Published in 1991

Isokinetic and isometric muscle strength combined with transcutaneous electrical muscle stimulation in primary fibromyalgia syndrome

Jacobsen, S., Wildschiødtz, G. & Danneskiold-Samsøe, B. sep. 1991 I : Journal of Rheumatology. 18, 9, s. 1390-3 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Twenty women with primary fibromyalgia syndrome and 20 age matched healthy women were investigated. The subjects performed maximum voluntary isokinetic contractions of the right quadriceps in an isokinetic dynamometer. Maximum voluntary isometric contractions of the right quadriceps were performed with superimposed transcutaneous electrical stimulation. The examination protocol was repeated after 1 h of resting. Isokinetic and isometric muscle strength was found to be, respectively, 45% (p = 0.0001) and 44% (p = 0.0001) lower in the patient group compared to the healthy subjects. The frequency of superimposed twitches was 65% in the patient group and 15% in the control group (p = 0.003). Patients with primary fibromyalgia have a lower maximum voluntary muscle strength than expected. The increased presence of superimposed electrically elicited twitches during maximum voluntary contraction indicates submaximal force application in primary fibromyalgia syndrome.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 18
Tidsskriftsnummer 9
Sider (fra-til) 1390-3
Antal sider 4
ISSN 0315-162X
Status Udgivet - sep. 1991

Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation

Jacobsen, S., Danneskiold-Samsøe, B. & Andersen, R. B. 1991 I : Scandinavian Journal of Rheumatology. 20, 4, s. 294-302 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

S-adenosylmethionine is a relatively new anti-inflammatory drug with analgesic and anti-depressant effects. Efficacy of 800 mg orally administered s-adenosylmethionine daily versus placebo for six weeks was investigated in 44 patients with primary fibromyalgia in double-blind settings. Tender point score, isokinetic muscle strength, disease activity, subjective symptoms (visual analog scale), mood parameters and side effects were evaluated. Improvements were seen for clinical disease activity (P = 0.04), pain experienced during the last week (P = 0.002), fatigue (P = 0.02), morning stiffness (P = 0.03) and mood evaluated by Face Scale (P = 0.006) in the actively treated group compared to placebo. The tender point score, isokinetic muscle strength, mood evaluated by Beck Depression Inventory and side effects did not differ in the two treatment groups. S-adenosylmethionine has some beneficial effects on primary fibromyalgia and could be an important option in the treatment hereof.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 20
Tidsskriftsnummer 4
Sider (fra-til) 294-302
Antal sider 9
ISSN 0300-9742
Status Udgivet - 1991

Radiologic manifestations of focal cerebral hyperemia in acute stroke

Olsen, T. S., Skriver, E. B. & Herning, M. mar. 1991 I : Acta Radiologica. 32, 2, s. 100-4 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In 16 acute stroke patients with focal cerebral hyperemia angiography and regional cerebral blood flow (rCBF) were studied 1 to 4 days post stroke. CT was performed twice with and without contrast enhancement 3 +/- 1 days and 16 +/- 4 days post stroke. Angiographic evidence of focal cerebral hyperemia was seen in 8 patients in the form of early filling veins. In 5 of these the hyperemic areas were located within infarcted areas and in 3 patients in areas which appeared normal on CT. In the remaining 8 patients the hyperemias were located perifocally around ischemic infarcts. Early filling veins were not seen in this type of hyperemia. The blood flow was higher and the transit time of the contrast medium was faster in the former type of hyperemia probably because of arteriovenous shunting. Contrast enhancement was not observed on the early CT but was typically seen in the infarcts on the late CT at a time when the hyperemic state is known to have vanished. It is concluded that focal cerebral hyperemia is not responsible for contrast enhancement on CT.

Originalsprog Engelsk
Tidsskrift Acta Radiologica
Vol/bind 32
Tidsskriftsnummer 2
Sider (fra-til) 100-4
Antal sider 5
ISSN 0284-1851
Status Udgivet - mar. 1991

Single cell morphology of muscle in patients with chronic muscle pain

Jacobsen, S., Bartels, E. M. & Danneskiold-Samsøe, B. 1991 I : Scandinavian Journal of Rheumatology. 20, 5, s. 336-43 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In 119 patients referred with suspected fibromyalgia, biopsies from the quadriceps muscle were analyzed for "rubber band" morphology, and isokinetic quadriceps strength was measured. Eighty-four fulfilled the criteria for fibromyalgia, 26 had chronic myofascial pain (CMP) and 9 had other diseases including 5 with concomitant fibromyalgia. Twenty-four CMP patients and 48 fibromyalgia patients were randomly selected to match with regard to sex, age, smoking and drinking habits. "Rubber band" morphology was blindly graded on a biopsy score scale from 0 to 2. A statistically significant difference in biopsy score was found between the two matched groups (P = 0.003); median biopsy score in fibromyalgia was 0.42 and 0.25 in CMP. A cut-off value at 0.33 gave a specificity of 71% and a sensitivity of 63%. Isokinetic muscle strength did not differ in the fibromyalgia and CMP groups and was not related to the biopsy score. "Rubber band" morphology is seen more often in fibromyalgia patients than in CMP patients. The exact genesis of this phenomenon is still unknown but theories connected with the possible pathogenesis of the syndrome are presented.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 20
Tidsskriftsnummer 5
Sider (fra-til) 336-43
Antal sider 8
ISSN 0300-9742
Status Udgivet - 1991

