Published in 2010

Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials

Bartels, E. M., Bliddal, H., Schøndorff, P. K., Altman, R. D., Zhang, W. & Christensen, R., 1 mar. 2010, I: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 18, 3, s. 289-96 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To estimate the efficacy and safety of diacerein as a pain-reducing agent in the treatment of osteoarthritis (OA), using meta-analysis of published randomized placebo-controlled trials (RCTs).
Originalsprog Engelsk
Tidsskrift Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Vol/bind 18
Udgave nummer 3
Sider (fra-til) 289-96
Antal sider 8
DOI
Status Udgivet - 1 mar. 2010

The predetermined sites of examination for tender points in fibromyalgia syndrome are frequently associated with myofascial trigger points

Ge, H., Wang, Y., Danneskiold-Samsøe, B., Nielsen, T. G. & Arendt-Nielsen, L., 1 jul. 2010, I: Journal of Pain. 11, 7, s. 644-51 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of this present study is to test the hypotheses that the 18 predetermined sites of examination for tender points (TP sites) in fibromyalgia syndrome (FMS) are myofascial trigger points (MTrPs), and that the induced pain from active MTrPs at TP sites may mimic fibromyalgia pain. Each TP site was evaluated with manual palpation followed by intramuscular electromyographic (EMG) registration of spontaneous electrical activity to confirm or refute the existence of an MTrP in 30 FMS patients. Overall spontaneous pain intensity and pain pattern were recorded before manual identification of MTrPs. Local and referred pain pattern from active MTrPs were drawn following manual palpation at TP sites. RESULTS: Showed that most of the TP sites are MTrPs. Local and referred pain from active MTrPs reproduced partly the overall spontaneous pain pattern. The total number of active MTrPs (r = .78, P <.0001), but not latent MTrPs (r = -.001, P = .99), was positively correlated with spontaneous pain intensity in FMS. The current study provides first evidence that pain from active MTrPs at TP sites mimics fibromyalgia pain. MTrPs may relate to generalized increased sensitivity in FMS due to central sensitization. PERSPECTIVE: This article underlies the importance of active MTrPs in FMS patients. Most of the TP sites in FMS are MTrPs. Active MTrPs may serve as a peripheral generator of fibromyalgia pain and inactivation of active MTrPs may thus be an alternative for the treatment of FMS.
Originalsprog Engelsk
Tidsskrift Journal of Pain
Vol/bind 11
Udgave nummer 7
Sider (fra-til) 644-51
Antal sider 8
ISSN 1526-5900
DOI
Status Udgivet - 1 jul. 2010

Validity, reliability and responsiveness of patient-reported outcome questionnaires when assessing hip and groin disability: a systematic review

Thorborg, K., Roos, E. M., Bartels, E. M., Petersen, J. & Hölmich, P., 1 dec. 2010, I: British Journal of Sports Medicine. 44, 16, s. 1186-96 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Novel treatment interventions are advancing rapidly in the management of hip and groin disability in the physically active young to middle-aged population.
Originalsprog Engelsk
Tidsskrift British Journal of Sports Medicine
Vol/bind 44
Udgave nummer 16
Sider (fra-til) 1186-96
Antal sider 11
ISSN 0306-3674
DOI
Status Udgivet - 1 dec. 2010

Published in 2009

. Inddragelse af fysisk inaktivitet og uhensigtsmæssig kost samt tobak og alkohol som risikofaktorer i patientregistreringen

Tønnesen, H., Hejgaard, T. & Hjalsted, B., 2009, . Inddragelse af fysisk inaktivitet og uhensigtsmæssig kost samt tobak og alkohol som risikofaktorer i patientregistreringen. København: Sundhedsstyrelsen

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

Originalsprog Dansk
Titel . Inddragelse af fysisk inaktivitet og uhensigtsmæssig kost samt tobak og alkohol som risikofaktorer i patientregistreringen
Udgivelsessted København
Forlag Sundhedsstyrelsen
Publikationsdato 2009
Status Udgivet - 2009

4p16.3 haplotype modifying age at onset of Huntington disease

Nørremølle, A., Budtz-Jørgensen, E., Fenger, K., Nielsen, J. E., Sørensen, S. A. & Hasholt, L., mar. 2009, I: Clinical Genetics. 75, 3, s. 244-50 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A computer-aided detection system for rheumatoid arthritis MRI data interpretation and quantification of synovial activity

Kubassove, O., Boesen, M., Cimmino, M. A. & Bliddal, H., 2009, I: European Journal of Radiology. 74, 3, s. e67-72

