Published in 2000

Who benefits from treatment and rehabilitation in a stroke Unit? A community-based study

Jorgensen, H. S., Kammersgaard, L. P., Houth, J., Nakayama, H., Raaschou, H. O., Larsen, K., Hübbe, P. & Olsen, T. S., feb. 2000, I : Stroke. 31, 2, s. 434-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The beneficial effects of treatment and rehabilitation of patients with acute stroke in a dedicated stroke unit (SU) are well established. We wanted to examine if these effects are limited to certain groups of patients or if they apply to all patients independent of age, sex, comorbidity, and initial stroke severity.
Originalsprog Engelsk
Tidsskrift Stroke
Vol/bind 31
Udgave nummer 2
Sider (fra-til) 434-9
Antal sider 6
ISSN 0039-2499
Status Udgivet - feb. 2000

Published in 1999

Leukocytosis is a common finding in the acute phase of stroke. A detrimental effect of leukocytosis on stroke outcome has been suggested, and trials aiming at reducing the leukocyte response in acute stroke are currently being conducted. However, the influence of leukocytosis on stroke outcome has not been clarified.
Originalsprog Engelsk
Tidsskrift Journal of Stroke & Cerebrovascular Diseases
Udgivelsesdato 1999
Vol/bind 8
Tidsskriftsnummer 4
Sider 259-63
Antal sider 5
ISSN 1052-3057
Status Udgivet

Maximal isometric strength of the cervical musculature in 100 healthy volunteers

Jordan, A., Mehlsen, J., Bülow, P. M., Ostergaard, K. & Danneskiold-Samsøe, B., 1 jul. 1999, I : Spine. 24, 13, s. 1343-8 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A descriptive study involving maximal isometric strength measurements of the cervical musculature.
Originalsprog Engelsk
Tidsskrift Spine
Vol/bind 24
Udgave nummer 13
Sider (fra-til) 1343-8
Antal sider 6
ISSN 0362-2436
Status Udgivet - 1 jul. 1999

Predicted impact of intravenous thrombolysis on prognosis of general population of stroke patients: simulation model

Jørgensen, H. S., Nakayama, H., Kammersgaard, L. P., Raaschou, H. O. & Olsen, T. S., 31 jul. 1999, I : B M J (Clinical Research Edition). 319, 7205, s. 288-9 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift B M J (Clinical Research Edition)
Vol/bind 319
Udgave nummer 7205
Sider (fra-til) 288-9
Antal sider 2
ISSN 0959-8138
Status Udgivet - 31 jul. 1999

Treatment and rehabilitation on a stroke unit improves 5-year survival. A community-based study

Jørgensen, H. S., Kammersgaard, L. P., Nakayama, H., Raaschou, H. O., Larsen, K., Hübbe, P. & Olsen, T. S., maj 1999, I : Stroke. 30, 5, s. 930-3 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

We have previously reported a marked reduction in mortality up to 1 year after treatment and rehabilitation on a stroke unit versus on general neurological and medical wards in unselected stroke patients. In the present study we wanted to test the hypothesis that this mortality-reducing effect is not temporary but is long lasting.
Originalsprog Engelsk
Tidsskrift Stroke
Vol/bind 30
Udgave nummer 5
Sider (fra-til) 930-3
Antal sider 4
ISSN 0039-2499
Status Udgivet - maj 1999

What determines good recovery in patients with the most severe strokes?: The Copenhagen Stroke Study

Jørgensen, H. S., Reith, J., Nakayama, H., Kammersgaard, L. P., Raaschou, H. O. & Olsen, T. S. okt 1999 I : Stroke. 30, 10, s. 2008-12 5 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Even patients with the most severe strokes sometimes experience a remarkably good recovery. We evaluated possible predictors of a good outcome to search for new therapeutic strategies.
Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato okt 1999
Vol/bind 30
Tidsskriftsnummer 10
Sider 2008-12
Antal sider 5
ISSN 0039-2499
Status Udgivet

