Published in 2001

Modtagelse, initial undersøgelse og behandling af svært tilskadekomne i Danmark

Boesen, M. P., Falck Larsen, C., Lippert, F. K., Schultz Larsen, M., Röck, N. D. & Lang-Jensen, T., 2001, 3 s.

Publikation: AndetAndet bidragForskning

Originalsprog Dansk
Publikationsdato 2001
Antal sider 3
Status Udgivet - 2001

We compared two different treatments for displaced distal radius Colles' type fractures (Older type 3 and 4), at two hospitals. We found bridging external fixation superior to reduction and fixation in a dorsal plaster cast regarding both the end-anatomic results at 3 months and the functional scores at 3 and 9 months (modified Gartland and Werley).

Originalsprog Engelsk
Tidsskrift International Orthopaedics
Vol/bind 24
Tidsskriftsnummer 6
Sider (fra-til) 358-60
Antal sider 3
ISSN 0341-2695
Status Udgivet - 2001

Potentially reversible factors during the very acute phase of stroke and their impact on the prognosis: is there a large therapeutic potential to be explored?

Jørgensen, H. S., Reith, J., Nakayama, H., Kammersgaard, L. P., Houth, J. G., Raaschou, H. O., Olsen, T. S. & Copenhagen Stroke Study 2001 I : Cerebrovascular Diseases. 11, 3, s. 207-11 5 s.

Publikation: Forskning - peer reviewTidsskriftartikel

In the Copenhagen Stroke Study, we evaluated the combined impact on stroke outcome of potentially treatable factors such as acute body temperature, blood glucose, and stroke in progression. The patients were stratified into two groups: (1) patients with 'good' prognostic parameters (body temperature on admission <or = 37.0 degrees C and plasma glucose on admission <or = 6.5 mmol/l and who did not develop stroke in progression) and (2) patients with correspondingly 'poor' prognostic parameters. A poor outcome was observed in 4% of the patients with good prognostic parameters versus in 49% of the patients with poor prognostic parameters (p <0.01). In the multivariate analysis which also included stroke severity, blood glucose contributed significantly to poor outcome with an odds ratio (OR) of 1.2/1.0 mmol/l increase, body temperature with an OR of 2.2/1 degrees C increase, and stroke in progression with an OR of 2.9. However, the combined effect of all three factors was more than additive with an OR of 10.0 (95% CI 1.5-56; p <0.01). We have shown that in human stroke a strong and more than additive association exists between potentially reversible parameters and outcome. Intervention trials can prove whether these marked relations are causal.
Originalsprog Engelsk
Tidsskrift Cerebrovascular Diseases
Udgivelsesdato 2001
Vol/bind 11
Tidsskriftsnummer 3
Sider 207-11
Antal sider 5
ISSN 1015-9770
DOI
Status Udgivet

Published in 2000

Behandling og rehabilitering på apopleksiafsnit øger 5-års-overlevelsen

Jørgensen, H. S., Kammersgaard, L. P., Nakayama, H., Raaschou, H. O., Larsen, K. J., Hübbe, P. & Olsen, T. S., 12 jun. 2000, I : Ugeskrift for Laeger. 162, 24, s. 3450-2 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Treatment of stroke patients in specialised stroke units has become more frequent, but the longterm effect of this treatment has not been determined. In this prospective, community-based study of 1241 unselected acute stroke patients we compared outcome between patients geographically randomised to treatment in a stroke unit or in a general neurological/medical ward, from the time of acute admission to the end of rehabilitation. Baseline characteristics were comparable between the two treatment groups regarding age, sex, marital status, pre-stroke residence, and stroke severity. Patients treated in the stroke unit had higher comorbidity with regard to hypertension and diabetes. Multivariate linear and logistic regression analyses were applied to estimate the independent influence of stroke unit treatment on outcome. Stroke unit treatment significantly reduced not only initial mortality, but also mortality within five years from stroke onset. The relative risk of dying within the first five years from stroke was reduced by 40%, p <0.01. Treatment and rehabilitation of unselected stroke patients in a stroke unit reduces initial mortality, discharge rate to nursing home, reduces cost of treatment, and improves longterm survival up to five years after stroke.
Bidragets oversatte titel Treatment and rehabilitation in an apoplexy unit increases the 5-year survival
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 162
Udgave nummer 24
Sider (fra-til) 3450-2
Antal sider 3
ISSN 0041-5782
Status Udgivet - 12 jun. 2000

