Published in 2012

Efficacy and safety og low energy diets in the treatment of older obese individuals.

Christensen, P., 2012, 1 udg. Freeriksberg: Eget Forlag. 74 s.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

Bidragets oversatte titel Indflydelse af vægttab eller træning på brusk hos overvægtige patienter med knæosteoartrose
Originalsprog Engelsk
Udgivelses sted Freeriksberg
Forlag Eget Forlag
Vol/bind 1
Udgave 1
Antal sider 74
ISBN (Trykt) 978-87-7611-539-5
Status Udgivet - 2012

Experimental knee joint pain during strength training and muscle strength gain in healthy subjects: a randomized controlled trial

Sørensen, T. J., Jørgensen, H. L., Hodges, P. W., Bliddal, H. & Henriksen, M., 2012, I : Arthritis Care & Research. 64, 1, s. 108-16 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Knee joint pain and reduced quadriceps strength are cardinal symptoms in many knee pathologies. In people with painful knee pathologies, quadriceps exercise reduces pain, improves physical function, and increases muscle strength. A general assumption is that pain compromises muscle function and thus may prevent effective rehabilitation. This study evaluated the effects of experimental knee joint pain during quadriceps strength training on muscle strength gain in healthy individuals.
Originalsprog Engelsk
Tidsskrift Arthritis Care & Research
Vol/bind 64
Udgave nummer 1
Sider (fra-til) 108-16
Antal sider 9
ISSN 2151-464X
DOI
Status Udgivet - 2012

Explaining poorer stroke outcomes in women: women surviving 3 months have more severe strokes than men despite a lower 3-month case fatality

Olsen, T. S., Andersen, Z. J. & Andersen, K. K., 2012, I : Gender Medicine. 9, 3, s. 147-53 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Women who survive stroke are more disabled and more often institutionalized than men.
Originalsprog Engelsk
Tidsskrift Gender Medicine
Vol/bind 9
Udgave nummer 3
Sider (fra-til) 147-53
Antal sider 7
ISSN 1550-8579
DOI
Status Udgivet - 2012

Feasibility of a standardized ultrasound examination in patients with rheumatoid arthritis: a quality improvement among rheumatologists cohort

Ellegaard, K., Torp-Pedersen, S., Christensen, R., Stoltenberg, M. B., Hansen, A., Lorenzen, T., Lindegaard, H., Juul, L., Rogind, H., Bulow, P., Cheysides, S., Kowalski, M. R., Danneskiold-Samsoe, B., Bliddal, H. & Jensen, D. V., 2012, I : B M C Musculoskeletal Disorders. 13, 1, s. 35

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

ABSTRACT: BACKGROUND: Quality improvement is important to facilitate valid patient outcomes. Standardized examination procedures may improve the validity of US. The aim of this study was to investigate the learning progress for rheumatologists during training of US examination of the hand in patients with rheumatoid arthritis (RA). METHODS: Rheumatologists with varying degrees of experience in US were instructed by skilled tutors. The program consisted of two days with hands-on training followed by personal US examinations performed in their individual clinics. Examinations were sent to the tutors for quality control. The US examinations were evaluated according to a scoring sheet containing 144 items. An acceptable examination was defined as >80% correct scores. RESULTS: Thirteen rheumatologists participated in the study. They included a total of 104 patients with RA. Only few of the initial examinations were scored below 80%, and as experience increased, the scores improved (p = 0.0004). A few participants displayed decreasing scores. The mean time spent performing the standardized examination procedure decreased from 34 min to less than 10 minutes (p = 0.0001). CONCLUSION: With systematic hands-on training, a rheumatologist can achieve a high level of proficiency in the conduction of US examinations of the joints of the hand in patients with RA. With experience, examination time decreases, while the level of correctness is maintained. The results indicate that US may be applied as a valid measurement tool suitable for clinical practice and in both single- and multi-centre trials.
Originalsprog Engelsk
Tidsskrift B M C Musculoskeletal Disorders
Vol/bind 13
Udgave nummer 1
Sider (fra-til) 35
ISSN 1471-2474
DOI
Status Udgivet - 2012
Our aim was to elucidate the relative amount of the different splice forms of FoxP3 mRNA in CD4+ T cells in peripheral blood (PB) compared to synovial fluid (SF) in RA and PsA patients. FoxP3 mRNA was measured using a quantitative real-time PCR method. CD4+ T cells were isolated from 17 paired samples of PB and SF from RA and PsA patients, and PB from 10 controls. FoxP3fl and FoxP3Δ2 mRNA was significantly increased (6.7 and 2.1-fold, respectively) in PB CD4+ T cells from RA patients compared to controls. FoxP3fl and Δ2 mRNA in SF CD4+ T cells was increased compared to controls in sero-negative RA and PsA, but not in sero-positive RA patients, who had a high FoxP3 expression in both PB and SF. The FoxP3Δ2Δ7 mRNA was barely detectable in patient samples, and not at all in healthy individuals. We provide evidence of an increased expression of FoxP3 splice forms in synovial CD4+ T cells from RA patients. A skewed, high expression profile of FoxP3, but not CTLA-4, in sero-negative RA and PsA, indicates that synovial CD4+ T cells may represent unique subsets of T cells which have been induced locally or selectively recruited to the joint.
Originalsprog Engelsk
Tidsskrift A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Vol/bind 120
Udgave nummer 5
Sider (fra-til) 387-96
Antal sider 10
ISSN 0903-4641
DOI
Status Udgivet - 2012