Published in 1998

Experimental study of oxidative DNA damage

Loft, S., Deng, X., Tuo, J., Wellejus, A., Sørensen, M. & Poulsen, H. E., dec. 1998, I : Free Radical Research. 29, 6, s. 525-39 15 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Animal experiments allow the study of oxidative DNA damage in target organs and the elucidation of dose-response relationships of carcinogenic and other harmful chemicals and conditions as well as the study of interactions of several factors. So far the effects of more than 50 different chemical compounds have been studied in animal experiments mainly in rats and mice, and generally with measurement of 8-oxodG with HPLC-EC. A large number of well-known carcinogens induce 8-oxodG formation in liver and/or kidneys. Moreover several animal studies have shown a close relationship between induction of dative DNA damage and tumour formation. In principle the level of oxidative DNA damage in an organ or cell may be studied by measurement of modified bases in extracted DNA by immunohistochemical visualisation, and from assays of strand breakage before and after treatment with repair enzymes. However, this level is a balance between the rates of damage and repair. Until the repair rates and capacity can be adequately assessed the rate of damage can only be estimated from the urinary excretion of repair products albeit only as an average of the entire body. A number of model compounds have been used to induce oxidative DNA damage in experimental animals. The hepatocarcinogen 2-nitropropane induces up to 10-fold increases in 8-oxodG levels in rat liver DNA. The level of 8-oxodG is also increased in kidneys and bone marrow but not in the testis. By means of 2-nitropropane we have shown correspondence between the increases in 8-oxodG in target organs and the urinary excretion of 8-oxodG and between 8-oxodG formation and the comet assay in bone marrow as well potent preventive effects of extracts of Brussels sprouts. Others have shown similar effects of green tea extracts and its components. Drawbacks of the use of 2-nitropropane as a model for oxidative DNA damage relate particularly to formation of 8-aminoguanine derivatives that may interfere with HPLC-EC assays and have unknown consequences. Other model compounds for induction of oxidative DNA damage, such as ferric nitriloacetate, iron dextran, potassium bromate and paraquat, are less potent and/or more organ specific. Inflammation and activation of an inflammatory response by phorbol esters or E. coli lipopolysaccharide (LPS) induce oxidative DNA damage in many target cells and enhance benzene-induced DNA damage in mouse bone marrow. Experimental studies provide powerful tools to investigate agents inducing and preventing oxidative damage to DNA and its role in carcinogenesis. So far, most animal experiments have concerned 8-oxodG and determination of additional damaged bases should be employed. An ideal animal model for prevention of oxidative DNA damage has yet to he developed.

Originalsprog Engelsk
Tidsskrift Free Radical Research
Vol/bind 29
Udgave nummer 6
Sider (fra-til) 525-39
Antal sider 15
ISSN 1071-5762
Status Udgivet - dec. 1998

Published in 1997

Double-blind, placebo-controlled cross-over study of intravenous S-adenosyl-L-methionine in patients with fibromyalgia

Volkmann, H., Nørregaard, J., Jacobsen, S., Danneskiold-Samsøe, B., Knoke, G. & Nehrdich, D., 1997, I : Scandinavian Journal of Rheumatology. 26, 3, s. 206-11 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The objective of this study was to test the efficacy of intravenously administered S-adenosyl-L-methionine (SAMe) in patients with fibromyalgia (FM). Thirty-four out-patients with fibromyalgia symptoms received SAMe 600 mg i.v. or placebo daily for 10 days in a cross-over trial. There was no significant difference in improvement in the primary outcome: tender point change between the two treatment groups. There was a tendency towards statistical significance in favour of SAMe on subjective perception of pain at rest (p = 0.08), pain on movement (p = 0.11), and overall well-being (p = 0.17) and slight improvement only on fatigue, quality of sleep, morning stiffness, and on the Fibromyalgia Impact Questionnaire for pain. No effect could be observed on isokinetic muscle strength, Zerrsen self-assessment questionnaire, and the face scale. No effect of SAMe in patients with FM was found in this short term study.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 26
Udgave nummer 3
Sider (fra-til) 206-11
Antal sider 6
ISSN 0300-9742
Status Udgivet - 1997

