 1351-0711 |
DOI | |
Status | Udgivet - 1 mar. 2019 |
Specht, I. O., Hammer, P. E. C., Flachs, E. M., Begtrup, L. M., Larsen, A. D., Hougaard, K. S., Hansen, J., Hansen, Å. M., Kolstad, H. A., Rugulies, R., Garde, A. H. & Bonde, J. P., 2019, I: PLoS One. 14, 4, s. e0215748 e0215748.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
BACKGROUND: Melatonin stimulates the production of progesterone, which is essential for the maintenance of pregnancy. Since melatonin in blood is reduced due to work under illuminated conditions during night work, it has been hypothesized that night work may increase the risk of preterm birth. Previous meta-analyses have not revealed increased risk of preterm birth in women working night shifts during pregnancy. Still, these studies might have been limited by inaccurate self-reports of timing, intensity and duration of night work most likely causing bias towards the null. The aim of this is study was to investigate if the frequency and duration of night work during the first (week 1-12) and second (week 13-22) trimester of pregnancy were associated with risk of preterm birth when objective and prospective data on night work are used.
METHOD: In a register-based prospective cohort study, we obtained individual day-to-day information on working hours from The Danish Working Hour Database (DWHD, a payroll database including all public service employees in administrative Danish Regions from 2007-2013) and information on preterm birth from the Danish Medical Birth Registry. Night-shift was defined as at least three working hours between 23:00 and 06:00. Preterm birth was defined as giving birth during gestational weeks 23-37. Odds of preterm birth according to working night shifts were analysed by logistic regression.
RESULTS: We identified 16,501 pregnant women eligible for the study, of which 10,202 women (61.8%) had at least one night-shift during the first 22 gestational weeks. The risk of preterm birth was not elevated among women working night shifts compared to women working only day shifts during either the first or second trimester. Within night-shift workers, the risk was not related to the number of night shifts, the duration of night shifts, consecutive night shifts or quick returns defined as short intervals between shifts. Odds of preterm birth was not related to change of working schedule from the first to second trimester, although women changing from night shifts in the first trimester to day work only in the second trimester displayed a weak increased odds of preterm birth (OR 1.21, 95%CI 0.98-1.49) compared to women working night shifts in both trimesters.
CONCLUSION: Our results, which are without bias from self-report of either exposure or outcome, are in line with the results of previous meta-analyses. Due to the detailed information on hours worked during pregnancy, we were able to investigate several dimensions of night work not previously investigated, of which none were associated with elevated risk of preterm birth.
Originalsprog | Engelsk |
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Artikelnummer | e0215748 |
Tidsskrift | PLoS One |
Vol/bind | 14 |
Udgave nummer | 4 |
Sider (fra-til) | e0215748 |
ISSN | 1932-6203 |
DOI | |
Status | Udgivet - 2019 |
Arce-Rodríguez, A., Volke, D. C., Bense, S., Häussler, S. & Nikel, P. I., jul. 2019, I: Microbial biotechnology. 12, 4, s. 799-813 15 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Toupin-April, K., Barton, J. L., Fraenkel, L., Meara, A., Li, L. C., Brooks, P., de Wit, M., Stacey, D., Légaré, F., Shea, B., Lyddiatt, A., Hofstetter, C., Christensen, R., Scholte Voshaar, M., Suarez-Almazor, M. E., Boonen, A., Meade, T., March, L., Jull, J. E., Campbell, W., & 13 flere , okt. 2019, I: Journal of Rheumatology. 46, 10, s. 1409-1414 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Shared Decision Making (SDM) Working Group aims to determine the core outcome domain set for measuring the effectiveness of SDM interventions in rheumatology trials.
METHODS: A white paper was developed to clarify the draft core domain set. It was then used to prepare for interviews to investigate reasons for lack of consensus on it and to suggest further improvements.
RESULTS: OMERACT scientists/clinicians (n = 13) and patients (n = 10) suggested limiting the core domain set to outcome domains, removing process domains, and clarifying remaining domains.