Published in 1990

Advances in Pain research and Therapy Volume 17

Andersen, R. B., Jacobsen, S., Danneskiold-Samsøe, B. & Bartels, E. M. 1990 Advances in Pain research and Therapy Volume 17. Bind 296-76

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

Originalsprog Engelsk
Titel Advances in Pain research and Therapy Volume 17
Vol/bind 296-76
Publikationsdato 1990
Status Udgivet - 1990

Migraeneauraen--karsygdom eller neuronsygdom?

Olsen, T. S., Friberg, L. & Lassen, N. A. 21 maj 1990 I : Ugeskrift for Laeger. 152, 21, s. 1507-9 3 s.

Publikation: Forskning - peer reviewTidsskriftartikel

During the migraine-aura cerebral blood flow (CBF) is reduced in areas corresponding to the neurological deficits and symptoms. Whether this CBF reduction is the primary cause of the neurological deficits (the vascular theory) or a secondary result of primary neuronal dysfunction in particular "spreading depression" (SD) (the neurogenic theory) is still under discussion. The latter theory is supported by CBF investigations performed during attacks of migraine with aura (MA). The CBF reduction was found to be modest (20-35%) and not sufficient to cause ischemia which usually demands reduction of CBF by more than 50%. In addition the low-flow area appeared to "spreading" in the same manner as that seen in SD in the rat ("spreading oligemia"). Recent studies indicate, however, that the CBF reduction in most cases, after all, is sufficient to cause ischemia and that "spreading oligemia" might be an artifact caused by "scattered radiation". Persistent neurological deficits, EEG abnormalities and infarcts on CT-scans are seen after MA, thus further supporting the theory of vascular dysfunction (vasospasm) and ischemia as the cause of the migraine-aura.
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Udgivelsesdato 21 maj 1990
Vol/bind 152
Tidsskriftsnummer 21
Sider 1507-9
Antal sider 3
ISSN 0041-5782
Status Udgivet

Primary fibromyalgia: clinical parameters in relation to serum procollagen type III aminoterminal peptide

Jacobsen, S., Jensen, L. T., Foldager, M. V. & Danneskiold-Samsøe, B. jun. 1990 I : British Journal of Rheumatology. 29, 3, s. 174-7 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Serum concentrations of procollagen type III aminoterminal peptide have previously been reported to be low in some patients with primary fibromyalgia and the aim of this study was to determine if such patients differ clinically from primary fibromyalgia patients with normal levels of procollagen type III aminoterminal peptide. Subjective symptoms, tender points and dynamic muscle strength in 45 women with primary fibromyalgia were related to serum concentrations of procollagen type III aminoterminal peptide. Patients with low serum concentrations of procollagen type III aminoterminal peptide had more symptoms, a higher frequency of tender points and lesser quality of sleep compared to patients with normal serum concentrations of procollagen type III aminoterminal peptide (P less than 0.05). They also had a lower dynamic muscle strength (P less than 0.0005). We conclude that the serum concentrations of procollagen type III aminoterminal peptide of primary fibromyalgia patients are connected to the disease impact.
Originalsprog Engelsk
Tidsskrift British Journal of Rheumatology
Vol/bind 29
Tidsskriftsnummer 3
Sider (fra-til) 174-7
Antal sider 4
ISSN 0263-7103
Status Udgivet - jun. 1990

Screening for autoantibodies in patients with primary fibromyalgia syndrome and a matched control group

Jacobsen, S., Høyer-Madsen, M., Danneskiold-Samsøe, B. & Wiik, A. jul. 1990 I : APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 98, 7, s. 655-8 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Primary fibromyalgia syndrome (PFS) is a non-articular rheumatic condition characterized by chronic muscular pain. We have performed screening for autoantibodies in 20 women with PFS and in 19 age-matched healthy women. Fifty-five percent of the PFS patients had anti-smooth muscle antibodies and 40% had anti-striated muscle antibodies. None of the control subjects had any muscle antibodies. There was no significant difference in frequency of the remaining autoantibodies between the groups investigated. The present study indicates autoimmune responses in PFS against antigens of the diseased tissue itself, a finding which may be secondary to the disease or have relevance to the still obscure pathogenesis of the syndrome.
Originalsprog Engelsk
Tidsskrift APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Vol/bind 98
Tidsskriftsnummer 7
Sider (fra-til) 655-8
Antal sider 4
ISSN 0903-4641
Status Udgivet - jul. 1990