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

RATIONAL AND OBJECTIVE: Disease assessment and follow-up of rheumatoid arthritis (RA) patients require objective evaluation and quantification. Magnetic resonance imaging (MRI) has a large potential to supplement such information for the clinician, however, time spent on data reading and interpretation slow down development in this area. Existing scoring systems of especially synovitis are too rigid and insensitive to measure early treatment response and quantify inflammation. This study tested a novel automated, computer system for analysis of dynamic MRI data acquired from patients with RA, Dynamika-RA, which incorporates efficient data processing and analysis techniques.
Originalsprog Engelsk
Tidsskrift European Journal of Radiology
Vol/bind 74
Udgave nummer 3
Sider (fra-til) e67-72
ISSN 0720-048X
DOI
Status Udgivet - 2009

A novel mutation in the NOD2 gene associated with Blau syndrome: a Norwegian family with four affected members

Milman, N., Ursin, K., Rødevand, E., Nielsen, F. C. & Hansen, T. V. O., 2009, I: Scandinavian Journal of Rheumatology. 38, 3, s. 190-7 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A Swedish family with de novo alpha-synuclein A53T mutation: evidence for early cortical dysfunction

Puschmann, A., Ross, O. A., Vilariño-Güell, C., Lincoln, S. J., Kachergus, J. M., Cobb, S. A., Lindquist, S. G., Nielsen, J. E., Wszolek, Z. K., Farrer, M., Widner, H., van Westen, D., Hägerström, D., Markopoulou, K., Chase, B. A., Nilsson, K., Reimer, J. & Nilsson, C., nov. 2009, I: Parkinsonism & related disorders. 15, 9, s. 627-32 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Behandlingseffekten på reumatoid artritis for de tre eksisterende tumornekrosefaktor-alpha-haemmende behandlinger. Metaanalytisk litteraturstudie--sekundaerpublikation

Christensen, R., Kristensen, L. E., Geborek, P., Danneskiold-Samsøe, B., Saxne, T. & Bliddal, H., 2009, I: Ugeskrift for Laeger. 171, 26, s. 2192-4 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Absolute treatment efficacy (via number needed to treat) of rheumatoid arthritis for each of the three available anti tumour necrosis factor alpha inhibiting therapies. Our aim was to indirectly compare the long-term efficacy of the available anti-tumour necrosis factor (TNF) therapies in patients with established rheumatoid arthritis. The results indicate that the absolute efficacy associated with use of these anti-TNF therapies is equivalent if applied in equivalent dosages. In standard dosages, infliximab (3 mg/kg/eight weeks) is only half as effective as adalimumab (40 mg/two weeks) and etanercept (25 mg twice weekly).
Bidragets oversatte titel The efficacy of the three available anti-tumour necrosis factor therapies in patients with rheumatoid arthritis. A meta-analytic literature review--secondary publication
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 171
Udgave nummer 26
Sider (fra-til) 2192-4
Antal sider 3
ISSN 0041-5782
Status Udgivet - 2009

Biomechanical characteristics of the eccentric Achilles tendon exercise

Henriksen, M., Aaboe, J., Bliddal, H. & Langberg, H., 11 dec. 2009, I: Journal of Biomechanics. 42, 16, s. 2702-7 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: Eccentric exercise has been shown to provide good short-term clinical results in the treatment of painful mid-portion chronic Achilles tendinopathies. However, the mechanisms behind the positive effects of eccentric rehabilitation regimes are not known, and research into the biomechanics of the exercise may improve our understanding.

METHODS: Sixteen healthy subjects performed one-legged full weight bearing ankle plantar and dorsiflexion exercises during which three-dimensional ground reaction forces (GRF), ankle joint kinematics and surface electromyography (EMG) of the lower leg muscles were recorded. Joint kinematics, GRF frequency contents, average EMG amplitudes, and Achilles tendon loads were calculated.

FINDINGS: The eccentric movement phase was characterized by a higher GRF frequency content in the 8-12 Hz range, and reduced EMG activity in the lower leg muscles. No differences in Achilles tendon loads were found.

INTERPRETATION: This descriptive study demonstrates differences in the movement biomechanics between the eccentric and concentric phases of one-legged full weight bearing ankle dorsal and plantar flexion exercises. In particular, the findings imply that although the tendon loads are similar, the tendon is vibrated at higher frequencies during the eccentric phase than during the concentric phases. This study provides data that may explain the mechanisms behind the effectiveness of eccentric exercises used in the treatment of Achilles tendinopathies.