CONCLUSION: A revised core domain set will undergo further consensus-building.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Rheumatology |
Vol/bind | 46 |
Udgave nummer | 10 |
Sider (fra-til) | 1409-1414 |
Antal sider | 6 |
ISSN | 0315-162X |
DOI | |
Status | Udgivet - okt. 2019 |
Henriksen, M., Alkjær, T., Raffalt, P. C., Jørgensen, L., Bartholdy, C., Hansen, S. H. & Bliddal, H., 2019, I: Pain medicine (Malden, Mass.).
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Objective: To investigate differences in gait variability induced by two different single-dose opioid formulations and an inert placebo in healthy volunteers and knee osteoarthritis patients.
Design: Experimental, randomized, double-blinded, crossover study of inert placebo (calcium tablets), 50 mg of tapentadol, and 100 mg of tramadol.
Setting: Laboratory setting.
Subjects: Healthy volunteers and knee osteoarthritis patients.
Methods: At three visits, separated by seven days, one tablet was administered per visit according to the randomization code. At each visit, a baseline measurement was done before tablet administration, after which hourly measurements were performed for six hours, yielding a total of seven measurements per visit. Gait variability was measured by three-dimensional gait analysis, recorded during six minutes of continuous treadmill walking at self-selected speed. One hundred seventy gait cycles were identified from detection of clear events of the knee joint angle trajectories. Gait variability was assessed as average standard deviations over a gait cycle of the sacrum displacements and accelerations; sagittal plane ankle, knee, and hip joint angles; step widths; and stride times.
Results: Twenty-four opioid-naïve and neurologically intact participants (12 healthy volunteers and 12 knee osteoarthritis patients) were included and completed the experiment. Tapentadol reduced the variability of sacrum displacements and accelerations compared with placebo and tramadol. There were no differences between experimental conditions regarding the variability in lower-extremity joint angle variability, step widths, or stride times.
Conclusions: In opioid-naïve and neurologically intact individuals, tapentadol seems to reduce movement variability during treadmill walking, compared with placebo and tramadol. This can be interpreted as a loss of adaptability that might increase the risk of falling if the system is perturbed.
Originalsprog | Engelsk |
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Tidsskrift | Pain medicine (Malden, Mass.) |
ISSN | 1526-2375 |
DOI | |
Status | Udgivet - 2019 |
Müller, F. C., Børgesen, H., Gosvig, K., Rodell, A., Booz, C., Schmidt, B., Krauss, B. & Boesen, M., 4 dec. 2019, I: European radiology experimental. 3, 1, s. 46
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Sulzgruber, P., Wassmann, S., Semb, A. G., Doehner, W., Widimsky, P., Gremmel, T., Kaski, J. C., Savarese, G., Rosano, G. M. C., Borghi, C., Kjeldsen, K., Torp-Pedersen, C., Schmidt, T. A., Lewis, B. S., Drexel, H., Tamargo, J., Atar, D., Agewall, S. & Niessner, A., 21 sep. 2019, I: European Heart Journal. 40, 36, s. 3010-3012 3 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Van Spil, W. E., Kubassova, O., Boesen, M., Bay-Jensen, A-C. & Mobasheri, A., jul. 2019, I: Biochemical Pharmacology. 165, s. 41-48 8 s.