Muscle strength, working capacity and effort in patients with fibromyalgia

Nørregaard, J., Bülow, P. M., Lykkegaard, J. J., Mehlsen, J. & Danneskiold-Samsøoe, B., 1 jun. 1997, I : Scandinavian Journal of Rehabilitation Medicine. 29, 2, s. 97-102 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The objective of the study was to evaluate the physical capacity and effort in patients with fibromyalgia. Muscle strength and the coefficient of variation of the strength measurements of 181 female fibromyalgia patients and 126 healthy females were compared. These measurements and ergometer exercise capacity, work status and psychometric scoring (SCL-90-R) were correlated. The fibromyalgia patients exhibited significant reduction in voluntary muscle strength of the knee and elbow, flexors and extensors in the order of 20-30%. However, the coefficient of variation was higher among patients, thus indicating lower effort. The physical performance during an ergometer test corresponded to a maximal oxygen consumption of 21 ml/kg-1 x min-1. The maximal increase in heart rate was only 63% (44-90%) of the predicted increase. Degree of effort or physical capacity did not correlate to psychometric scores. Work status was related to psychometric scoring, but not to physical capacity or effort. In conclusion, we found a low degree of effort but near normal physical capacity in the fibromyalgia patients.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rehabilitation Medicine
Vol/bind 29
Udgave nummer 2
Sider (fra-til) 97-102
Antal sider 6
ISSN 0036-5505
Status Udgivet - 1 jun. 1997

Published in 1995

Behandling af højt blodtryk hos patienter med akut apopleksi

Olsen, T. S., Jørgensen, H. S., Garde, E. & Lassen, N. A. 19 jun 1995 I : Ugeskrift for Laeger. 157, 25, s. 3623-5 3 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The study was performed to investigate how often reduction of high blood pressure (> or = 220 mmHg systolic and or > or = 120 mmHg diastolic) was attempted in patients with acute stroke or transient ischemic attacks (TIA). Of 1351 consecutive patients with acute stroke or TIA 119 had high blood pressure on admission. In 15 patients the stroke was so severe that treatment was not considered. In the remaining 104 patients reduction of the blood pressure was attempted in 28 (27%); in 23 patients immediately following admission. None of the patients had symptoms or signs of hypertensive encephalopathy. It is concluded that reduction of high blood pressure in patients with stroke or TIA is attempted too often. As autoregulation is commonly impaired in acute stroke, reduction of systemic blood pressure may enhance ischaemic tissue damage. Reduction of blood pressure in acute stroke should be considered only in case of hypertensive encephalopathy.
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Udgivelsesdato 19 jun 1995
Vol/bind 157
Tidsskriftsnummer 25
Sider 3623-5
Antal sider 3
ISSN 0041-5782
Status Udgivet

Blodtryksnedsaettelse kan forvaerre symptomerne ved akut apopleksi

Garde, E., Jørgensen, H. S., Olsen, T. S. & Lassen, N. A. 19 jun 1995 I : Ugeskrift for Laeger. 157, 25, s. 3630-1 2 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Patients with acute stroke often present with high blood pressure (BP) on hospital admission. Because hypertension is a risk factor for stroke, and because severe BP elevation may increase oedema and the risk of haemorrhage, acute antihypertensive therapy might seem reasonable. On the other hand, the increase in BP in the acute stage might be considered a beneficial pathophysiological response maintaining the perfusion pressure to the ischaemic area and, in particular, the surrounding penumbra. As illustrated in the case presented here, lowering the BP in the early stage may be associated with progression of neurological deficits, very likely due to a reduction of perfusion to the penumbra thus enlarging the infarct.
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Udgivelsesdato 19 jun 1995
Vol/bind 157
Tidsskriftsnummer 25
Sider 3630-1
Antal sider 2
ISSN 0041-5782
Status Udgivet

