Published in 2018

Better outcome from arthroscopic partial meniscectomy than skin incisions only? A sham-controlled randomised trial in patients aged 35-55 years with knee pain and an MRI-verified meniscal tear

Roos, E. M., Hare, K. B., Nielsen, S. M., Christensen, R. & Lohmander, L. S., 2 feb. 2018, I : BMJ Open. 8, 2, s. e019461

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: Compare arthroscopic partial meniscectomy to a true sham intervention.

METHODS: Sham-controlled superiority trial performed in three county hospitals in Denmark comparing arthroscopic partial meniscectomy to skin incisions only in patients aged 35-55 years with persistent knee pain and an MRI-confirmed medial meniscus lesion. A computer-generated table of random numbers generated two comparison groups. Participants and outcome assessors were blinded to group allocation. Exclusions were locking knees, high-energy trauma or severe osteoarthritis. Outcomes were collected at baseline, 3 and 24 months. We hypothesised no difference between groups. The primary outcome was the between-group difference in change from baseline to 2 years in the mean score across all five normalised Knee injury and Osteoarthritis Outcome Score (KOOS) subscales (KOOS5).

RESULTS: Forty-four patients (of the estimated 72) underwent randomisation; 22 in each group. Sixteen participants (36%) were non-blinded and eight participants (36%) from the sham group crossed over to the surgery group prior to the 2-year follow-up. At 2 years, both groups reported clinically relevant improvements (surgery 21.8, skin incisions only 13.6), the mean difference between groups was 8.2 in favour of surgery, which is slightly less than the cut-off of 10 prespecified to represent a clinically relevant difference; judged by the 95% CI (-3.4 to 19.8), a possibility of clinically relevant difference could not be excluded. In total, nine participants experienced 11 adverse events; six in the surgery group and three in the skin-incisions-only group.

CONCLUSION: We found greater improvement from arthroscopic partial meniscectomy compared with skin incisions only at 2 years, with the statistical uncertainty of the between-group difference including what could be considered clinically relevant. Because of the study being underpowered, nearly half in the sham group being non-blinded and one-third crossing over to surgery, the results cannot be generalised to the greater patient population.

TRIAL REGISTRATION NUMBER: NCT01264991.

Originalsprog Engelsk
Tidsskrift BMJ Open
Vol/bind 8
Udgave nummer 2
Sider (fra-til) e019461
ISSN 2044-6055
DOI
Status Udgivet - 2 feb. 2018

Billeddiagnostik ved lænde-ryg-smerter

Hansen, B. B., Hansen, P., Nordberg, C. L. & Boesen, M., 16 apr. 2018, I : Ugeskrift for Laeger. 180, 16

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Imaging of the spine is extensively applied in the assessment of patients with low back pain, who often expect imaging procedures to be undertaken. However, the majority of conventional imaging techniques have questionable precision in identifying the primary structural source of pain. This has led to increasing scientific interest in emerging new medical imaging modalities, since adequate correlation between imaging findings and symptoms is crucial for referring clinicians to optimize patient treatment plans. In this review, we present and discuss some recent new trends in various lumbar spine imaging techniques.

Bidragets oversatte titel Imaging of the spine in cases of low back pain
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 180
Udgave nummer 16
ISSN 0041-5782
Status Udgivet - 16 apr. 2018

Biological treatment in ankylosing spondylitis in the Nordic countries during 2010-2016: a collaboration between five biological registries

Glintborg, B., Lindström, U., Aaltonen, K., Kristianslund, E. K., Gudbjornsson, B., Chatzidionysiou, K., Askling, J., Nordström, D., Hetland, M. L., Di Giuseppe, D., Dreyer, L., Kristensen, L. E., Jørgensen, T. S., Eklund, K., Grondal, G., Ernestam, S., Joensuu, J., Törmänen, M., Skydsgaard, H., Hagfors, J., Kvien, T. K., Lie, E., Fagerli, K., Geirsson, A. J., Jonsson, H., Provan, S. A., Krogh, N. S. & Jacobsson, L., nov. 2018, I : Scandinavian Journal of Rheumatology. 47, 6, s. 465-474 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVES: Large-scale observational cohorts may be used to study the effectiveness and rare side effects of biological disease-modifying anti-rheumatic drugs (bDMARDs) in ankylosing spondylitis (AS), but may be hampered by differences in baseline characteristics and disease activity across countries. We aimed to explore the research infrastructure in the five Nordic countries regarding bDMARD treatment in AS.