Generaliserede smertetilstande

Amris, K. & Danneskiold-Samsøe, B., 2012, Reumatologi. 3 udg. København: FADL's Forlag, Bind 1. s. 393-404 12 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiUndervisning

Originalsprog Dansk
Titel Reumatologi
Antal sider 12
Vol/bind 1
Udgivelses sted København
Forlag FADL's Forlag
Publikationsdato 2012
Udgave 3
Sider 393-404
Kapitel 25
ISBN (Trykt) 978-87-7749-604-2
Status Udgivet - 2012
To evaluate the reliability and agreement of semi-quantitative scoring (SQS) and quantitative scoring (QS) systems. To compare the two types of scoring system and investigate the construct validity for both scoring systems.
Originalsprog Engelsk
Tidsskrift Rheumatology
Vol/bind 51
Udgave nummer 11
Sider (fra-til) 2034-8
Antal sider 5
ISSN 1462-0324
DOI
Status Udgivet - 2012

Higher Blood Glucose within the Normal Range Is Associated with More Severe Strokes

Martin, R. J., Ratan, R. R., Reding, M. J. & Olsen, T. S., 2012, I : Stroke Research and Treatment. 2012, s. 659610

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Background. Higher fasting blood glucose (FBG) concentrations in the hyperglycemic range are associated with more severe strokes. Whether this association also extends into patients with FBG in the normoglycemic range is unclear. We studied the association of stroke severity and FBG in normoglycemic patients with ischemic stroke in a median of 7 days after stroke when the initial glycemic stress response has resolved. Method and Material. Included were 361 nondiabetic ischemic stroke patients with admission fasting blood glucose within 70-130 mg/dL admitted into an acute stroke rehabilitation unit in a median of 7 days after stroke. Data including neuroimaging, vital signs, cardiovascular risk factors, and admission functional independence measure (AFIM) were recorded prospectively. Results. FBG correlated with stroke severity in the normoglycemic 70-130 mg/dL range (FBG-AFIM correlation coefficient -0.17; P = 0.003). Odds ratio for more severe injury (below average AFIM score) was 2.02 for patients with FBG 110-130 mg/dL compared to FBG 70-90 mg/dL (95% confidence interval 1.10-3.73, P = 0.022). Each mg/dL increase in FBG was associated with an average decrease of 0.25 FIM points. In a multiple linear regression model, FBG was associated with more severe stroke (P = 0.002). Conclusion. One week after ischemic stroke, FBG within the normoglycemic range was associated with stroke severity.
Originalsprog Engelsk
Tidsskrift Stroke Research and Treatment
Vol/bind 2012
Sider (fra-til) 659610
ISSN 2042-0056
DOI
Status Udgivet - 2012

Identifying core domains to assess flare in rheumatoid arthritis: an OMERACT international patient and provider combined Delphi consensus

Bartlett, S. J., Hewlett, S., Bingham, C. O., Woodworth, T. G., Alten, R., Pohl, C., Choy, E. H., Sanderson, T., Boonen, A., Bykerk, V., Leong, A. L., Strand, V., Furst, D. E., Christensen, R. & OMERACT RA Flare Working Group, 2012, I : Annals of the Rheumatic Diseases. 71, 11, s. 1855-60 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

For rheumatoid arthritis (RA), there is no consensus on how to define and assess flare. Variability in flare definitions impairs understanding of findings across studies and limits ability to pool results. The OMERACT RA Flare Group sought to identify domains to define RA flares from patient and healthcare professional (HCP) perspectives.
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 71
Udgave nummer 11
Sider (fra-til) 1855-60
Antal sider 6
ISSN 0003-4967
DOI
Status Udgivet - 2012

Implications for Knee Osteoarthritis and Plantar Heel Pain.