Ojenskader ved hobbyarbejde med maskinelt håndvaerktøj

Hölmich, L. R., Hölmich, P. & Lohmann, M. 10 apr. 1995 I : Ugeskrift for laeger. 157, 15, s. 2131-4 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Data from the EU-project EHLASS (European Home and Leisure Accident Surveillance System) collected from five Danish hospitals during the period 1989-1991 contained 185,551 accidents occurring at home and during leisure time. The population in the catchment area is approximately 700,000. Of these accidents, 9900 involved eye-injury, 2940 of these occurred during hobby-activities, and 1460 of these while the subject was using either drilling-, welding- or grinding-equipment. The incidence of eye-injuries occurring during the use of these machines has risen from 0.6/1000/year in 1989 to 0.7/1000/year in 1990 and to 0.8/1000/year in 1991. In 98% of the cases the patients were men, 30% were between 20 and 29 years of age. A common activity at the time of the accident was "car-repairing". Foreign-body-lesions were seen in 60% of the cases, and actinic conjunctivitis in 30%. None of the injuries were serious, but they were often very painful and demanding of resources. All the injuries could have been avoided by the use of proper eye protection.

Originalsprog Dansk
Tidsskrift Ugeskrift for laeger
Vol/bind 157
Tidsskriftsnummer 15
Sider (fra-til) 2131-4
Antal sider 4
ISSN 0041-5782
Status Udgivet - 10 apr. 1995

The twitch interpolation technique for study of fatigue of human quadriceps muscle

Bülow, P. M., Nørregaard, J., Mehlsen, J. & Danneskiold-Samsøe, B., 1 nov. 1995, I : Journal of Neuroscience Methods. 62, 1-2, s. 103-9 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of the study was to examine if the twitch interpolation technique could be used to objectively measure fatigue in the quadriceps muscle in subjects performing submaximally. The 'true' maximum isometric quadriceps torque was determined in 21 healthy subject using the twitch interpolation technique. Then an endurance test was performed in which the subjects made repeated isometric contractions at 50% of the 'true' maximum torque for 4 s, separated by 6 s rest periods. During the test, the force response to single electrical stimulation (twitch amplitude) was measured at 50% and 25% of the estimated maximum torque. In 10 subjects, the test was repeated 2-4 weeks later. Twitch amplitudes at 50% of maximum torque declined exponentially with time in 20 of 21 subjects. The distribution of the exponential rate constant was skewed with a mean of 4.6 h-1 and range of 0.3-21.5 h-1. After logarithmical transformation, the distribution of the exponential rate constant fitted closely to a normal distribution, and the inter-individual variation was SD = 1.15 compared to an intra-individual variation of 0.29. The coefficient of correlation for repeated determination was 0.91 (P <0.001, n = 10). In conclusion, the twitch technique can be used for objectively measuring fatigue of the quadriceps muscle.
Originalsprog Engelsk
Tidsskrift Journal of Neuroscience Methods
Vol/bind 62
Udgave nummer 1-2
Sider (fra-til) 103-9
Antal sider 7
ISSN 0165-0270
Status Udgivet - 1 nov. 1995

Published in 1994

Absence of vasoactive peptide release from brain to cerebral circulation during onset of migraine with aura

Friberg, L., Olesen, J., Olsen, T. S., Karle, A., Ekman, R. & Fahrenkrug, J., feb. 1994, I : Cephalalgia. 14, 1, s. 47-54 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In eight patients carotid angiography was required for evaluation of transient neurological attacks. Cerebral blood flow results, angiography and clinical observations subsequently suggested the diagnosis of migraine. We measured plasma concentrations of substance P(SP), neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) in repeated blood samples obtained from the carotid artery and the internal jugular vein in conjunction with cerebral angiography followed by 4 to 6 repeated recordings of regional cerebral blood flow (rCBF) with the intracarotid Xenon-133 injection technique. This technique is known to induce attacks of migraine with aura in many sufferers. Four patients developed aura symptoms. In three this was succeeded by throbbing headache. Typical, migraine-related, focal hypoperfusion occurred in conjunction with the aura symptoms. The remaining four patients had no symptoms or rCBF changes. There were no systematic or statistically significant changes over time in arterial-venous plasma concentrations or in the release rates of any of the peptides. All migraineurs had an overall elevated mean CGRP value compared to control values from the literature. The overall plasma levels of the potent vasoconstrictor NPY were higher (p <0.10) in the group that developed symptoms and rCBF changes (136 pmol/l) than in the non-symptomatic group (97 pmol/l). The difference in NPY levels could perhaps be associated with the focal rCBF decrease seen in the attack group.
Originalsprog Engelsk
Tidsskrift Cephalalgia
Vol/bind 14
Udgave nummer 1
Sider (fra-til) 47-54
Antal sider 8
ISSN 0333-1024
Status Udgivet - feb. 1994

