Published in 2005

Evidence based prevention of hamstring injuries in sport

Petersen, J. & Hölmich, P. jun. 2005 I : British Journal of Sports Medicine. 39, 6, s. 319-23 5 s.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

A common soft tissue injury in sports involving sprinting and jumping is the hamstring strain. A major problem with hamstring strains is the high incidence of reinjury. Muscle injuries can be classified as direct or indirect and are typically grouped into three categories according to severity. A number of potential risk factors have been proposed for hamstring strains. Only a few are evidence based and some are mainly based on theoretical assumptions. There is a lack of clinical research on the effectiveness of rehabilitation programmes for hamstring strains. Although the initial treatment of rest, ice, compression, and elevation is accepted for muscle strains, no consensus exists for their rehabilitation. Not much evidence based research has been carried out on prevention of hamstring strain. To our knowledge only two prospective studies have so far been published. As the injuries are common in football and other sports involving sprinting and jumping, there is a need for further research preferably in the form of randomised controlled trials.

Originalsprog Engelsk
Tidsskrift British Journal of Sports Medicine
Vol/bind 39
Tidsskriftsnummer 6
Sider (fra-til) 319-23
Antal sider 5
ISSN 0306-3674
DOI
Status Udgivet - jun. 2005

Learning effect of isokinetic measurements in healthy subjects, and reliability and comparability of Biodex and Lido dynamometers

Lund, H., Søndergaard, K., Zachariassen, T., Christensen, R., Bülow, P., Henriksen, M., Bartels, E. M., Danneskiold-Samsøe, B. & Bliddal, H., mar. 2005, I : Clinical Physiology and Functional Imaging. 25, 2, s. 75-82 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of this study was to examine the learning effect during a set of isokinetic measurements, to evaluate the reliability of the Biodex System 3 PRO dynamometer, and to compare the Biodex System 3 PRO and the Lido Active dynamometers on both extension and flexion over the elbow and the knee at 60 degrees s(-1). Thirteen (nine women, four men) healthy participants were measured five times using the Biodex and once using the Lido dynamometer. The intervals between the first four tests were 20 min, and 1 week between tests 4 and 5. Between Biodex and Lido measurements there was a 20 min time interval. When comparing the first five measurements (Biodex), no systematic effect over time and an excellent reliability were found with respect to elbow and knee flexion and extension. No difference in muscle strength (Nm) between the Biodex and Lido was observed for knee flexion (P = 0.59), knee extension (P = 0.18) and elbow extension (P = 0.63). However, elbow flexion showed a 14.8% (95% CI: 11.2-18.4%; P = 0.0001) higher peak torque on Biodex. In conclusion, no learning effect was observed and the Biodex proved to be a highly reliable isokinetic dynamometer. A difference was observed when comparing Biodex and Lido on elbow flexion, but the difference did not outrange the expected variation found with a typical isokinetic measurement, which is why both sets of equipment seem applicable in clinical practice.

Originalsprog Engelsk
Tidsskrift Clinical Physiology and Functional Imaging
Vol/bind 25
Udgave nummer 2
Sider (fra-til) 75-82
Antal sider 8
ISSN 1475-0961
DOI
Status Udgivet - mar. 2005

Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia

Laigaard, J., Sørensen, T., Placing, S., Holck, P., Fröhlich, C., Wøjdemann, K. R., Sundberg, K., Shalmi, A-C., Tabor, A., Nørgaard-Pedersen, B., Ottesen, B., Christiansen, M. & Wewer, U. M., jul. 2005, I : Obstetrics and Gynecology. 106, 1, s. 144-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVES: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia.

METHODS: We developed a semiautomated, time-resolved, immunofluorometric assay for the quantification of ADAM12 in serum. The assay detected ADAM12 in a range of 78-1248 microg/L. Serum samples derived from women in the first trimester of a normal pregnancy (n = 324) and from women who later developed preeclampsia during pregnancy (n = 160) were obtained from the First Trimester Copenhagen Study. ADAM12 levels were assayed in these serum samples. Serum levels of ADAM12 were converted to multiples of the median (MoM) after log-linear regression of concentration versus gestational age.