Fatalt forløbende Strongyloides stercoralis-infektion hos patient uden forudgående kendt immunsuppression

Sørensen, M., Andersen, O., Friis-Møller, A. & Kvinesdal, B. B., 15 maj 2000, I : Ugeskrift for Laeger. 162, 20, s. 2894-5 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A case of fatal infection with Strongyloides stercoralis in a previously healthy young African with no known immunosuppression is reported. The patient suffered severe gastrointestinal bleeding and despite intensive treatment died of multiorgan failure. Postmortem, signs of ulcerating T-cell lymphoma were found in a jejunal specimen, and the patient was found to be infected with HTLV-1. Gastrointestinal bleeding in relation to infection with Strongyloides stercoralis is discussed as well as possible relations between the severity of infection, lymphoma and HTLV-1.

Bidragets oversatte titel Fatal outcome of Strongyloides stercoralis infection in a patient with no previously known immunosuppression
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 162
Udgave nummer 20
Sider (fra-til) 2894-5
Antal sider 2
ISSN 0041-5782
Status Udgivet - 15 maj 2000
Hypothermia reduces neuronal damage in animal stroke models. Whether hypothermia is neuroprotective in patients with acute stroke remains to be clarified. In this case-control study, we evaluated the feasibility and safety of inducing modest hypothermia by a surface cooling method in awake patients with acute stroke.
Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato sep 2000
Vol/bind 31
Tidsskriftsnummer 9
Sider 2251-6
Antal sider 6
ISSN 0039-2499
Status Udgivet

QTc interval length and QT dispersion as predictors of mortality in patients with non-insulin-dependent diabetes

Christensen, P. K., Gall, M. A., Major-Pedersen, A., Sato, A., Rossing, P., Breum, L., Pietersen, A., Kastrup, J. & Parving, H. H., jul. 2000, I : Scandinavian Journal of Clinical and Laboratory Investigation. 60, 4, s. 323-32 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Patients with non-insulin-dependent diabetes (NIDDM) are at independent risk of cardiovascular death. The reason is only partially understood. The aim of our study was therefore to evaluate the impact of corrected QT interval length (QTc) and QT dispersion (QT-disp) on mortality in a cohort of 324 Caucasian NIDDM patients. A resting 12-lead ECG was recorded at baseline. Maximum (QT-max) and minimum QT (QT-min) intervals were measured, and QT-max was corrected for heart rate (QTc-max). QT-disp was defined as the difference between QT-max and QT-min. QTc-max was 454 (376-671) ms(1/2) (median (range)) and QT-disp 61 (0-240) ms. Prolonged QTc interval (PQTc), defined as QTc-max > 440 ms(1/2), was present in 67% of the patients and prolonged QT-disp (PQT-disp), defined as QT-disp > 50 ms, was present in 51%. During the 9-year follow-up period, 100 patients died (52 from cardiovascular diseases). Thirty-seven percent of the patients with PQTc died compared with 17% with normal QTc interval (p<0.001). The Cox proportional hazard model, including putative risk factors at baseline, revealed the following independent predictors of all cause mortality; QTc-max (p<0.05), age (p<0.0001), albuminuria (p<0.01), retinopathy (p<0.01), HbA1c (p<0.05), insulin treatment (p<0.01), total cholesterol (p<0.01), serum creatinine (p<0.05) and presence of cardiac heart disease based on Minnesota coded ECG (p<0.001). Whereas QT-disp was not a predictor, QTc-max interval was an independent predictor of cardiovascular mortality. Our study showed a high prevalence of QTc and QT-disp abnormalities and indicated that QTc-max but not QT-disp is an independent predictor of all cause and cardiovascular mortality in NIDDM patients.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Clinical and Laboratory Investigation
Vol/bind 60
Udgave nummer 4
Sider (fra-til) 323-32
Antal sider 10
ISSN 0036-5513
Status Udgivet - jul. 2000

