Published in 2011

The effects of rose hip (Rosa canina) on plasma antioxidative activity and C-reactive protein in patients with rheumatoid arthritis and normal controls: A prospective cohort study

Kirkeskov, B., Christensen, R., Bügel, S. G., Bliddal, H., Danneskiold-Samsøe, B., Christensen, L. P. & Andersen, J. R., 17 mar. 2011, I : Phytomedicine. 18, 11, s. 953-958

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVES: Rose hip (Rosa canina) has been used as an herbal remedy against a wide range of ailments including inflammatory disorders. The anti-inflammatory and antioxidant properties of rose hips have been evaluated in vitro and active constituents have been isolated. Rose hip contains antioxidant nutrients and an anti-inflammatory galactolipid. Rheumatoid arthritis (RA) is an inflammatory disease where activated cells release reactive oxygen substances. Thus it could be relevant to investigate if rose hip had an anti-inflammatory and/or antioxidant effect in this situation. METHODS: In this open case-control study 20 female patients with RA and 10 female controls were given 10.5g rose hip powder daily (Litozin(®)) for 28 days. Blood samples were analysed at baseline and follow-up for the capacity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase and the inflammatory marker C-reactive protein (CRP). The participants kept a food diary for the first 3 days and the last 3 days of the intervention period. The RA-patients completed The Stanford Health Assessment Questionnaire at baseline and follow-up. RESULTS: CRP-concentrations of both patients and healthy controls did not change. Nor was any effect found on the activity of antioxidant enzymes. There was no difference in food intake at baseline, but in the last week the RA-group reduced their energy intake. CONCLUSIONS: 10.5g Litozin(®) in 28 days had neither effect on clinical symptoms or laboratory measurements in patients with RA or healthy controls. This is in contrast to previous intervention studies with rose hip powder that found a reduction in the concentration of CRP. The results of the present study indicate that a daily amount of approximately 10g rose hip powder for one month has no anti-inflammatory and/or antioxidant effect.
Originalsprog Engelsk
Tidsskrift Phytomedicine
Vol/bind 18
Udgave nummer 11
Sider (fra-til) 953-958
ISSN 0944-7113
DOI
Status Udgivet - 17 mar. 2011

The Efficacy of Disulfiram for the Treatment of Alcohol Use Disorder

Jørgensen, C. H., Pedersen, B. & Tønnesen, H., okt. 2011, I : Alcoholism: Clinical and Experimental Research. 35, 10

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Background:  Alcohol use disorders (AUD) involving hazardous, harmful, and addictive misuse of alcohol are widespread in most parts of the world. The aim of this study was to review the effect of disulfiram in the treatment of patients with AUD. The effect of disulfiram was evaluated according to the primary outcome of an intake of alcohol below 30 and 20 g/d for men and women, respectively, as well as secondary outcomes such as days until relapse, alcohol intake, and numbers of drinking days. Methods:  A systematic review of the literature was conducted using MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL). Results:  Eleven randomized controlled trials were included with a total of 1,527 patients. They compared disulfiram treatment with placebo, none or other abstinence-supportive treatments. Overall, 6 studies reported of a significant better effect on abstinence for patients treated with disulfiram. Six of 9 studies measuring secondary outcomes reported that patients treated with disulfiram had significantly more days until relapse and fewer drinking days, respectively. The quality of the included studies was moderate. Heterogeneity was significant in most of the meta-analyses, but valid results were found regarding the effect of disulfiram versus placebo over 12 months and unsupervised disulfiram versus other or no treatment. The vast majority of significant studies were of shorter duration, while only 3 studies of 12 months were significant regarding more days until relapse and/or reduction in drinking days. Conclusions:  Supervised treatment with disulfiram has some effect on short-term abstinence and days until relapse as well as number of drinking days when compared with placebo, none, or other treatments for patients with alcohol dependency or abuse. Long-term effect on abstinence has not been evaluated yet. However, there is a need for more homogeneous and high-quality studies in the future regarding the efficacy of disulfiram.
Originalsprog Engelsk
Tidsskrift Alcoholism: Clinical and Experimental Research
Vol/bind 35
Udgave nummer 10
ISSN 0145-6008
DOI
Status Udgivet - okt. 2011

The Influence of Radiographic Severity on the Relationship between Muscle Strength and Joint Loading in Obese Knee Osteoarthritis Patients

Aaboe, J., Bliddal, H., Alkjaer, T., Boesen, M. & Henriksen, M., 2011, I : Arthritis Today. 2011, s. 571519