RESULTS: Serum ADAM12 levels in women who developed preeclampsia during pregnancy had a mean log MoM of -0.066, which was significantly lower than the mean log MoM of -0.001 for ADAM12 levels observed in serum samples from women with normal pregnancy (P = .008). The mean log MoM was even lower in serum derived from preeclamptic women whose infant's weight at birth was less than 2,500 g (n = 27, mean log MoM of -0.120, P = .053).

CONCLUSION: The maternal serum levels of ADAM12 are significantly lower during the first trimester in women who later develop preeclampsia during pregnancy when compared with levels in women with normal pregnancies. Because the secreted form of ADAM12 cleaves insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-5, the IGF axis may play a role in preeclampsia. ADAM12 may be a useful early marker for preeclampsia.

LEVEL OF EVIDENCE: II-2.

Originalsprog Engelsk
Tidsskrift Obstetrics and Gynecology
Vol/bind 106
Udgave nummer 1
Sider (fra-til) 144-9
Antal sider 6
ISSN 0029-7844
DOI
Status Udgivet - jul. 2005

Published in 2004

Plasma TNF binding capacity profiles during treatment with etanercept in rheumatoid arthritis

Gudbrandsdottir, S., Bliddal, H., Petri, A., Terslev, L., Danneskiold-Samsøe, B., Bjørnhart, B., Bendtzen, K. & Müller, K., 1 jan. 2004, I : Scandinavian Journal of Rheumatology. 33, 6, s. 385-8 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Etanercept (Enbrel) induces a rapid and sustained decline in disease activity in the majority of patients with refractory rheumatoid arthritis (RA). In these patients neutralization of TNFalpha and lymphotoxin (LT), previously termed TNFbeta is mediated by etanercept itself, as well as by naturally occurring soluble TNF receptors. However, the clinical response to treatment with etanercept may vary. Previously, pharmacokinetic studies have focused on the molar concentrations of etanercept, but very little is known about the kinetics of bioactive etanercept in patients treated with etanercept. The purpose of this study was to evaluate kinetics, including inter- and intraindividual variations of the total TNF binding capacity, in RA patients who were on a standard treatment schedule with etanercept.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 33
Udgave nummer 6
Sider (fra-til) 385-8
Antal sider 4
ISSN 0300-9742
Status Udgivet - 1 jan. 2004

Test-retest reliability of trunk accelerometric gait analysis

Henriksen, M., Lund, H., Moe-Nilssen, R., Bliddal, H. & Danneskiold-Samsøe, B., jun. 2004, I : Gait & posture. 19, 3, s. 288-97 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The purpose of this study was to determine the test-retest reliability of a trunk accelerometric gait analysis in healthy subjects. Accelerations were measured during walking using a triaxial accelerometer mounted on the lumbar spine of the subjects. Six men and 14 women (mean age 35.2; range 18-57) underwent the same protocol on 2 consecutive days. The raw acceleration signals from six self-selected walking speeds were transformed into a horizontal-vertical coordinate system to remove unwanted variability caused by gravity. Acceleration root mean square values, cadences, step and stride lengths were then computed and interpolated using quadratic curve fits and point estimates were calculated at a standardised walking speed of 1.35 m/s. Relative reliability was determined using two models of intraclass correlation coefficients (ICC(1,1) and ICC(3,1)) to assess any systematic shifts and absolute reliability was determined using measurement error (ME). The results of the study showed high ICC values (0.77-0.96) and ME values of 0.007-0.01 g for mean acceleration; 0.009 m for step lengths; 0.022 m for stride length and 1.644 step/min for cadences. In conclusion, the method was found to be reliable and may have a definite potential in clinical gait analysis.

Originalsprog Engelsk
Tidsskrift Gait & posture
Vol/bind 19
Udgave nummer 3
Sider (fra-til) 288-97
Antal sider 10
ISSN 0966-6362
DOI
Status Udgivet - jun. 2004

Vitamin D insufficiency in Greenlanders on a westernized fare: ethnic differences in calcitropic hormones between Greenlanders and Danes