Who benefits from treatment and rehabilitation in a stroke Unit? A community-based study

Jorgensen, H. S., Kammersgaard, L. P., Houth, J., Nakayama, H., Raaschou, H. O., Larsen, K., Hübbe, P. & Olsen, T. S., feb. 2000, I : Stroke. 31, 2, s. 434-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The beneficial effects of treatment and rehabilitation of patients with acute stroke in a dedicated stroke unit (SU) are well established. We wanted to examine if these effects are limited to certain groups of patients or if they apply to all patients independent of age, sex, comorbidity, and initial stroke severity.
Originalsprog Engelsk
Tidsskrift Stroke
Vol/bind 31
Udgave nummer 2
Sider (fra-til) 434-9
Antal sider 6
ISSN 0039-2499
Status Udgivet - feb. 2000

Published in 1999

Leukocytosis is a common finding in the acute phase of stroke. A detrimental effect of leukocytosis on stroke outcome has been suggested, and trials aiming at reducing the leukocyte response in acute stroke are currently being conducted. However, the influence of leukocytosis on stroke outcome has not been clarified.
Originalsprog Engelsk
Tidsskrift Journal of Stroke & Cerebrovascular Diseases
Udgivelsesdato 1999
Vol/bind 8
Tidsskriftsnummer 4
Sider 259-63
Antal sider 5
ISSN 1052-3057
Status Udgivet

Maximal isometric strength of the cervical musculature in 100 healthy volunteers

Jordan, A., Mehlsen, J., Bülow, P. M., Ostergaard, K. & Danneskiold-Samsøe, B., 1 jul. 1999, I : Spine. 24, 13, s. 1343-8 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A descriptive study involving maximal isometric strength measurements of the cervical musculature.
Originalsprog Engelsk
Tidsskrift Spine
Vol/bind 24
Udgave nummer 13
Sider (fra-til) 1343-8
Antal sider 6
ISSN 0362-2436
Status Udgivet - 1 jul. 1999

Predicted impact of intravenous thrombolysis on prognosis of general population of stroke patients: simulation model

Jørgensen, H. S., Nakayama, H., Kammersgaard, L. P., Raaschou, H. O. & Olsen, T. S., 31 jul. 1999, I : B M J (Clinical Research Edition). 319, 7205, s. 288-9 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift B M J (Clinical Research Edition)
Vol/bind 319
Udgave nummer 7205
Sider (fra-til) 288-9
Antal sider 2
ISSN 0959-8138
Status Udgivet - 31 jul. 1999

Treatment and rehabilitation on a stroke unit improves 5-year survival. A community-based study

Jørgensen, H. S., Kammersgaard, L. P., Nakayama, H., Raaschou, H. O., Larsen, K., Hübbe, P. & Olsen, T. S., maj 1999, I : Stroke. 30, 5, s. 930-3 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

We have previously reported a marked reduction in mortality up to 1 year after treatment and rehabilitation on a stroke unit versus on general neurological and medical wards in unselected stroke patients. In the present study we wanted to test the hypothesis that this mortality-reducing effect is not temporary but is long lasting.
Originalsprog Engelsk
Tidsskrift Stroke
Vol/bind 30
Udgave nummer 5
Sider (fra-til) 930-3
Antal sider 4
ISSN 0039-2499
Status Udgivet - maj 1999

