Published in 2010

Ernæringsstatus og -forløb hos apopleksipatienter under rehabilitering

Tolstrup Andersen, U., Skyhøj Olsen, T., Poulsen, I., Fogh Nielsen, M. & Rikardt Andersen, J., 2010, I : Klinisk Sygepleje. 24, 4, s. 4-9 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Originalsprog Dansk
Tidsskrift Klinisk Sygepleje
Vol/bind 24
Udgave nummer 4
Sider (fra-til) 4-9
Antal sider 5
ISSN 0902-2767
Status Udgivet - 2010

Expression of full-length and splice forms of FoxP3 in rheumatoid arthritis

Ryder, L. R., Danielsen, A. L. W., Madsen, H. O., Ødum, N., Ryder, L. P., Bliddal, H., Danneskiold-Samsøe, B., Ribel-Madsen, S. & Bartels, E. M., 1 aug. 2010, I : Scandinavian Journal of Rheumatology. 39, 4, s. 279-86 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of our study was to compare the presence of full-length and alternative splice forms of FoxP3 mRNA in CD4 cells from rheumatoid arthritis (RA) patients and healthy controls.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 39
Udgave nummer 4
Sider (fra-til) 279-86
Antal sider 8
ISSN 0300-9742
DOI
Status Udgivet - 1 aug. 2010

Fatigue in fibromyalgia: a conceptual model informed by patient interviews

Humphrey, L., Arbuckle, R., Mease, P., Williams, D. A., Danneskiold-Samsøe, B. & Gilbert, C., 1 jan. 2010, I : B M C Musculoskeletal Disorders. 11, s. 216

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Fatigue is increasingly recognized as an important symptom in fibromyalgia (FM). Unknown however is how fatigue is experienced by individuals in the context of FM. We conducted qualitative research in order to better understand aspects of fatigue that might be unique to FM as well as the impact it has on patients' lives. The data obtained informed the development of a conceptual model of fatigue in FM.
Originalsprog Engelsk
Tidsskrift B M C Musculoskeletal Disorders
Vol/bind 11
Sider (fra-til) 216
ISSN 1471-2474
DOI
Status Udgivet - 1 jan. 2010
It is generally believed that differences in age, stroke characteristics, and cardiovascular risk factors account for observed sex-specific differences in stroke survival.
Originalsprog Engelsk
Tidsskrift Gender Medicine
Vol/bind 7
Udgave nummer 4
Sider (fra-til) 284-95
Antal sider 12
ISSN 1550-8579
DOI
Status Udgivet - 1 aug. 2010

Fibromyalgi som neurogen smertetilstand

Amris, K. & Jespersen, A., 14 jun. 2010, I : Ugeskrift for Laeger. 172, 24, s. 1832-5 4 s.

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Fibromyalgia is characterised by chronic widespread pain and mechanical hyperalgesia. It is associated with a higher pain intensity, fewer pain-free intervals and more pronounced pain-related interference in function than other musculoskeletal pain conditions. Increasing evidence supports an underlying augmented central pain processing which includes sensitization of pain-transmitting neurons and dysfunction of pain inhibitory pathways. If this permanent change in the function of the nociceptive system is shown to equal fibromyalgia, the condition may be considered a neuropathic pain condition.
Bidragets oversatte titel [Fibromyalgia as a neuropathic pain condition]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 172
Udgave nummer 24
Sider (fra-til) 1832-5
Antal sider 4
Status Udgivet - 14 jun. 2010

Fysiologiske aendringer ved fibromyalgi

Bliddal, H., Bartels, E. M., Jespersen, A. & Danneskiold-Samsøe, B., 14 jun. 2010, I : Ugeskrift for Laeger. 172, 24, s. 1830-2 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A number of physiological changes, some measurable as changes in biomarkers, have been described in fibromyalgia (FM). These include changes in cytokine serum levels and elevated levels of some neurotransmitters in the cerebrospinal fluid. None of these measurements have been validated for diagnosis or follow-up in FM. It is suggested that non-invasive methods which hold the potential to evaluate the severity of FM and serve as therapy targets should be developed in the future.
Bidragets oversatte titel [Physiological changes in fibromyalgia]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 172
Udgave nummer 24
Sider (fra-til) 1830-2
Antal sider 3
ISSN 0041-5782
Status Udgivet - 14 jun. 2010