Rejnmark, L., Hansen, J. C., Heickendorff, L., Lauridsen, A. L., Mulvad, G., Siggaard, C., Skjoldborg, H., Sørensen, T. B., Pedersen, E. B., Mosekilde, L. & Jørgensen, M. E., mar. 2004, I : Calcified Tissue International. 74, 3, s. 255-63 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Greenlanders living in Nuuk on a westernized fare (group B), 54 Greenlanders (group C), and 43 Danes (Group D) living in Denmark (55 degrees N) on a westernized fare. Blood specimens were drawn both summer and winter. Vitamin D insufficiency (plasma 25 OHD <40 nmol/l) was common in all four study groups during summer (23-74%) and winter (42-81%). Compared to groups A and D, vitamin D insufficiency was significantly more frequent in groups B and C. In all groups, summer levels of 25 OHD were above winter levels. Multiple regression analysis revealed a significant effect of ethnicity. Compared to Danes, Greenlanders had higher 1,25-dihydroxyvitamin D levels, but lower 25 OHD and PTH levels despite relatively low plasma calcium concentrations. In addition to ethnicity, 25(OH)D levels were influenced by age, season (summer > winter), and diet (a traditional Inuit diet>westernized diet). Ethnic differences exist between Greenlanders and Danes. Our results suggest that Greenlanders may have an inherent lower "set-point" for calcium-regulated PTH release or an enhanced renal 1,25(OH)(2)D production. In addition to ethnicity, age, season, and diet were important determinants of vitamin D status. Changes from a traditional to a westernized fare are associated with a reduced vitamin D status in Greenlanders. Vitamin D supplementation should be considered.

Originalsprog Engelsk
Tidsskrift Calcified Tissue International
Vol/bind 74
Udgave nummer 3
Sider (fra-til) 255-63
Antal sider 9
ISSN 0171-967X
DOI
Status Udgivet - mar. 2004

Published in 2003

Affective disorders in neurological diseases: a case register-based study

Nilsson, F. M., Kessing, L. V., Sørensen, T. M., Andersen, P. K. & Bolwig, T. G., jul. 2003, I : Acta Psychiatrica Scandinavica. 108, 1, s. 41-50 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: To investigate the temporal relationships between a range of neurological diseases and affective disorders.

METHOD: Data derived from linkage of the Danish Psychiatric Central Register and the Danish National Hospital Register. Seven cohorts with neurological index diagnoses and two control group diagnoses were followed for up to 21 years. The incidences of affective disorders in the different groups were compared with the control groups, using competing risks to consider the risk of affective disorder and the risk of death in the same analysis.

RESULTS: We found an increased incidence of affective disorders in dementia, Parkinson's disease, epilepsy, stroke and intracerebral haemorrhage compared with control groups. The association was found to be the strongest for dementia and Parkinson's disease. In hospitalized patients, with incident multiple sclerosis, the incidence of affective disorder was lower than the incidence in the control groups.

CONCLUSION: In neurological diseases there seems to be an increased incidence of affective disorders. The elevated incidence was found to be particularly high for dementia and Parkinson's disease (neurodegenerative diseases).

Originalsprog Engelsk
Tidsskrift Acta Psychiatrica Scandinavica
Vol/bind 108
Udgave nummer 1
Sider (fra-til) 41-50
Antal sider 10
ISSN 0001-690X
Status Udgivet - jul. 2003

TNF-alpha-blokker-behandling af artrit--fire års opfølgning

Petri, A., Dreyer, L., Danneskiold-Samsøe, B., Terslev, L. & Bliddal, H., 24 nov. 2003, I : Ugeskrift for Laeger. 165, 48, s. 4649-52 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Bidragets oversatte titel Anti-TNF-alpha-treatment of arthritis--4-year follow-up
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 165
Udgave nummer 48
Sider (fra-til) 4649-52
Antal sider 4
ISSN 0041-5782
Status Udgivet - 24 nov. 2003

Published in 2002

Admission body temperature predicts long-term mortality after acute stroke: the Copenhagen Stroke Study

Kammersgaard, L. P., Jørgensen, H. S., Rungby, J., Reith, J., Nakayama, H., Weber, U. J., Houth, J. & Olsen, T. S. jul 2002 I : Stroke. 33, 7, s. 1759-62 4 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Body temperature is considered crucial in the management of acute stroke patients. Recently hypothermia applied as a therapy for stroke has been demonstrated to be feasible and safe in acute stroke patients. In the present study, we investigated the predictive role of admission body temperature to the long-term mortality in stroke patients.
Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato jul 2002
Vol/bind 33
Tidsskriftsnummer 7
Sider 1759-62
Antal sider 4
ISSN 0039-2499
Status Udgivet

OBJECTIVE: To investigate the time relation between dementia and major affective disorders (major depression and mania).

METHODS: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models.

RESULTS: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life.