What determines good recovery in patients with the most severe strokes?: The Copenhagen Stroke Study

Jørgensen, H. S., Reith, J., Nakayama, H., Kammersgaard, L. P., Raaschou, H. O. & Olsen, T. S. okt 1999 I : Stroke. 30, 10, s. 2008-12 5 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Even patients with the most severe strokes sometimes experience a remarkably good recovery. We evaluated possible predictors of a good outcome to search for new therapeutic strategies.
Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato okt 1999
Vol/bind 30
Tidsskriftsnummer 10
Sider 2008-12
Antal sider 5
ISSN 0039-2499
Status Udgivet

Published in 1998

Experimental study of oxidative DNA damage

Loft, S., Deng, X., Tuo, J., Wellejus, A., Sørensen, M. & Poulsen, H. E., dec. 1998, I : Free Radical Research. 29, 6, s. 525-39 15 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Animal experiments allow the study of oxidative DNA damage in target organs and the elucidation of dose-response relationships of carcinogenic and other harmful chemicals and conditions as well as the study of interactions of several factors. So far the effects of more than 50 different chemical compounds have been studied in animal experiments mainly in rats and mice, and generally with measurement of 8-oxodG with HPLC-EC. A large number of well-known carcinogens induce 8-oxodG formation in liver and/or kidneys. Moreover several animal studies have shown a close relationship between induction of dative DNA damage and tumour formation. In principle the level of oxidative DNA damage in an organ or cell may be studied by measurement of modified bases in extracted DNA by immunohistochemical visualisation, and from assays of strand breakage before and after treatment with repair enzymes. However, this level is a balance between the rates of damage and repair. Until the repair rates and capacity can be adequately assessed the rate of damage can only be estimated from the urinary excretion of repair products albeit only as an average of the entire body. A number of model compounds have been used to induce oxidative DNA damage in experimental animals. The hepatocarcinogen 2-nitropropane induces up to 10-fold increases in 8-oxodG levels in rat liver DNA. The level of 8-oxodG is also increased in kidneys and bone marrow but not in the testis. By means of 2-nitropropane we have shown correspondence between the increases in 8-oxodG in target organs and the urinary excretion of 8-oxodG and between 8-oxodG formation and the comet assay in bone marrow as well potent preventive effects of extracts of Brussels sprouts. Others have shown similar effects of green tea extracts and its components. Drawbacks of the use of 2-nitropropane as a model for oxidative DNA damage relate particularly to formation of 8-aminoguanine derivatives that may interfere with HPLC-EC assays and have unknown consequences. Other model compounds for induction of oxidative DNA damage, such as ferric nitriloacetate, iron dextran, potassium bromate and paraquat, are less potent and/or more organ specific. Inflammation and activation of an inflammatory response by phorbol esters or E. coli lipopolysaccharide (LPS) induce oxidative DNA damage in many target cells and enhance benzene-induced DNA damage in mouse bone marrow. Experimental studies provide powerful tools to investigate agents inducing and preventing oxidative damage to DNA and its role in carcinogenesis. So far, most animal experiments have concerned 8-oxodG and determination of additional damaged bases should be employed. An ideal animal model for prevention of oxidative DNA damage has yet to he developed.

Originalsprog Engelsk
Tidsskrift Free Radical Research
Vol/bind 29
Udgave nummer 6
Sider (fra-til) 525-39
Antal sider 15
ISSN 1071-5762
Status Udgivet - dec. 1998

Published in 1997

Double-blind, placebo-controlled cross-over study of intravenous S-adenosyl-L-methionine in patients with fibromyalgia