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Objective. To investigate the relationship between knee muscle strength and the external knee adduction moment during walking in obese knee osteoarthritis patients and whether disease severity influences this relationship. Methods. This cross-sectional study included 136 elderly obese (BMI > 30) adults with predominant medial knee osteoarthritis. Muscle strength, standing radiographic severity as measured by the Kellgren and Lawrence scale, and the peak external knee adduction moment were measured at self-selected walking speed. Results. According to radiographic severity, patients were classified as "less severe" (KL 1-2, N = 73) or "severe" (KL 3-4, N = 63). A significant positive association was demonstrated between the peak knee adduction moment and hamstring muscle strength in the whole cohort (P = .047). However, disease severity did not influence the relationship between muscle strength and dynamic medial knee joint loading. Severe patients had higher peak knee adduction moment and more varus malalignment (P <.001). Conclusion. Higher hamstring muscle strength relates to higher estimates of dynamic knee joint loading in the medial compartment. No such relationship existed for quadriceps muscle strength. Although cross sectional, the results suggest that hamstrings function should receive increased attention in future studies and treatments that aim at halting disease progression.
Originalsprog Engelsk
Tidsskrift Arthritis Today
Vol/bind 2011
Sider (fra-til) 571519
ISSN 0969-7039
DOI
Status Udgivet - 2011

The navicular position test - a reliable measure of the navicular bone position during rest and loading

Spörndly-Nees, S., Dåsberg, B., Nielsen, R. O., Boesen, M. I. & Jørgensen, H. L., 2011, I : International journal of sports physical therapy. 6, 3, s. 199-205 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Lower limb injuries are a large problem in athletes. However, there is a paucity of knowledge on the relationship between alignment of the medial longitudinal arch (MLA) of the foot and development of such injuries. A reliable and valid test to quantify foot type is needed to be able to investigate the relationship between arch type and injury likelihood. Feiss Line is a valid clinical measure of the MLA. However, no study has investigated the reliability of the test.
Originalsprog Engelsk
Tidsskrift International journal of sports physical therapy
Vol/bind 6
Udgave nummer 3
Sider (fra-til) 199-205
Antal sider 7
Status Udgivet - 2011

The number needed to treat for second-generation biologics when treating established rheumatoid arthritis: a systematic quantitative review of randomized controlled trials

Kristensen, L. E., Jakobsen, A. K., Bartels, E. M., Geborek, P., Bliddal, H., Saxne, T., Danneskiold-Samsøe, B. & Christensen, R., 2011, I : Scandinavian Journal of Rheumatology. 40, 1, s. 1-7 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To evaluate the number needed to treat (NNT) and the number needed to harm (NNH) of the second-generation biologics abatacept, certolizumab, golimumab, rituximab, and tocilizumab in patients with established rheumatoid arthritis (RA) taking concomitant methotrexate (MTX).
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 40
Udgave nummer 1
Sider (fra-til) 1-7
Antal sider 7
ISSN 0300-9742
DOI
Status Udgivet - 2011

The potential of smoking cessation programmes and a smoking ban in public places: comparing gain in life expectancy and cost effectiveness

Højgaard, B., Olsen, K. R., Pisinger, C., Tønnesen, H. & Gyrd-Hansen, D., 2011, I : Scandinavian Journal of Public Health. 39, 8, s. 785-96 12 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Interventions aimed at reducing the number of smokers are generally believed to be cost effective. However as the cost of the interventions should be paid up front whereas the gains in life years only appear in the future--the budgetary consequences might be a barrier to implementing such interventions.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Public Health
Vol/bind 39
Udgave nummer 8
Sider (fra-til) 785-96
Antal sider 12
ISSN 1403-4948
DOI
Status Udgivet - 2011

The role of Campylobacter jejuni cytolethal distending toxin in gastroenteritis: toxin detection, antibody production, and clinical outcome