Publikation: Bidrag til tidsskrift › Review › peer review
The success of disease-modifying osteoarthritis drug (DMOAD) development is still elusive. While there have been successes in preclinical and early clinical studies, phase 3 clinical trials have failed so far and there is still no approved, widely available DMOAD on the market. The latest research suggests that, among other causes, poor trial outcomes might be explained by the fact that osteoarthritis (OA) is a heterogeneous disease with distinct phenotypes. OA trials might be more successful if they would address and target a specific phenotype. The increasing availability of advanced techniques to detect particular OA characteristics expands the possibilities to distinguish between such potential OA phenotypes. Magnetic resonance imaging is among the key imaging techniques to stratify and monitor patients with changes in bone, cartilage and inflammation. Biochemical markers have mainly used as secondary parameters and could further delineate phenotypes. Moreover, post-hoc analyses of trial data have suggested the existence of distinct pain phenotypes and their relevance in the design of clinical trials. Although ongoing work in the field supports the concept of OA heterogeneity, this has not yet resulted in more effective treatment options. This paper reviews the current knowledge about potential OA phenotypes and suggests that combining patient clinical data, quantitative imaging, biochemical markers and utilizing data-driven approaches in patient selection and efficacy assessment will allow for more successful development of effective DMOADs.
Originalsprog | Engelsk |
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Tidsskrift | Biochemical Pharmacology |
Vol/bind | 165 |
Sider (fra-til) | 41-48 |
Antal sider | 8 |
ISSN | 0006-2952 |
DOI | |
Status | Udgivet - jul. 2019 |
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
Rosendahl, A., Krogh, S. & Kasch, H., 24 apr. 2019, I: Scandinavian Journal of Pain. 19, 2, s. 299-307 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Amris, K., Jones, L. E. & Williams, A. C. D. C., 2019, I: Pain Reports . 4, 6, s. e794 e794.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Introduction: Survivors of torture are for many reasons at particularly high risk for inadequate assessment and management of pain. Among the many health problems associated with torture, persistent pain is frequent, particularly pain in the musculoskeletal system. The pathophysiology underlying post-torture pain is largely unknown, but pain inflicted in torture may have profound effects on neurophysiology and pain processing.
Methods: A narrative review of assessment and treatment studies, informed by clinical experience, was undertaken.
Results: The clinical presentation in survivors of torture shares characteristics with other chronic primary pain syndromes, including chronic widespread pain. Unfortunately, such pain is often misunderstood and dismissed as a manifestation of psychological distress, both in specialist psychosocially oriented torture services and in mainstream health care. This means that pain is at risk of not being recognized, assessed, or managed as a problem in its own right.
Conclusions: The available research literature on rehabilitation for torture survivors is predominantly targeted at mental health problems, and studies of effectiveness of pain management in torture survivors are lacking. Rehabilitation is identified as a right in the UN Convention on Torture, aiming to restore as far as possible torture survivors' health and capacity for full participation in society. It is therefore important that pain and its consequences are adequately addressed in rehabilitative efforts. This article summarizes the current status on assessment and management of pain problems in the torture survivor.
Originalsprog | Engelsk |
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Artikelnummer | e794 |
Tidsskrift | Pain Reports |
Vol/bind | 4 |
Udgave nummer | 6 |
Sider (fra-til) | e794 |
ISSN | 2471-2531 |
DOI | |
Status | Udgivet - 2019 |
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.
Chiarotto, A., Kaiser, U., Choy, E., Christensen, R., Conaghan, P. G., Cowern, M., Gill, M., de Wit, M., Gargon, E., Horgan, B., Kirkham, J. J., Simon, L. S., Singh, J. A., Tugwell, P., Turk, D. C. & Mease, P. J., okt. 2019, I: Journal of Rheumatology. 46, 10, s. 1355-1359 5 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
OBJECTIVE: Establishing a research agenda on standardizing pain measurement in clinical trials in rheumatic and musculoskeletal diseases (RMD).
METHODS: Discussion during a meeting at the Outcome Measures in Rheumatology (OMERACT) 2018, prepared by a systematic review of existing core outcome sets and a patient online survey.
RESULTS: Several key questions were debated: Is pain a symptom or a disease? Are pain core (sub)domains consistent across RMD? How to account for pain mechanistic descriptors (e.g., central sensitization) in pain measurement?