Volkmann, H., Nørregaard, J., Jacobsen, S., Danneskiold-Samsøe, B., Knoke, G. & Nehrdich, D., 1997, I : Scandinavian Journal of Rheumatology. 26, 3, s. 206-11 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The objective of this study was to test the efficacy of intravenously administered S-adenosyl-L-methionine (SAMe) in patients with fibromyalgia (FM). Thirty-four out-patients with fibromyalgia symptoms received SAMe 600 mg i.v. or placebo daily for 10 days in a cross-over trial. There was no significant difference in improvement in the primary outcome: tender point change between the two treatment groups. There was a tendency towards statistical significance in favour of SAMe on subjective perception of pain at rest (p = 0.08), pain on movement (p = 0.11), and overall well-being (p = 0.17) and slight improvement only on fatigue, quality of sleep, morning stiffness, and on the Fibromyalgia Impact Questionnaire for pain. No effect could be observed on isokinetic muscle strength, Zerrsen self-assessment questionnaire, and the face scale. No effect of SAMe in patients with FM was found in this short term study.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 26
Udgave nummer 3
Sider (fra-til) 206-11
Antal sider 6
ISSN 0300-9742
Status Udgivet - 1997

Muscle strength, working capacity and effort in patients with fibromyalgia

Nørregaard, J., Bülow, P. M., Lykkegaard, J. J., Mehlsen, J. & Danneskiold-Samsøoe, B., 1 jun. 1997, I : Scandinavian Journal of Rehabilitation Medicine. 29, 2, s. 97-102 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The objective of the study was to evaluate the physical capacity and effort in patients with fibromyalgia. Muscle strength and the coefficient of variation of the strength measurements of 181 female fibromyalgia patients and 126 healthy females were compared. These measurements and ergometer exercise capacity, work status and psychometric scoring (SCL-90-R) were correlated. The fibromyalgia patients exhibited significant reduction in voluntary muscle strength of the knee and elbow, flexors and extensors in the order of 20-30%. However, the coefficient of variation was higher among patients, thus indicating lower effort. The physical performance during an ergometer test corresponded to a maximal oxygen consumption of 21 ml/kg-1 x min-1. The maximal increase in heart rate was only 63% (44-90%) of the predicted increase. Degree of effort or physical capacity did not correlate to psychometric scores. Work status was related to psychometric scoring, but not to physical capacity or effort. In conclusion, we found a low degree of effort but near normal physical capacity in the fibromyalgia patients.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rehabilitation Medicine
Vol/bind 29
Udgave nummer 2
Sider (fra-til) 97-102
Antal sider 6
ISSN 0036-5505
Status Udgivet - 1 jun. 1997

Published in 1995

Behandling af højt blodtryk hos patienter med akut apopleksi

Olsen, T. S., Jørgensen, H. S., Garde, E. & Lassen, N. A. 19 jun 1995 I : Ugeskrift for Laeger. 157, 25, s. 3623-5 3 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The study was performed to investigate how often reduction of high blood pressure (> or = 220 mmHg systolic and or > or = 120 mmHg diastolic) was attempted in patients with acute stroke or transient ischemic attacks (TIA). Of 1351 consecutive patients with acute stroke or TIA 119 had high blood pressure on admission. In 15 patients the stroke was so severe that treatment was not considered. In the remaining 104 patients reduction of the blood pressure was attempted in 28 (27%); in 23 patients immediately following admission. None of the patients had symptoms or signs of hypertensive encephalopathy. It is concluded that reduction of high blood pressure in patients with stroke or TIA is attempted too often. As autoregulation is commonly impaired in acute stroke, reduction of systemic blood pressure may enhance ischaemic tissue damage. Reduction of blood pressure in acute stroke should be considered only in case of hypertensive encephalopathy.
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Udgivelsesdato 19 jun 1995
Vol/bind 157
Tidsskriftsnummer 25
Sider 3623-5
Antal sider 3
ISSN 0041-5782
Status Udgivet