Mortensen, N. P., Schiellerup, P., Boisen, N., Klein, B. M., Locht, H., Abuoun, M., Newell, D. & Krogfelt, K. A. 2011 I : A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 119, 9, s. 626-34 9 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The role of Campylobacter jejuni cytolethal distending toxin (CDT) on clinical outcome after gastroenteritis was investigated. Clinical data, blood serum samples, and Campylobacter spp. isolated, from each of 30 patients were collected over a period of 6 months. The CDT encoding genes, cdtABC, characterized by PCR, revealed that all but one of the C. jejuni strains had the wild-type sequence. Sequencing of cdtABC from this strain showed two major deletions. From all of the strains, CDT titers were determined, and toxin neutralizing antibodies were documented using an in vitro assay. Three of the thirty clinical isolates, including the one with the mutant cdtABC coding genes, did not have a detectable CDT activity. Analyzing the relationship between CDT titer, serum neutralization of CDT, and the clinical outcome showed that campylobacteriosis caused by CDT-negative strains was clinically indistinguishable from that of patients infected with an isolate that produced high levels of CDT. These results suggest that CDT does not solely determine severity of infection and clinical outcome.
Originalsprog Engelsk
Tidsskrift A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Udgivelsesdato 2011
Vol/bind 119
Tidsskriftsnummer 9
Sider 626-34
Antal sider 9
ISSN 0903-4641
DOI
Status Udgivet

Toward Development of a Fibromyalgia Responder Index and Disease Activity Score: OMERACT Module Update

Mease, P. J., Clauw, D. J., Christensen, R., Crofford, L. J., Gendreau, R. M., Martin, S. A., Simon, L. S., Strand, V., Williams, D. A., Arnold, L. M. & the OMERACT Fibromyalgia Working Group, 1 jul. 2011, I : Journal of Rheumatology. 38, 7, s. 1487-1495 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Following development of the core domain set for fibromyalgia (FM) in Outcome Measures in Rheumatology Clinical Trials (OMERACT) meetings 7 to 9, the FM working group has progressed toward the development of an FM responder index and a disease activity score based on these domains, utilizing outcome indices of these domains from archived randomized clinical trials in FM. Possible clinical domains that could be included in a responder index and disease activity score include pain, fatigue, sleep disturbance, cognitive dysfunction, mood disturbance, tenderness, stiffness, and functional impairment. Outcome measures for these domains demonstrate good to adequate psychometric properties, although measures of cognitive dysfunction need to be further developed. The approach used in the development of responder indices and disease activity scores for rheumatoid arthritis and ankylosing spondylitis represents heuristic models for our work, but FM is challenging in that there is no clear algorithm of treatment that defines disease activity based on treatment decisions, nor are there objective markers that define thresholds of severity or response to treatment. The process of developing candidate dichotomous responder definitions and continuous quantitative disease activity measures is described, along with participant discussions from OMERACT 10. Final results of this work will be published in a separate report pending completion of analyses.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 38
Udgave nummer 7
Sider (fra-til) 1487-1495
Antal sider 9
ISSN 0315-162X
DOI
Status Udgivet - 1 jul. 2011
To investigate disease activity, treatment response, and drug survival, and predictors thereof, among Danish patients with psoriatic arthritis (PsA) receiving their first treatment series with a tumor necrosis factor α (TNFα) inhibitor.
Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatism
Vol/bind 63
Udgave nummer 2
Sider (fra-til) 382-90
Antal sider 9
ISSN 0004-3591
DOI
Status Udgivet - 1 feb. 2011
The ankle region is frequently involved in juvenile idiopathic arthritis (JIA) but difficult to examine clinically due to its anatomical complexity. The aim of the study was to evaluate the role of ultrasonography (US) of the ankle and midfoot (ankle region) in JIA. Doppler-US detected synovial hypertrophy, effusion and hyperemia and US was used for guidance of steroid injection and to assess treatment efficacy.
Originalsprog Engelsk
Tidsskrift Pediatric Rheumatology Online Journal
Vol/bind 9
Udgave nummer 1
Sider (fra-til) 4
ISSN 1546-0096
DOI
Status Udgivet - 2011
To investigate the predictive ability of core outcomes applied in RA trials, including ultrasound (US) Doppler (USD) measurements differentiating patients who remain on anti-TNF-α therapy following 1 year.
Originalsprog Engelsk
Tidsskrift Rheumatology
Vol/bind 50
Udgave nummer 3
Sider (fra-til) 506-12
Antal sider 7
ISSN 1462-0324
DOI
Status Udgivet - 2011

Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial

Bliddal, H., Leeds, A. R., Stigsgaard, L., Astrup, A. & Christensen, R., 5 aug. 2011, I : Annals of the Rheumatic Diseases. 70, s. 1798-1803

