Published in 1983

Regulation of regional cerebral blood flow during and between migraine attacks

Lauritzen, M., Olsen, T. S., Lassen, N. A. & Paulson, O. B. nov 1983 I : Annals of Neurology. 14, 5, s. 569-72 4 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Cerebrovascular reactivity to voluntary hyperventilation, moderate hypertension, and physiological activation was studied in nine patients during induced migraine attacks and in four patients between their attacks. Regional cerebral blood flow was measured by the xenon 133 injection technique in 254 areas of one hemisphere. The partly hypoperfused hemisphere allowed for comparison of adjacent hypoperfused and normally perfused brain areas. During attacks the carbon dioxide reactivity was decreased to 2.8 +/- 0.8% per mm Hg in the oligemic regions compared with 5.8 +/- 0.8% per mm Hg in the normally perfused brain. Blood pressure autoregulation was normal in all brain regions. Regional blood flow increase in response to physiological activation was severely impaired in the hypoperfused brain areas, whereas neighboring normally perfused regions reacted normally. Confinement of the regulation abnormalities to the area of the oligemia supports our suggestion that the blood flow changes are caused by a change in local metabolism. Between attacks of migraine, the patients had normal regulation of brain circulation.
Originalsprog Engelsk
Tidsskrift Annals of Neurology
Udgivelsesdato nov 1983
Vol/bind 14
Tidsskriftsnummer 5
Sider 569-72
Antal sider 4
ISSN 0364-5134
DOI
Status Udgivet

Published in 1982

Originalsprog Engelsk
Tidsskrift Journal of Cerebral Blood Flow and Metabolism
Udgivelsesdato 1982
Vol/bind 2 Suppl 1
Sider S35-7
ISSN 0271-678X
Status Udgivet

Left-right cortical asymmetries of regional cerebral blood flow during listening to words

Nishizawa, Y., Olsen, T. S., Larsen, B. & Lassen, N. A. aug 1982 I : Journal of Neurophysiology. 48, 2, s. 458-66 9 s.

Publikation: Forskning - peer reviewTidsskriftartikel

1. Regional cerebral blood flow (rCBF) was measured during rest and during listening to simple words. The xenon-133 intracarotid technique was used and results were obtained from 254 regions of seven right hemispheres and seven left hemispheres. The measurements were performed just after carotid angiography, carried out to exclude space occupying lesions. In all subjects the angiogram was normal. All were right handed. 2. Mean hemispheric blood flow of both left and right hemispheres increased 10% from the resting measurement during the listening task. This increase was due in part to activation of the entire hemisphere. The focal rCBF increases were localized to the superior part of the temporal regions, the prefrontal regions, the frontal eye fields, and the orbitofrontal regions. Significant asymmetries were found in particular in the superior temporal region with the left side showing a more widespread and intense increase, averaging 29% as compared to 18% on the right side. This left-sided dominance during verbal stimulation should be compared to the right-sided dominance of rCBF during nonverbal sound discrimination reported by Roland et al. (25, 26), who used precisely the same technique as in the present study.
Originalsprog Engelsk
Tidsskrift Journal of Neurophysiology
Udgivelsesdato aug 1982
Vol/bind 48
Tidsskriftsnummer 2
Sider 458-66
Antal sider 9
ISSN 0022-3077
Status Udgivet

Published in 1981

Estrogens and portal hypertension in cirrhosis of the liver

Gluud, C., Henriksen, H. H. & Svenstrup, B. 1 jan. 1981 I : New England Journal of Medicine. 304, 1, s. 52

Publikation: Forskning - peer reviewTidsskriftartikel

Originalsprog Engelsk
Tidsskrift New England Journal of Medicine
Vol/bind 304
Tidsskriftsnummer 1
Sider (fra-til) 52
ISSN 0028-4793
DOI
Status Udgivet - 1 jan. 1981

Focal cerebral hyperemia in acute stroke. Incidence, pathophysiology and clinical significance

Olsen, T. S., Larsen, B., Skriver, E. B., Herning, M., Enevoldsen, E. & Lassen, N. A. 1981 I : Stroke. 12, 5, s. 598-607 10 s.

Publikation: Forskning - peer reviewTidsskriftartikel

In a consecutive study comprising 41 patients with completed stroke of less than 72 hours duration, cerebral angiography and measurements of the regional cerebral blood flow (rCBF) were performed within 24 hours after admission. The rCBF study was done using the 133-Xenon intracarotid injection method and a 254 multi-detector camera. CT scan was done 24 hours after the rCBF study. Focal cerebral hyperemia was found in 16 patients. The study revealed 3 different types of hyperemia: Border-zone hyperemia, surrounding ischemic areas, was seen in patients with occluded arteries on angiography, presumably resulting from accumulation of acid metabolites in the border-zone of acute infarcts. Postischemic hyperemia was seen in patients without occlusion, presumably due to recanalization of a prior occluded artery. Remote hyperemia was found distant from the infarcted area, presumably due to local tissue pressure on brain tissue. Cortical infarcts (10 patients) all had extensive hyperemic areas. Because the 254 detector camera has an excellent resolution in the cortical surface, our findings strongly suggest that all acute cerebral infarcts are, in fact, associated with hyperemic areas. The hyperemic areas are often extensive and vascular reactivity is commonly impaired. It is suggested that treatment aimed at reducing blood flow in hyperemic areas might improve prognosis.
Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato 1981
Vol/bind 12
Tidsskriftsnummer 5
Sider 598-607
Antal sider 10
ISSN 0039-2499
Status Udgivet

The possible role of hypertension on rCBF in acute stroke

Olsen, T. S., Larsen, B., Skriver, E. B., Herning, M., Enevoldsen, E. & Lassen, N. A. 1981 I : Journal of Cerebral Blood Flow and Metabolism. s. 508-9 2 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Originalsprog Engelsk
Tidsskrift Journal of Cerebral Blood Flow and Metabolism
Sider (fra-til) 508-9
Antal sider 2
ISSN 0271-678X
Status Udgivet - 1981

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