Published in 2010

It is generally believed that differences in age, stroke characteristics, and cardiovascular risk factors account for observed sex-specific differences in stroke survival.
Originalsprog Engelsk
Tidsskrift Gender Medicine
Vol/bind 7
Udgave nummer 4
Sider (fra-til) 284-95
Antal sider 12
ISSN 1550-8579
DOI
Status Udgivet - 1 aug. 2010

Fibromyalgi som neurogen smertetilstand

Amris, K. & Jespersen, A., 14 jun. 2010, I : Ugeskrift for Laeger. 172, 24, s. 1832-5 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Fibromyalgia is characterised by chronic widespread pain and mechanical hyperalgesia. It is associated with a higher pain intensity, fewer pain-free intervals and more pronounced pain-related interference in function than other musculoskeletal pain conditions. Increasing evidence supports an underlying augmented central pain processing which includes sensitization of pain-transmitting neurons and dysfunction of pain inhibitory pathways. If this permanent change in the function of the nociceptive system is shown to equal fibromyalgia, the condition may be considered a neuropathic pain condition.
Bidragets oversatte titel [Fibromyalgia as a neuropathic pain condition]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 172
Udgave nummer 24
Sider (fra-til) 1832-5
Antal sider 4
Status Udgivet - 14 jun. 2010

Fysiologiske aendringer ved fibromyalgi

Bliddal, H., Bartels, E. M., Jespersen, A. & Danneskiold-Samsøe, B., 14 jun. 2010, I : Ugeskrift for Laeger. 172, 24, s. 1830-2 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A number of physiological changes, some measurable as changes in biomarkers, have been described in fibromyalgia (FM). These include changes in cytokine serum levels and elevated levels of some neurotransmitters in the cerebrospinal fluid. None of these measurements have been validated for diagnosis or follow-up in FM. It is suggested that non-invasive methods which hold the potential to evaluate the severity of FM and serve as therapy targets should be developed in the future.
Bidragets oversatte titel [Physiological changes in fibromyalgia]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 172
Udgave nummer 24
Sider (fra-til) 1830-2
Antal sider 3
ISSN 0041-5782
Status Udgivet - 14 jun. 2010

Gait changes in patients with knee osteoarthritis are replicated by experimental knee pain

Henriksen, M., Nielsen, T. G., Aaboe, J., Andriacchi, T. P. & Bliddal, H., 1 apr. 2010, I : Arthritis Care & Research. 62, 4, s. 501-9 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Medial knee osteoarthritis (OA) is characterized by pain and associated with abnormal knee moments during walking. The relationship between knee OA pain and gait changes remains to be clarified, and a better understanding of this link could advance the treatment and prevention of disease progression. This study investigated changes in knee moments during walking following experimental knee pain in healthy volunteers, and whether these changes replicated the joint moments observed in medial knee OA patients.
Originalsprog Engelsk
Tidsskrift Arthritis Care & Research
Vol/bind 62
Udgave nummer 4
Sider (fra-til) 501-9
Antal sider 9
ISSN 2151-464X
DOI
Status Udgivet - 1 apr. 2010

Increased trapezius pain sensitivity is not associated with increased tissue hardness

Andersen, H., Ge, H., Arendt-Nielsen, L., Danneskiold-Samsøe, B. & Nielsen, T. G., 1 maj 2010, I : Journal of Pain. 11, 5, s. 491-9 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Fatiguing exercise can affect muscle pain sensitivity and muscle hardness, as seen with work-related neck and shoulder pain. Objective methods to assess muscle pain sensitivity are important because the reliability of manual assessment is generally poor. The aim of this study was (1) to compare coexistence of tender points identified by manual palpation and pressure algometry or hardness assessments and (2) to examine the influence of exercise on muscle pain sensitivity and hardness. Fourteen sites in the upper trapezius muscle were selected for assessments in 12 healthy subjects. Pressure pain thresholds and muscle hardness were examined by computer-controlled pressure algometry at baseline, immediately after static or dynamic exercise, and 20 minutes after static or dynamic exercise. Before recording of pressure pain thresholds, the trapezius muscle was examined for tender points by manual palpation. Two sites with low pressure pain thresholds were typical locations for tender points, and these were the least hard sites. However, manually detected tender points were often (29%) not colocalized with most sensitive sites according to the pressure algometry. A heterogeneous distribution of pressure pain sensitivity and muscle hardness was found in the upper trapezius. The short duration of exercise until exhaustion did not change muscle sensitivity or muscle hardness in asymptomatic muscles. PERSPECTIVE: This study confirms clinical findings with heterogeniosity in pain sensitivity and hardness across the upper trapezius muscle. Developments of new techniques that objectively can identify tender points are important, but thus far, manual palpation is best clinical practice.
Originalsprog Engelsk
Tidsskrift Journal of Pain
Vol/bind 11
Udgave nummer 5
Sider (fra-til) 491-9
Antal sider 9
ISSN 1526-5900
DOI
Status Udgivet - 1 maj 2010