Gait changes in patients with knee osteoarthritis are replicated by experimental knee pain

Henriksen, M., Nielsen, T. G., Aaboe, J., Andriacchi, T. P. & Bliddal, H., 1 apr. 2010, I : Arthritis Care & Research. 62, 4, s. 501-9 9 s.

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Medial knee osteoarthritis (OA) is characterized by pain and associated with abnormal knee moments during walking. The relationship between knee OA pain and gait changes remains to be clarified, and a better understanding of this link could advance the treatment and prevention of disease progression. This study investigated changes in knee moments during walking following experimental knee pain in healthy volunteers, and whether these changes replicated the joint moments observed in medial knee OA patients.
Originalsprog Engelsk
Tidsskrift Arthritis Care & Research
Vol/bind 62
Udgave nummer 4
Sider (fra-til) 501-9
Antal sider 9
ISSN 2151-464X
DOI
Status Udgivet - 1 apr. 2010

Health and the need for health promotion in hospital patients

Oppedal, K., Nesvåg, S., Pedersen, B., Skjøtskift, S., Aarstad, A. K. H., Ullaland, S., Pedersen, K. L., Vevatne, K. & Tønnesen, H., 13 okt. 2010, I : European Journal of Public Health.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: Integrated health promotion improves clinical outcomes after hospital treatment. The first step towards implementing evidence-based health promotion in hospitals is to estimate the need for health promoting activities directed at hospital patients. The aim of this study was to identify the distribution and association of individual health risk factors in a Norwegian hospital population and to estimate the need for health promotion in this population. METHODS: We used a validated documentation model (HPH-DATA Model) to identify the prevalence of patients with nutritional risk (measurements of waist and weight), self-reported physical inactivity, daily smoking and hazardous drinking. We used logistic regression to describe the associations between health risk factors and demographic characteristics. RESULTS: Out of 10 included patients, 9 (N = 1522) had one or more health risk factors. In total 68% (N = 1026) were overweight, 44% (N = 660) at risk of under-nutrition, 38% (N = 574) physically inactive, 19% (N = 293) were daily smokers and 4% (N = 54) hazardous drinkers. We identified a new clinical relevant association between under-nutrition and smoking. The association between hazardous drinking and smoking was sustained. CONCLUSION: Nearly all patients included in this study had one or more health risk factors that could aggravate clinical outcomes. There is a significant need, and potential, for health-promoting interventions. Multi-factorial interventions may be frequently indicated and should be the subject of interventional studies.
Originalsprog Engelsk
Tidsskrift European Journal of Public Health
ISSN 1101-1262
DOI
Status Udgivet - 13 okt. 2010

Increased trapezius pain sensitivity is not associated with increased tissue hardness

Andersen, H., Ge, H., Arendt-Nielsen, L., Danneskiold-Samsøe, B. & Nielsen, T. G., 1 maj 2010, I : Journal of Pain. 11, 5, s. 491-9 9 s.