Biochemical changes in relation to a maximal exercise test in patients with fibromyalgia

Nørregaard, J., Bülow, P. M., Mehlsen, J. & Danneskiold-Samsøe, B., 1 mar. 1994, I : Clinical Physiology and Functional Imaging. 14, 2, s. 159-67 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Patients with fibromyalgia often complain of fatigue and pain during exercise and of worsening of pain days after exercise. The aim of the study described here was to determine if abnormal changes in potassium or lactate could be observed during an exercise test in fibromyalgia. Whether an abnormal incline in plasma creatine kinase or myoglobin could be observed days after the test was studied also. Fifteen female fibromyalgia patients and 15 age- and sex-matched controls performed a stepwise incremental maximal bicycle-ergometer test. Blood samples were collected from a catheter in a cubital vein. The changes in heart rate, potassium levels, and haematocrit during the exercise test were similar in the two groups. The maximal obtained lactate concentration was 4.2 mmol l-1 (3.5-5.6) in the patients as compared to 4.9 mmol l-1 (3.9-5.9) in the controls (NS). The estimated anaerobic threshold of 2 mmol l-1 was reached at a heart rate of 124 min-1 in the patients with fibromyalgia as compared to 140 min-1 in the controls (P = 0.02). In relation to workload, the patients scored higher on a Borg scale for perceived exertion during exercise, but if the Borg score was related to lactate no significant difference was found. The patients reported 86% and 79% of maximal pain in the thighs on the visual analogue scale 1 and 2 days after the test, but the creatine kinase and myoglobin concentrations were not increased.
Originalsprog Engelsk
Tidsskrift Clinical Physiology and Functional Imaging
Vol/bind 14
Udgave nummer 2
Sider (fra-til) 159-67
Antal sider 9
ISSN 1475-0961
Status Udgivet - 1 mar. 1994

Cerebral oxygen extraction, oxygen consumption, and regional cerebral blood flow during the aura phase of migraine

Friberg, L., Olesen, J., Lassen, N. A., Olsen, T. S. & Karle, A. maj 1994 I : Stroke. 25, 5, s. 974-9 6 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The aura phase of migraine is associated with focal blood flow changes, but it has been largely unknown whether these changes are correlated to changes in the cerebral metabolism.
Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato maj 1994
Vol/bind 25
Tidsskriftsnummer 5
Sider 974-9
Antal sider 6
ISSN 0039-2499
Status Udgivet

In 92 migraine patients and 44 healthy control subjects we recorded regional cerebral blood flow (rCBF) with single photon emission computerized tomography and (133) Xe inhalation or with i.v. (99m) Tc-HMPAO. Migraine patients were studied interictally. A quantitated analysis of right-left asymmetry indices in a fixed set of regions of interest was compared with the normal asymmetry indices in the healthy controls. An asymmetry index deviating more than ± 2.5 S.D.s in normals was defined as pathological asymmetry. By quantitated analysis 47% of images from patients with aura attacks and 48% of images from patients without aura attacks were established to contain higher rate of asymmetries, the difference being statistically significant (p < 0.05, Wilcoxon). A blinded visual analysis and scoring by a four level scale were done by four experienced observers. rCBF images from 18% of patients having attacks with aura and from 19% of patients without aura attacks was scored as containing abnormal right-left asymmetries by the visual analysis. Images from healthy controls were all scored to be normal. In 37% of the images (all from patients) there was lack of consensus among observers (κ = 0.28). There was no correlation between visual or quantitated abnormalities and age, duration of migraine, frequency of attacks or prophylactic medication. No correlation could be established between asymmetries and the usual side of headache or aura symptoms. Two conclusions emerged: (1) visual evaluation of interictal migraine rCBF images is insufficient to pick up abnormalities; (2) almost 50% of the migraine sufferers had abnormal rCBF/asymmetries. However, these are discrete compared with those typically seen during the aura phase of a migraine attack. One explanation to the patchy rCBF patterns might be that they reflect interictal cerebrovascular dysregulation which might to be a common feature in both types of migraine.

