Published in 2007

Impairment of the dynamic control of the lumbopelvic complex in LBP has gained increased focus both clinically and experimentally. The objectives of this study were to determine the reliability of inclinometry as a measure of dynamic lumbopelvic control. Lumbopelvic reposition accuracy during pelvic tilts was measured in 39 healthy subjects using an inclinometer attached to the skin at S2 level. The reposition accuracy was measured in sitting, standing and supported standing. Tests were performed three times with a 20 min recess between tests. Only data from the last two test sequences were used in order to account for learning effects. Intraclass correlation coefficients were low for the sitting (0.54) and supported standing positions (0.36). In the standing position, a significant difference between test and retest was observed (P = 0.003) and further reliability analysis was therefore abandoned. It is concluded that inclinometry is not reliable for measuring the dynamic lumbopelvic control in any of the test positions and prior work utilising inclinometry to evaluate dynamic lumbopelvic control should be interpreted with caution.

Originalsprog Engelsk
Tidsskrift European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Vol/bind 16
Udgave nummer 6
Sider (fra-til) 733-40
Antal sider 8
ISSN 0940-6719
Status Udgivet - jun. 2007

Epidemiological and clinical studies on hand eczema in a population-based twin sample

Jørkov, A. L., 2007, Københavns Universitet.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandling

Experimental quadriceps muscle pain impairs knee joint control during walking

Henriksen, M., Alkjaer, T., Lund, H., Simonsen, E. B., Graven-Nielsen, T., Danneskiold-Samsøe, B. & Bliddal, H., jul. 2007, I: Journal of applied physiology (Bethesda, Md. : 1985). 103, 1, s. 132-9 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Pain is a cardinal symptom in musculoskeletal diseases involving the knee joint, and aberrant movement patterns and motor control strategies are often present in these patients. However, the underlying neuromuscular mechanisms linking pain to movement and motor control are unclear. To investigate the functional significance of muscle pain on knee joint control during walking, three-dimensional gait analyses were performed before, during, and after experimentally induced muscle pain by means of intramuscular injections of hypertonic saline (5.8%) into vastus medialis (VM) muscle of 20 healthy subjects. Isotonic saline (0.9%) was used as control. Surface electromyography (EMG) recordings of VM, vastus lateralis (VL), biceps femoris, and semitendinosus muscles were synchronized with the gait analyses. During experimental muscle pain, the loading response phase peak knee extensor moments were attenuated, and EMG activity in the VM and VL muscles was reduced. Compressive forces, adduction moments, knee joint kinematics, and hamstring EMG activity were unaffected by pain. Interestingly, the observed changes persisted when the pain had vanished. The results demonstrate that muscle pain modulated the function of the quadriceps muscle, resulting in impaired knee joint control and joint instability during walking. The changes are similar to those observed in patients with knee pain. The loss of joint control during and after pain may leave the knee joint prone to injury and potentially participate in the chronicity of musculoskeletal problems, and it may have clinically important implications for rehabilitation and training of patients with knee pain of musculoskeletal origin.

Originalsprog Engelsk
Tidsskrift Journal of applied physiology (Bethesda, Md. : 1985)
Vol/bind 103
Udgave nummer 1
Sider (fra-til) 132-9
Antal sider 8
ISSN 8750-7587
Status Udgivet - jul. 2007

Increased cancer risk in patients referred to hospital with suspected fibromyalgia

Dreyer, L., Mellemkjaer, L., Kendall, S., Jensen, B., Danneskiold-Samsøe, B. & Bliddal, H., jan. 2007, I: Journal of Rheumatology. 34, 1, s. 201-6 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: To analyze whether fibromyalgia (FM) and FM-like symptoms are related to an increased incidence of cancer.

METHODS: We identified 1361 patients referred on suspicion of FM in the period 1984-99 from hospital records. Following the American College of Rheumatology (ACR) criteria, patients were divided into subgroups with and without confirmed FM. The cohort was followed to the end of 1999 and linked to the files of the Danish Cancer Register. Site-specific standardized incidence ratios (SIR) were calculated.