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Fatiguing exercise can affect muscle pain sensitivity and muscle hardness, as seen with work-related neck and shoulder pain. Objective methods to assess muscle pain sensitivity are important because the reliability of manual assessment is generally poor. The aim of this study was (1) to compare coexistence of tender points identified by manual palpation and pressure algometry or hardness assessments and (2) to examine the influence of exercise on muscle pain sensitivity and hardness. Fourteen sites in the upper trapezius muscle were selected for assessments in 12 healthy subjects. Pressure pain thresholds and muscle hardness were examined by computer-controlled pressure algometry at baseline, immediately after static or dynamic exercise, and 20 minutes after static or dynamic exercise. Before recording of pressure pain thresholds, the trapezius muscle was examined for tender points by manual palpation. Two sites with low pressure pain thresholds were typical locations for tender points, and these were the least hard sites. However, manually detected tender points were often (29%) not colocalized with most sensitive sites according to the pressure algometry. A heterogeneous distribution of pressure pain sensitivity and muscle hardness was found in the upper trapezius. The short duration of exercise until exhaustion did not change muscle sensitivity or muscle hardness in asymptomatic muscles. PERSPECTIVE: This study confirms clinical findings with heterogeniosity in pain sensitivity and hardness across the upper trapezius muscle. Developments of new techniques that objectively can identify tender points are important, but thus far, manual palpation is best clinical practice.
Originalsprog Engelsk
Tidsskrift Journal of Pain
Vol/bind 11
Udgave nummer 5
Sider (fra-til) 491-9
Antal sider 9
ISSN 1526-5900
DOI
Status Udgivet - 1 maj 2010

Intra-articular hyaluronan is without clinical effect in knee osteoarthritis: a multicentre, randomised, placebo-controlled, double-blind study of 337 patients followed for 1 year

Jørgensen, A., Stengaard-Pedersen, K., Simonsen, L. O., Jensen, M. P., Eriksen, C., Bliddal, H., Pedersen, N. W., Bødtker, S., Hørslev-Petersen, K., Snerum, L. Ø., Egund, N. & Frimer-Larsen, H., 2010, I : Annals of the Rheumatic Diseases. 69, 6, s. 1097-1102 6 s.

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Objective To examine the long-term efficacy and safety of five intra-articular injections with hyaluronan in knee osteoarthritis. Methods A multicentre, randomised, placebo-controlled double-blind study of 337 patients fulfilling the American College of Rheumatology (ACR) criteria for knee osteoarthritis (clinical and laboratory) and with a Lequesne algofunctional index score (LFI) of 10 or greater. Patients received a hyaluronan product (sodium hyaluronate; Hyalgan) (n= 167) or saline (n= 170) intra-articularly weekly for 5 weeks and were followed up to 1 year. Time to recurrence was the primary efficacy parameter. LFI, pain on walking 50 m based on visual analogue scale (VAS pain 50 m), paracetamol consumption, patients' global assessment, Nottingham health profile, joint effusion and number of responders were secondary efficacy parameters. The efficacy parameters were analysed by intention to treat (ITT) and per protocol (PP). All adverse events (AE) were recorded as safety parameters. Results Time to recurrence showed no significant treatment effect (ITT analysis, p = 0.26). Change from baseline in LFI and VAS pain 50 m for the ITT population showed no treatment effect. Paracetamol consumption, patients' global assessment, responder rates and AE displayed no significant difference between treatment groups, analysed by both ITT and PP. Treatment compliance was 95% in the hyaluronan group and 99% in the placebo group. No safety problems were registered. Conclusion In patients fulfilling the ACR criteria for osteoarthritis of the knee with moderate to severe disease activity (LFI >= 10), five intra-articular injections of hyaluronan did not improve pain, function, paracetamol consumption or other efficacy parameters 3, 6, 9 and 12 months after the treatment
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 69
Udgave nummer 6
Sider (fra-til) 1097-1102
Antal sider 6
ISSN 0003-4967
DOI
Status Udgivet - 2010

Is neuropathic pain underdiagnosed in musculoskeletal pain conditions? The Danish PainDETECTive study

Jespersen, A., Amris, K., Bliddal, H., Andersen, S., Lavik, B., Janssen, H. & Poulsen, P. B., 1 aug. 2010, I : Current Medical Research and Opinion. 26, 8, s. 2041-5 5 s.

