Published in 2011

The ankle region is frequently involved in juvenile idiopathic arthritis (JIA) but difficult to examine clinically due to its anatomical complexity. The aim of the study was to evaluate the role of ultrasonography (US) of the ankle and midfoot (ankle region) in JIA. Doppler-US detected synovial hypertrophy, effusion and hyperemia and US was used for guidance of steroid injection and to assess treatment efficacy.
Originalsprog Engelsk
Tidsskrift Pediatric Rheumatology Online Journal
Vol/bind 9
Udgave nummer 1
Sider (fra-til) 4
ISSN 1546-0096
DOI
Status Udgivet - 2011
To investigate the predictive ability of core outcomes applied in RA trials, including ultrasound (US) Doppler (USD) measurements differentiating patients who remain on anti-TNF-α therapy following 1 year.
Originalsprog Engelsk
Tidsskrift Rheumatology
Vol/bind 50
Udgave nummer 3
Sider (fra-til) 506-12
Antal sider 7
ISSN 1462-0324
DOI
Status Udgivet - 2011

Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial

Bliddal, H., Leeds, A. R., Stigsgaard, L., Astrup, A. & Christensen, R., 5 aug. 2011, I : Annals of the Rheumatic Diseases. 70, s. 1798-1803

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: To evaluate 1-year symptomatic improvement in obese patients with knee osteoarthritis (OA) on an intensive low-energy diet (LED) maintained by frequent consultations with a dietician compared to minimal attention. METHODS: The LED programme consisted of group therapy with dietary consultations and two periods of a low-calorie diet of 810 kcal/day during weeks 0-8 and weeks 32-36. The control group only received dietary instruction and attention for 2 h at baseline, and at weeks 8, 32, 36 and 52. The primary end point (total Western Ontario and McMaster Universities (WOMAC) index) was assessed as the mean group difference during and after 1 year. RESULTS: The study population consisted of 89 patients, 89% women, average age 63 years. After 1 year, mean weight loss in the LED group was -10.9 kg (11%) versus -3.6 kg (4%) in the control group (p
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 70
Sider (fra-til) 1798-1803
ISSN 0003-4967
DOI
Status Udgivet - 5 aug. 2011

Published in 2010

1H NMR spectroscopy-based interventional metabolic phenotyping: a cohort study of rheumatoid arthritis patients

Lauridsen, M. B., Bliddal, H., Christensen, R. D. K., Danneskiold-Samsøe, B., Bennett, R., Keun, H., Lindon, J. C., Nicholson, J. K., Christiansen, M. H. D., Jaroszewski, J. W., Hansen, S. H. & Cornett, C., 3 sep. 2010, I : Journal of Proteome Research. 9, 9, s. 4545-53 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

1H NMR spectroscopy-based metabolic phenotyping was used to identify biomarkers in the plasma of patients with rheumatoid arthritis (RA). Forty-seven patients with RA (23 with active disease at baseline and 24 in remission) and 51 healthy subjects were evaluated during a one-year follow-up with assessments of disease activity (DAS-28) and 1H NMR spectroscopy of plasma samples. Discriminant analysis provided evidence that the metabolic profiles predicted disease severity. Cholesterol, lactate, acetylated glycoprotein, and lipid signatures were found to be candidate biomarkers for disease severity. The results also supported the link between RA and coronary artery disease. Repeated assessment using mixed linear models showed that the predictors obtained from metabolic profiles of plasma at baseline from patients with active RA were significantly different from those of patients in remission (P=0.0007). However, after 31 days of optimized therapy, the two patient groups were not significantly different (P=0.91). The metabolic profiles of both groups of RA patients were different from the healthy subjects. 1H NMR-based metabolic phenotyping of plasma samples in patients with RA is well suited for discovery of biomarkers and may be a potential approach for disease monitoring and personalized medication for RA therapy.
Originalsprog Engelsk
Tidsskrift Journal of Proteome Research
Vol/bind 9
Udgave nummer 9
Sider (fra-til) 4545-53
Antal sider 9
ISSN 1535-3893
DOI
Status Udgivet - 3 sep. 2010