Intra-articular hyaluronan is without clinical effect in knee osteoarthritis: a multicentre, randomised, placebo-controlled, double-blind study of 337 patients followed for 1 year

Jørgensen, A., Stengaard-Pedersen, K., Simonsen, L. O., Jensen, M. P., Eriksen, C., Bliddal, H., Pedersen, N. W., Bødtker, S., Hørslev-Petersen, K., Snerum, L. Ø., Egund, N. & Frimer-Larsen, H., 2010, I : Annals of the Rheumatic Diseases. 69, 6, s. 1097-1102 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Objective To examine the long-term efficacy and safety of five intra-articular injections with hyaluronan in knee osteoarthritis. Methods A multicentre, randomised, placebo-controlled double-blind study of 337 patients fulfilling the American College of Rheumatology (ACR) criteria for knee osteoarthritis (clinical and laboratory) and with a Lequesne algofunctional index score (LFI) of 10 or greater. Patients received a hyaluronan product (sodium hyaluronate; Hyalgan) (n= 167) or saline (n= 170) intra-articularly weekly for 5 weeks and were followed up to 1 year. Time to recurrence was the primary efficacy parameter. LFI, pain on walking 50 m based on visual analogue scale (VAS pain 50 m), paracetamol consumption, patients' global assessment, Nottingham health profile, joint effusion and number of responders were secondary efficacy parameters. The efficacy parameters were analysed by intention to treat (ITT) and per protocol (PP). All adverse events (AE) were recorded as safety parameters. Results Time to recurrence showed no significant treatment effect (ITT analysis, p = 0.26). Change from baseline in LFI and VAS pain 50 m for the ITT population showed no treatment effect. Paracetamol consumption, patients' global assessment, responder rates and AE displayed no significant difference between treatment groups, analysed by both ITT and PP. Treatment compliance was 95% in the hyaluronan group and 99% in the placebo group. No safety problems were registered. Conclusion In patients fulfilling the ACR criteria for osteoarthritis of the knee with moderate to severe disease activity (LFI >= 10), five intra-articular injections of hyaluronan did not improve pain, function, paracetamol consumption or other efficacy parameters 3, 6, 9 and 12 months after the treatment
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 69
Udgave nummer 6
Sider (fra-til) 1097-1102
Antal sider 6
ISSN 0003-4967
DOI
Status Udgivet - 2010

Is neuropathic pain underdiagnosed in musculoskeletal pain conditions? The Danish PainDETECTive study

Jespersen, A., Amris, K., Bliddal, H., Andersen, S., Lavik, B., Janssen, H. & Poulsen, P. B., 1 aug. 2010, I : Current Medical Research and Opinion. 26, 8, s. 2041-5 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In all, 19-22% of the adult Danish population suffer from chronic pain - most frequently in the musculoskeletal system. Different pain management strategies depending on pain mechanism (neuropathic/nociceptive) make diagnosing the pain condition especially important.
Originalsprog Engelsk
Tidsskrift Current Medical Research and Opinion
Vol/bind 26
Udgave nummer 8
Sider (fra-til) 2041-5
Antal sider 5
ISSN 0300-7995
DOI
Status Udgivet - 1 aug. 2010
A food supplement containing fish oils, urtica dioica, zinc, and vitamin E (Phytalgic) for osteoarthritis (OA) has now been tested in a placebo-controlled trial for 3 months and according to the authors has a very large clinical effect, considerably larger than that of any other known product. Even experts endorsing nutraceuticals for OA symptoms would probably agree that a nutraceutical with an effect size above 0.5 is rarely seen. Despite our concerns about the fact that trial registration took place after the study was completed and the likelihood that patients would note the taste of fish, a circumstance that would lead to detection bias, we consider these data promising though with a high risk of bias.
Originalsprog Engelsk
Tidsskrift Arthritis Research & Therapy
Vol/bind 12
Udgave nummer 1
Sider (fra-til) 105
ISSN 1478-6354
DOI
Status Udgivet - 1 jan. 2010

Is there any interaction between domestic radon exposure and air pollution from traffic in relation to childhood leukemia risk?