Severe non-occlusive ischemic stroke in young heroid addicts

Jensen, R., Olsen, T. S. & Winther, BB. 1990 I : Acta Neurologica Scandinavica. s. 354-7 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Dansk
Tidsskrift Acta Neurologica Scandinavica
Sider (fra-til) 354-7
Antal sider 4
ISSN 0001-6314
Status Udgivet - 1990

Surecut 0.6 mm liver biopsy in the diagnosis of cirrhosis

Torp-Pedersen, S., Vyberg, M., Smith, E., Højgaard, L., Hansen, U., Stadeager, C., Schlichting, P., Juul, N. & Gluud, C. aug. 1990 I : Liver. 10, 4, s. 217-20 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Liver biopsy with the 0.6 mm (23 gauge) Surecut needle was compared to conventional Menghini biopsy in the diagnosis of cirrhosis. Seventy-seven consecutive patients (mainly alcoholics) with a clinical indication for liver biopsy had both biopsies performed simultaneously. In 71 patients sufficient material for a morphological diagnosis concerning liver architecture was obtained with both biopsy techniques (Surecut insufficient in 5 cases and Menghini insufficient in 2 cases). The biopsies were classified as cirrhosis or non-cirrhosis. There was agreement in 69 cases (97%, confidence limits 90-100%). Using the result of the Menghini biopsy as the final diagnosis, the predictive values for a positive and negative diagnosis for the Surecut needle were 96% and 98%, respectively. There were no complications to either of the biopsies. It is suggested that the 0.6 mm Surecut biopsy may be used in the diagnosis of cirrhosis in cases where conventional Menghini needle biopsy is contraindicated.
Originalsprog Engelsk
Tidsskrift Liver
Vol/bind 10
Tidsskriftsnummer 4
Sider (fra-til) 217-20
Antal sider 4
ISSN 0106-9543
Status Udgivet - aug. 1990
Originalsprog Engelsk
Tidsskrift Annals of Neurology
Udgivelsesdato 1990
Sider 791-8
Antal sider 8
ISSN 0364-5134
Status Udgivet
Ten years of study has resulted in considerable but fragmented knowledge about regional cerebral blood flow in migraine with aura (classic migraine). In the present study, the number of repeatedly studied patients (n = 63) was large enough to determine statistically significant sequences of events and statistically significant spatial relations. The first observable event was a decrease of regional cerebral blood flow posteriorly in one cerebral hemisphere. Further development of this pathological process was accompanied by the aura symptoms. Thereafter headache occurred while regional cerebral blood flow remained decreased. During the headache phase, regional cerebral blood flow gradually changed from abnormally low to abnormally high without apparent change in headache. In some patients headache disappeared while regional cerebral blood flow remained increased. Although regional cerebral blood flow reduction and aura symptoms in the great majority of patients were unilateral, one-third had bilateral headache. Unilateral headache usually localized to the side on which regional cerebral blood flow was reduced and from which the aura symptoms originated (i.e., aura symptoms were perceived to occur contralaterally but presumably originated in the hypoperfused hemisphere). Our results suggest a simple model for migraine attacks: A pathological disturbance in one cerebral hemisphere causes the aura symptoms and after a time delay, it also causes the headache by stimulating local vascular nociceptors. Bilateral headache caused by a unilateral cerebral disturbance may be explained by recent neuroanatomical and neurophysiological findings.
Originalsprog Engelsk
Tidsskrift Annals of Neurology
Udgivelsesdato dec 1990
Vol/bind 28
Tidsskriftsnummer 6
Sider 791-8
Antal sider 8
ISSN 0364-5134
DOI
Status Udgivet

Transperineal seed-implantation guided by biplanar transrectal ultrasound

Holm, H. H., Torp-Pedersen, S. & Myschetzky, P. 1990 I : Urology. 36, 3, s. 249-52 4 s.