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In all, 19-22% of the adult Danish population suffer from chronic pain - most frequently in the musculoskeletal system. Different pain management strategies depending on pain mechanism (neuropathic/nociceptive) make diagnosing the pain condition especially important.
Originalsprog Engelsk
Tidsskrift Current Medical Research and Opinion
Vol/bind 26
Udgave nummer 8
Sider (fra-til) 2041-5
Antal sider 5
ISSN 0300-7995
DOI
Status Udgivet - 1 aug. 2010
A food supplement containing fish oils, urtica dioica, zinc, and vitamin E (Phytalgic) for osteoarthritis (OA) has now been tested in a placebo-controlled trial for 3 months and according to the authors has a very large clinical effect, considerably larger than that of any other known product. Even experts endorsing nutraceuticals for OA symptoms would probably agree that a nutraceutical with an effect size above 0.5 is rarely seen. Despite our concerns about the fact that trial registration took place after the study was completed and the likelihood that patients would note the taste of fish, a circumstance that would lead to detection bias, we consider these data promising though with a high risk of bias.
Originalsprog Engelsk
Tidsskrift Arthritis Research & Therapy
Vol/bind 12
Udgave nummer 1
Sider (fra-til) 105
ISSN 1478-6354
DOI
Status Udgivet - 1 jan. 2010

Is there any interaction between domestic radon exposure and air pollution from traffic in relation to childhood leukemia risk?

Bräuner, E. V., Andersen, C. E., Andersen, H. P., Gravesen, P., Lind, M., Ulbak, K., Hertel, O., Schüz, J. & Raaschou-Nielsen, O., nov. 2010, I : Cancer causes & control : CCC. 21, 11, s. 1961-4 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: In a recent population-based case-control study using 2,400 cases of childhood cancer, we found a statistically significant association between residential radon and acute lymphoblastic leukemia risk.

HYPOTHESIS: Traffic exhaust in the air enhances the risk association between radon and childhood leukemia.

METHODS: We included 985 cases of childhood leukemia and 1,969 control children. We used validated models to calculate residential radon and street NO(x) concentrations for each home. Conditional logistic regression analyses were used to analyze the effect of radon on childhood leukemia risk within different strata of air pollution and traffic density.

RESULTS: The relative risk for childhood leukemia in association with a 10(3) Bq/m(3)-years increase in radon was 1.77 (1.11, 2.82) among those exposed to high levels of NO(x) and 1.23 (0.79, 1.91) for those exposed to low levels of NO(x) (p(interaction,) 0.17). Analyses for different morphological subtypes of leukemia and within different strata of traffic density showed a non-significant pattern of stronger associations between radon and childhood leukemia within strata of higher traffic density at the street address.

INTERPRETATION: Air pollution from traffic may enhance the effect of radon on the risk of childhood leukemia. The observed tendency may also be attributed to chance.

Originalsprog Engelsk
Tidsskrift Cancer causes & control : CCC
Vol/bind 21
Udgave nummer 11
Sider (fra-til) 1961-4
Antal sider 4
ISSN 0957-5243
DOI
Status Udgivet - nov. 2010
Originalsprog Engelsk
Udgivelses sted Umeå
Vol/bind Umeå University Medical Dissertations
Udgave 1349
Antal sider 93
ISBN (Trykt) 978-91-7264-993-4
Status Udgivet - 2010

Mortality in a cohort of Danish patients with fibromyalgia: increased frequency of suicide

