Published in 2006

Den fysisk inaktive operationspatient

Kjaer, M., Suetta, C. & Tønnesen, H., 4 dec. 2006, I: Ugeskrift for Laeger. 168, 49, s. 4322-4 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Major surgery is associated with a decrease in muscle strength, muscle mass and functional performance. However, early intervention with intensive physical training seems to counteract the loss in muscle mass and muscle function as well as to shorten the postoperative length of stay in hospital. In addition, a sufficient intake of protein seems to be a central element in the treatment of postoperative patients to reduce the protein degradation normally seen with immobilisation and surgery. Knowledge regarding the potential effect of preoperative physical activity is sparse.
Bidragets oversatte titel [The physically-inactive surgical patient]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 168
Udgave nummer 49
Sider (fra-til) 4322-4
Antal sider 3
Status Udgivet - 4 dec. 2006

Den rygende og drikkende patient

Tønnesen, H. & Møller, A., 4 dec. 2006, I: Ugeskrift for Laeger. 168, 49, s. 4293-6 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Daily smokers and heavy drinkers develop two to four times more complications after major as well as minor surgery. Increased postoperative morbidity is probably due to tobacco and alcohol-related organ dysfunctions which are, however, reversible during abstinence. Preoperative smoking cessation intervention for six to eight weeks significantly reduces postoperative complications after knee and hip replacement. Four weeks of preoperative alcohol intervention significantly improves organ functions before surgery, and reduces complications after colorectal surgery. Preoperative prevention programs are cost-effective. In conclusion, according to present evidence the smoking and drinking patient should be identified, informed, and offered preoperative prevention whenever possible.
Bidragets oversatte titel [The smoking and drinking patient]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 168
Udgave nummer 49
Sider (fra-til) 4293-6
Antal sider 4
Status Udgivet - 4 dec. 2006

Estrogen directly attenuates human osteoclastogenesis, but has no effect on resorption by mature osteoclasts

Sørensen, M. G., Henriksen, K., Dziegiel, M. H., Tankó, L. B. & Karsdal, M. A., aug. 2006, I: D N A and Cell Biology. 25, 8, s. 475-83 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Estrogen deficiency arising with the menopause promotes marked acceleration of bone resorption, which can be restored by hormone replacement therapy. The inhibitory effects of estrogen seem to involve indirect cytokine- mediated effects via supporting bone marrow cells, but direct estrogen-receptor mediated effects on the bone-resorbing osteoclasts have also been proposed. Little information is available on whether estrogens modulate human osteoclastogenesis or merely inhibit the functional activity of osteoclasts. To clarify whether estrogens directly modulate osteoclastic activities human CD14+ monocytes were cultured in the presence of M-CSF and RANKL to induce osteoclast differentiation. Addition of 0.1-10 nM 17beta-estradiol to differentiating osteoclasts resulted in a dose-dependent reduction in tartrate resistant acid phosphatase (TRACP) activity reaching 60% at 0.1 nM. In addition, 17beta-estradiol inhibited bone resorption, as measured by the release of the C-terminal crosslinked telopeptide (CTX), by 60% at 0.1 nM, but had no effect on the overall cell viability. In contrast to the results obtained with differentiating osteoclasts, addition of 17beta-estradiol (0.001-10 nM) to mature osteoclasts did not affect bone resorption or TRACP activity. We investigated expression of the estrogen receptors, using immunocytochemistry and Western blotting. We found that ER-alpha is expressed in osteoclast precursors, whereas ER- beta is expressed at all stages, indicating that the inhibitory effect of estrogen on osteoclastogenesis is mediated by ER-alpha for the major part. In conclusion, these results suggest that the in vivo effects of estrogen are mediated by reduction of osteoclastogenesis rather than direct inhibition of the resorptive activity of mature osteoclasts.