METHOD: This observational cohort study was based on data from biological registries in Denmark (DANBIO), Sweden (SRQ/ARTIS), Finland (ROB-FIN), Norway (NOR-DMARD), and Iceland (ICEBIO). Data were collected for the years 2010-2016. Registry coverage, registry inventory (patient characteristics, disease activity measures), and national guidelines for bDMARD prescription in AS were described per country. Incident (first line) and prevalent bDMARD use per capita, country, and year were calculated. In AS patients who started first line bDMARDs during 2010-2016 (n = 4392), baseline characteristics and disease activity measures were retrieved.

RESULTS: Registry coverage of bDMARD-treated patients ranged from 60% to 95%. All registries included extensive prospectively collected data at patient level. Guidelines regarding choice of first line drug and prescription patterns varied across countries. During the period 2010-2016 prevalent bDMARD use increased (p < 0.001), whereas incident use tended to decrease (p for trend < 0.004), with large national variations (e.g. 2016 incidence: Iceland 10.7/100 000, Finland 1.7/100 000). Baseline characteristics were similar regarding C-reactive protein, but differed for other variables, including the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (range 3.5-6.3) and Ankylosing Spondylitis Disease Activity Score (ASDAS) (2.7-3.8) (both p < 0.0001).

CONCLUSION: Collaboration across the five Nordic biological registries regarding bDMARD use in AS is feasible but national differences in coverage, prescription patterns, and patient characteristics must be taken into account depending on the scientific question.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 47
Udgave nummer 6
Sider (fra-til) 465-474
Antal sider 10
ISSN 0300-9742
DOI
Status Udgivet - nov. 2018

Body mass index and age at natural menopause: an international pooled analysis of 11 prospective studies

Zhu, D., Chung, H-F., Pandeya, N., Dobson, A. J., Kuh, D., Crawford, S. L., Gold, E. B., Avis, N. E., Giles, G. G., Bruinsma, F., Adami, H-O., Weiderpass, E., Greenwood, D. C., Cade, J. E., Mitchell, E. S., Woods, N. F., Brunner, E. J., Simonsen, M. K. & Mishra, G. D., aug. 2018, I : European Journal of Epidemiology. 33, 8, s. 699-710 12 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Current evidence on the association between body mass index (BMI) and age at menopause remains unclear. We investigated the relationship between BMI and age at menopause using data from 11 prospective studies. A total of 24,196 women who experienced menopause after recruitment was included. Baseline BMI was categorised according to the WHO criteria. Age at menopause, confirmed by natural cessation of menses for ≥ 12 months, was categorised as < 45 years (early menopause), 45-49, 50-51 (reference category), 52-53, 54-55, and ≥ 56 years (late age at menopause). We used multinomial logistic regression models to estimate multivariable relative risk ratios (RRRs) and 95% confidence intervals (CI) for the associations between BMI and age at menopause. The mean (standard deviation) age at menopause was 51.4 (3.3) years, with 2.5% of the women having early and 8.1% late menopause. Compared with those with normal BMI (18.5-24.9 kg/m2), underweight women were at a higher risk of early menopause (RRR 2.15, 95% CI 1.50-3.06), while overweight (1.52, 1.31-1.77) and obese women (1.54, 1.18-2.01) were at increased risk of late menopause. Overweight and obesity were also significantly associated with around 20% increased risk of menopause at ages 52-53 and 54-55 years. We observed no association between underweight and late menopause. The risk of early menopause was higher among obese women albeit not significant (1.23, 0.89-1.71). Underweight women had over twice the risk of experiencing early menopause, while overweight and obese women had over 50% higher risk of experiencing late menopause.

Originalsprog Engelsk
Tidsskrift European Journal of Epidemiology
Vol/bind 33
Udgave nummer 8
Sider (fra-til) 699-710
Antal sider 12
ISSN 0393-2990
DOI
Status Udgivet - aug. 2018

Burden of rheumatoid arthritis in the Nordic region, 1990-2015: a comparative analysis using the Global Burden of Disease Study 2015

Kiadaliri, A. A., Kristensen, L-E. & Englund, M., mar. 2018, I : Scandinavian Journal of Rheumatology. 47, 2, s. 1-101 101 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: To report mortality and disability due to rheumatoid arthritis (RA) in the Nordic region (Denmark, Finland, Greenland, Iceland, Norway, and Sweden) using data from the Global Burden of Disease Study (GBD) 2015.

