Published in 2010

Prehabilitation and early rehabilitation after spinal surgery: randomized clinical trial

Nielsen, P. R., Jørgensen, L. D., Dahl, B., Pedersen, T. & Tønnesen, H., 1 feb. 2010, I : Clinical Rehabilitation. 24, 2, s. 137-48 12 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To evaluate the outcome after spinal surgery when adding prehabilitation to the early rehabilitation.
Originalsprog Engelsk
Tidsskrift Clinical Rehabilitation
Vol/bind 24
Udgave nummer 2
Sider (fra-til) 137-48
Antal sider 12
ISSN 0269-2155
DOI
Status Udgivet - 1 feb. 2010
Originalsprog Engelsk
Tidsskrift Cochrane Database of Systematic Reviews
Udgave nummer 2
ISSN 1469-493X
Status Udgivet - 2010

QT interval prolongation during spontaneous episodes of hypoglycaemia in type 1 diabetes: the impact of heart rate correction

Christensen, T. F., Tarnow, L., Randløv, J., Kristensen, L. E., Struijk, J. J., Eldrup, E. & Hejlesen, O. K., sep. 2010, I : Diabetologia. 53, 9, s. 2036-41 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

AIMS/HYPOTHESIS: Prolongation of the heart rate corrected QT interval (QTc) is seen during episodes of hypoglycaemia in type 1 diabetes. We studied the relationship between spontaneous hypoglycaemia and the QT interval and hypothesised that the choice of heart rate correction affects the observed change in QTc.

METHODS: Twenty-one participants with type 1 diabetes (aged 58 +/- 10 years with duration of diabetes 34 +/- 12 years) had continuous glucose and ECG monitoring for 72 h. QT and RR intervals were measured during hypoglycaemia (blood glucose or continuous glucose measurements <or=3.5 mmol/l) and compared with euglycaemia (5-12 mmol/l). QT intervals were measured using the semi-automated tangent method from signal-averaged ECG and corrected using Bazett's formula, Fridericia's formula, the nomogram method and a linear subject-specific method.

RESULTS: Hypoglycaemia was present in 14 participants. With Bazett's formula, QTc changed significantly from euglycaemia to hypoglycaemia (422 +/- 30 vs 432 +/- 33 ms; p = 0.02). Heart rate, QT intervals and QTc corrected with formulas other than Bazett's were not associated with a significant change (p = 0.07-0.29). During hypoglycaemia, significantly lower values of QTc compared with the subject-specific method were seen for Fridericia's formula (p = 0.02) and the nomogram method (p = 0.04).

CONCLUSIONS/INTERPRETATION: Spontaneous hypoglycaemia was associated with a modest increase in QTc. Bazett's formula resulted in overcorrection of QTc while both Fridericia's formula and the nomogram method undercorrected the QTc compared with the subject-specific method during hypoglycaemia. The results may indicate that the use of a fixed heart rate correction formula can lead to misleading results in investigations of spontaneous hypoglycaemia.

Originalsprog Engelsk
Tidsskrift Diabetologia
Vol/bind 53
Udgave nummer 9
Sider (fra-til) 2036-41
Antal sider 6
ISSN 0012-186X
DOI
Status Udgivet - sep. 2010

Reliability and Responsiveness of Dynamic Contrast Enhanced Magnetic Resonance Imaging in Arthritis.