Originalsprog Engelsk
Tidsskrift D N A and Cell Biology
Vol/bind 25
Udgave nummer 8
Sider (fra-til) 475-83
Antal sider 9
ISSN 1044-5498
DOI
Status Udgivet - aug. 2006

Impulse-forces during walking are not increased in patients with knee osteoarthritis

Henriksen, M., Simonsen, E. B., Graven-Nielsen, T., Lund, H., Danneskiold-Samsøe, B. & Bliddal, H., aug. 2006, I: Acta Orthopaedica . 77, 4, s. 650-6 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: Impulsive forces in the knee joint have been suspected to be a co-factor in the development and progression of knee osteoarthritis. We thus evaluated the impulsive sagittal ground reaction forces (iGRF), shock waves and lower extremity joint kinematics at heel strike during walking in knee osteoarthritis (OA) patients and compared them to those in healthy subjects.

SUBJECTS AND METHODS: We studied 9 OA patients and 10 healthy subjects using three-dimensional gait analyses concentrated on the heel strike. Impulse GRF (iGRF) was measured together with peak accelerations (PA) at the tibial tuberosity and sacrum. Sagittal lower extremity joint angles at heel strike were extracted from the gait analyses. As OA is painful and pain might alter movement strategies, the patient group was also evaluated following pain relief by intraarticular lidocaine injections.

RESULTS: The two groups showed similar iGRF, similar tibial and sacral PA, and similar joint angles at heel strike. Following pain relief, the OA patients struck the ground with more extended hip and knee joints and lower tibial PA compared to the painful condition. Although such changes occurred after pain relief, all parameters were within their normal ranges.

INTERPRETATION: OA patients and healthy subjects show similar impulse-forces and joint kinematics at heel strike. Following pain relief in the patient group, changes in tibial PA and in hip and knee joint angles were observed but these were still within the normal range. Our findings make us question the hypothesis that impulse-forces generated at heel strike during walking contribute to progression of OA.

Originalsprog Engelsk
Tidsskrift Acta Orthopaedica
Vol/bind 77
Udgave nummer 4
Sider (fra-til) 650-6
Antal sider 7
ISSN 1745-3674
DOI
Status Udgivet - aug. 2006

Increased joint loads during walking--a consequence of pain relief in knee osteoarthritis

Henriksen, M., Simonsen, E. B., Alkjaer, T., Lund, H., Graven-Nielsen, T., Danneskiold-Samsøe, B. & Bliddal, H., dec. 2006, I: The Knee. 13, 6, s. 445-50 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Joint pain is a primary symptom in knee osteoarthritis (OA), but the effect of pain and pain relief on the knee joint mechanics of walking is not clear. In this study, the effects of local knee joint analgesia on knee joint loads during walking were studied in a group of knee osteoarthritis patients. A group of healthy subjects was included as a reference group. The joint loads were calculated from standard gait analysis data obtained with standardised walking speed (4 km/h). The gait analyses were performed before and after pain relief by intra-articular injections of 10 mL lidocaine (1%). Pre-injection measurements revealed lower joint loads in the OA group compared to the reference group. Following injections pain during walking decreased significantly and the joint loads increased in the OA group during the late single support phase to a level comparable to the reference group. Although the patients walked with less compressive knee joint forces compared to the reference group, the effects of pain relief may accelerate the degenerative changes.

Originalsprog Engelsk
Tidsskrift The Knee
Vol/bind 13
Udgave nummer 6
Sider (fra-til) 445-50
Antal sider 6
ISSN 0968-0160
DOI
Status Udgivet - dec. 2006

Long-term recurrence and death rates after acute pancreatitis

Lund, H., Tønnesen, H., Tønnesen, M. H. & Olsen, O., 1 feb. 2006, I: Scandinavian Journal of Gastroenterology. 41, 2, s. 234-8 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

The aim of this study was to compare long-term recurrence and death rates after a first episode of acute pancreatitis in patients with and without gallstones. Additionally, it was of interest to find out if there were factors predictive of readmission or death.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Gastroenterology
Vol/bind 41
Udgave nummer 2
Sider (fra-til) 234-8
Antal sider 5
ISSN 0036-5521
DOI
Status Udgivet - 1 feb. 2006

Lægens rolle i rehabilitering

Tønnesen, H., Bendix, A. F. & Hendriksen, C., 2006, København: Laegeforeningens Forlag.