CONCLUSIONS: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.

Originalsprog Engelsk
Tidsskrift Journal of neurology, neurosurgery, and psychiatry
Vol/bind 73
Udgave nummer 1
Sider (fra-til) 40-4
Antal sider 5
ISSN 0022-3050
Status Udgivet - jul. 2002

Published in 2001

Early infection and prognosis after acute stroke: the Copenhagen Stroke Study

Kammersgaard, L. P., Jørgensen, H. S., Reith, J., Nakayama, H., Houth, J. G., Weber, U. J., Pedersen, P. M. & Olsen, T. S. 2001 I : Journal of Stroke & Cerebrovascular Diseases. 10, 5, s. 217-221 5 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Infection is a frequent complication in the early course of acute stroke and may adversely affect stroke outcome. In the present study, we investigate early infection developing in patients within 3 days of admission to the hospital and its independent relation to recovery and stroke outcome. In addition, we identify predictors for early infections, infection subtypes, and their relation to initial stroke severity.
Originalsprog Engelsk
Tidsskrift Journal of Stroke & Cerebrovascular Diseases
Udgivelsesdato 2001
Vol/bind 10
Tidsskriftsnummer 5
Sider 217-221
Antal sider 5
ISSN 1052-3057
DOI
Status Udgivet

Effects of a Brussels sprouts extract on oxidative DNA damage and metabolising enzymes in rat liver

Sørensen, M., Jensen, B. R., Poulsen, H. E., Deng, X., Tygstrup, N., Dalhoff, K. & Loft, S., jun. 2001, I : Food and Chemical Toxicology. 39, 6, s. 533-40 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The apparent anticarcinogenic effect of cruciferous vegetables found in numerous epidemiological and experimental studies has been associated with their influence on phase I and phase II metabolising enzymes as well as on the antioxidant status. In the present study we investigated the effect of administration of a Brussels sprouts extract on the expression at the mRNA level and/or catalytic activity in rat liver of three phase I enzymes [cytochrome P450-1A2 (CYP1A2),-2B1/2 (CYP2B1/2) and-2E1 (CYP2E1)] and two phase II enzyme [NADPH:quinone reductase (QR) and glutathione S-transferase pi 7 (GSTpi)], all previously suggested to be induced by vegetables. We also examined the activity and/or expression of several important antioxidant enzymes: glutathione peroxidase (GPx), catalase and gamma-glutamyl-cysteine synthetase (GCS) and the activity of the repair enzyme 8-oxoguanine DNA glycosylase (OGG1). QR, GPx and catalase activity was also assessed in the kidneys. In order to examine a possible effect of the Brussels sprouts related to oxidative stress, we measured oxidative DNA damage in terms of 7-hydro-8-oxo-2'-deoxyguanosine (8-oxodG) and lipid peroxidation in terms of malondialdehyde (MDA) formation in the liver. Oral administration of an aqueous Brussels sprouts extract for 4 days was found to induce the expression of GST 1.3-fold (P < 0.05) and the activity of QR 2.6-fold in rat liver (P < 0.05). No significant differences were seen in the expression of the phase I enzymes. No differences in antioxidant enzyme activity/expression or OGG1 activity were observed. In a second experiment, administration of the Brussels sprouts extract for 3 or 7 days was found to increase the level of 8-oxodG in rat liver from 0.75 to 0.97 per 10(5) dG and from 0.81 to 0.97 per 10(5) dG, respectively (P < 0.05). No effects on MDA levels were found. The present results support the data obtained in several studies that consumption of cruciferous vegetables is capable of inducing various phase II enzyme systems. However, the observed increase in oxidative DNA damage raises the question of whether greatly increased ingestion of cruciferous vegetables is beneficial.