Originalsprog Engelsk
Tidsskrift Journal of Biomechanics
Vol/bind 42
Udgave nummer 16
Sider (fra-til) 2702-7
Antal sider 6
ISSN 0021-9290
DOI
Status Udgivet - 11 dec. 2009

Birt-Hogg-Dubé syndrome: diagnosis and management

Menko, F. H., van Steensel, M. A. M., Giraud, S., Friis-Hansen, L., Richard, S., Ungari, S., Nordenskjöld, M., Hansen, T. V., Solly, J., Maher, E. R. & European BHD Consortium, dec. 2009, I: The Lancet Oncology. 10, 12, s. 1199-206 8 s.

Publikation: Bidrag til tidsskriftReviewpeer review

Blood glucose in acute stroke

Olsen, T. S., 2009, I: Expert Review of Neurotherapeutics. 9, 3, s. 409-19 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Udgivelsesdato: 2009-Mar
Originalsprog Engelsk
Tidsskrift Expert Review of Neurotherapeutics
Vol/bind 9
Udgave nummer 3
Sider (fra-til) 409-19
Antal sider 10
DOI
Status Udgivet - 2009
Udgivelsesdato: 2009-Dec
Originalsprog Engelsk
Tidsskrift European journal of oncology nursing : the official journal of European Oncology Nursing Society
Vol/bind 13
Udgave nummer 5
Sider (fra-til) 344-9
Antal sider 5
DOI
Status Udgivet - 2009

Can stimulating massage improve joint repositioning error in patients with knee osteoarthritis?

Lund, H., Henriksen, M., Bartels, E. M., Danneskiold-Samsøe, B. & Bliddal, H., 2009, I: Journal of Geriatric Physical Therapy. 32, 3, s. 111-6 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

PURPOSE: The purpose of this study was to investigate the effect of massage applied to the thigh muscles on joint repositioning error (JRE) in patients suffering from osteoarthritis (OA).We hypothesized that stimulating massage of the muscles around an osteoarthritic knee joint, could improve the neuromuscular function and thereby optimize the positive and minimize the negative performance factors in relation to an exercise program.

METHODS: In a cross-over design, 19 patients with knee osteoarthritis, mean age of 73.1 years (SD: 9.4; range 56 to 88 years), recruited from the local department of rheumatology, were randomly allocated to either receive massage and a week later, act as controls or vice versa. The applied massage consisted of stimulating massage of the quadriceps femoris, sartorious, gracilus, and hamstrings muscles for 10 min on the affected leg. Participants had their JRE measured before and immediately after the 10 min massage and control sessions. Data were analyzed by using paired t-test.

RESULTS: No significant change in JRE was observed (95% CI: -0.62 degrees to 0.85 degrees, p = 0.738).

CONCLUSION: Massage has no effect on the immediate joint repositioning error in patients with knee osteoarthritis, ie, if an improved JRE is important for improving the performance factors when exercising, stimulating massage may not be recommendable to use.

Originalsprog Engelsk
Tidsskrift Journal of Geriatric Physical Therapy
Vol/bind 32
Udgave nummer 3
Sider (fra-til) 111-6
Antal sider 6
ISSN 1539-8412
Status Udgivet - 2009

Cancer incidence among patients with alcohol use disorders--long-term follow-up

Thygesen, L. C., Mikkelsen, P., Andersen, T. V., Tønnesen, H., Juel, K., Becker, U. & Grønbaek, M., 2009, I: Alcohol and Alcoholism. 44, 4, s. 387-91 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of this study was to compare the cancer morbidity in a large cohort of patients with alcohol use disorders in the general Danish population.
Originalsprog Engelsk
Tidsskrift Alcohol and Alcoholism
Vol/bind 44
Udgave nummer 4
Sider (fra-til) 387-91
Antal sider 5
ISSN 0735-0414
DOI
Status Udgivet - 2009

Chromosomal deletion unmasking a recessive disease: 22q13 deletion syndrome and metachromatic leukodystrophy

Bisgaard, A-M., Kirchhoff, M., Nielsen, J. E., Kibaek, M., Lund, A., Schwartz, M. & Christensen, E., feb. 2009, I: Clinical Genetics. 75, 2, s. 175-9 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Disease-modifying anti-rheumatic drugs til behandling af ankyloserende spondylitis