A European multicenter randomized double-blind placebo-controlled monotherapy clinical trial of milnacipran in treatment of fibromyalgia

Branco, J. C., Zachrisson, O., Perrot, S., Mainguy, Y. & Multinational Coordinator Study Group, 1 apr. 2010, I : Journal of Rheumatology. 37, 4, s. 851-9 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

This randomized, double-blind, placebo-controlled, multicenter study investigated the efficacy and safety of milnacipran in the treatment of fibromyalgia (FM) in a European population.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 37
Udgave nummer 4
Sider (fra-til) 851-9
Antal sider 9
ISSN 0315-162X
DOI
Status Udgivet - 1 apr. 2010

Adaptations of upper trapezius muscle activity during sustained contractions in women with fibromyalgia

Falla, D. L., Andersen, H., Danneskiold-Samsøe, B., Arendt-Nielsen, L. & Farina, D., 1 jun. 2010, I : Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology. 20, 3, s. 457-64 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The study compared the distribution of electromyographic (EMG) signal amplitude in the upper trapezius muscle in 10 women with fibromyalgia and in 10 healthy women before and after experimentally-induced muscle pain. Surface EMG signals were recorded over the right upper trapezius muscle with a 10 x 5 grid of electrodes during 90 degrees shoulder abduction sustained for 60s. The control subjects repeated the abduction task following injections of isotonic and hypertonic (painful) saline into the upper trapezius muscle. The EMG amplitude was computed for each electrode pair and provided a topographical map of the distribution of muscle activity. The pain level rated by the patients at the beginning of the sustained contraction was 5.9+/-1.5. The peak pain intensity for the control group following the injection of hypertonic saline was 6.0+/-1.6. During the sustained contractions, the EMG amplitude increased relatively more in the cranial than caudal region of the upper trapezius muscle for the control subjects (shift in the distribution of EMG amplitude: 2.3+/-1.3mm; P
Originalsprog Engelsk
Tidsskrift Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology
Vol/bind 20
Udgave nummer 3
Sider (fra-til) 457-64
Antal sider 8
DOI
Status Udgivet - 1 jun. 2010

Biologics for rheumatoid arthritis: an overview of Cochrane reviews

Singh, J. A., Christensen, R., Wells, G. A., Suarez-Almazor, M. E., Buchbinder, R., Lopez-Olivo, M. A., Ghogomu, E. T. & Tugwell, P., 1 jan. 2010, I : São Paulo medical journal = Revista paulista de medicina. 128, 5, s. 309-10 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

the biologic disease-modifying anti-rheumatic drugs (DMARDs) are very effective in treating rheumatoid arthritis (RA), however there is a lack of head-to-head comparison studies.
Originalsprog Engelsk
Tidsskrift São Paulo medical journal = Revista paulista de medicina
Vol/bind 128
Udgave nummer 5
Sider (fra-til) 309-10
Antal sider 2
Status Udgivet - 1 jan. 2010

Center-size as a predictor of weight-loss outcome in multicenter trials including a low-calorie diet

Gasteyger, C., Christensen, R., Larsen, T. M., Vercruysse, F., Toubro, S. & Astrup, A., 1 nov. 2010, I : Obesity. 18, 11, s. 2160-4 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