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: To evaluate 1-year symptomatic improvement in obese patients with knee osteoarthritis (OA) on an intensive low-energy diet (LED) maintained by frequent consultations with a dietician compared to minimal attention. METHODS: The LED programme consisted of group therapy with dietary consultations and two periods of a low-calorie diet of 810 kcal/day during weeks 0-8 and weeks 32-36. The control group only received dietary instruction and attention for 2 h at baseline, and at weeks 8, 32, 36 and 52. The primary end point (total Western Ontario and McMaster Universities (WOMAC) index) was assessed as the mean group difference during and after 1 year. RESULTS: The study population consisted of 89 patients, 89% women, average age 63 years. After 1 year, mean weight loss in the LED group was -10.9 kg (11%) versus -3.6 kg (4%) in the control group (p
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 70
Sider (fra-til) 1798-1803
ISSN 0003-4967
DOI
Status Udgivet - 5 aug. 2011

Will emergency and surgical patients participate in and complete alcohol interventions? A systematic review

Pedersen, B., Oppedal, K., Egund, L. & Tønnesen, H., 1 jan. 2011, I : B M C Surgery. 11, s. 26

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

ABSTRACT:
Originalsprog Engelsk
Tidsskrift B M C Surgery
Vol/bind 11
Sider (fra-til) 26
ISSN 1471-2482
DOI
Status Udgivet - 1 jan. 2011

Ældre

Hendriksen, C., 2011, Klinisk Social Medicin og Rehabilitering. København: FADL's Forlag

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Social Medicin og Rehabilitering
Udgivelses sted København
Forlag FADL's Forlag
Publikationsdato 2011
Kapitel 12
Status Udgivet - 2011

Published in 2010

1H NMR spectroscopy-based interventional metabolic phenotyping: a cohort study of rheumatoid arthritis patients

Lauridsen, M. B., Bliddal, H., Christensen, R. D. K., Danneskiold-Samsøe, B., Bennett, R., Keun, H., Lindon, J. C., Nicholson, J. K., Christiansen, M. H. D., Jaroszewski, J. W., Hansen, S. H. & Cornett, C., 3 sep. 2010, I : Journal of Proteome Research. 9, 9, s. 4545-53 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

1H NMR spectroscopy-based metabolic phenotyping was used to identify biomarkers in the plasma of patients with rheumatoid arthritis (RA). Forty-seven patients with RA (23 with active disease at baseline and 24 in remission) and 51 healthy subjects were evaluated during a one-year follow-up with assessments of disease activity (DAS-28) and 1H NMR spectroscopy of plasma samples. Discriminant analysis provided evidence that the metabolic profiles predicted disease severity. Cholesterol, lactate, acetylated glycoprotein, and lipid signatures were found to be candidate biomarkers for disease severity. The results also supported the link between RA and coronary artery disease. Repeated assessment using mixed linear models showed that the predictors obtained from metabolic profiles of plasma at baseline from patients with active RA were significantly different from those of patients in remission (P=0.0007). However, after 31 days of optimized therapy, the two patient groups were not significantly different (P=0.91). The metabolic profiles of both groups of RA patients were different from the healthy subjects. 1H NMR-based metabolic phenotyping of plasma samples in patients with RA is well suited for discovery of biomarkers and may be a potential approach for disease monitoring and personalized medication for RA therapy.
Originalsprog Engelsk
Tidsskrift Journal of Proteome Research
Vol/bind 9
Udgave nummer 9
Sider (fra-til) 4545-53
Antal sider 9
ISSN 1535-3893
DOI
Status Udgivet - 3 sep. 2010

A European multicenter randomized double-blind placebo-controlled monotherapy clinical trial of milnacipran in treatment of fibromyalgia

Branco, J. C., Zachrisson, O., Perrot, S., Mainguy, Y. & Multinational Coordinator Study Group, 1 apr. 2010, I : Journal of Rheumatology. 37, 4, s. 851-9 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

This randomized, double-blind, placebo-controlled, multicenter study investigated the efficacy and safety of milnacipran in the treatment of fibromyalgia (FM) in a European population.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 37
Udgave nummer 4
Sider (fra-til) 851-9
Antal sider 9
ISSN 0315-162X
DOI
Status Udgivet - 1 apr. 2010

Adaptations of upper trapezius muscle activity during sustained contractions in women with fibromyalgia

