Published in 2015

CD1d knockout mice aggravated contact hypersensitivity responses due to reduced interleukin-10 production predominantly by regulatory B cells

Fjelbye, J., Antvorskov, J. C., Buschard, K. S., Issazadeh-Navikas, S. & Engkilde, K., 2015, I: Experimental Dermatology. 24, 11, s. 853-6 doi:10.1111/exd.12792.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Circulating Micro-RNA Profiles in Responders to Adalimumab Plus Methotrexate Versus Methotrexate Alone: A Placebo-Controlled Clinical Trial

OPERA study group, 2015, I: Arthritis & Rheumatology. 67, S10, s. 3832-5 4 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatology
Vol/bind 67
Udgave nummer S10
Sider (fra-til) 3832-5
Antal sider 4
ISSN 1537-2960
Status Udgivet - 2015

OBJECTIVE: To compare reported birth weight (BW) information in school health records with BW from medical birth records, and to investigate if maternal and offspring characteristics were associated with any discrepancies.

DESIGN: Register-based cohort study.

SETTING: Denmark, 1973-1991.

PARTICIPANTS: The study was based on BW recorded in the Copenhagen School Health Records Register (CSHRR) and in The Medical Birth Register (MBR). The registers were linked via the Danish personal identification number.

PRIMARY AND SECONDARY OUTCOME MEASURES: Statistical comparisons of BW in the registers were performed using t tests, Pearson's correlation coefficients, Bland-Altman plots and κ coefficients. Odds of BW discrepancies >100 g were examined by logistic regressions.

RESULTS: The study population included 47 534 children. From 1973 to 1979 when BW was grouped in 500 g intervals in the MBR, mean BW differed significantly between the registers. During 1979-1991 when BW was recorded in 10 and 1 g intervals, mean BW did not significantly differ between the two registers. BW from both registers was highly correlated (0.93-0.97). Odds of a BW discrepancy significantly increased with parity, the child's age at recall and by marital status (children of married women had the highest odds).

CONCLUSIONS: Overall, BW information in school health records agreed very well with BW from medical birth records, suggesting that reports of BWs in school health records in Copenhagen, Denmark generally are valid.

Originalsprog Engelsk
Tidsskrift B M J Open
Vol/bind 5
Udgave nummer 11
Sider (fra-til) e008628
ISSN 2044-6055
Status Udgivet - 2015

BACKGROUND: The relationship between non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) is currently debated. Using observational data from the South Swedish Arthritis Treatment Group register, we thus aimed to compare clinical development and treatment adherence between nr-axSpA and AS patients during three years of anti-TNF (tumor necrosis factor) therapy in clinical practice, and to explore the impact of inflammatory activity measured by CRP (C-reactive protein) at treatment initiation.

METHODS: Nr-axSpA and AS patients (n = 86/238) in southern Sweden, commencing anti-TNF therapy 1999-2011, were followed during three years. Anti-TNF cessation was defined as stopping therapy, without restarting another anti-TNF agent within three months. Differences in the three year developments of patient's visual analogue scale (VAS) scores for global health and pain, EuroQol 5-Dimensions utility, evaluator's global disease activity assessment, CRP, and ESR (erythrocyte sedimentation rate) were assessed by repeated ANOVA. Anti-TNF adherence was compared by Log rank test and Cox regression. In a subanalysis, the same outcomes were studied after splitting both groups into patients with/without baseline CRP elevation.

RESULTS: Nr-axSpA patients were more often female and had lower acute phase reactants at baseline. Apart from CRP, which remained lower in the nr-axSpA group throughout follow-up (p = 0.004), no between-group differences were detected regarding clinical developments (p >0.1 for all comparisons) or anti-TNF adherence (hazard ratio: 1.1 (95 % CI 0.7 to 1.8) for the nr-axSpA vs. AS group) during three years. Elevated baseline CRP was similarly associated with superior clinical outcomes and treatment adherence in both groups.

CONCLUSIONS: With the exception of constantly lower CRP levels in the nr-axSpA group, three years anti-TNF therapy resulted in similar clinical outcomes and treatment adherence in nr-axSpA and AS patients, thus strengthening the hypothesis that these diagnoses represent different aspects/phases of the same disease.