It has not been studied yet whether factors such as the number of subjects recruited by specialized centers for multicenter trials may influence weight loss during a low-calorie diet (LCD). This study aimed at determining whether the number of recruited subjects per center might predict relative weight loss. This is a post hoc analysis of an existing database: 701 obese subjects (77% women, 23% men, mean BMI: 38.9 kg/m(2)) were enrolled at 22 sites (4-85 subjects/site) in five countries to follow a LCD providing 800-1,000 kcal/day during 8 weeks. The main outcome measure was the percentage weight loss after the 8-week LCD. Mean weight loss differed significantly between participating centers (5.8-11.8% of the initial weight; P <0.001). There was a significant positive correlation between relative weight loss and the number of recruited subjects per center (r = 0.38; P <0.001). In a multiple stepwise regression analysis, the number of recruited subjects per center appeared to be the main predictive factor of weight loss (R(2) = 0.07; P <0.001). As the number of participants within each center is clustered, we applied a hierarchical model to model the average weight loss vs. the number of participants included at each center. This model allows to predict that for 10 extra patients in a center, the average weight loss would increase by 0.5%. This is the first study suggesting that the number of recruited subjects per center may impact weight loss, and could therefore be considered as a new predictor for weight loss that is independent from the individual.
Originalsprog Engelsk
Tidsskrift Obesity
Vol/bind 18
Udgave nummer 11
Sider (fra-til) 2160-4
Antal sider 5
ISSN 1930-7381
DOI
Status Udgivet - 1 nov. 2010

Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients: a pragmatic randomized clinical trial

Riecke, B. F., Christensen, R., Christensen, P., Leeds, A. R., Boesen, M., Lohmander, L. S., Astrup, A. & Bliddal, H., 1 jun. 2010, I : Osteoarthritis and Cartilage. 18, 6, s. 746-54 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To evaluate in a prospective, randomized clinical trial (RCT), symptom response among obese knee osteoarthritis (OA) patients following a feasible, intensive weight-loss program for 16 weeks.
Originalsprog Engelsk
Tidsskrift Osteoarthritis and Cartilage
Vol/bind 18
Udgave nummer 6
Sider (fra-til) 746-54
Antal sider 9
ISSN 1063-4584
DOI
Status Udgivet - 1 jun. 2010

Comparison of two co-registration methods for real-time ultrasonography fused with MRI: a phantom study

Ewertsen, C., Ellegaard, K., Boesen, M., Torp-Pedersen, S. & Nielsen, M. B., 1 jun. 2010, I : Ultraschall in der Medizin. 31, 3, s. 296-301 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To test the accuracy of spatial registration of real-time ultrasonography (US) fused with MRI in a phantom.
Originalsprog Engelsk
Tidsskrift Ultraschall in der Medizin
Vol/bind 31
Udgave nummer 3
Sider (fra-til) 296-301
Antal sider 6
ISSN 0172-4614
DOI
Status Udgivet - 1 jun. 2010
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 69
Udgave nummer 3
Sider (fra-til) 454
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2010
Originalsprog Engelsk
Tidsskrift Imaging in Medicine
Vol/bind 2
Udgave nummer 6
Sider (fra-til) 617-21
Antal sider 5
ISSN 1755-5191
DOI
Status Udgivet - 2010

Diagnose, behandling og prognose ved fibromyalgi

Danneskiold-Samsøe, B., Bartels, E. M., Amris, K. & Bliddal, H., 14 jun. 2010, I : Ugeskrift for Laeger. 172, 24, s. 1827-30 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

It is important to recognize the diagnosis of fibromyalgia (FM) to adequately advise patients with this chronic pain disease. FM coexists with other rheumatic diseases and may therefore serve as a confounder in connection with estimation of disease activity. The aetiology and pathogenesis of FM remain unknown, although central sensitisation seems to play a major role. Following exclusion of a number of differential diagnoses, the remaining patients have several treatment options including centrally-acting medication.
Bidragets oversatte titel [Fibromyalgia diagnosis, treatment and prognosis]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 172
Udgave nummer 24
Sider (fra-til) 1827-30
Antal sider 4
Status Udgivet - 14 jun. 2010
Anterior knee tendon problems are seldom reported in badminton players although the game is obviously stressful to the lower extremities.
Originalsprog Engelsk
Tidsskrift British Journal of Sports Medicine
Vol/bind 44
Udgave nummer 2
Sider (fra-til) 134-9
Antal sider 6
ISSN 0306-3674
DOI
Status Udgivet - 1 feb. 2010

Dynamic godalinum enhanced magnetic resonance imaging allows accurate assessment of the synovial inflammatory activity in rheumatoid arhritis knee joints. A comparison with synovial histology.