Originalsprog Engelsk
Tidsskrift Food and Chemical Toxicology
Vol/bind 39
Udgave nummer 6
Sider (fra-til) 533-40
Antal sider 8
ISSN 0278-6915
Status Udgivet - jun. 2001

Manual and oral apraxia in acute stroke, frequency and influence on functional outcome: The Copenhagen Stroke Study

Pedersen, P. M., Jørgensen, H. S., Kammersgaard, L. P., Nakayama, H., Raaschou, H. O. & Olsen, T. S., sep. 2001, I : American Journal of Physical Medicine and Rehabilitation. 80, 9, s. 685-92 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To determine the frequency of manual and oral apraxia in acute stroke and to examine the influence of these symptoms on functional outcome.
Originalsprog Engelsk
Tidsskrift American Journal of Physical Medicine and Rehabilitation
Vol/bind 80
Udgave nummer 9
Sider (fra-til) 685-92
Antal sider 8
ISSN 0894-9115
Status Udgivet - sep. 2001

Modtagelse, initial undersøgelse og behandling af svært tilskadekomne i Danmark

Boesen, M. P., Falck Larsen, C., Lippert, F. K., Schultz Larsen, M., Röck, N. D. & Lang-Jensen, T., 2001, 3 s.

Publikation: AndetAndet bidragForskning

Originalsprog Dansk
Publikationsdato 2001
Antal sider 3
Status Udgivet - 2001

We compared two different treatments for displaced distal radius Colles' type fractures (Older type 3 and 4), at two hospitals. We found bridging external fixation superior to reduction and fixation in a dorsal plaster cast regarding both the end-anatomic results at 3 months and the functional scores at 3 and 9 months (modified Gartland and Werley).

Originalsprog Engelsk
Tidsskrift International Orthopaedics
Vol/bind 24
Tidsskriftsnummer 6
Sider (fra-til) 358-60
Antal sider 3
ISSN 0341-2695
Status Udgivet - 2001

Potentially reversible factors during the very acute phase of stroke and their impact on the prognosis: is there a large therapeutic potential to be explored?

Jørgensen, H. S., Reith, J., Nakayama, H., Kammersgaard, L. P., Houth, J. G., Raaschou, H. O., Olsen, T. S. & Copenhagen Stroke Study 2001 I : Cerebrovascular Diseases. 11, 3, s. 207-11 5 s.

Publikation: Forskning - peer reviewTidsskriftartikel

In the Copenhagen Stroke Study, we evaluated the combined impact on stroke outcome of potentially treatable factors such as acute body temperature, blood glucose, and stroke in progression. The patients were stratified into two groups: (1) patients with 'good' prognostic parameters (body temperature on admission <or = 37.0 degrees C and plasma glucose on admission <or = 6.5 mmol/l and who did not develop stroke in progression) and (2) patients with correspondingly 'poor' prognostic parameters. A poor outcome was observed in 4% of the patients with good prognostic parameters versus in 49% of the patients with poor prognostic parameters (p <0.01). In the multivariate analysis which also included stroke severity, blood glucose contributed significantly to poor outcome with an odds ratio (OR) of 1.2/1.0 mmol/l increase, body temperature with an OR of 2.2/1 degrees C increase, and stroke in progression with an OR of 2.9. However, the combined effect of all three factors was more than additive with an OR of 10.0 (95% CI 1.5-56; p <0.01). We have shown that in human stroke a strong and more than additive association exists between potentially reversible parameters and outcome. Intervention trials can prove whether these marked relations are causal.
Originalsprog Engelsk
Tidsskrift Cerebrovascular Diseases
Udgivelsesdato 2001
Vol/bind 11
Tidsskriftsnummer 3
Sider 207-11
Antal sider 5
ISSN 1015-9770
DOI
Status Udgivet

Published in 2000

Behandling og rehabilitering på apopleksiafsnit øger 5-års-overlevelsen

Jørgensen, H. S., Kammersgaard, L. P., Nakayama, H., Raaschou, H. O., Larsen, K. J., Hübbe, P. & Olsen, T. S., 12 jun. 2000, I : Ugeskrift for Laeger. 162, 24, s. 3450-2 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Treatment of stroke patients in specialised stroke units has become more frequent, but the longterm effect of this treatment has not been determined. In this prospective, community-based study of 1241 unselected acute stroke patients we compared outcome between patients geographically randomised to treatment in a stroke unit or in a general neurological/medical ward, from the time of acute admission to the end of rehabilitation. Baseline characteristics were comparable between the two treatment groups regarding age, sex, marital status, pre-stroke residence, and stroke severity. Patients treated in the stroke unit had higher comorbidity with regard to hypertension and diabetes. Multivariate linear and logistic regression analyses were applied to estimate the independent influence of stroke unit treatment on outcome. Stroke unit treatment significantly reduced not only initial mortality, but also mortality within five years from stroke onset. The relative risk of dying within the first five years from stroke was reduced by 40%, p <0.01. Treatment and rehabilitation of unselected stroke patients in a stroke unit reduces initial mortality, discharge rate to nursing home, reduces cost of treatment, and improves longterm survival up to five years after stroke.
Bidragets oversatte titel Treatment and rehabilitation in an apoplexy unit increases the 5-year survival
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 162
Udgave nummer 24
Sider (fra-til) 3450-2
Antal sider 3
ISSN 0041-5782
Status Udgivet - 12 jun. 2000