Axelsen, M. B., Poggenborg, R. P., Kubassova, O., Boesen, M., Hørslev-Petersen, K., Bliddal, H., Hanson, L. P. G. & Østergaard, M., 2010, I : Annals of the Rheumatic Diseases. 69, 3, s. 348 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 69
Udgave nummer 3
Sider (fra-til) 348
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2010
The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Function Index (BASFI) and the Bath Ankylosing Spondylitis Global Score (BAS-G) (ranges 0-10) have gained widespread in use as self-reported measures of disease activity, functional impairment and overall well-being in patients with ankylosing spondylitis and other spondyloarthropathies (SpA). In Denmark, BASDAI, BASFI and BAS-G are systematically used to monitor treatment response in patients treated with tumour necrosis factor (TNF) inhibitors. The purpose of the present study was to examine the reproducibility of the indices in anti-TNF-treated SpA patients already familiar with the use of the indices. Testing was performed twice on two different days (median interval 7 days, range 4-10 days) under standardised conditions in 26 out-clinic patients (median age 39 years, range 22-56 years). Limits of agreement were calculated as the 95% likely range for the difference between paired scores. Test-retest results were significantly intercorrelated with r (s) = 0.90 for BASDAI, 0.92 for BASFI and 0.74 for BAS-G. Limits of agreement for BASDAI, BASFI and BAS-G were +/-1.8, +/-1.4 and +/-3.2, respectively. Reproducibility as expressed as the mean of individual standard deviations was significantly poorer for BAS-G than for BASDAI and BASFI (p <0.01). Internal consistency reliability and construct validity of BASDAI and BASFI were acceptable. In conclusion, in a sample of anti-TNF-treated patients experienced with the use of BASDAI, BASFI and BAS-G, random measurement errors of the scores were not negligible. The finding should be considered when monitoring anti-TNF treatment in daily clinical practice.
Originalsprog Engelsk
Tidsskrift Clinical Rheumatology
Vol/bind 29
Udgave nummer 8
Sider (fra-til) 849-54
Antal sider 6
ISSN 0770-3198
DOI
Status Udgivet - 1 aug. 2010

Risk reduction before surgery. The role of the primary care provider in preoperative smoking and alcohol cessation

Tønnesen, H., Faurschou, P., Ralov, H., Mølgaard-Nielsen, D., Thomas, G. & Backer, V., 1 jan. 2010, I : B M C Health Services Research. 10, s. 121

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Daily smokers and hazardous drinkers are high-risk patients, developing 2-4 times more complications after surgery. Preoperative smoking and alcohol cessation for four to eight weeks prior to surgery halves this complication rate. The patients' preoperative contact with the surgical departments might be too brief for the hospital to initiate these programmes. Therefore, it was relevant to evaluate a new clinical practice which combined the general practitioner's (GP) referral to surgery with a referral to a smoking and alcohol intervention in the surgical pathway.
Originalsprog Engelsk
Tidsskrift B M C Health Services Research
Vol/bind 10
Sider (fra-til) 121
ISSN 1472-6963
DOI
Status Udgivet - 1 jan. 2010

Rökfrihet vid kirurgiska ingrepp. Rökstopp minskar komplikationsrisken drastiskt

Lindström, D., Tønnesen, H. & Adami, J., 2010, I : Laekartidningen. 107, 43, s. 2634-5 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Bidragets oversatte titel Rökfrihet vid kirurgiska ingrepp. Rökstopp minskar komplikationsrisken drastiskt
Originalsprog Svensk
Tidsskrift Laekartidningen
Vol/bind 107
Udgave nummer 43
Sider (fra-til) 2634-5
Antal sider 2
ISSN 0023-7205
Status Udgivet - 2010
Widespread pain and pain hypersensitivity are the hallmark of fibromyalgia, a complex pain condition linked to central sensitization. In this study the painDETECT questionnaire (PDQ), validated to identify neuropathic pain and based on pain quality items, was applied in a cross-sectional sample of patients with chronic widespread pain (CWP). The aims of the study were to assess the patient-reported sensory neuropathic symptoms by PDQ and to correlate these with tender point (TP) count and pressure-pain thresholds. Eighty-one patients (75 F, 6 M) with CWP (ACR-criteria) filled in the PDQ. Manual TP examination was conducted according to ACR guidelines. Computerized cuff pressure algometry was used for the assessment of pressure-pain detection thresholds (PDT, unit: kPa) and pressure-pain tolerance thresholds (PTT, unit: kPa). Mean TP count was 14.32 (range: 2-18), mean PDQ score 22.75 (range: 5-37). Mean PDT was 8.8 kPa (range: 2-36) and mean PTT 30.9 kPa (range: 4-85). Deep-tissue hyperalgesia was the predominant somatosensory symptom reported in 83%, but other neuropathic symptoms were also frequent, e.g. burning 51% and prickling 47%. Statistically significant correlations were found between PDQ score and TP count: r=0.35 (p
Originalsprog Engelsk
Tidsskrift Journal of Pain
Vol/bind 151
Udgave nummer 3
Sider (fra-til) 664-9
Antal sider 6
ISSN 1526-5900
DOI
Status Udgivet - 1 dec. 2010

Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials

Bartels, E. M., Bliddal, H., Schøndorff, P. K., Altman, R. D., Zhang, W. & Christensen, R., 1 mar. 2010, I : Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 18, 3, s. 289-96 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To estimate the efficacy and safety of diacerein as a pain-reducing agent in the treatment of osteoarthritis (OA), using meta-analysis of published randomized placebo-controlled trials (RCTs).
Originalsprog Engelsk
Tidsskrift Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Vol/bind 18
Udgave nummer 3
Sider (fra-til) 289-96
Antal sider 8
DOI
Status Udgivet - 1 mar. 2010

The predetermined sites of examination for tender points in fibromyalgia syndrome are frequently associated with myofascial trigger points

Ge, H., Wang, Y., Danneskiold-Samsøe, B., Nielsen, T. G. & Arendt-Nielsen, L., 1 jul. 2010, I : Journal of Pain. 11, 7, s. 644-51 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of this present study is to test the hypotheses that the 18 predetermined sites of examination for tender points (TP sites) in fibromyalgia syndrome (FMS) are myofascial trigger points (MTrPs), and that the induced pain from active MTrPs at TP sites may mimic fibromyalgia pain. Each TP site was evaluated with manual palpation followed by intramuscular electromyographic (EMG) registration of spontaneous electrical activity to confirm or refute the existence of an MTrP in 30 FMS patients. Overall spontaneous pain intensity and pain pattern were recorded before manual identification of MTrPs. Local and referred pain pattern from active MTrPs were drawn following manual palpation at TP sites. RESULTS: Showed that most of the TP sites are MTrPs. Local and referred pain from active MTrPs reproduced partly the overall spontaneous pain pattern. The total number of active MTrPs (r = .78, P <.0001), but not latent MTrPs (r = -.001, P = .99), was positively correlated with spontaneous pain intensity in FMS. The current study provides first evidence that pain from active MTrPs at TP sites mimics fibromyalgia pain. MTrPs may relate to generalized increased sensitivity in FMS due to central sensitization. PERSPECTIVE: This article underlies the importance of active MTrPs in FMS patients. Most of the TP sites in FMS are MTrPs. Active MTrPs may serve as a peripheral generator of fibromyalgia pain and inactivation of active MTrPs may thus be an alternative for the treatment of FMS.
Originalsprog Engelsk
Tidsskrift Journal of Pain
Vol/bind 11
Udgave nummer 7
Sider (fra-til) 644-51
Antal sider 8
ISSN 1526-5900
DOI
Status Udgivet - 1 jul. 2010

Validity, reliability and responsiveness of patient-reported outcome questionnaires when assessing hip and groin disability: a systematic review

Thorborg, K., Roos, E. M., Bartels, E. M., Petersen, J. & Hölmich, P., 1 dec. 2010, I : British Journal of Sports Medicine. 44, 16, s. 1186-96 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Novel treatment interventions are advancing rapidly in the management of hip and groin disability in the physically active young to middle-aged population.
Originalsprog Engelsk
Tidsskrift British Journal of Sports Medicine
Vol/bind 44
Udgave nummer 16
Sider (fra-til) 1186-96
Antal sider 11
ISSN 0306-3674
DOI
Status Udgivet - 1 dec. 2010

Published in 2009

. Inddragelse af fysisk inaktivitet og uhensigtsmæssig kost samt tobak og alkohol som risikofaktorer i patientregistreringen

Tønnesen, H., Hejgaard, T. & Hjalsted, B., 2009, . Inddragelse af fysisk inaktivitet og uhensigtsmæssig kost samt tobak og alkohol som risikofaktorer i patientregistreringen. København: Sundhedsstyrelsen

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

Originalsprog Dansk
Titel . Inddragelse af fysisk inaktivitet og uhensigtsmæssig kost samt tobak og alkohol som risikofaktorer i patientregistreringen
Udgivelses sted København
Forlag Sundhedsstyrelsen
Publikationsdato 2009
Status Udgivet - 2009