Bräuner, E. V., Andersen, C. E., Andersen, H. P., Gravesen, P., Lind, M., Ulbak, K., Hertel, O., Schüz, J. & Raaschou-Nielsen, O., nov. 2010, I : Cancer causes & control : CCC. 21, 11, s. 1961-4 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: In a recent population-based case-control study using 2,400 cases of childhood cancer, we found a statistically significant association between residential radon and acute lymphoblastic leukemia risk.

HYPOTHESIS: Traffic exhaust in the air enhances the risk association between radon and childhood leukemia.

METHODS: We included 985 cases of childhood leukemia and 1,969 control children. We used validated models to calculate residential radon and street NO(x) concentrations for each home. Conditional logistic regression analyses were used to analyze the effect of radon on childhood leukemia risk within different strata of air pollution and traffic density.

RESULTS: The relative risk for childhood leukemia in association with a 10(3) Bq/m(3)-years increase in radon was 1.77 (1.11, 2.82) among those exposed to high levels of NO(x) and 1.23 (0.79, 1.91) for those exposed to low levels of NO(x) (p(interaction,) 0.17). Analyses for different morphological subtypes of leukemia and within different strata of traffic density showed a non-significant pattern of stronger associations between radon and childhood leukemia within strata of higher traffic density at the street address.

INTERPRETATION: Air pollution from traffic may enhance the effect of radon on the risk of childhood leukemia. The observed tendency may also be attributed to chance.

Originalsprog Engelsk
Tidsskrift Cancer causes & control : CCC
Vol/bind 21
Udgave nummer 11
Sider (fra-til) 1961-4
Antal sider 4
ISSN 0957-5243
DOI
Status Udgivet - nov. 2010
Originalsprog Engelsk
Udgivelses sted Umeå
Vol/bind Umeå University Medical Dissertations
Udgave 1349
Antal sider 93
ISBN (Trykt) 978-91-7264-993-4
Status Udgivet - 2010

Mortality in a cohort of Danish patients with fibromyalgia: increased frequency of suicide

Dreyer, L., Kendall, S., Danneskiold-Samsøe, B., Bartels, E. M. & Bliddal, H., 1 okt. 2010, I : Arthritis & Rheumatism. 62, 10, s. 3101-8 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A previous study demonstrated an association between self-reported widespread body pain and increased mortality. The aim of this study was to analyze whether fibromyalgia (FM) and FM-like symptoms are related to increased mortality.
Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatism
Vol/bind 62
Udgave nummer 10
Sider (fra-til) 3101-8
Antal sider 8
ISSN 0004-3591
DOI
Status Udgivet - 1 okt. 2010
This review article discusses the aspects of sports medicine where musculoskeletal Doppler ultrasound has valuable contribution in diagnosis and/or treatment of some of the typical musculoskeletal sports injuries. Also, conditions where the Doppler ultrasound has no value are discussed. Some guidelines and recommendations are based on personal experience since no evidence in literature exists. The basic technical background of Doppler ultrasound and typical artefacts will be discussed, in order to understand and interpret the Doppler result. Recommendations for the Doppler settings are given in relevant sections. Ultrasound guided treatments where the Doppler result is used as a guide are mentioned and discussed.
Originalsprog Engelsk
Tidsskrift Clinical and Experimental Rheumatology
Vol/bind 28
Udgave nummer 1
Sider (fra-til) 103-13
Antal sider 11
ISSN 0392-856X
Status Udgivet - 2010

Når patienten er syg, selvom undersøgelsesresultaterne er normale

Jensen, T. S., Bliddal, H. & Fink, P. K., 14 jun. 2010, I : Ugeskrift for Laeger. 172, 24, s. 1811

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Bidragets oversatte titel [When the patients is ill and the examination results are normal]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 172
Udgave nummer 24
Sider (fra-til) 1811
ISSN 0041-5782
Status Udgivet - 14 jun. 2010