Publikation: Bog/antologi/afhandling/rapportBog

Originalsprog Dansk
Udgivelsessted København
Forlag Laegeforeningens Forlag
Status Udgivet - 2006

Reproducibility of ultrasound and magnetic resonance imaging measurements of tendon size

Brushøj, C., Henriksen, B. M., Albrecht-Beste, E., Hölmich, P., Larsen, K. & Bachmann Nielsen, M. nov. 2006 I : Acta Radiologica. 47, 9, s. 954-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

PURPOSE: To investigate the intra- and inter-tester reproducibility of measurements of the Achilles tendon, tibialis anterior tendon, and the tibialis posterior tendon in football players using ultrasound (US) and magnetic resonance imaging (MRI).

MATERIAL AND METHODS: Eleven asymptomatic football players were examined. Using a standardized US scanning protocol, the tendons were examined by two observers with US for thickness, width, and cross-sectional area. One observer conducted the procedure twice. The subjects also underwent an MRI examination, and the assessment of tendon size was conducted twice by two observers.

RESULTS: The best reproducibility judged by coefficient of variation (CV) and 95% confidence interval was determined for the Achilles tendon on both US and MRI. The variability of US on measurements on the tibialis anterior and tibialis posterior tendons was less than that when using MRI. In 12 out of 18 measurements, there were systematic differences between observers as judged by one-sided F-test.

CONCLUSION: The reproducibility of the three tendons was limited. Precaution should be taken when looking for minor quantitative changes, i.e., training-induced hypertrophy, and when doing so, the Achilles tendon should be used.

Originalsprog Engelsk
Tidsskrift Acta Radiologica
Vol/bind 47
Tidsskriftsnummer 9
Sider (fra-til) 954-9
Antal sider 6
ISSN 0284-1851
DOI
Status Udgivet - nov. 2006

Risk reduction: perioperative smoking intervention

Møller, A. & Tønnesen, H., 1 jun. 2006, I: Best Practice & Research: Clinical Anaesthesiology. 20, 2, s. 237-48 12 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Smoking is a well-known risk factor for perioperative complications. Smokers experience an increased incidence of respiratory complications during anaesthesia and an increased risk of postoperative cardiopulmonary complications, infections and impaired wound healing. Smokers have a greater risk of postoperative intensive care admission. Even passive smoking is associated with increased risk at operation. Preoperative smoking intervention 6-8 weeks before surgery can reduce the complications risk significantly. Four weeks of abstinence from smoking seems to improve wound healing. An intensive, individual approach to smoking intervention results in a significantly better postoperative outcome. Future research should focus upon the effect of a shorter period of preoperative smoking cessation. All smokers admitted for surgery should be informed of the increased risk, recommended preoperative smoking cessation, and offered a smoking intervention programme whenever possible.
Originalsprog Engelsk
Tidsskrift Best Practice & Research: Clinical Anaesthesiology
Vol/bind 20
Udgave nummer 2
Sider (fra-til) 237-48
Antal sider 12
ISSN 1753-3740
Status Udgivet - 1 jun. 2006

The effect of computerized tailored brief advice on at-risk drinking in subcritically injured trauma patients

Neumann, T., Neuner, B., Weiss-Gerlach, E., Tønnesen, H., Gentilello, L. M., Wernecke, K-D., Schmidt, K., Schröder, T., Wauer, H., Heinz, A., Mann, K., Müller, J. M., Haas, N., Kox, W. J. & Spies, C. D., 1 okt. 2006, I: Journal of Trauma. 61, 4, s. 805-14 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