A computer-aided detection system for rheumatoid arthritis MRI data interpretation and quantification of synovial activity

Kubassove, O., Boesen, M., Cimmino, M. A. & Bliddal, H., 2009, I : European Journal of Radiology. 74, 3, s. e67-72

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

RATIONAL AND OBJECTIVE: Disease assessment and follow-up of rheumatoid arthritis (RA) patients require objective evaluation and quantification. Magnetic resonance imaging (MRI) has a large potential to supplement such information for the clinician, however, time spent on data reading and interpretation slow down development in this area. Existing scoring systems of especially synovitis are too rigid and insensitive to measure early treatment response and quantify inflammation. This study tested a novel automated, computer system for analysis of dynamic MRI data acquired from patients with RA, Dynamika-RA, which incorporates efficient data processing and analysis techniques.
Originalsprog Engelsk
Tidsskrift European Journal of Radiology
Vol/bind 74
Udgave nummer 3
Sider (fra-til) e67-72
ISSN 0720-048X
DOI
Status Udgivet - 2009

Behandlingseffekten på reumatoid artritis for de tre eksisterende tumornekrosefaktor-alpha-haemmende behandlinger. Metaanalytisk litteraturstudie--sekundaerpublikation

Christensen, R., Kristensen, L. E., Geborek, P., Danneskiold-Samsøe, B., Saxne, T. & Bliddal, H., 2009, I : Ugeskrift for Laeger. 171, 26, s. 2192-4 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Absolute treatment efficacy (via number needed to treat) of rheumatoid arthritis for each of the three available anti tumour necrosis factor alpha inhibiting therapies. Our aim was to indirectly compare the long-term efficacy of the available anti-tumour necrosis factor (TNF) therapies in patients with established rheumatoid arthritis. The results indicate that the absolute efficacy associated with use of these anti-TNF therapies is equivalent if applied in equivalent dosages. In standard dosages, infliximab (3 mg/kg/eight weeks) is only half as effective as adalimumab (40 mg/two weeks) and etanercept (25 mg twice weekly).
Bidragets oversatte titel The efficacy of the three available anti-tumour necrosis factor therapies in patients with rheumatoid arthritis. A meta-analytic literature review--secondary publication
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 171
Udgave nummer 26
Sider (fra-til) 2192-4
Antal sider 3
ISSN 0041-5782
Status Udgivet - 2009

Biomechanical characteristics of the eccentric Achilles tendon exercise

Henriksen, M., Aaboe, J., Bliddal, H. & Langberg, H., 11 dec. 2009, I : Journal of Biomechanics. 42, 16, s. 2702-7 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: Eccentric exercise has been shown to provide good short-term clinical results in the treatment of painful mid-portion chronic Achilles tendinopathies. However, the mechanisms behind the positive effects of eccentric rehabilitation regimes are not known, and research into the biomechanics of the exercise may improve our understanding.

METHODS: Sixteen healthy subjects performed one-legged full weight bearing ankle plantar and dorsiflexion exercises during which three-dimensional ground reaction forces (GRF), ankle joint kinematics and surface electromyography (EMG) of the lower leg muscles were recorded. Joint kinematics, GRF frequency contents, average EMG amplitudes, and Achilles tendon loads were calculated.

FINDINGS: The eccentric movement phase was characterized by a higher GRF frequency content in the 8-12 Hz range, and reduced EMG activity in the lower leg muscles. No differences in Achilles tendon loads were found.

INTERPRETATION: This descriptive study demonstrates differences in the movement biomechanics between the eccentric and concentric phases of one-legged full weight bearing ankle dorsal and plantar flexion exercises. In particular, the findings imply that although the tendon loads are similar, the tendon is vibrated at higher frequencies during the eccentric phase than during the concentric phases. This study provides data that may explain the mechanisms behind the effectiveness of eccentric exercises used in the treatment of Achilles tendinopathies.