Henriksen, M., LB, J. & Aaboe, J., 2012, I : Current Obesity Reports. 1, 3, s. 160-5 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Current Obesity Reports
Vol/bind 1
Udgave nummer 3
Sider (fra-til) 160-5
Antal sider 5
Status Udgivet - 2012
Obese subjects are commonly deficient in several micronutrients. Weight loss, although beneficial, may also lead to adverse changes in micronutrient status and body composition. The objective of the study is to assess changes in micronutrient status and body composition in obese individuals after a dietary weight loss program.
Originalsprog Engelsk
Tidsskrift European Journal of Clinical Nutrition
Vol/bind 66
Udgave nummer 4
Sider (fra-til) 504-9
Antal sider 6
ISSN 0954-3007
DOI
Status Udgivet - 2012

Indirect treatment comparison of abatacept with methotrexate versus other biologic agents for active rheumatoid arthritis despite methotrexate therapy in the United kingdom

Guyot, P., Taylor, P. C., Christensen, R., Pericleous, L., Drost, P., Eijgelshoven, I., Bergman, G. & Lebmeier, M., 2012, I : Journal of Rheumatology. 39, 6, s. 1198-206 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To compare the efficacy of abatacept and alternative biologic disease-modifying antirheumatic drugs (DMARD) in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX) in the United Kingdom.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 39
Udgave nummer 6
Sider (fra-til) 1198-206
Antal sider 9
ISSN 0315-162X
DOI
Status Udgivet - 2012

MRI in Knee Osteoarthritis: Application in diet intervention

Gudbergsen, H., 2012, 1 udg. Frederiksberg: Eget Forlag. 69 s.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

Originalsprog Engelsk
Udgivelses sted Frederiksberg
Forlag Eget Forlag
Vol/bind 1
Udgave 1
Antal sider 69
Status Udgivet - 2012

Pain and fatigue in chronic noncancer pain patients: How strong is the relationship?

Kendall, S., Holm, NR., Højsted, J., Nielsen, P. R., Jensen, N-H. & Sjøgren, P., 2012.

Publikation: KonferencebidragPosterForskningpeer review

Originalsprog Engelsk
Publikationsdato 2012
Status Udgivet - 2012
Begivenhed 14th World Congress on Pain : International Association for the Study of Pain - Milano, Italien
Varighed: 27 aug. 201231 aug. 2012

Konference

Konference 14th World Congress on Pain
Land Italien
By Milano
Periode 27/08/201231/08/2012

Psoriatic arthritis - a follow-up study applying dynamic MRI, conventional MRI and clinical measures

Poggenborg, R. P., Bøyesen, P., Wiell, C., Pedersen, S. J., Sørensen, I. J., Madsen, O. R., Slot, O., Møller, J. M., Boesen, M., Bliddal, H., Kubassova, O. & Østergaard, M., 2012, I : Annals of the Rheumatic Diseases. 71, 3 suppl., s. 711 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 71
Udgave nummer 3 suppl.
Sider (fra-til) 711
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2012
Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatism
Vol/bind S451-2
Udgave nummer 2
Sider (fra-til) S451-2
Antal sider 2
ISSN 0004-3591
Status Udgivet - 2012

Residential radon and lung cancer incidence in a Danish cohort

Bräuner, E. V., Andersen, C. E., Sørensen, M., Andersen, Z. J., Gravesen, P., Ulbak, K., Hertel, O., Pedersen, C., Overvad, K., Tjønneland, A. & Raaschou-Nielsen, O., okt. 2012, I : Environmental Research. 118, s. 130-6 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