METHOD: Using the results of GBD 2015, we present rates and trends in prevalence, mortality, years of life lost, years lived with disability (YLD), and disability-adjusted life-years (DALYs) of RA in the Nordic region during 1990-2015.

RESULTS: In 2015, the age-standardized prevalence of RA was higher in the Nordic region than the global level (0.44%, 95% uncertainty interval 0.40-0.48%, vs 0.35%, 0.32-0.38%). For women (men), DALYs increased by 2.4% (12.9%), from 29 263 (10 909) in 1990 to 29 966 (12 311) in 2015. The burden of RA as a proportion of total DALYs in women (men) increased from 0.90% (0.29%) in 1990 to 0.94% (0.36%) in 2015. Age-standardized DALY rates declined in all countries except Denmark and Greenland between 1990 and 2015. Of 315 conditions studied, RA was ranked as the 16th (37th) leading cause of YLD in women (men) in the region. Of 195 countries studied, Greenland, Finland, Denmark, Norway, Sweden, and Iceland had the 7th, 11th, 28th, 38th, 48th, and 78th highest age-standardized YLD rates for RA, respectively.

CONCLUSIONS: The prevalence of RA in the Nordic region is higher than the global average. Current trends in population growth and ageing suggest a potential increase in RA burden in the coming decades in the region that should be considered in healthcare resources allocation.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 47
Udgave nummer 2
Sider (fra-til) 1-101
Antal sider 101
ISSN 0300-9742
DOI
Status Udgivet - mar. 2018

Carotid intima-media thickness (IMT) and ankle brachial index (ABI) are non-invasive indicators of generalised atherosclerosis. The aim was to determine the association between carotid IMT and ABI in subjects with and without diabetes mellitus (DM), and to analyse specific age change-points. We included 2744 subjects from the Copenhagen City Heart Study (mean age (SD) 56.6 (17.2) years, 56.8% women and body mass index (BMI) 25.4 (4.1) kg/m2). Carotid IMT and ABI measurements were performed during the fifth examination. Of the 2744 subjects, 125 subjects (4.6%) had DM. Average carotid IMT was 0.667 (0.145) mm and ABI was 1.06 (0.14). Subjects with DM were older, had higher BMI and systolic blood pressure (SBP) (all p < .001). Carotid IMT was higher in subjects with DM (0.754 (0.150) mm) compared to subjects without DM (0.662 (0.144) mm) (p < .001), whereas there was no difference in ABI between the two groups. ABI was inversely associated with carotid IMT (slope = -0.17 [-0.207; -0.137] (p < .001). The association remained significant after adjustment for risk factors both in subjects with DM (slope = -0.168 [-0.328; -0.007], p = .040), and in subjects without DM (slope = -0.100 [-0.148; -0.052], p < .001), with a stronger effect of carotid IMT on ABI among subjects with DM. Carotid IMT and ABI were inversely associated in subjects with DM and without DM, but with a stronger effect in subjects with DM. Age and ABI revealed a change-point with a stronger inverse association among subjects aged >60 years.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Clinical and Laboratory Investigation
Vol/bind 78
Udgave nummer 6
Sider (fra-til) 464-469
Antal sider 6
ISSN 0036-5513
DOI
Status Udgivet - 2018
Originalsprog Engelsk
Artikelnummer SAT0081
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 77
Udgave nummer Suppl. 2
Sider (fra-til) 903
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2018

Changes in job strain and subsequent weight gain: a longitudinal study, based on the Danish Nurse Cohort

Vesterlund, G. K., Keller, A. C. & Heitmann, B. L., apr. 2018, I : Public Health Nutrition. 21, 6, s. 1131-1138 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: Obesity as well as job strain is increasing, and job strain might contribute to weight gain. The objective of the current study was to examine associations between longitudinal alterations in the components of job strain and subsequent weight gain.