Madsen, O. R. & Egsmose, C., 2009, I: Ugeskrift for Laeger. 171, 33, s. 2268-72 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Ankylosing spondylitis (AS) is an inflammatory disorder affecting the axial skeleton, peripheral joints, entheses and extra-articular sites. Patients with early disease, a higher level of erythrocyte sedimentation rate and/or peripheral arthritis might benefit from sulfasalazine. Otherwise, there is no evidence that disease-modifying anti-rheumatic (DMARDs) have a therapeutic effect in AS. Clinical evidence that greater TNF-inhibitor effectiveness can be achieved by combining with a DMARD is lacking, but further studies should be performed. More research is needed to clarify the role of DMARDs in the treatment of AS.
Bidragets oversatte titel [Disease-modifying anti-rheumatic drugs for treatment of ankylosing spondylitis]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 171
Udgave nummer 33
Sider (fra-til) 2268-72
Antal sider 5
ISSN 0041-5782
Status Udgivet - 2009

Effect of preoperative smoking cessation interventions on postoperative complications and smoking cessation

Thomsen, T., Tønnesen, H. & Møller, A. M., 1 maj 2009, I: British Journal of Surgery. 96, 5, s. 451-61 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of this study was to examine the effect of preoperative smoking cessation interventions on postoperative complications and smoking cessation itself.
Originalsprog Engelsk
Tidsskrift British Journal of Surgery
Vol/bind 96
Udgave nummer 5
Sider (fra-til) 451-61
Antal sider 11
ISSN 0007-1323
DOI
Status Udgivet - 1 maj 2009

Bibliografisk note

HEHMVU

Effect of whole body vibration exercise on muscle strength and proprioception in females with knee osteoarthritis

Trans, T., Aaboe, J., Henriksen, M., Christensen, R., Bliddal, H. & Lund, H., aug. 2009, I: The Knee. 16, 4, s. 256-61 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The purpose of this study was to assess the effect of whole body vibration (WBV) exercise on muscle strength and proprioception in female patients with osteoarthritis in the knee (knee-OA). A single blinded, randomised, controlled trial was performed in an outpatient clinic on 52 female patients diagnosed with knee-OA (mean age 60.4 years+/-9.6). They were randomly assigned to one of 3 groups: 1. WBV-exercise on a stable platform (VibM; n=17 (mean age, 61.5+/-9.2)), WBV-exercise on a balance board (VibF; n=18 (mean age, 58.7+/-11.0)), or control group (Con; n=18 (mean age, 61.1+/-8.5)). The WBV groups trained twice a week for 8 weeks, with a progressively increasing intensity. The WBV groups performed unloaded static WBV exercise. The following were measured: knee muscle strength (extension/flexion) and proprioception (threshold for detection of passive movement (TDPM)). Self-reported disease status was measured using WOMAC. It was found that muscle strength increased significantly (p<0.001) in VibM compared to Con. Isometric knee-extension significantly increased (p=0.021) in VibM compared to Con. TDPM was significantly improved (p=0.033) in VibF compared to Con, while there was a tendency (p=0.051) for VibM to perform better compared to Con. There were no effects in the self-reported disease status measures. This study showed that the WBV-exercise regime on a stable platform (VibM) yielded increased muscle strength, while the WBV-exercise on a balance board (VibF) showed improved TDPM. The WBV-exercise is a time-saving and safe method for rehabilitation of women with knee-OA.

Originalsprog Engelsk
Tidsskrift The Knee
Vol/bind 16
Udgave nummer 4
Sider (fra-til) 256-61
Antal sider 6
ISSN 0968-0160
DOI
Status Udgivet - aug. 2009

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

Osorio, A., Milne, R. L., Pita, G., Peterlongo, P., Heikkinen, T., Simard, J., Chenevix-Trench, G., Spurdle, A. B., Beesley, J., Chen, X., Healey, S., Neuhausen, S. L., Ding, Y. C., Couch, F. J., Wang, X., Lindor, N., Manoukian, S., Barile, M., Viel, A., Tizzoni, L., & 31 flereSzabo, C. I., Foretova, L., Zikan, M., Claes, K., Greene, M. H., Mai, P., Rennert, G., Lejbkowicz, F., Barnett-Griness, O., Andrulis, I. L., Ozcelik, H., Weerasooriya, N., Gerdes, A-M., Thomassen, M., Cruger, D. G., Caligo, M. A., Friedman, E., Kaufman, B., Laitman, Y., Cohen, S., Kontorovich, T., Gershoni-Baruch, R., Dagan, E., Jernström, H., Askmalm, M. S., Arver, B., Malmer, B., Domchek, S. M., Nathanson, K. L., Hansen, T. V. O. & kConFab, 15 dec. 2009, I: British Journal of Cancer. 101, 12, s. 2048-54 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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