Falla, D. L., Andersen, H., Danneskiold-Samsøe, B., Arendt-Nielsen, L. & Farina, D., 1 jun. 2010, I : Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology. 20, 3, s. 457-64 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The study compared the distribution of electromyographic (EMG) signal amplitude in the upper trapezius muscle in 10 women with fibromyalgia and in 10 healthy women before and after experimentally-induced muscle pain. Surface EMG signals were recorded over the right upper trapezius muscle with a 10 x 5 grid of electrodes during 90 degrees shoulder abduction sustained for 60s. The control subjects repeated the abduction task following injections of isotonic and hypertonic (painful) saline into the upper trapezius muscle. The EMG amplitude was computed for each electrode pair and provided a topographical map of the distribution of muscle activity. The pain level rated by the patients at the beginning of the sustained contraction was 5.9+/-1.5. The peak pain intensity for the control group following the injection of hypertonic saline was 6.0+/-1.6. During the sustained contractions, the EMG amplitude increased relatively more in the cranial than caudal region of the upper trapezius muscle for the control subjects (shift in the distribution of EMG amplitude: 2.3+/-1.3mm; P
Originalsprog Engelsk
Tidsskrift Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology
Vol/bind 20
Udgave nummer 3
Sider (fra-til) 457-64
Antal sider 8
DOI
Status Udgivet - 1 jun. 2010

Biologics for rheumatoid arthritis: an overview of Cochrane reviews

Singh, J. A., Christensen, R., Wells, G. A., Suarez-Almazor, M. E., Buchbinder, R., Lopez-Olivo, M. A., Ghogomu, E. T. & Tugwell, P., 1 jan. 2010, I : São Paulo medical journal = Revista paulista de medicina. 128, 5, s. 309-10 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

the biologic disease-modifying anti-rheumatic drugs (DMARDs) are very effective in treating rheumatoid arthritis (RA), however there is a lack of head-to-head comparison studies.
Originalsprog Engelsk
Tidsskrift São Paulo medical journal = Revista paulista de medicina
Vol/bind 128
Udgave nummer 5
Sider (fra-til) 309-10
Antal sider 2
Status Udgivet - 1 jan. 2010

Brief smoking cessation intervention in relation to breast cancer surgery: a randomized controlled trial

Thomsen, T., Tønnesen, H., Okholm, M., Kroman, N., Maibom, A., Sauerberg, M-L. & Møller, A., 1 nov. 2010, I : Nicotine & Tobacco Research. 12, 11, s. 1118-24 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Smokers are more prone to develop postoperative complications. Smoking cessation intervention beginning 4-8 weeks prior to surgery improves the postoperative outcome. Cancer patients, however, often undergo surgery less than 4 weeks after diagnosis. The primary objective of this study was therefore to examine if a brief smoking cessation intervention shortly before breast cancer surgery would influence postoperative complications and smoking cessation.
Originalsprog Engelsk
Tidsskrift Nicotine & Tobacco Research
Vol/bind 12
Udgave nummer 11
Sider (fra-til) 1118-24
Antal sider 7
ISSN 1462-2203
DOI
Status Udgivet - 1 nov. 2010

Bibliografisk note

HEHMVU

Center-size as a predictor of weight-loss outcome in multicenter trials including a low-calorie diet

Gasteyger, C., Christensen, R., Larsen, T. M., Vercruysse, F., Toubro, S. & Astrup, A., 1 nov. 2010, I : Obesity. 18, 11, s. 2160-4 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

It has not been studied yet whether factors such as the number of subjects recruited by specialized centers for multicenter trials may influence weight loss during a low-calorie diet (LCD). This study aimed at determining whether the number of recruited subjects per center might predict relative weight loss. This is a post hoc analysis of an existing database: 701 obese subjects (77% women, 23% men, mean BMI: 38.9 kg/m(2)) were enrolled at 22 sites (4-85 subjects/site) in five countries to follow a LCD providing 800-1,000 kcal/day during 8 weeks. The main outcome measure was the percentage weight loss after the 8-week LCD. Mean weight loss differed significantly between participating centers (5.8-11.8% of the initial weight; P <0.001). There was a significant positive correlation between relative weight loss and the number of recruited subjects per center (r = 0.38; P <0.001). In a multiple stepwise regression analysis, the number of recruited subjects per center appeared to be the main predictive factor of weight loss (R(2) = 0.07; P <0.001). As the number of participants within each center is clustered, we applied a hierarchical model to model the average weight loss vs. the number of participants included at each center. This model allows to predict that for 10 extra patients in a center, the average weight loss would increase by 0.5%. This is the first study suggesting that the number of recruited subjects per center may impact weight loss, and could therefore be considered as a new predictor for weight loss that is independent from the individual.
Originalsprog Engelsk
Tidsskrift Obesity
Vol/bind 18
Udgave nummer 11
Sider (fra-til) 2160-4
Antal sider 5
ISSN 1930-7381
DOI
Status Udgivet - 1 nov. 2010

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