Axelsen, M. B., Stoltenberg, M., Kubassova, O., Boesen, M., Bliddal, H., Hørslev-Petersen, K., Hanson, L. P. G. & Østergaard, M., 2010, I : Annals of the Rheumatic Diseases. 69, 3, s. 347-348 2 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 69
Udgave nummer 3
Sider (fra-til) 347-348
Antal sider 2
ISSN 0003-4967
Status Udgivet - 2010

Effects of nordic walking and exercise in type 2 diabetes mellitus: a randomized controlled trial

Gram, B., Christensen, R., Christiansen, C. H. & Gram, J., 1 sep. 2010, I : Clinical Journal of Sport Medicine. 20, 5, s. 355-61 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Both Nordic walking and Exercise on Prescription have potential as elements in the management of type 2 diabetes mellitus. These programs are recommended, but their effectiveness has not yet been established. The aim was to evaluate the efficacy of these 2 interventions compared with standard information on physical activity.
Originalsprog Engelsk
Tidsskrift Clinical Journal of Sport Medicine
Vol/bind 20
Udgave nummer 5
Sider (fra-til) 355-61
Antal sider 7
ISSN 1050-642X
DOI
Status Udgivet - 1 sep. 2010

Efficacy of abatacept and tocilizumab in rheumatoid arthritis patients treated in clinical practice. Results from the nationwide danish DANBIO registry.

Leffers, H. C., Østergaard, M., Glintborg, B., Krogh, N. S., Henriksen, H. F., Tarp, U., Lorenzen, T., Hansen, A., Hansen, M. S., Jacobsen, M. S. & Hetland, M. L., 2010, I : Arthritis & Rheumatism. 62, 10, s. 754-755 2 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatism
Vol/bind 62
Udgave nummer 10
Sider (fra-til) 754-755
Antal sider 2
ISSN 0004-3591
Status Udgivet - 2010

Ernæringsstatus og -forløb hos apopleksipatienter under rehabilitering

Tolstrup Andersen, U., Skyhøj Olsen, T., Poulsen, I., Fogh Nielsen, M. & Rikardt Andersen, J., 2010, I : Klinisk Sygepleje. 24, 4, s. 4-9 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Originalsprog Dansk
Tidsskrift Klinisk Sygepleje
Vol/bind 24
Udgave nummer 4
Sider (fra-til) 4-9
Antal sider 5
ISSN 0902-2767
Status Udgivet - 2010

Expression of full-length and splice forms of FoxP3 in rheumatoid arthritis

Ryder, L. R., Danielsen, A. L. W., Madsen, H. O., Ødum, N., Ryder, L. P., Bliddal, H., Danneskiold-Samsøe, B., Ribel-Madsen, S. & Bartels, E. M., 1 aug. 2010, I : Scandinavian Journal of Rheumatology. 39, 4, s. 279-86 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of our study was to compare the presence of full-length and alternative splice forms of FoxP3 mRNA in CD4 cells from rheumatoid arthritis (RA) patients and healthy controls.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 39
Udgave nummer 4
Sider (fra-til) 279-86
Antal sider 8
ISSN 0300-9742
DOI
Status Udgivet - 1 aug. 2010

Fatigue in fibromyalgia: a conceptual model informed by patient interviews

Humphrey, L., Arbuckle, R., Mease, P., Williams, D. A., Danneskiold-Samsøe, B. & Gilbert, C., 1 jan. 2010, I : B M C Musculoskeletal Disorders. 11, s. 216

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Fatigue is increasingly recognized as an important symptom in fibromyalgia (FM). Unknown however is how fatigue is experienced by individuals in the context of FM. We conducted qualitative research in order to better understand aspects of fatigue that might be unique to FM as well as the impact it has on patients' lives. The data obtained informed the development of a conceptual model of fatigue in FM.
Originalsprog Engelsk
Tidsskrift B M C Musculoskeletal Disorders
Vol/bind 11
Sider (fra-til) 216
ISSN 1471-2474
DOI
Status Udgivet - 1 jan. 2010

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