RESULTS: We found no association between FM and cancer in 1132 female patients with confirmed FM at our institution (SIR 1.2, 95% CI 0.8-1.8). In 106 women referred for muscle pain and/or tenderness who did not meet the criteria for FM, an increased overall SIR was observed (SIR 2.5, 95% CI 1.2-4.6), with increased risk for breast cancer (SIR 4.8, 95% CI 1.6-11.3) and lymphatic and hematological cancers (SIR 10.6, 95% CI 1.2-38.2). There were 4 lung cancers in 84 men with confirmed FM (SIR 12.6, 95% CI 3.4-32.4).

CONCLUSION: Neither confirmed FM nor those without confirmed FM predicted cancer. An increased risk of breast cancer was found among those who did not meet the ACR criteria for FM. These patients should be investigated if they develop any new or warning symptoms of malignancy, and treating physicians should be vigilant with screening procedures such as mammography.

Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 34
Udgave nummer 1
Sider (fra-til) 201-6
Antal sider 6
ISSN 0315-162X
Status Udgivet - jan. 2007

Intra-observer and inter-observer agreement of the manual examination of the lumbar spine in chronic lowback pain

Qvistgaard, E., Rasmussen, J. H., Laetgaard, J., Hecksher-Sørensen, S. & Bliddal, H., feb. 2007, I: European Spine Journal. s. 277-82

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Intratumor genetic heterogeneity of breast carcinomas as determined by fine needle aspiration and TaqMan low density array

Lyng, M. B., Laenkholm, A-V., Pallisgaard, N., Vach, W., Knoop, A., Bak, M. & Ditzel, H. J., 2007, I: Cellular oncology : the official journal of the International Society for Cellular Oncology. 29, 5, s. 361-72 12 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Introduction of new guidelines for emergency patients: motivational counselling among smokers

Backer, V., Nelbom, B. M., Duus, B. R. & Tønnesen, H., 1 jul. 2007, I: Clinical Respiratory Journal. 1, 1, s. 37-41 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Smoking is the most important risk factor for morbidity and mortality in hospital patients. Patient contact with the healthcare system should include smoking cessation counselling. Emergency admissions are seldom given this opportunity. Objective: The aim of the study was to illustrate the implementation of motivational counselling in a department of acute surgery.
Originalsprog Engelsk
Tidsskrift Clinical Respiratory Journal
Vol/bind 1
Udgave nummer 1
Sider (fra-til) 37-41
Antal sider 5
ISSN 1752-6981
Status Udgivet - 1 jul. 2007

Kønsforskelle ved autoimmune sygdomme illustreret ved reumatoid artritis

Danneskiold-Samsøe, B., Bartels, E. M. & Dreyer, L., 18 jun. 2007, I: Ugeskrift for læger [online]. 169, 25, s. 2440-2 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Many autoimmune diseases like rheumatoid arthritis (RA) show gender differences. RA is triggered by an interaction between genetic, hormonal, environmental and behavioural factors. 75% of cases are women under the age of 60; lover the age 60 the gender ratio is 1:1. Different genotypes predispose for RA. Pregnancy often suppresses RA, as does oral contraception. Lactation, smoking (w), BMI > 30, heavy vibrations and certain dust particles (m) may trigger RA, while the effect of male hormones is uncertain. Future prevention should focus on environment, behavioural factors and genetic profiling.