One-third of injured patients treated in the emergency department (ED) have an alcohol use disorder (AUD). Few are screened and receive counseling because ED staff have little time for additional tasks. We hypothesized that computer technology can screen and provide an intervention that reduces at-risk drinking (British Medical Association criteria) in injured ED patients.
Originalsprog Engelsk
Tidsskrift Journal of Trauma
Vol/bind 61
Udgave nummer 4
Sider (fra-til) 805-14
Antal sider 10
ISSN 0022-5282
DOI
Status Udgivet - 1 okt. 2006

Ultrasound findings in adductor related groin pain

Hölmich, P. & Bachmann Nielsen, M. dec. 2006 I : Ultraschall in der Medizin (Stuttgart, Germany : 1980). 27, 6, s. 509-11 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Ultraschall in der Medizin (Stuttgart, Germany : 1980)
Vol/bind 27
Tidsskriftsnummer 6
Sider (fra-til) 509-11
Antal sider 3
ISSN 0172-4614
DOI
Status Udgivet - dec. 2006

BACKGROUND: High resolution colour Doppler ultrasound shows intratendinous Doppler activity in patients with chronic Achilles tendinopathy. Treatment of this neovascularisation with sclerosing therapy seems to relieve the pain. However, the procedure often has to be repeated.

OBJECTIVE: To investigate the effect of electrocoagulation of the neovessels on tendon pain and tendon vascularity in patients with chronic Achilles tendinopathy.

METHODS: Colour Doppler ultrasound guided electrocoagulation was used on vessels in the ventral portion of the Achilles tendon in 11 patients (seven men, four women, mean age 41 years) with painful chronic mid-portion Achilles tendinosis. A unipolar coagulation device was used.

RESULTS: One patient dropped out after two months (dissatisfied with the results). The remaining 10 patients (91%) were satisfied. These 10 patients were still satisfied at six months of follow up and had returned to their previous level of activity. All 10 patients were "cured" after one treatment. The patient who dropped out received two treatments because of lack of progress. There was significantly reduced pain (Likert pain scale, 0-10) during activity, from a median of 7 (range 4 to 10) at baseline to 0 (0 to 8) at six months' follow up (p<0.005); and at rest, from 1.5 (1 to 5) to 0 (0 to 8) (p = 0.005). In all patients, vascularisation was unchanged at the six months follow up, with no significant change in semiquantitative or quantitative colour scoring.

CONCLUSIONS: Coagulation in the area with vessels entering the tendon appears to be effective treatment for painful chronic mid-tendinous Achilles tendinopathy. No effect on the intratendinous Doppler activity could be detected, suggesting that the effect is independent of changes in blood flow. Localisation of hyperaemia appears to be the key to the pathology and for targeting the treatment. One explanation could be that the effect is obtained by destruction of nerves accompanying the vessels.

Originalsprog Engelsk
Tidsskrift British Journal of Sports Medicine
Vol/bind 40
Udgave nummer 9
Sider (fra-til) 761-6
Antal sider 6
ISSN 0306-3674
DOI
Status Udgivet - sep. 2006

Published in 2005

Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption

Karsdal, M. A., Henriksen, K., Sørensen, M. G., Gram, J., Schaller, S., Dziegiel, M. H., Heegaard, A-M., Christophersen, P., Martin, T., Christiansen, C. & Bollerslev, J., feb. 2005, I: American Journal of Pathology. 166, 2, s. 467-76 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Patients with defective osteoclastic acidification have increased numbers of osteoclasts, with decreased resorption, but bone formation that remains unchanged. We demonstrate that osteoclast survival is increased when acidification is impaired, and that impairment of acidification results in inhibition of bone resorption without inhibition of bone formation. We investigated the role of acidification in human osteoclastic resorption and life span in vitro using inhibitors of chloride channels (NS5818/NS3696), the proton pump (bafilomycin) and cathepsin K. We found that bafilomycin and NS5818 dose dependently inhibited acidification of the osteoclastic resorption compartment and bone resorption. Inhibition of bone resorption by inhibition of acidification, but not cathepsin K inhibition, augmented osteoclast survival, which resulted in a 150 to 300% increase in osteoclasts compared to controls. We investigated the effect of inhibition of osteoclastic acidification in vivo by using the rat ovariectomy model with twice daily oral dosing of NS3696 at 50 mg/kg for 6 weeks. We observed a 60% decrease in resorption (DPYR), increased tartrate-resistant acid phosphatase levels, and no effect on bone formation evaluated by osteocalcin. We speculate that attenuated acidification inhibits dissolution of the inorganic phase of bone and results in an increased number of nonresorbing osteoclasts that are responsible for the coupling to normal bone formation. Thus, we suggest that acidification is essential for normal bone remodeling and that attenuated acidification leads to uncoupling with decreased bone resorption and unaffected bone formation.

