Published in 2011

Identifying Preliminary Domains to Detect and Measure Rheumatoid Arthritis Flares: Report of the OMERACT 10 RA Flare Workshop

Bingham, C. O., Alten, R., Bartlett, S. J., Bykerk, V. P., Brooks, P. M., Choy, E., Christensen, R., Furst, D. E., Hewlett, S. E., Leong, A., May, J. E., Montie, P., Pohl, C., Sanderson, T. C., Strand, V., Woodworth, T. G. & for the OMERACT RA Flare Definition Working Group, 1 aug. 2011, I : Journal of Rheumatology. 38, 8, s. 1751-1758 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Background. While disease flares in rheumatoid arthritis (RA) are a recognized aspect of the disease process, there is limited formative research to describe them. METHODS: The Outcome Measures in Rheumatology Clinical Trials (OMERACT) RA Flare Definition Working Group is conducting an international research project to understand the specific characteristics and impact of episodic disease worsening, or "flare," so that outcome measures can be developed or modified to reflect this uncommonly measured, but very real and sometimes disabling RA disease feature. Patient research partners provided critical insights into the multidimensional nature of flare. The perspectives of patients and healthcare and research professionals are being integrated to ensure that any outcome measurement to detect flares fulfills the first OMERACT criteria of Truth. Through an iterative data-driven Delphi process, a preliminary list of key domains has been identified to evaluate flare. RESULTS: At OMERACT 10, consensus was achieved identifying features of flare in addition to the existing core set for RA, including fatigue, stiffness, symptom persistence, systemic features, and participation. Patient self-report of flare was identified as a component of the research agenda needed to establish criterion validity for a flare definition; this can be used in prospective studies to further evaluate the Discrimination and Feasibility components of the OMERACT filter for a flare outcome measure. CONCLUSION: Our work to date has provided better understanding of key aspects of the RA disease process as episodic, potentially disabling disease worsening even when a patient is in low disease activity. It also highlights the importance of developing ways to enhance communication between patients and clinicians and improve the ability to achieve "tight control" of disease.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 38
Udgave nummer 8
Sider (fra-til) 1751-1758
Antal sider 8
ISSN 0315-162X
DOI
Status Udgivet - 1 aug. 2011

Introduction--microorganisms and the locomotor system

Wollheim, F. A. & Locht, H., 2011, I : Best Practice & Research: Clinical Rheumatology. 25, 3, s. 333-5 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Best Practice & Research: Clinical Rheumatology
Vol/bind 25
Udgave nummer 3
Sider (fra-til) 333-5
Antal sider 3
ISSN 1521-6942
DOI
Status Udgivet - 2011

Is it possible to reduce the knee joint compression force during level walking with hiking poles?

Jensen, S. B., Henriksen, M., Aaboe, J., Hansen, L., Simonsen, E. B. & Alkjaer, T., 2011, I : Scandinavian journal of medicine & science in sports. 21, 6, s. E195-E200

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Walking with hiking poles has become a popular way of exercising. Walking with poles is advocated as a physical activity that significantly reduces the loading of the hip, knee and ankle joints. We have previously observed that pole walking does not lead to a reduction of the load on the knee joint. However, it is unclear whether an increased force transmitted through the poles can reduce the load on the knee joint. Thus, the purpose of the present study was to investigate if an increased load transmitted through the arms to the poles could reduce the knee joint compression force during level walking with poles. We hypothesized that an increased pole force would result in a reduction of the knee joint compression force. Gait analyses from 10 healthy subjects walking with poles were obtained. The pole force was measured simultaneously during the gait analyses. The knee joint compression forces were estimated by using a biomechanical knee joint model. The results showed that the subjects were able to increase the pole force by 2.4 times the normal pole force. However, this did not lead to a reduction in the knee joint compressive force and we rejected our hypothesis. In conclusion, the use of poles during level walking does not seem to reduce knee joint compressive loads. However, it is possible that the use of poles in other populations (e.g. osteoarthritis patients) and in terrain would unload the knee joint. This should be investigated in the future.
Originalsprog Engelsk
Tidsskrift Scandinavian journal of medicine & science in sports
Vol/bind 21
Udgave nummer 6
Sider (fra-til) E195-E200
ISSN 0905-7188
DOI
Status Udgivet - 2011

Konsekvenser af tortur i et reumatologisk perspektiv

Amris, K., 2011, Klinisk Reumatologi. Danneskiold-Samsøe, B., Bliddal, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1. s. 279-288 10 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Henning Bliddal, Eva Ejlersen Währens
Antal sider 10
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 279-288
Kapitel 19
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Medicinsk billeddiagnostik

Boesen, M. & Ellegaard, K., 2011, Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1. s. 313-337 25 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 25
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 313-337
Kapitel 22
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Motor responses to experimental Achilles tendon pain