Originalsprog Engelsk
Tidsskrift Arthritis Research & Therapy
Vol/bind 17
Udgave nummer 1
Sider (fra-til) 378
ISSN 1478-6354
Status Udgivet - 2015

Comprehensive MALDI-TOF biotyping of the non-redundant Harvard Pseudomonas aeruginosa PA14 transposon insertion mutant library

Oumeraci, T., Jensen, V., Talbot, S. R., Hofmann, W., Kostrzewa, M., Schlegelberger, B., von Neuhoff, N. & Häussler, S., 2015, I: PLoS One. 10, 2, s. e0117144

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Concomitant fibromyalgia in rheumatoid arthritis is associated with the more frequent use of biological therapy: a cross-sectional study

Lage-Hansen, P. R., Chrysidis, S., Lage-Hansen, M., Hougaard, A., Ejstrup, L. & Amris, K., 16 jul. 2015, I: Scandinavian Journal of Rheumatology. s. 1-4 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVES: To compare the 28-joint Disease Activity Score (DAS28) and its components in patients with rheumatoid arthritis (RA) with and without concomitant fibromyalgia (FM), and to investigate the use of biological treatment in the two groups.

METHOD: Questionnaires developed to diagnose FM were handed out among RA patients during their planned visits. Values for DAS28 were obtained from the DANBIO registry. Demographic data and data on patients' medical treatment, disease duration, serological and radiological status were retrieved from patients' files. The χ(2) test and an unpaired t-test were applied to investigate group differences in the use of biological therapy, baseline characteristics, patient-reported outcomes, and DAS28 between groups when appropriate.

RESULTS: Questionnaires were completed by 162 out of 264 (61%) patients. Twenty-five patients (15.4%) with concomitant FM were identified. No group differences were found regarding disease duration, age, gender, and serological status. Of the RA patients with concomitant FM, 64% were treated with biological therapy vs. 32% of RA patients without concomitant FM (p = 0.002). The mean DAS28 in the FM group was 4.4 compared to 2.9 in the non-FM group (p < 0.001). Elevated DAS28 in the FM group resulted from a high tender joint count (p = 0.003) and a high visual analogue scale (VAS)-global score (p < 0.001). Erosions were more frequent in the non-FM group (p = 0.04).

CONCLUSIONS: Concomitant FM in patients with RA is associated with a higher DAS28 due to subjective parameters and with the more frequent use of biological treatments. This raises the question of whether the more frequent use of biologics in these patients is justified by inflammation, or is instead due to persistent pain and other centrally mediated symptoms.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Sider (fra-til) 1-4
Antal sider 4
ISSN 0300-9742
Status Udgivet - 16 jul. 2015

OBJECTIVE: To investigate concussion epidemiology in the first football (soccer) division of Qatar.

DESIGN: Prospective cohort study.

SETTING: Professional First Division Football League of Qatar.

PARTICIPANTS: All first team players were included at the beginning of each season.

INTERVENTIONS: Daily collection of training and match exposure from August 2008 until April 2012 by club medical staff. Head injuries during training and match play were recorded on standardized injury cards.

MAIN OUTCOME MEASURES: Injury incidence was calculated as number of injuries per hour exposed to risk and expressed as rate per 1000 hours.

RESULTS: The incidence of concussions in professional club football in Qatar is 0.016 (0.000-0.033) per 1000 hours of exposure.

CONCLUSIONS: The concussion incidence is only 25% of that in the previous European studies using the same time loss injury definition. This raises the possibility that concussions are underreported. Further research is necessary. In the meantime, concussion education of players, club medical, and support staff is warranted, in keeping with the Zurich concussion consensus call for the need for an increase in knowledge translation.