Originalsprog Engelsk
Tidsskrift European journal of neurology : the official journal of the European Federation of Neurological Societies
Udgivelsesdato sep 1994
Vol/bind 1
Tidsskriftsnummer 1
Sider 35-43
Antal sider 9
ISSN 1351-5101
DOI
Status Udgivet

Magnetisk resonans-spektroskopi ved fibromyalgi. En undersøgelse af fosfat-31 spektra fra skeletmuskulaturen i hvile, under og efter arbejde

Jacobsen, S., Jensen, K. E., Thomsen, C., Danneskiold-Samsøe, B. & Henriksen, O., 14 nov. 1994, I : Ugeskrift for Laeger. 156, 46, s. 6841-4 4 s.

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31phosphorus nuclear magnetic resonance (31P NMR) spectroscopy of painful calf muscle was performed in 12 patients with fibromyalgia and 7 healthy subjects during rest, aerobic and anaerobic exercising conditions, and postexercise recovery. Ratios of inorganic phosphate and creatine phosphate (Pi/PCr) and pH were calculated from the collected 31P NMR spectra. Resting values of Pi/PCr were normal in the patients. Patients only tolerated 49% of the workload tolerated by the controls (P = 0.005). Patients and controls had similar rates of Pi/PCr and pH changes during work and recovery. The controls were able to change their Pi/PCr and pH more than the patients, due to the greater workload reached. However, statistical significance was only reached for the anaerobic static exercise (P = 0.003). It was concluded that fibromyalgia patients have a reduced voluntary capacity for work, but with a biochemical response to work and recovery similar to healthy subjects.
Bidragets oversatte titel Magnetic resonance spectroscopy in fibromyalgia. A study of phosphate-31 spectra from skeletal muscles during rest and after exercise
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 156
Udgave nummer 46
Sider (fra-til) 6841-4
Antal sider 4
ISSN 0041-5782
Status Udgivet - 14 nov. 1994

Published in 1993

The primary objectives of this study were to examine to what extent fibromyalgia patients later on developed presumpted causative somatic diseases and to examine symptoms and muscle strength some years after the diagnosis of fibromyalgia was established. A secondary objective was to describe the overlap between fibromyalgia and chronic fatigue syndrome. Only in two of 91 the muscle pain was found to be caused by another somatic disease during the median 4 year follow-up period. In one of the 83 attending subjects a somatic disease associated with muscle symptoms was established at the follow-up visit. 60 out of 83 reported increased pain, 8 reported improvement of pain. The 83 subjects showed no significant fall in muscle strength during the follow-up period. The majority reported severe fatigue but only one fifth fulfilled the proposed chronic fatigue syndrome criteria.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 22
Udgave nummer 1
Sider (fra-til) 35-8
Antal sider 4
ISSN 0300-9742
Status Udgivet - 1993

Bone mass and turnover in fibromyalgia

Jacobsen, S., Gam, A., Egsmose, C., Olsen, M., Danneskiold-Samsøe, B. & Jensen, G. F., maj 1993, I : Journal of Rheumatology. 20, 5, s. 856-9 4 s.

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Physical inactivity accelerates bone loss. Since patients with fibromyalgia are relatively physically inactive, bone mass and markers of bone metabolism were determined in 12 premenopausal women with fibromyalgia and in healthy age matched female control subjects. No differences were found in lumbar bone mineral density, femoral neck bone mineral density, serum levels of alkaline phosphatase, osteocalcin, ionized calcium and phosphate. The urinary excretion of both hydroxyproline and calcium relative to urinary creatinine excretion was significantly higher in patients with fibromyalgia, p = 0.01. This was linked to lower urinary creatinine excretion (p = 0.02) probably reflecting lower physical activity in the patients with fibromyalgia. We conclude that bone mass and turnover are generally not affected in premenopausal women with fibromyalgia.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 20
Udgave nummer 5
Sider (fra-til) 856-9
Antal sider 4
ISSN 0315-162X
Status Udgivet - maj 1993

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