DESIGN: The study was designed as a prospective cohort study with three questionnaire surveys enabling measurement of job-strain alterations over 6 years and subsequent measurements of weight gain after further 10 years of follow-up. ANCOVA and trend analyses were conducted. Job demands were measured as job busyness and speed, and control as amount of influence.

SETTING: Employed nurses in Denmark.

SUBJECTS: We included a sub-sample of 6188 female nurses from the Danish Nurse Cohort, which consisted of the nurses who participated in surveys in 1993, 1999 and 2009.

RESULTS: A linear trend in weight gain was seen in nurses who were often busy in 1999 between those who were rarely v. sometimes v. often busy in 1993 (P=0·03), with the largest weight gain in individuals with sustained high busyness in both years. Loss of influence between 1993 and 1999 was associated with larger subsequent weight gain than sustained high influence (P=0·003) or sustained low influence (P=0·02). For speed, no associations were found.

CONCLUSIONS: Busyness, speed and influence differed in their relationship to subsequent weight gain. A decrease in job influence and a sustained burden of busyness were most strongly related to subsequent weight gain. Focus on job strain reduction and healthy diet is essential for public health.

Originalsprog Engelsk
Tidsskrift Public Health Nutrition
Vol/bind 21
Udgave nummer 6
Sider (fra-til) 1131-1138
Antal sider 8
ISSN 1368-9800
DOI
Status Udgivet - apr. 2018

Comparative effectiveness and prognostic factors for outcome of surgical and non-surgical management of lumbar spinal stenosis in an elderly population: protocol for an observational study

Brøgger, H. A., Maribo, T., Christensen, R. & Schiøttz-Christensen, B., 19 dec. 2018, I : BMJ Open. 8, 12, s. e024949

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

INTRODUCTION: Lumbar spinal stenosis is a common cause of low back and leg pain in the elderly and affects both physical activity and quality of life. First-line treatments are non-surgical options but if unsuccessful, surgery is advocated. The literature is not clear as to the outcome of surgery compared with non-surgical treatment, and the optimal time for surgery is not explicit. This observational study is designed to investigate the course of treatment, compare effectiveness of surgical and non-surgical management in patients with lumbar spinal stenosis and identify prognostic factors for outcome in the context of current clinical practice.

MATERIALS AND ANALYSIS: Prospectively registered data on treatment, outcome and patient characteristics are collected from nationwide registers on health and social issues, a clinical registry of people with chronic back pain and hospital medical records. Primary outcome is change in physical function measured by the Zurich Claudication Questionnaire. Secondary outcomes are changes in symptom severity, pain-related function, health-related quality of life and general self-efficacy. Outcomes are assessed at baseline and 6 and 12 months. Outcomes at 12 months will be compared for patients who undergo surgery for lumbar spinal stenosis and patients managed non-surgically, using different analytical approaches. Prespecified prognostic factors of interest at baseline include treatment allocation, back and leg pain intensity, comorbidity, duration of symptoms, pretreatment function, self-rated health, income, general self-efficacy and MRI-graded severity of central stenosis.

ETHICS AND DISSEMINATION: The study has been evaluated by the Regional Committees on Health Research for Southern Denmark (S-20172000-200) and notified to the Danish Data Protection Agency (18/22336). All participants provide consent. Findings will be disseminated in peer-reviewed publications and presented at national and international conferences according to the Strengthening the Reporting of Observational Studies in Epidemiology and Prognosis Research Strategy statements. Potential sources of bias will be addressed using Risk of Bias in Non-randomised Studies of Interventions.

TRIAL REGISTRATION NUMBER: NCT03548441; Pre-results.

Originalsprog Engelsk
Tidsskrift BMJ Open
Vol/bind 8
Udgave nummer 12
Sider (fra-til) e024949
ISSN 2044-6055
DOI
Status Udgivet - 19 dec. 2018

COMPOSITIONAL MAGNETIC RESONANCE IMAGING OF CARTILAGE AND MENISCI IN KNEE OSTEOARTHRITIS

Hangaard, S., 30 maj 2018, 66 s.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

Originalsprog Engelsk
Antal sider 66
Status Udgivet - 30 maj 2018

Concentration of 25-hydroxyvitamin D from neonatal dried blood spots and the relation to gestational age, birth weight and Ponderal Index: the D-tect study