Henriksen, M., Aaboe, J., Nielsen, T. G., Bliddal, H. & Jørgensen, H. L., 1 apr. 2011, I : British Journal of Sports Medicine. 45, 5, s. 393-8 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Achilles tendinopathies are characterised by pain and reduced function, and heavy-load exercises have been shown to be effective in the treatment of painful chronic Achilles tendinopathies. However, basic information is needed on how the biomechanics and neuromuscular control of the exercise are affected by Achilles tendon pain.
Originalsprog Engelsk
Tidsskrift British Journal of Sports Medicine
Vol/bind 45
Udgave nummer 5
Sider (fra-til) 393-8
Antal sider 6
ISSN 0306-3674
DOI
Status Udgivet - 1 apr. 2011

Neck exercises, physical and cognitive behavioural-graded activity as a treatment for adult whiplash patients with chronic neck pain: design of a randomised controlled trial

Hansen, I. R., Søgaard, K., Christensen, R., Thomsen, B., Manniche, C. & Juul-Kristensen, B., 2011, I : B M C Musculoskeletal Disorders. 12, s. 274

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Many patients suffer from chronic neck pain following a whiplash injury. A combination of cognitive, behavioural therapy with physiotherapy interventions has been indicated to be effective in the management of patients with chronic whiplash-associated disorders. The objective is to present the design of a randomised controlled trial (RCT) aimed at evaluating the effectiveness of a combined individual physical and cognitive behavioural-graded activity program on self-reported general physical function, in addition to neck function, pain, disability and quality of life in patients with chronic neck pain following whiplash injury compared with a matched control group measured at baseline and 4 and 12 months after baseline.
Originalsprog Engelsk
Tidsskrift B M C Musculoskeletal Disorders
Vol/bind 12
Sider (fra-til) 274
ISSN 1471-2474
DOI
Status Udgivet - 2011

Observation-based assessment of functional ability in patients with chronic widespread pain: a cross-sectional study

Amris, K., Wæhrens, E. E., Jespersen, A., Bliddal, H. & Danneskiold-Samsøe, B., 2011, I : Pain. 152, 11, s. 2470-6 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Knowledge about functional ability, including activities of daily living (ADL), in patients with chronic widespread pain (CWP) and fibromyalgia (FMS) is largely based on self-report. The purpose of this study was to assess functional ability by using standardised, observation-based assessment of ADL performance and to examine the relationship between self-reported and observation-based measures of disability. A total of 257 women with CWP, 199 (77%) fulfilling the American College of Rheumatology tender point criteria for FMS, were evaluated with the Assessment of Motor and Process Skills (AMPS), an observation-based assessment providing linear measures of ADL motor and ADL process skill ability (unit: logits). A cutoff for effortless and independent ADL task performance is set at 2.0 for the motor scale and 1.0 for the process scale. A total of 248 (96.5%) had ability measures below the 2.00 ADL motor cutoff and 107 (41.6%) below the 1.00 ADL process cutoff, indicating increased effort and/or inefficiency during task performance as well as a potential need of assistance for community living. Mean ADL motor ability measure was 1.07 and was significantly lower in patients diagnosed with FMS than plain CWP (1.02 vs 1.27 logits, P=.001). Mean ADL process ability measure was 1.09 logits and was without difference between FMS and plain CWP (1.07 vs 1.16 logits, P=.064). Only weak to moderate correlations between self-reported functional ability and observation-based AMPS ability measures were observed. The results of the study support the notion of considerable performance difficulties in women with CWP. The everyday life problems are substantial and place the individual at risk of need of support for community living.
Originalsprog Engelsk
Tidsskrift Pain
Vol/bind 152
Udgave nummer 11
Sider (fra-til) 2470-6
Antal sider 7
ISSN 0304-3959
DOI
Status Udgivet - 2011

Osteoarthritis – a role for weight management in rheumatology practice: an update

Bliddal, H., Christensen, P., Riecke, B. F., Aaboe, J., Bartels, E. M. & Christensen, R. D. K., 2011, I : Clinical Obesity. 1, 1, s. 50-2 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Dansk
Tidsskrift Clinical Obesity
Vol/bind 1
Udgave nummer 1
Sider (fra-til) 50-2
Antal sider 3
Status Udgivet - 2011

Osteoartrose (OA, artrose)

Bliddal, H., 2011, Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1. s. 173-189 17 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 17
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 173-189
Kapitel 12
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Predictors of adipose tissue concentrations of organochlorine pesticides in a general Danish population

Bräuner, E. V., Raaschou-Nielsen, O., Gaudreau, E., Leblanc, A., Tjønneland, A., Overvad, K. & Sørensen, M., 3 nov. 2011, I : Journal of Exposure Science and Environmental Epidemiology. 22, 1, s. 52-9 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Organochlorine pesticides are ubiquitously present in the environment and suspected of carcinogenic, neurological and immunological effects. Our objective was to identify determinants of adipose tissue levels of organochlorine pesticides experienced by a general Danish population. Adipose tissue was collected upon enrolment of 245 randomly selected persons from a prospective cohort of 57,053 persons enrolled between 1993 and 1997. We examined geography, gender, age, lactation, body mass index (BMI) and intake of nine dietary groups and tap water drinks, as potential determinants of dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene, hexachlorocyclohexane, dieldrin, hexachlorobenzene, cis-nonachlor, trans-nonachlor and oxychlordane. Living in Copenhagen city and age at enrolment showed positive associations with all compounds. BMI was positively associated with all compounds except cis-nonachlor. Fatty-fish consumption showed positive associations with cis-nonachlor, trans-nonachlor, DDT and dieldrin and fruit and vegetables were inversely associated with dieldrin. Determinant estimates of trans-nonachlor were similar to estimates of total chlordanes while cis-nonachlor and oxychlordane seemed to differ. This is one of the first studies of organochlorine pesticides predictors in adipose tissue and contributes to the ongoing debate about exposure sources of these compounds. Single determinants varied among the individual compounds, even within related chlordane residues, suggesting that organochlorine pesticides should not be treated as a homogenous group.