Bidragets oversatte titel Gender differences in autoimmune diseases illustrated by rheumatoid arthritis
Originalsprog Dansk
Tidsskrift Ugeskrift for læger [online]
Vol/bind 169
Udgave nummer 25
Sider (fra-til) 2440-2
Antal sider 3
ISSN 1603-6824
Status Udgivet - 18 jun. 2007

Lack of association between level of Plasminogen Activator Inhibitor-1 and estimates of tumor angiogenesis in early breast cancer

Danish Breast Cancer Cooperative Group (DBCG) Tumor Biology Committee, 2007, I: Acta Oncologica. 46, 6, s. 782-91 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Molecular composition of IMP1 ribonucleoprotein granules

Jønson, L., Vikesaa, J., Krogh, A., Nielsen, L. K., Hansen, T. VO., Borup, R., Johnsen, A. H., Christiansen, J. & Nielsen, F. C., maj 2007, I: Molecular & cellular proteomics : MCP. 6, 5, s. 798-811 14 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Osteoclasts prefer aged bone

Henriksen, K., Leeming, D. J., Byrjalsen, I., Nielsen, R. H., Sorensen, M. G., Dziegiel, M. H., Martin, T. J., Christiansen, C., Qvist, P. & Karsdal, M. A., jun. 2007, I: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 18, 6, s. 751-9 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

UNLABELLED: We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of aged bones.

INTRODUCTION: Osteoclasts resorb aging bone in order to repair damage and maintain the quality of bone. The mechanism behind the targeting of aged bone for remodeling is not clear. We investigated whether bones endogenously possess the ability to control osteoclastic resorption.

METHODS: To biochemically distinguish aged and young bones; we measured the ratio between the age-isomerized betaCTX fragment and the non-isomerized alphaCTX fragment. By measurement of TRACP activity, CTX release, number of TRACP positive cells and pit area/pit number, we evaluated osteoclastogenesis as well as osteoclast resorption on aged and young bones.

RESULTS: We found that the alphaCTX/betaCTX ratio is 3:1 in young compared to aged bones, and we found that both alpha and betaCTX are released by osteoclasts during resorption. Osteoclastogenesis was augmented on aged compared to young bones, and the difference was enhanced under low serum conditions. We found that mature osteoclasts resorb more on aged than on young bone, despite unchanged adhesion and morphology.

CONCLUSIONS: These data indicate that the age of the bone plays an important role in controlling osteoclast-mediated resorption, with significantly higher levels of osteoclast differentiation and resorption on aged bones when compared to young bones.

Originalsprog Engelsk
Tidsskrift Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Vol/bind 18
Udgave nummer 6
Sider (fra-til) 751-9
Antal sider 9
ISSN 0937-941X
Status Udgivet - jun. 2007

Pain from torture

Williams, A. C. D. C. & Amris, K., 15 dec. 2007, I: Pain. 133, 1-3, s. 5-8 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Pain
Vol/bind 133
Udgave nummer 1-3
Sider (fra-til) 5-8
Antal sider 4
ISSN 0304-3959
Status Udgivet - 15 dec. 2007

Pharmaceutical treatment of asthma symptoms in elite athletes - doping or therapy?

Backer, V., Lund, T. & Pedersen, L., dec. 2007, I: Scandinavian journal of medicine & science in sports. 17, 6, s. 615-22 8 s.

Publikation: Bidrag til tidsskriftReviewpeer review

Propofol increased the interleukin-6 to interleukin-10 ratio more than isoflurane after surgery in long-term alcoholic patients

Von Dossow, V., Baur, S., Sander, M., Tønnesen, H., Marks, C., Paschen, C., Berger, G. & Spies, C. D., 2007, I: Journal of International Medical Research. 35, 3, s. 395-405 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

This study investigated the effect of an anaesthetic regimen on the immune response in 40 long-term alcoholic patients undergoing surgery. Patients were randomly allocated to receive either propofol or isoflurane during surgery. Plasma cytokines interleukin (IL)-6 and IL-10 were measured at defined times and rates of post-operative infections were documented. The IL-6/IL-10 ratio significantly increased with propofol compared with isoflurane on day 1 after surgery and the IL-10 level significantly increased with isoflurane on day 1 after surgery. The overall post-operative infection rate was significantly higher in isoflurane-treated patients. Our findings indicate that propofol anaesthesia might be the more favourable regimen, with the IL-6/IL-10 ratio indicating an attenuation of the immune imbalance after surgery in long-term alcoholic patients. These results support the undertaking of a properly powered clinical trial to determine if propofol anaesthesia can reduce the postoperative infection rate in this special patient population.
Originalsprog Engelsk
Tidsskrift Journal of International Medical Research
Vol/bind 35
Udgave nummer 3
Sider (fra-til) 395-405
Antal sider 11
ISSN 0300-0605
Status Udgivet - 2007