Originalsprog Engelsk
Tidsskrift American Journal of Pathology
Vol/bind 166
Udgave nummer 2
Sider (fra-til) 467-76
Antal sider 10
ISSN 0002-9440
DOI
Status Udgivet - feb. 2005

Evidence based prevention of hamstring injuries in sport

Petersen, J. & Hölmich, P. jun. 2005 I : British Journal of Sports Medicine. 39, 6, s. 319-23 5 s.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

A common soft tissue injury in sports involving sprinting and jumping is the hamstring strain. A major problem with hamstring strains is the high incidence of reinjury. Muscle injuries can be classified as direct or indirect and are typically grouped into three categories according to severity. A number of potential risk factors have been proposed for hamstring strains. Only a few are evidence based and some are mainly based on theoretical assumptions. There is a lack of clinical research on the effectiveness of rehabilitation programmes for hamstring strains. Although the initial treatment of rest, ice, compression, and elevation is accepted for muscle strains, no consensus exists for their rehabilitation. Not much evidence based research has been carried out on prevention of hamstring strain. To our knowledge only two prospective studies have so far been published. As the injuries are common in football and other sports involving sprinting and jumping, there is a need for further research preferably in the form of randomised controlled trials.

Originalsprog Engelsk
Tidsskrift British Journal of Sports Medicine
Vol/bind 39
Tidsskriftsnummer 6
Sider (fra-til) 319-23
Antal sider 5
ISSN 0306-3674
DOI
Status Udgivet - jun. 2005

Evidence for health promotion in hospitals

Tønnesen, H., Fugleholm, A. M. & Jørgensen, S. J., 2005, Health promotion in hospitals: Evidence and quality management. Copenhagen: WHO Regional Office for Europe

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

Originalsprog Engelsk
Titel Health promotion in hospitals: Evidence and quality management
Udgivelsessted Copenhagen
Forlag WHO Regional Office for Europe
Publikationsdato 2005
Status Udgivet - 2005

Forebyggelse på danske sygehuse

Goldstein, H. & Tønnesen, H., 7 mar. 2005, I: Ugeskrift for Laeger. 167, 10, s. 1177-80 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Bidragets oversatte titel [Preventive medicine in Danish hospitals]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 167
Udgave nummer 10
Sider (fra-til) 1177-80
Antal sider 4
ISSN 0041-5782
Status Udgivet - 7 mar. 2005

How do we handle it in Denmark: Implementation of codes for DRG and HP - First experiences in Denmark

Tønnesen, H., Thygesen, V. & Petersen, N. S., 2005, I: Journal für Anästhesie und Intensivbehandlung. 12

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Journal für Anästhesie und Intensivbehandlung
Vol/bind 12
Status Udgivet - 2005

Learning effect of isokinetic measurements in healthy subjects, and reliability and comparability of Biodex and Lido dynamometers