Keller, A., Händel, M. N., Frederiksen, P., Jacobsen, R., Cohen, A. S., McGrath, J. J. & Heitmann, B. L., jun. 2018, I : The British journal of nutrition. 119, 12, s. 1416-1423 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Studies have suggested that vitamin D status at birth may be associated with a range of neonatal outcomes. The aim of this study was to assess the association between neonatal 25-hydroxyvitamin D3 (25(OH)D3) concentration and gestational age, birth weight, Ponderal Index and size for gestational age. Neonatal capillary blood stored as dried blood spots was used to assess 25(OH)D3 concentrations among 2686 subjects selected from a random population sub-sample of individuals, born in Denmark from 1 May 1981 to 31 December 2002. There was an inverse association between 25(OH)D3 concentration and gestational age at birth of -0·006 (95 % CI -0·009, -0·003, P<0·001) weeks of gestation per 1 nmol/l increase in 25(OH)D3 concentration. An inverted U-shaped association between 25(OH)D3 and birth weight and Ponderal Index (P=0·04) was found, but no association with size for gestational age was shown. This study suggests that neonatal 25(OH)D3 concentration is associated with anthropometric measures at birth known to be correlated with many subsequent health outcomes such as obesity and type 2 diabetes.

Originalsprog Engelsk
Tidsskrift The British journal of nutrition
Vol/bind 119
Udgave nummer 12
Sider (fra-til) 1416-1423
Antal sider 8
ISSN 0007-1145
DOI
Status Udgivet - jun. 2018

Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis

Sode, J., Vogel, U., Bank, S., Andersen, P. S., Hetland, M. L., Locht, H., Heegaard, N. H. H. & Andersen, V. 2018 I : The pharmacogenomics journal.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Several genetic variants in Toll-like receptor (TLR) and nuclear factor (NF)-κB signalling pathways have been reported associated with responsiveness to tumour necrosis factor inhibitor (anti-TNF) treatment in rheumatoid arthritis (RA). The present study was undertaken to replicate these findings. In a retrospective case-case study including 1007 Danish anti-TNF-treated RA patients, we genotyped 7 previously reported associated single-nucleotide polymorphisms (SNPs) in these pathways. Furthermore, 5 SNPs previously reported by our group were genotyped in a subcohort (N=469). Primary analyses validated the IRAK3 rs11541076 variant as associated (odds ratio (OR)=1.33, 95% confidence interval (CI): 1.00-1.77, P-value=0.047) with a positive treatment response (EULAR (European League Against Rheumatism) good/moderate vs none response at 4±2 months), and found the NLRP3 rs461266 variant associated (OR=0.75, 95% CI: 0.60-0.94, P=0.014) with a negative treatment response. Meta-analyses combining data from previous studies suggested smaller effect sizes of associations between variant alleles of CHUK rs11591741, NFKBIB rs3136645 and rs9403 and a negative treatment response. In conclusion, this study validates rs11541076 in IRAK3, a negative regulator of TLR signalling, as a predictor of anti-TNF treatment response, and suggests true positive associations of previously reported SNPs within genes encoding activators/inhibitors of NF-κB (CHUK, MYD88, NFKBIB, and NLRP3).The Pharmacogenomics Journal advance online publication, 4 October 2016; doi:10.1038/tpj.2016.66.

Originalsprog Engelsk
Tidsskrift The pharmacogenomics journal
ISSN 1470-269X
DOI
Status E-pub ahead of print - 2018

Correction to: Recommendations for the management of rheumatoid arthritis in the Eastern Mediterranean region: an adolopment of the 2015 American College of Rheumatology guidelines

Arayssi, T., Harfouche, M., Darzi, A., Al Emadi, S., Alnaqbi, K. A., Badsha, H., Al Balushi, F., Dib, C., Elzorkany, B., Halabi, H., Hammoudeh, M., Hazer, W., Masri, B., Merashli, M., Omair, M., Salloum, N., Uthman, I., Zahirovic, S., Ziade, N., Bannuru, R. R., McAlindon, T., Nomier, M. A., Singh, J. A., Christensen, R., Tugwell, P., Schünemann, H. & Akl, E. A., nov. 2018, I : Clinical Rheumatology. 37, 11, s. 2961-2962 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In the original version of this article the first name of the co-author was incorrectly spelled as "Khaled A. Alnaqbi". The correct spelling should have been "Khalid A. Alnaqbi". This is now presented correctly in this article.