Open access publishing. And now, e-publication bias

Jakobsen, A. K., Christensen, R. D. K., Persson, R., Bartels, E. M. & Kristensen, L. E., 1 jan. 2010, I : B M J. 340, s. c2243

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift B M J
Vol/bind 340
Sider (fra-til) c2243
ISSN 0959-8146
Status Udgivet - 1 jan. 2010

Performance-based assessment of activities of daily living (ADL) ability among women with chronic widespread pain

Wæhrens, E. E., Amris, K. & Fisher, A. G., 1 sep. 2010, I : Pain. 150, 3, s. 535-41 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Functional ability, including the ability to perform activities of daily living (ADL), is considered a core outcome domain in chronic pain clinical trials and is usually assessed through generic or disease-specific self-report questionnaires. Research, however, indicates that self-report and performance-based assessment of ADL offer distinct but complementary information about ability. The present study, therefore, investigated the applicability of a performance-based measure of ADL ability, the Assessment of Motor and Process Skills (AMPS), among 50 women with chronic widespread pain. The investigated psychometric properties of the AMPS included discrimination between a sample of healthy women and those with chronic widespread pain, as well as stability when no intervention was provided and sensitivity to change following intervention. Data were obtained based on a repeated measures design performing AMPS evaluations twice pre- and twice post-rehabilitation. Results indicated that the ADL motor ability measures of the participants were significantly lower than those of healthy women of same age, the ADL motor and ADL process ability measures remained stable when no intervention was provided and the ADL motor ability measures were sensitive to change following a 2-week interdisciplinary rehabilitation program. A weak correlation (r(s)=-0.35) was found between self-reported ADL ability as measured by the physical function subscale of the Functional Impact Questionnaire (FIQ) and performance-based ADL motor measures, and no correlation (r(s)=-0.02) was found between FIQ ADL measures and ADL process ability, supporting the need for both performance-based and self-reported assessment of ADL.
Originalsprog Engelsk
Tidsskrift Pain
Vol/bind 150
Udgave nummer 3
Sider (fra-til) 535-41
Antal sider 7
DOI
Status Udgivet - 1 sep. 2010

QT interval prolongation during spontaneous episodes of hypoglycaemia in type 1 diabetes: the impact of heart rate correction

Christensen, T. F., Tarnow, L., Randløv, J., Kristensen, L. E., Struijk, J. J., Eldrup, E. & Hejlesen, O. K., sep. 2010, I : Diabetologia. 53, 9, s. 2036-41 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

AIMS/HYPOTHESIS: Prolongation of the heart rate corrected QT interval (QTc) is seen during episodes of hypoglycaemia in type 1 diabetes. We studied the relationship between spontaneous hypoglycaemia and the QT interval and hypothesised that the choice of heart rate correction affects the observed change in QTc.

METHODS: Twenty-one participants with type 1 diabetes (aged 58 +/- 10 years with duration of diabetes 34 +/- 12 years) had continuous glucose and ECG monitoring for 72 h. QT and RR intervals were measured during hypoglycaemia (blood glucose or continuous glucose measurements <or=3.5 mmol/l) and compared with euglycaemia (5-12 mmol/l). QT intervals were measured using the semi-automated tangent method from signal-averaged ECG and corrected using Bazett's formula, Fridericia's formula, the nomogram method and a linear subject-specific method.

RESULTS: Hypoglycaemia was present in 14 participants. With Bazett's formula, QTc changed significantly from euglycaemia to hypoglycaemia (422 +/- 30 vs 432 +/- 33 ms; p = 0.02). Heart rate, QT intervals and QTc corrected with formulas other than Bazett's were not associated with a significant change (p = 0.07-0.29). During hypoglycaemia, significantly lower values of QTc compared with the subject-specific method were seen for Fridericia's formula (p = 0.02) and the nomogram method (p = 0.04).

CONCLUSIONS/INTERPRETATION: Spontaneous hypoglycaemia was associated with a modest increase in QTc. Bazett's formula resulted in overcorrection of QTc while both Fridericia's formula and the nomogram method undercorrected the QTc compared with the subject-specific method during hypoglycaemia. The results may indicate that the use of a fixed heart rate correction formula can lead to misleading results in investigations of spontaneous hypoglycaemia.

Originalsprog Engelsk
Tidsskrift Diabetologia
Vol/bind 53
Udgave nummer 9
Sider (fra-til) 2036-41
Antal sider 6
ISSN 0012-186X
DOI
Status Udgivet - sep. 2010

Reliability and Responsiveness of Dynamic Contrast Enhanced Magnetic Resonance Imaging in Arthritis.