Originalsprog Engelsk
Tidsskrift Journal of Exposure Science and Environmental Epidemiology
Vol/bind 22
Udgave nummer 1
Sider (fra-til) 52-9
Antal sider 8
ISSN 1559-0631
DOI
Status Udgivet - 3 nov. 2011

Predictors of early and late case-fatality in a nationwide Danish study of 26,818 patients with first-ever ischemic stroke

Andersen, K. K., Andersen, Z. J. & Olsen, T. S., 2011, I : Stroke. 42, 10, s. 2806-12 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Predictors of early case-fatality (3-day, 7-day, and 30-day) in first-ever ischemic stroke were identified and compared with predictors of late case-fatality (90-day and 1-year).
Originalsprog Engelsk
Tidsskrift Stroke
Vol/bind 42
Udgave nummer 10
Sider (fra-til) 2806-12
Antal sider 7
ISSN 0039-2499
DOI
Status Udgivet - 2011
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 70
Udgave nummer 3 (Suppl.)
Sider (fra-til) 114
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2011
To study the predictive value of baseline radiographs and low-field (0.2T) MRI scans for the symptomatic outcome of clinically significant weight loss in obese patients with knee osteoarthritis.
Originalsprog Engelsk
Tidsskrift B M C Musculoskeletal Disorders
Vol/bind 12
Sider (fra-til) 56
ISSN 1471-2474
DOI
Status Udgivet - 1 jan. 2011

Rehabilitering

Wæhrens, E. E., Amris, K. & Lund, H., 2011, Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1. s. 373-381 9 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 9
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 373-381
Kapitel 24
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Rehabilitering af den reumatologiske patient

Amris, K. & Lund, H., 2011, Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1. s. 393-405 13 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 13
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 393-405
Kapitel 26
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients

Ge, H-Y., Wang, Y., Fernández-de-las-Peñas, C., Graven-Nielsen, T., Danneskiold-Samsøe, B. & Arendt-Nielsen, L., 2011, I : Arthritis Research & Therapy. 13, 2, s. R48

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

It has previously been reported that local and referred pain from active myofascial trigger points (MTPs) in the neck and shoulder region contribute to fibromyalgia (FM) pain and that the pain pattern induced from active MTPs can reproduce parts of the spontaneous clinical FM pain pattern. The current study investigated whether the overall spontaneous FM pain pattern can be reproduced by local and referred pain from active MTPs located in different muscles.
Originalsprog Engelsk
Tidsskrift Arthritis Research & Therapy
Vol/bind 13
Udgave nummer 2
Sider (fra-til) R48
ISSN 1478-6354
DOI
Status Udgivet - 2011
Originalsprog Engelsk
Tidsskrift Pain
Vol/bind 152
Udgave nummer 7
Sider (fra-til) 1685-1686
ISSN 0304-3959
DOI
Status Udgivet - 2011

Reumatoid artrit

Danneskiold-Samsøe, B. & Herlin, T., 2011, Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1. s. 135-172 38 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 38
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 135-172
Kapitel 11
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Rheumatoid factor and its interference with cytokine measurements: problems and solutions

Bartels, E. M., Falbe Wätjen, I., Littrup Andersen, E., Danneskiold-Samsøe, B., Bliddal, H. & Ribel-Madsen, S., 2011, I : Arthritis Today. 2011, s. 741071

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Use of cytokines as biomarkers for disease is getting more widespread. Cytokines are conveniently determined by immunoassay, but interference from present antibodies is known to cause problems. In rheumatoid arthritis (RA), interference of rheumatoid factor (RF) may be problematic. RF covers a group of autoantibodies from immunoglobulin subclasses and is present in 65-80% of RA patients. Partly removal of RF is possible by precipitation. This study aims at determining the effects of presence of RF in blood and synovial fluid on cytokine measurements in samples from RA patients and finding possible solutions for recognized problems. IL-1β, IL-4, IL-6, and IL-8 were determined with multiplex immunoassays (MIA) in samples from RA patients prior to and after polyethylene glycol (PEG 6000) precipitation. Presence of RF does interfere with MIA. PEG 6000 precipitation abolishes this RF interference. We recommend PEG precipitation for all immunoassay measurements of plasma samples from RA patients.
Originalsprog Engelsk
Tidsskrift Arthritis Today
Vol/bind 2011
Sider (fra-til) 741071
ISSN 0969-7039
DOI
Status Udgivet - 2011

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