Originalsprog Engelsk
Tidsskrift Clinical Rheumatology
Vol/bind 37
Udgave nummer 11
Sider (fra-til) 2961-2962
Antal sider 2
ISSN 0770-3198
DOI
Status Udgivet - nov. 2018

Correction: Opportunities and challenges for real-world studies on chronic inflammatory joint diseases through data enrichment and collaboration between national registers: the Nordic example

Chatzidionysiou, K., Hetland, M. L., Frisell, T., Giuseppe, D. D., Hellgren, K., Glintborg, B., Nordström, D., Aaltonen, K., Törmänen, M. R. K., Kristianslund, E. K., Kvien, T. K., Provan, S. A., Gudbjörnsson, B., Dreyer, L., Kristensen, L. E., Jørgensen, T. S., Jacobsson, L. & Askling, J., 2018

Publikation: AndetAndet bidragForskning

[This corrects the article DOI: 10.1136/rmdopen-2018-000655.].

Originalsprog Engelsk
Publikationsdato 2018
Udgave 1
Vol/bind 4
DOI
Status Udgivet - 2018
Navn RMD Open
ISSN 2056-5933

Cross-sectional associations between maternal self-efficacy and dietary intake and physical activity in four-year-old children of first-time Swedish mothers

Rohde, J. F., Bohman, B., Berglind, D., Hansson, L. M., Frederiksen, P., Mortensen, E. L., Heitmann, B. L. & Rasmussen, F., 1 jun. 2018, I : Appetite. 125, s. 131-138 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: Healthy dietary and physical activity behaviours are established early in life where children learn by observing their parents. Therefore, parents can act as role models and influence their children toward a healthier lifestyle. Besides a strong association between parental and child health behaviours, parents also influence their children's health behaviours through socio-cognitive processes, where perceived self-efficacy is the central component. The objective was to examine if parental self-efficacy among Swedish mothers was associated with their four-year-old children's dietary and physical activity behaviours.

METHODS: This cross-sectional study was based on information from control participants that took part in the Swedish primary prevention trial of childhood obesity (PRIMROSE) (n = 420 mother-child pairs). Linear regression models were used to examine the associations between parental self-efficacy (Parental Self-Efficacy for Promoting Healthy Physical Activity and Dietary Behaviours in Children Scale) and children's dietary intake (parent reported) and levels of physical activity (accelerometer) with adjustments for potential confounders.

RESULTS: Mothers' efficacy beliefs in promoting healthy dietary or physical activity behaviours in their children were associated with a slightly higher consumption of fruit and vegetables among their children (β: 0.03 [95%CI: 0.01; 0.04] P < 0.001) and slightly higher levels of moderate-to-vigorous activity (β: 0.43 [95%CI: 0.05; 0.81] P = 0.03). Mothers' belief in their ability to limit unhealthy dietary and physical activity behaviours was inversely associated with children's intake of unhealthy snacks (β: -0.06 [95%CI: -0.10; -0.02] P < 0.01).

CONCLUSION: Our cross-sectional study suggests weak positive correlations between maternal self-efficacy and healthy dietary and physical activity behaviours, and weak inverse associations between maternal self-efficacy and unhealthy dietary and physical activity behaviours among their children.

Originalsprog Engelsk
Tidsskrift Appetite
Vol/bind 125
Sider (fra-til) 131-138
Antal sider 8
ISSN 0195-6663
DOI
Status Udgivet - 1 jun. 2018

Day-to-Day Reliability of Nonlinear Methods to Assess Walking Dynamics

Raffalt, P. C., Alkjær, T., Brynjólfsson, B., Jørgensen, L., Bartholdy, C. & Henriksen, M., 1 dec. 2018, I : Journal of Biomechanics. 140, 12