Fatalt forløbende Strongyloides stercoralis-infektion hos patient uden forudgående kendt immunsuppression

Sørensen, M., Andersen, O., Friis-Møller, A. & Kvinesdal, B. B., 15 maj 2000, I : Ugeskrift for Laeger. 162, 20, s. 2894-5 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A case of fatal infection with Strongyloides stercoralis in a previously healthy young African with no known immunosuppression is reported. The patient suffered severe gastrointestinal bleeding and despite intensive treatment died of multiorgan failure. Postmortem, signs of ulcerating T-cell lymphoma were found in a jejunal specimen, and the patient was found to be infected with HTLV-1. Gastrointestinal bleeding in relation to infection with Strongyloides stercoralis is discussed as well as possible relations between the severity of infection, lymphoma and HTLV-1.

Bidragets oversatte titel Fatal outcome of Strongyloides stercoralis infection in a patient with no previously known immunosuppression
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 162
Udgave nummer 20
Sider (fra-til) 2894-5
Antal sider 2
ISSN 0041-5782
Status Udgivet - 15 maj 2000
Hypothermia reduces neuronal damage in animal stroke models. Whether hypothermia is neuroprotective in patients with acute stroke remains to be clarified. In this case-control study, we evaluated the feasibility and safety of inducing modest hypothermia by a surface cooling method in awake patients with acute stroke.
Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato sep 2000
Vol/bind 31
Tidsskriftsnummer 9
Sider 2251-6
Antal sider 6
ISSN 0039-2499
Status Udgivet

QTc interval length and QT dispersion as predictors of mortality in patients with non-insulin-dependent diabetes

Christensen, P. K., Gall, M. A., Major-Pedersen, A., Sato, A., Rossing, P., Breum, L., Pietersen, A., Kastrup, J. & Parving, H. H., jul. 2000, I : Scandinavian Journal of Clinical and Laboratory Investigation. 60, 4, s. 323-32 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Patients with non-insulin-dependent diabetes (NIDDM) are at independent risk of cardiovascular death. The reason is only partially understood. The aim of our study was therefore to evaluate the impact of corrected QT interval length (QTc) and QT dispersion (QT-disp) on mortality in a cohort of 324 Caucasian NIDDM patients. A resting 12-lead ECG was recorded at baseline. Maximum (QT-max) and minimum QT (QT-min) intervals were measured, and QT-max was corrected for heart rate (QTc-max). QT-disp was defined as the difference between QT-max and QT-min. QTc-max was 454 (376-671) ms(1/2) (median (range)) and QT-disp 61 (0-240) ms. Prolonged QTc interval (PQTc), defined as QTc-max > 440 ms(1/2), was present in 67% of the patients and prolonged QT-disp (PQT-disp), defined as QT-disp > 50 ms, was present in 51%. During the 9-year follow-up period, 100 patients died (52 from cardiovascular diseases). Thirty-seven percent of the patients with PQTc died compared with 17% with normal QTc interval (p<0.001). The Cox proportional hazard model, including putative risk factors at baseline, revealed the following independent predictors of all cause mortality; QTc-max (p<0.05), age (p<0.0001), albuminuria (p<0.01), retinopathy (p<0.01), HbA1c (p<0.05), insulin treatment (p<0.01), total cholesterol (p<0.01), serum creatinine (p<0.05) and presence of cardiac heart disease based on Minnesota coded ECG (p<0.001). Whereas QT-disp was not a predictor, QTc-max interval was an independent predictor of cardiovascular mortality. Our study showed a high prevalence of QTc and QT-disp abnormalities and indicated that QTc-max but not QT-disp is an independent predictor of all cause and cardiovascular mortality in NIDDM patients.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Clinical and Laboratory Investigation
Vol/bind 60
Udgave nummer 4
Sider (fra-til) 323-32
Antal sider 10
ISSN 0036-5513
Status Udgivet - jul. 2000

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