Lund, H., Søndergaard, K., Zachariassen, T., Christensen, R., Bülow, P., Henriksen, M., Bartels, E. M., Danneskiold-Samsøe, B. & Bliddal, H., mar. 2005, I: Clinical Physiology and Functional Imaging. 25, 2, s. 75-82 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of this study was to examine the learning effect during a set of isokinetic measurements, to evaluate the reliability of the Biodex System 3 PRO dynamometer, and to compare the Biodex System 3 PRO and the Lido Active dynamometers on both extension and flexion over the elbow and the knee at 60 degrees s(-1). Thirteen (nine women, four men) healthy participants were measured five times using the Biodex and once using the Lido dynamometer. The intervals between the first four tests were 20 min, and 1 week between tests 4 and 5. Between Biodex and Lido measurements there was a 20 min time interval. When comparing the first five measurements (Biodex), no systematic effect over time and an excellent reliability were found with respect to elbow and knee flexion and extension. No difference in muscle strength (Nm) between the Biodex and Lido was observed for knee flexion (P = 0.59), knee extension (P = 0.18) and elbow extension (P = 0.63). However, elbow flexion showed a 14.8% (95% CI: 11.2-18.4%; P = 0.0001) higher peak torque on Biodex. In conclusion, no learning effect was observed and the Biodex proved to be a highly reliable isokinetic dynamometer. A difference was observed when comparing Biodex and Lido on elbow flexion, but the difference did not outrange the expected variation found with a typical isokinetic measurement, which is why both sets of equipment seem applicable in clinical practice.

Originalsprog Engelsk
Tidsskrift Clinical Physiology and Functional Imaging
Vol/bind 25
Udgave nummer 2
Sider (fra-til) 75-82
Antal sider 8
ISSN 1475-0961
DOI
Status Udgivet - mar. 2005

Præoperativt rygeophør og alkoholstop

Faurschou, P., Ralov, H., Holm, R. H. & Tønnesen, H., 2005, I: Månedsskr Prakt Lægegern. 4

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Dansk
Tidsskrift Månedsskr Prakt Lægegern
Vol/bind 4
ISSN 0373-2746
Status Udgivet - 2005

Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia

Laigaard, J., Sørensen, T., Placing, S., Holck, P., Fröhlich, C., Wøjdemann, K. R., Sundberg, K., Shalmi, A-C., Tabor, A., Nørgaard-Pedersen, B., Ottesen, B., Christiansen, M. & Wewer, U. M., jul. 2005, I: Obstetrics and Gynecology. 106, 1, s. 144-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVES: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia.

METHODS: We developed a semiautomated, time-resolved, immunofluorometric assay for the quantification of ADAM12 in serum. The assay detected ADAM12 in a range of 78-1248 microg/L. Serum samples derived from women in the first trimester of a normal pregnancy (n = 324) and from women who later developed preeclampsia during pregnancy (n = 160) were obtained from the First Trimester Copenhagen Study. ADAM12 levels were assayed in these serum samples. Serum levels of ADAM12 were converted to multiples of the median (MoM) after log-linear regression of concentration versus gestational age.

RESULTS: Serum ADAM12 levels in women who developed preeclampsia during pregnancy had a mean log MoM of -0.066, which was significantly lower than the mean log MoM of -0.001 for ADAM12 levels observed in serum samples from women with normal pregnancy (P = .008). The mean log MoM was even lower in serum derived from preeclamptic women whose infant's weight at birth was less than 2,500 g (n = 27, mean log MoM of -0.120, P = .053).

CONCLUSION: The maternal serum levels of ADAM12 are significantly lower during the first trimester in women who later develop preeclampsia during pregnancy when compared with levels in women with normal pregnancies. Because the secreted form of ADAM12 cleaves insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-5, the IGF axis may play a role in preeclampsia. ADAM12 may be a useful early marker for preeclampsia.

LEVEL OF EVIDENCE: II-2.

Originalsprog Engelsk
Tidsskrift Obstetrics and Gynecology
Vol/bind 106
Udgave nummer 1
Sider (fra-til) 144-9
Antal sider 6
ISSN 0029-7844
DOI
Status Udgivet - jul. 2005

Pages