Originalsprog Engelsk
Tidsskrift Journal of Biomechanics
Vol/bind 42
Udgave nummer 16
Sider (fra-til) 2702-7
Antal sider 6
ISSN 0021-9290
DOI
Status Udgivet - 11 dec. 2009

Blood glucose in acute stroke

Olsen, T. S., 2009, I : Expert Review of Neurotherapeutics. 9, 3, s. 409-19 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Udgivelsesdato: 2009-Mar
Originalsprog Engelsk
Tidsskrift Expert Review of Neurotherapeutics
Vol/bind 9
Udgave nummer 3
Sider (fra-til) 409-19
Antal sider 10
DOI
Status Udgivet - 2009
Udgivelsesdato: 2009-Dec
Originalsprog Engelsk
Tidsskrift European journal of oncology nursing : the official journal of European Oncology Nursing Society
Vol/bind 13
Udgave nummer 5
Sider (fra-til) 344-9
Antal sider 5
DOI
Status Udgivet - 2009

Can stimulating massage improve joint repositioning error in patients with knee osteoarthritis?

Lund, H., Henriksen, M., Bartels, E. M., Danneskiold-Samsøe, B. & Bliddal, H., 2009, I : Journal of Geriatric Physical Therapy. 32, 3, s. 111-6 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

PURPOSE: The purpose of this study was to investigate the effect of massage applied to the thigh muscles on joint repositioning error (JRE) in patients suffering from osteoarthritis (OA).We hypothesized that stimulating massage of the muscles around an osteoarthritic knee joint, could improve the neuromuscular function and thereby optimize the positive and minimize the negative performance factors in relation to an exercise program.

METHODS: In a cross-over design, 19 patients with knee osteoarthritis, mean age of 73.1 years (SD: 9.4; range 56 to 88 years), recruited from the local department of rheumatology, were randomly allocated to either receive massage and a week later, act as controls or vice versa. The applied massage consisted of stimulating massage of the quadriceps femoris, sartorious, gracilus, and hamstrings muscles for 10 min on the affected leg. Participants had their JRE measured before and immediately after the 10 min massage and control sessions. Data were analyzed by using paired t-test.

RESULTS: No significant change in JRE was observed (95% CI: -0.62 degrees to 0.85 degrees, p = 0.738).

CONCLUSION: Massage has no effect on the immediate joint repositioning error in patients with knee osteoarthritis, ie, if an improved JRE is important for improving the performance factors when exercising, stimulating massage may not be recommendable to use.

Originalsprog Engelsk
Tidsskrift Journal of Geriatric Physical Therapy
Vol/bind 32
Udgave nummer 3
Sider (fra-til) 111-6
Antal sider 6
ISSN 1539-8412
Status Udgivet - 2009

Cancer incidence among patients with alcohol use disorders--long-term follow-up

Thygesen, L. C., Mikkelsen, P., Andersen, T. V., Tønnesen, H., Juel, K., Becker, U. & Grønbaek, M., 2009, I : Alcohol and Alcoholism. 44, 4, s. 387-91 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of this study was to compare the cancer morbidity in a large cohort of patients with alcohol use disorders in the general Danish population.
Originalsprog Engelsk
Tidsskrift Alcohol and Alcoholism
Vol/bind 44
Udgave nummer 4
Sider (fra-til) 387-91
Antal sider 5
ISSN 0735-0414
DOI
Status Udgivet - 2009

Disease-modifying anti-rheumatic drugs til behandling af ankyloserende spondylitis

Madsen, O. R. & Egsmose, C., 2009, I : Ugeskrift for Laeger. 171, 33, s. 2268-72 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Ankylosing spondylitis (AS) is an inflammatory disorder affecting the axial skeleton, peripheral joints, entheses and extra-articular sites. Patients with early disease, a higher level of erythrocyte sedimentation rate and/or peripheral arthritis might benefit from sulfasalazine. Otherwise, there is no evidence that disease-modifying anti-rheumatic (DMARDs) have a therapeutic effect in AS. Clinical evidence that greater TNF-inhibitor effectiveness can be achieved by combining with a DMARD is lacking, but further studies should be performed. More research is needed to clarify the role of DMARDs in the treatment of AS.
Bidragets oversatte titel [Disease-modifying anti-rheumatic drugs for treatment of ankylosing spondylitis]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 171
Udgave nummer 33
Sider (fra-til) 2268-72
Antal sider 5
ISSN 0041-5782
Status Udgivet - 2009

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