CONCLUSION: Characterizing and assessing the spectrum of pain experience across RMD in a standardized fashion is the objective of the OMERACT Pain Working Group.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Rheumatology |
Vol/bind | 46 |
Udgave nummer | 10 |
Sider (fra-til) | 1355-1359 |
Antal sider | 5 |
ISSN | 0315-162X |
DOI | |
Status | Udgivet - okt. 2019 |
Højgaard, P., Ellegaard, K., Nielsen, S. M., Christensen, R., Guldberg-Møller, J., Ballegaard, C., Dreyer, L., Mease, P., de Wit, M., Skov, L., Glintborg, B., Bliddal, H., Bartels, E. M., Amris, K. & Kristensen, L. E., 1 jun. 2019, I: Arthritis Care & Research. 71, 6, s. 798-810 13 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
OBJECTIVE: To study the prognostic value of widespread pain and of musculoskeletal ultrasound (US) examination for subsequent treatment outcomes in patients with psoriatic arthritis (PsA).
METHODS: An exploratory prospective cohort study enrolled patients with PsA initiating biologic or conventional synthetic disease-modifying antirheumatic drugs in routine care. Clinical, US, and patient-reported measures were collected at baseline and after 4 months. Widespread nonarthritic pain (WP) was defined as a Widespread Pain Index score of ≥4 with pain in ≥4 of 5 regions. PsA activity by US was defined as color Doppler (yes/no) in selected entheses, joints, or tendons. The main response criteria included the American College of Rheumatology 20% improvement, the Disease Activity in Psoriatic Arthritis 50% improvement, and minimal disease activity. The primary analyses were age- and sex-adjusted logistic regression.
RESULTS: WP was present in 24 of 69 included patients (35%) and was associated with worse patient-reported and composite baseline measures, while US and other objective findings were similar to those in patients without WP. The odds of reaching minimal disease activity after 4 months were significantly greater for patients enrolled without WP (odds ratio 18.43 [95% confidence interval 1.51, 224.41]; P = 0.022), while WP did not impair other response measures. Patients with baseline color Doppler activity (n = 42 [61%]) had a worse objective PsA burden, but their chance of treatment response was comparable to those without color Doppler.
CONCLUSION: More than one-third of patients with PsA presented with WP, which was associated with worse patient-reported scores and failure to achieve minimal disease activity following conventional synthetic or biologic disease-modifying antirheumatic drug therapy. PsA activity by color Doppler US had no influence on subsequent treatment response in this PsA cohort.
Originalsprog | Engelsk |
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Tidsskrift | Arthritis Care & Research |
Vol/bind | 71 |
Udgave nummer | 6 |
Sider (fra-til) | 798-810 |
Antal sider | 13 |
ISSN | 2151-464X |
DOI | |
Status | Udgivet - 1 jun. 2019 |
© 2018, American College of Rheumatology.
Andersen, K. M., Kelly, A., Lyddiatt, A., Bingham, C. O., Bykerk, V. P., Batterman, A., Westreich, J., Jones, M. K., Cross, M., Brooks, P. M., March, L., Shea, B., Tugwell, P., Simon, L. S., Christensen, R. & Bartlett, S. J., sep. 2019, I: Journal of Rheumatology. 46, 9, s. 1168-1172 5 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) Safety Working Group is identifying core safety domains that matter most to patients with rheumatic disease.
METHODS: International focus groups were held with 39 patients with inflammatory arthritis to identify disease-modifying antirheumatic drug (DMARD) experiences and concerns. Themes were identified by pragmatic thematic coding and discussed in small groups by meeting attendees.
RESULTS: Patients view DMARD side effects as a continuum and consider the cumulative effect on day-to-day function. Disease and drug experiences, personal factors, and life circumstances influence tolerance of side effects and treatment persistence.
CONCLUSION: Patients weigh overall adverse effects and benefits over time in relation to experiences and life circumstances.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Rheumatology |
Vol/bind | 46 |
Udgave nummer | 9 |
Sider (fra-til) | 1168-1172 |
Antal sider | 5 |
ISSN | 0315-162X |
DOI | |
Status | Udgivet - sep. 2019 |