Dreyer, L., Kendall, S., Danneskiold-Samsøe, B., Bartels, E. M. & Bliddal, H., 1 okt. 2010, I : Arthritis & Rheumatism. 62, 10, s. 3101-8 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A previous study demonstrated an association between self-reported widespread body pain and increased mortality. The aim of this study was to analyze whether fibromyalgia (FM) and FM-like symptoms are related to increased mortality.
Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatism
Vol/bind 62
Udgave nummer 10
Sider (fra-til) 3101-8
Antal sider 8
ISSN 0004-3591
DOI
Status Udgivet - 1 okt. 2010
This review article discusses the aspects of sports medicine where musculoskeletal Doppler ultrasound has valuable contribution in diagnosis and/or treatment of some of the typical musculoskeletal sports injuries. Also, conditions where the Doppler ultrasound has no value are discussed. Some guidelines and recommendations are based on personal experience since no evidence in literature exists. The basic technical background of Doppler ultrasound and typical artefacts will be discussed, in order to understand and interpret the Doppler result. Recommendations for the Doppler settings are given in relevant sections. Ultrasound guided treatments where the Doppler result is used as a guide are mentioned and discussed.
Originalsprog Engelsk
Tidsskrift Clinical and Experimental Rheumatology
Vol/bind 28
Udgave nummer 1
Sider (fra-til) 103-13
Antal sider 11
ISSN 0392-856X
Status Udgivet - 2010

Når patienten er syg, selvom undersøgelsesresultaterne er normale

Jensen, T. S., Bliddal, H. & Fink, P. K., 14 jun. 2010, I : Ugeskrift for Laeger. 172, 24, s. 1811

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Bidragets oversatte titel [When the patients is ill and the examination results are normal]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 172
Udgave nummer 24
Sider (fra-til) 1811
ISSN 0041-5782
Status Udgivet - 14 jun. 2010

Nutrition restriction in late-gestation and postnatal overfeeding change metabolic preferences in skeletal muscle longissimus dorsi of sheep

Hou, L., Nilsson, E., Dixen, K., Hansen, J. B., Vaag, A. & Nielsen, M. O., 1 dec. 2010, I : EAAP Scientific Series. 127, 1, s. 187-188 2 s.

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Originalsprog Engelsk
Bogserie EAAP Scientific Series
Vol/bind 127
Udgave nummer 1
Sider (fra-til) 187-188
Antal sider 2
ISSN 0071-2477
Status Udgivet - 1 dec. 2010

Open access publishing. And now, e-publication bias

Jakobsen, A. K., Christensen, R. D. K., Persson, R., Bartels, E. M. & Kristensen, L. E., 1 jan. 2010, I : B M J. 340, s. c2243

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift B M J
Vol/bind 340
Sider (fra-til) c2243
ISSN 0959-8146
Status Udgivet - 1 jan. 2010

Performance-based assessment of activities of daily living (ADL) ability among women with chronic widespread pain

Wæhrens, E. E., Amris, K. & Fisher, A. G., 1 sep. 2010, I : Pain. 150, 3, s. 535-41 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Functional ability, including the ability to perform activities of daily living (ADL), is considered a core outcome domain in chronic pain clinical trials and is usually assessed through generic or disease-specific self-report questionnaires. Research, however, indicates that self-report and performance-based assessment of ADL offer distinct but complementary information about ability. The present study, therefore, investigated the applicability of a performance-based measure of ADL ability, the Assessment of Motor and Process Skills (AMPS), among 50 women with chronic widespread pain. The investigated psychometric properties of the AMPS included discrimination between a sample of healthy women and those with chronic widespread pain, as well as stability when no intervention was provided and sensitivity to change following intervention. Data were obtained based on a repeated measures design performing AMPS evaluations twice pre- and twice post-rehabilitation. Results indicated that the ADL motor ability measures of the participants were significantly lower than those of healthy women of same age, the ADL motor and ADL process ability measures remained stable when no intervention was provided and the ADL motor ability measures were sensitive to change following a 2-week interdisciplinary rehabilitation program. A weak correlation (r(s)=-0.35) was found between self-reported ADL ability as measured by the physical function subscale of the Functional Impact Questionnaire (FIQ) and performance-based ADL motor measures, and no correlation (r(s)=-0.02) was found between FIQ ADL measures and ADL process ability, supporting the need for both performance-based and self-reported assessment of ADL.
Originalsprog Engelsk
Tidsskrift Pain
Vol/bind 150
Udgave nummer 3
Sider (fra-til) 535-41
Antal sider 7
DOI
Status Udgivet - 1 sep. 2010

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