Axelsen, M. B., Poggenborg, R. P., Kubassova, O., Boesen, M., Hørslev-Petersen, K., Bliddal, H., Hanson, L. P. G. & Østergaard, M., 2010, I : Annals of the Rheumatic Diseases. 69, 3, s. 348 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 69
Udgave nummer 3
Sider (fra-til) 348
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2010
The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Function Index (BASFI) and the Bath Ankylosing Spondylitis Global Score (BAS-G) (ranges 0-10) have gained widespread in use as self-reported measures of disease activity, functional impairment and overall well-being in patients with ankylosing spondylitis and other spondyloarthropathies (SpA). In Denmark, BASDAI, BASFI and BAS-G are systematically used to monitor treatment response in patients treated with tumour necrosis factor (TNF) inhibitors. The purpose of the present study was to examine the reproducibility of the indices in anti-TNF-treated SpA patients already familiar with the use of the indices. Testing was performed twice on two different days (median interval 7 days, range 4-10 days) under standardised conditions in 26 out-clinic patients (median age 39 years, range 22-56 years). Limits of agreement were calculated as the 95% likely range for the difference between paired scores. Test-retest results were significantly intercorrelated with r (s) = 0.90 for BASDAI, 0.92 for BASFI and 0.74 for BAS-G. Limits of agreement for BASDAI, BASFI and BAS-G were +/-1.8, +/-1.4 and +/-3.2, respectively. Reproducibility as expressed as the mean of individual standard deviations was significantly poorer for BAS-G than for BASDAI and BASFI (p <0.01). Internal consistency reliability and construct validity of BASDAI and BASFI were acceptable. In conclusion, in a sample of anti-TNF-treated patients experienced with the use of BASDAI, BASFI and BAS-G, random measurement errors of the scores were not negligible. The finding should be considered when monitoring anti-TNF treatment in daily clinical practice.
Originalsprog Engelsk
Tidsskrift Clinical Rheumatology
Vol/bind 29
Udgave nummer 8
Sider (fra-til) 849-54
Antal sider 6
ISSN 0770-3198
DOI
Status Udgivet - 1 aug. 2010
Widespread pain and pain hypersensitivity are the hallmark of fibromyalgia, a complex pain condition linked to central sensitization. In this study the painDETECT questionnaire (PDQ), validated to identify neuropathic pain and based on pain quality items, was applied in a cross-sectional sample of patients with chronic widespread pain (CWP). The aims of the study were to assess the patient-reported sensory neuropathic symptoms by PDQ and to correlate these with tender point (TP) count and pressure-pain thresholds. Eighty-one patients (75 F, 6 M) with CWP (ACR-criteria) filled in the PDQ. Manual TP examination was conducted according to ACR guidelines. Computerized cuff pressure algometry was used for the assessment of pressure-pain detection thresholds (PDT, unit: kPa) and pressure-pain tolerance thresholds (PTT, unit: kPa). Mean TP count was 14.32 (range: 2-18), mean PDQ score 22.75 (range: 5-37). Mean PDT was 8.8 kPa (range: 2-36) and mean PTT 30.9 kPa (range: 4-85). Deep-tissue hyperalgesia was the predominant somatosensory symptom reported in 83%, but other neuropathic symptoms were also frequent, e.g. burning 51% and prickling 47%. Statistically significant correlations were found between PDQ score and TP count: r=0.35 (p
Originalsprog Engelsk
Tidsskrift Journal of Pain
Vol/bind 151
Udgave nummer 3
Sider (fra-til) 664-9
Antal sider 6
ISSN 1526-5900
DOI
Status Udgivet - 1 dec. 2010

Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials

Bartels, E. M., Bliddal, H., Schøndorff, P. K., Altman, R. D., Zhang, W. & Christensen, R., 1 mar. 2010, I : Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 18, 3, s. 289-96 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To estimate the efficacy and safety of diacerein as a pain-reducing agent in the treatment of osteoarthritis (OA), using meta-analysis of published randomized placebo-controlled trials (RCTs).
Originalsprog Engelsk
Tidsskrift Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Vol/bind 18
Udgave nummer 3
Sider (fra-til) 289-96
Antal sider 8
DOI
Status Udgivet - 1 mar. 2010

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