Blodtryksnedsaettelse kan forvaerre symptomerne ved akut apopleksi

Garde, E., Jørgensen, H. S., Olsen, T. S. & Lassen, N. A. 19 jun 1995 I : Ugeskrift for Laeger. 157, 25, s. 3630-1 2 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Patients with acute stroke often present with high blood pressure (BP) on hospital admission. Because hypertension is a risk factor for stroke, and because severe BP elevation may increase oedema and the risk of haemorrhage, acute antihypertensive therapy might seem reasonable. On the other hand, the increase in BP in the acute stage might be considered a beneficial pathophysiological response maintaining the perfusion pressure to the ischaemic area and, in particular, the surrounding penumbra. As illustrated in the case presented here, lowering the BP in the early stage may be associated with progression of neurological deficits, very likely due to a reduction of perfusion to the penumbra thus enlarging the infarct.
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Udgivelsesdato 19 jun 1995
Vol/bind 157
Tidsskriftsnummer 25
Sider 3630-1
Antal sider 2
ISSN 0041-5782
Status Udgivet

Ojenskader ved hobbyarbejde med maskinelt håndvaerktøj

Hölmich, L. R., Hölmich, P. & Lohmann, M. 10 apr. 1995 I : Ugeskrift for laeger. 157, 15, s. 2131-4 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Data from the EU-project EHLASS (European Home and Leisure Accident Surveillance System) collected from five Danish hospitals during the period 1989-1991 contained 185,551 accidents occurring at home and during leisure time. The population in the catchment area is approximately 700,000. Of these accidents, 9900 involved eye-injury, 2940 of these occurred during hobby-activities, and 1460 of these while the subject was using either drilling-, welding- or grinding-equipment. The incidence of eye-injuries occurring during the use of these machines has risen from 0.6/1000/year in 1989 to 0.7/1000/year in 1990 and to 0.8/1000/year in 1991. In 98% of the cases the patients were men, 30% were between 20 and 29 years of age. A common activity at the time of the accident was "car-repairing". Foreign-body-lesions were seen in 60% of the cases, and actinic conjunctivitis in 30%. None of the injuries were serious, but they were often very painful and demanding of resources. All the injuries could have been avoided by the use of proper eye protection.

Originalsprog Dansk
Tidsskrift Ugeskrift for laeger
Vol/bind 157
Tidsskriftsnummer 15
Sider (fra-til) 2131-4
Antal sider 4
ISSN 0041-5782
Status Udgivet - 10 apr. 1995

The twitch interpolation technique for study of fatigue of human quadriceps muscle

Bülow, P. M., Nørregaard, J., Mehlsen, J. & Danneskiold-Samsøe, B., 1 nov. 1995, I : Journal of Neuroscience Methods. 62, 1-2, s. 103-9 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of the study was to examine if the twitch interpolation technique could be used to objectively measure fatigue in the quadriceps muscle in subjects performing submaximally. The 'true' maximum isometric quadriceps torque was determined in 21 healthy subject using the twitch interpolation technique. Then an endurance test was performed in which the subjects made repeated isometric contractions at 50% of the 'true' maximum torque for 4 s, separated by 6 s rest periods. During the test, the force response to single electrical stimulation (twitch amplitude) was measured at 50% and 25% of the estimated maximum torque. In 10 subjects, the test was repeated 2-4 weeks later. Twitch amplitudes at 50% of maximum torque declined exponentially with time in 20 of 21 subjects. The distribution of the exponential rate constant was skewed with a mean of 4.6 h-1 and range of 0.3-21.5 h-1. After logarithmical transformation, the distribution of the exponential rate constant fitted closely to a normal distribution, and the inter-individual variation was SD = 1.15 compared to an intra-individual variation of 0.29. The coefficient of correlation for repeated determination was 0.91 (P <0.001, n = 10). In conclusion, the twitch technique can be used for objectively measuring fatigue of the quadriceps muscle.
Originalsprog Engelsk
Tidsskrift Journal of Neuroscience Methods
Vol/bind 62
Udgave nummer 1-2
Sider (fra-til) 103-9
Antal sider 7
ISSN 0165-0270
Status Udgivet - 1 nov. 1995

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