High-level occupational radon exposure is an established risk factor for lung cancer. We assessed the long-term association between residential radon and lung cancer risk using a prospective Danish cohort using 57,053 persons recruited during 1993-1997. We followed each cohort member for cancer occurrence until 27 June 2006, identifying 589 lung cancer cases. We traced residential addresses from 1 January 1971 until 27 June 2006 and calculated radon at each of these addresses using information from central databases regarding geology and house construction. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for lung cancer risk associated with residential radon exposure with and without adjustment for sex, smoking variables, education, socio-economic status, occupation, body mass index, air pollution and consumption of fruit and alcohol. Potential effect modification by sex, traffic-related air pollution and environmental tobacco smoke was assessed. Median estimated radon was 35.8 Bq/m(3). The adjusted IRR for lung cancer was 1.04 (95% CI: 0.69-1.56) in association with a 100 Bq/m(3) higher radon concentration and 1.67 (95% CI: 0.69-4.04) among non-smokers. We found no evidence of effect modification. We find a positive association between radon and lung cancer risk consistent with previous studies but the role of chance cannot be excluded as these associations were not statistically significant. Our results provide valuable information at the low-level radon dose range.

Originalsprog Engelsk
Tidsskrift Environmental Research
Vol/bind 118
Sider (fra-til) 130-6
Antal sider 7
ISSN 0013-9351
DOI
Status Udgivet - okt. 2012

Separation of active early rheumatoid arthritis patients and healthy controls by conventional and dynamic contrast-enhanced MRI.

Axelsen, M. B., Ejbjerg, B., Hetland, M. L., Hørslev-Petersen, K., Lauridsen, U. B., Majgaard, O., Boesen, M., Kubassova, O., Bliddal, H. & Østergaard, M., 2012, I : Scandinavian Journal of Rheumatology. Supplement. 41, 126 suppl., s. 28-9 2 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Bogserie Scandinavian Journal of Rheumatology. Supplement
Vol/bind 41
Udgave nummer 126 suppl.
Sider (fra-til) 28-9
Antal sider 2
ISSN 0301-3847
Status Udgivet - 2012

Statistical principles for prospective study protocols: design, analysis, and reporting

Christensen, R. & Langberg, H., 2012, I : International journal of sports physical therapy. 7, 5, s. 504-11 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In the design of scientific studies it is essential to decide on which scientific questions one aims to answer, just as it is important to decide on the correct statistical methods to use to answer these questions. The correct use of statistical methods is crucial in all aspects of research to quantify relationships in data. Despite an increased focus on statistical content and complexity of biomedical research these topics remain difficult for most researchers. Statistical methods enable researchers to condense large spreadsheets with data into means, proportions, and difference between means, risk differences, and other quantities that convey information. One of the goals in biomedical research is to develop parsimonious models - meaning as simple as possible. This approach is valid if the subsequent research report (the article) is written independent of whether the results are "statistically significant" or not. In the present paper we outline the considerations and suggestions on how to build a trial protocol, with an emphasis on having a rigorous protocol stage, always leading to a full article manuscript, independent of statistical findings. We conclude that authors, who find (rigorous) protocol writing too troublesome, will realize that they have already written the first half of the final paper if they follow these recommendations; authors simply need to change the protocols future tense into past tense. Thus, the aim of this clinical commentary is to describe and explain the statistical principles for trial protocols in terms of design, analysis, and reporting of findings.
Originalsprog Engelsk
Tidsskrift International journal of sports physical therapy
Vol/bind 7
Udgave nummer 5
Sider (fra-til) 504-11
Antal sider 8
Status Udgivet - 2012

Stroke and long-term exposure to outdoor air pollution from nitrogen dioxide: a cohort study

Andersen, Z. J., Kristiansen, L. C., Andersen, K. K., Olsen, T. S., Hvidberg, M., Jensen, S. S., Ketzel, M., Loft, S., Sørensen, M., Tjønneland, A., Overvad, K. & Raaschou-Nielsen, O., 2012, I : Stroke. 43, 2, s. 320-5 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Years of exposure to tobacco smoke substantially increase the risk for stroke. Whether long-term exposure to outdoor air pollution can lead to stroke is not yet established. We examined the association between long-term exposure to traffic-related air pollution and incident and fatal stroke in a prospective cohort study.
Originalsprog Engelsk
Tidsskrift Stroke
Vol/bind 43
Udgave nummer 2
Sider (fra-til) 320-5
Antal sider 6
ISSN 0039-2499
DOI
Status Udgivet - 2012

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