Pseudomonas aeruginosa cupA-encoded fimbriae expression is regulated by a GGDEF and EAL domain-dependent modulation of the intracellular level of cyclic diguanylate

Meissner, A., Wild, V., Simm, R., Rohde, M., Erck, C., Bredenbruch, F., Morr, M., Römling, U. & Häussler, S., okt. 2007, I: Environmental Microbiology. 9, 10, s. 2475-85 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Reliability and normative values of the foot line test: a technique to assess foot posture

Brushøj, C., Larsen, K., Nielsen, MB. & Hölmich, P. 2007 I : Journal of Orthopaedic and Sports Physical Therapy. 37, 11, s. 703-7

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

STUDY DESIGN: Test-retest reliability. OBJECTIVE: To examine the reliability and report normative values of a novel test, the foot line test (FLT), to describe foot morphology. BACKGROUND: Numerous foot examinations are performed each day, but most existing examination techniques have considerable limitations regarding reliability and validity. METHODS: One hundred thirty subjects with mean foot size 44 (41-50 European size) participated. Two examiners, blinded to each other's measurements, measured the right foot of the subjects twice and the left foot once. The position of the most medial aspect of the navicular in the mediolateral direction was projected vertically onto a piece of paper placed under the subject's foot, and compared to the position of the forefoot and hindfoot to obtain the FLT value. RESULTS: FLT values ranged from -8 to 14 mm, with a mean (+/-SD) of 3.7 +/- 3.4 mm. The intratester reproducibility reported by SEM was 0.8 mm for tester 1 and 0.9 mm for tester 2, while intertester SEM was 1.4 mm for the right foot and 1.3 mm for the left foot. The intrarater ICC was 0.95 for tester 1 and 0.94 for tester 2, while the interrater ICC was 0.86 (left foot) and 0.83 (right foot). There was no significant association between foot size and FLT values. CONCLUSION: The FLT is a reproducible technique to assess foot posture.
Originalsprog Engelsk
Tidsskrift Journal of Orthopaedic and Sports Physical Therapy
Vol/bind 37
Tidsskriftsnummer 11
Sider (fra-til) 703-7
ISSN 0190-6011
Status Udgivet - 2007

Teenagernes egen alkoholforebyggelse: En etnografisk undersøgelse - Sekundærpublikation

Jørgensen, M. H., Curtis, T., Christensen, P. H. & Grønbæk, M. N., 8 okt. 2007, I: Ugeskrift for Laeger. 169, 41, s. 3495-3497 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Based on ethnographic research with 13-16-year-olds in a rural Danish community the article reports on strategies of harm minimization employed by teenage drinkers. Participating teenagers were more concerned about social than health risks. They preferred drinking in the company of peers whom they knew and trusted, and they helped each other to minimize harm. Hence, teenage peer groups may be considered a resource for health promotion.

Bidragets oversatte titel Ethnographic research on strategies of harm minimization employed by teenage drinkers
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 169
Udgave nummer 41
Sider (fra-til) 3495-3497
Antal sider 3
ISSN 0041-5782
Status Udgivet - 8 okt. 2007
To compare the efficacy of adalimumab, etanercept, and infliximab in patients with established rheumatoid arthritis (RA) taking concomitant methotrexate (MTX) by calculating the number needed to treat (NNT) using three different methods.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 36
Udgave nummer 6
Sider (fra-til) 411-7
Antal sider 7
ISSN 0300-9742
Status Udgivet - 2007