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The present study investigated the day-to-day reliability (quantified by the absolute and relative reliability) of nonlinear methods used to assess human locomotion dynamics. Twenty-four participants of whom twelve were diagnosed with knee osteoarthritis completed 5 min of treadmill walking at self-selected preferred speed on two separate days. Lower limb kinematics were recorded at 100 Hz and hip, knee, and ankle joint angles, three-dimensional (3D) sacrum marker displacement and stride time intervals were extracted for 170 consecutive strides. The largest Lyapunov exponent and correlation dimension were calculated for the joint angle and sacrum displacement data using three different state space reconstruction methods (group average, test-retest average, individual time delay and embedding dimension). Sample entropy and detrended fluctuation analysis (DFA) were applied to the stride time interval time series. Relative reliability was assessed using intraclass correlation coefficients and absolute reliability was determined using measurement error (ME). For both joint angles and sacrum displacement, there was a general pattern that the group average state space reconstruction method provided the highest relative reliability and lowest ME compared to the individual and test-retest average methods. The DFA exhibited good reliability, while the sample entropy showed poor reliability. The results comprise a reference material that can inspire and guide future studies of nonlinear gait dynamics.

Originalsprog Engelsk
Tidsskrift Journal of Biomechanics
Vol/bind 140
Udgave nummer 12
ISSN 0021-9290
DOI
Status Udgivet - 1 dec. 2018

BACKGROUND: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC).

PURPOSE: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA.

STUDY TYPE: Cross-sectional.

POPULATION: Eighty-five obese patients with knee OA.

FIELD STRENGTH/SEQUENCES: 1.5T. Inversion recovery sequence with four inversion times.

ASSESSMENT: T1 relaxation times were calculated for posterior weight-bearing femoral cartilage and the posterior horns of the menisci. Meniscus degeneration sum score (0-2) was assessed as increased signal/no signal (1/0) and tear/no tear (1/0).

STATISTICAL TESTS: T1 relaxation times were compared using Student's t-test. Comparison of cartilage and meniscus T1 relaxation times was done by regression analysis. Analysis of variance (ANOVA) was used for comparison of meniscal T1 relaxation times among the three summed morphological scores (0-2). Statistical analyses were performed with a level of significance at 0.05.

RESULTS: For lateral menisci, morphology sum scores of 0, 1, and 2 were found in 13, 58, and 14 patients and for medial menisci in 2, 30, and 30 patients, respectively. Mean T1 relaxation times were 441 msec, 480 msec, and 497 msec for cartilage, lateral menisci, and medial menisci, respectively. T1 relaxation times for the menisci were similar (P = 0.53), and a weak correlation was found between dGEMRIC and dGEMRIM in the lateral compartments (R = 0.26). Comparing dGEMRIM between different morphology sum scores showed no differences (P > 0.4).

DATA CONCLUSION: I.a. dGEMRIM showed no correlation between the degree of meniscal degeneration and meniscus T1 relaxation times. I.a. dGEMRIM do not seem to deliver useful information about meniscus degeneration to be suitable for clinical applications, but i.a. dGEMRIC may still be considered an alternative contrast-saving method for cartilage.

LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;48:1700-1706.

Originalsprog Engelsk
Tidsskrift Journal of magnetic resonance imaging : JMRI
Vol/bind 48
Udgave nummer 6
Sider (fra-til) 1700-1706
Antal sider 7
ISSN 1053-1807
DOI
Status Udgivet - dec. 2018
Originalsprog Engelsk
Udgivelses sted [Kbh.]
Forlag University of Copenhagen, Faculty of Health and Medical Sciences
Antal sider 270
Status Udgivet - 2018

Disease Modifying Therapies in Psoriatic Arthritis: Prognostic Factors and Treatment Outcomes

Højgaard, P., 28 feb. 2018, Eget forlag, København. 78 s.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

Originalsprog Engelsk
Forlag Eget forlag, København
Antal sider 78
Status Udgivet - 28 feb. 2018

Diverse hepatic microbial DNA fingerprints in healthy lean and obese steatotic humans

Bagger, J. I., Suppli, M. P., Nielsen, T., Lelouvier, B., Broha, A., Demant, M. G., Kønig, M. J., Strandberg, C., Lund, A., Vilsbøll, T. & Knop, F. K. 2 okt. 2018 (Accepteret/In press)

Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

Originalsprog Engelsk
Publikationsdato 2 okt. 2018
Status Accepteret/In press - 2 okt. 2018
Begivenhed 54th EASD Annual Meeting: EASD 2018 - Berlin, Tyskland
Varighed: 1 okt. 20185 okt. 2018
https://www.easd.org/programme-2018.html

Konference

Konference 54th EASD Annual Meeting
Land Tyskland
By Berlin
Periode 01/10/201805/10/2018
Internetadresse

Pages