Originalsprog Engelsk
Tidsskrift Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
Vol/bind 25
Tidsskriftsnummer 1
Sider (fra-til) 73-4
Antal sider 2
ISSN 1050-642X
Status Udgivet - jan. 2015

Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition

Blanka, A., Düvel, J., Dötsch, A., Klinkert, B., Abraham, W-R., Kaever, V., Ritter, C., Narberhaus, F. & Häussler, S., 14 apr. 2015, I: Science signaling. 8, 372, s. ra36

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Contribution of Veillonella parvula to Pseudomonas aeruginosa-mediated pathogenicity in a murine tumor model system

Pustelny, C., Komor, U., Pawar, V., Lorenz, A., Bielecka, A., Moter, A., Gocht, B., Eckweiler, D., Müsken, M., Grothe, C., Lünsdorf, H., Weiss, S. & Häussler, S., jan. 2015, I: Infection and Immunity. 83, 1, s. 417-29 13 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Contributions to the understanding of osteoarthitis pain

Jørgensen, T. S., 2015, 1 udg. Aalborg: Aalborg Universitetsforlag. 98 s.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandling

Originalsprog Engelsk
Udgivelsessted Aalborg
Forlag Aalborg Universitetsforlag
Vol/bind 1
Udgave 1
Antal sider 98
Status Udgivet - 2015
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 74
Udgave nummer Suppl. 2
Sider (fra-til) 1263
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2015

Cross talk between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa

Bielecki, P., Jensen, V., Schulze, W., Gödeke, J., Strehmel, J., Eckweiler, D., Nicolai, T., Bielecka, A., Wille, T., Gerlach, R. G. & Häussler, S., 27 jul. 2015, I: Nucleic Acids Research. 43, 13, s. 6413-25 13 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Deciding treatment for miscarriage--experiences of women and healthcare professionals

Olesen, M. L., Graungaard, A. H. & Husted, G. R., jun. 2015, I: Scandinavian Journal of Caring Sciences. 29, 2, s. 386-94 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Deep transcriptome profiling of clinical Klebsiella pneumoniae isolates reveals strain and sequence type-specific adaptation

Bruchmann, S., Muthukumarasamy, U., Pohl, S., Preusse, M., Bielecka, A., Nicolai, T., Hamann, I., Hillert, R., Kola, A., Gastmeier, P., Eckweiler, D. & Häussler, S., nov. 2015, I: Environmental Microbiology. 17, 11, s. 4690-710 21 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Development of a Draft Core Set of Domains for Measuring Shared Decision Making in Osteoarthritis: An OMERACT Working Group on Shared Decision Making

Toupin-April, K., Barton, J., Fraenkel, L., Li, L., Grandpierre, V., Guillemin, F., Rader, T., Stacey, D., Légaré, F., Jull, J., Petkovic, J., Scholte-Voshaar, M., Welch, V., Lyddiatt, A., Hofstetter, C., De Wit, M., March, L., Meade, T., Christensen, R., Gaujoux-Viala, C., & 5 flereSuarez-Almazor, M. E., Boonen, A., Pohl, C., Martin, R. & Tugwell, P. S., dec. 2015, I: Journal of Rheumatology. 42, 12, s. 2442-7 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: Despite the importance of shared decision making for delivering patient-centered care in rheumatology, there is no consensus on how to measure its process and outcomes. The aim of this Outcome Measures in Rheumatology (OMERACT) working group is to determine the core set of domains for measuring shared decision making in intervention studies in adults with osteoarthritis (OA), from the perspectives of patients, health professionals, and researchers.

METHODS: We followed the OMERACT Filter 2.0 method to develop a draft core domain set by (1) forming an OMERACT working group; (2) conducting a review of domains of shared decision making; and (3) obtaining opinions of all those involved using a modified nominal group process held at a session activity at the OMERACT 12 meeting.

RESULTS: In all, 26 people from Europe, North America, and Australia, including 5 patient research partners, participated in the session activity. Participants identified the following domains for measuring shared decision making to be included as part of the draft core set: (1) identifying the decision, (2) exchanging information, (3) clarifying views, (4) deliberating, (5) making the decision, (6) putting the decision into practice, and (7) assessing the effect of the decision. Contextual factors were also suggested.

CONCLUSION: We proposed a draft core set of shared decision-making domains for OA intervention research studies. Next steps include a workshop at OMERACT 13 to reach consensus on these proposed domains in the wider OMERACT group, as well as to detail subdomains and assess instruments to develop a core outcome measurement set.

Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 42
Udgave nummer 12
Sider (fra-til) 2442-7
Antal sider 6
ISSN 0315-162X
Status Udgivet - dec. 2015

Development of EULAR recommendations for the reporting of clinical trial extension studies in rheumatology

Buch, M. H., Silva-Fernandez, L., Carmona, L., Aletaha, D., Christensen, R., Combe, B., Emery, P., Ferraccioli, G., Guillemin, F., Kvien, T. K., Landewe, R., Pavelka, K., Saag, K., Smolen, J. S., Symmons, D., van der Heijde, D., Welling, J., Wells, G., Westhovens, R., Zink, A., & 1 flereBoers, M., jun. 2015, I: Annals of the Rheumatic Diseases. 74, 6, s. 963-9 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVES: Our initiative aimed to produce recommendations on post-randomised controlled trial (RCT) trial extension studies (TES) reporting using European League Against Rheumatism (EULAR) standard operating procedures in order to achieve more meaningful output and standardisation of reports.

METHODS: We formed a task force of 22 participants comprising RCT experts, clinical epidemiologists and patient representatives. A two-stage Delphi survey was conducted to discuss the domains of evaluation of a TES and definitions. A '0-10' agreement scale assessed each domain and definition. The resulting set of recommendations was further refined and a final vote taken for task force acceptance.

RESULTS: Seven key domains and individual components were evaluated and led to agreed recommendations including definition of a TES (100% agreement), minimal data necessary (100% agreement), method of data analysis (agreement mean (SD) scores ranging between 7.9 (0.84) and 9.0 (2.16)) and reporting of results as well as ethical issues. Key recommendations included reporting of absolute numbers at each stage from the RCT to TES with reasons given for drop-out at each stage, and inclusion of a flowchart detailing change in numbers at each stage and focus (mean (SD) agreement 9.9 (0.36)). A final vote accepted the set of recommendations.

CONCLUSIONS: This EULAR task force provides recommendations for implementation in future TES to ensure a standardised approach to reporting. Use of this document should provide the rheumatology community with a more accurate and meaningful output from future TES, enabling better understanding and more confident application in clinical practice towards improving patient outcomes.

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 74
Udgave nummer 6
Sider (fra-til) 963-9
Antal sider 7
ISSN 0003-4967
Status Udgivet - jun. 2015

OBJECTIVE: To investigate whether the Assessment of Motor and Process Skills (AMPS), the physical function subscales of the Fibromyalgia Impact Questionnaire (FIQ PF) and the 36-item Short Form (SF-36 PF) can identify subgroups of women with fibromyalgia with clinically relevant differences in ability to perform activities of daily living.

DESIGN: Cross-sectional study.

SUBJECTS: A total of 257 women with fibromyalgia.

METHODS: Participants were evaluated with the AMPS (measuring activities of daily living motor and activities of daily living process ability), FIQ and SF-36. AMPS independence cut-offs were used to divide the participants into 4 subgroups. Clinically relevant differences between subgroups were investigated based on the AMPS, FIQ PF and SF-36 PF.

RESULT: Participants in the 4 AMPS-derived subgroups demon-strated clinically relevant differences in observed activities of daily living motor and process ability. Neither the FIQ PF nor the SF-36 PF could differentiate between subgroups with clinically relevant differences in AMPS activities of daily living process ability.

CONCLUSION: Activities of daily living process skills reflect underlying organizational and adaptive capacities of the individual and are relevant targets for interventions aiming at improving activities of daily living ability. Since self-report instruments do not capture differences in activities of daily living process ability, clinicians should include observations-based assessment of activities of daily living ability in order to individualize interventions offered.

Originalsprog Engelsk
Tidsskrift Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine
ISSN 1651-2081
Status Udgivet - 19 okt. 2015

Do "Evidence-Based Recommendations" Need to Reveal the Evidence? Minimal Criteria Supporting an "Evidence Claim"

Christensen, R., Singh, J. A., Wells, G. A. & Tugwell, P. S., okt. 2015, I: Journal of Rheumatology. 42, 10, s. 1737-9 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 42
Udgave nummer 10
Sider (fra-til) 1737-9
Antal sider 3
ISSN 0315-162X
Status Udgivet - okt. 2015