Publikation: Forskning - peer reviewTidsskriftartikel

A new method for precise transperineal placement of therapeutic sources in prostatic cancer is described. The method is a modification of the technique described in 1983 by Holm and coworkers. Insertion of needles is monitored by transverse as well as longitudinal transrectal ultrasound.
Originalsprog Engelsk
Tidsskrift Urology
Udgivelsesdato 1990
Vol/bind 36
Tidsskriftsnummer 3
Sider 249-52
Antal sider 4
ISSN 0090-4295
Status Udgivet

Published in 1989

Patients with polymyositis show changes in muscle protein charges

Bartels, E. M., Jacobsen, S., Rasmussen, L. & Danneskiold-Samsøe, B. dec. 1989 I : Journal of Rheumatology. 16, 12, s. 1542-4 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Polymyositis (PM) appears with indolent proximal muscle weakness and is an inflammatory disease with breakdown of muscle cells. In our study the protein charge concentrations of the contractile proteins in the A and I bands were determined, applying a microelectrode technique. Patients with PM show a lower protein charge concentration than healthy control subjects which may be caused by the breakdown and removal of the proteins in the contractile filaments. A tool to judge the state of the disease as well as an aid in diagnosis may have been found in this method.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 16
Tidsskriftsnummer 12
Sider (fra-til) 1542-4
Antal sider 3
ISSN 0315-162X
Status Udgivet - dec. 1989

Published in 1987

Epilepsy after stroke

Olsen, T. S., Høgenhaven, H. & Thage, O. 1987 I : Neurology. 37, 7, s. 1209-11 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Development of epilepsy was studied prospectively in a group of 77 consecutive stroke patients. Included were stroke patients less than 75 years old admitted within the first 3 days after the stroke. Excluded were patients with subarachnoid hemorrhage, vertebrobasilar stroke, and patients with other severe diseases. Cerebral angiography, CT, and EEG were performed in all patients. The patients were followed clinically for 2 to 4 years. Seven patients (9%) developed epilepsy. Of 23 patients with lesions involving the cortex, 6 (26%) developed epilepsy. Of 54 patients in whom the cortex was not involved, only 1 (2%) developed epilepsy. Patients with persisting paresis and cortical involvement seem to be at particularly high risk of developing epilepsy, as 50% of such patients (6 of 12) developed the disease.
Originalsprog Engelsk
Tidsskrift Neurology
Vol/bind 37
Tidsskriftsnummer 7
Sider (fra-til) 1209-11
Antal sider 3
ISSN 0028-3878
Status Udgivet - 1987

Establishment of the relative antiinflammatory potency of deflazacort and prednisone in polymyalgia rheumatica

Lund, B., Egsmose, C., Jørgensen, S. & Krogsgaard, M. R. dec. 1987 I : Calcified Tissue International. 41, 6, s. 316-320 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Conventional glucocorticoids exert a negative influence on calcium balance, and long-term treatment with these agents leads to osteopenia. Deflazacort is an oxazoline derivative of prednisolone with documented calcium-sparing properties when compared to prednisone on a weight basis. The purpose of the present study was to determine the relative antiinflammatory potency of deflazacort and prednisone. In a randomized, cross-over, double-blind trial, 11 patients, all suffering from polymyalgia rheumatica, and all on a stable maintenance dose of prednisone, were treated with equimolar doses of prednisone and deflazacort (i.e., weight ratio 1:1.2) for two consecutive 2-week periods. Following deflazacort treatment, significant rises compared with initial values were seen in erythrocyte sedimentation rate (ESR), plasma fibrinogen, serum alkaline phosphatase, and general pain and tenderness. No changes were seen following prednisone treatment. Subsequently, in a similar regimen, prednisone was compared with deflazacort at a weight ratio of 1:1.2 in 10 patients, 1:1.5 in another 10 patients, and 1:1.8 in still another 10 patients for purposes of dose titration. Again, significant rises were seen in ESR, plasma fibrinogen, and serum alkaline phosphatase following the lowest dose of deflazacort, whereas no changes were seen following the higher doses of deflazacort or prednisone. In conclusion, the relative antiinflammatory potency of deflazacort and prednisone lies between 0.83 and 0.66 on a weight basis (1.02 and 0.82 on a molar basis) as evaluated by clinical and biochemical parameters reflecting disease activity in polymyalgia. This disease appears to represent a sensitive, reliable and reproducible clinical model for assessment of the relative antiinflammatory potency of glucocorticoids.

Originalsprog Engelsk
Tidsskrift Calcified Tissue International
Vol/bind 41
Tidsskriftsnummer 6
Sider (fra-til) 316-320
Antal sider 5
ISSN 0171-967X
Status Udgivet - dec. 1987

Focal ischaemia caused by instability of cerebrovascular tone during attacks of hemiplegic migraine. A regional cerebral blood flow study

Friberg, L., Olsen, T. S., Roland, P. E. & Lassen, N. A. aug 1987 I : Brain. 110 ( Pt 4), s. 917-34 18 s.

Publikation: Forskning - peer reviewTidsskriftartikel

During the course of hemiplegic migraine in 3 patients, changes in regional cerebral blood flow (rCBF) were recorded by the intracarotid 133Xe method and a 254 multidetector camera covering one hemisphere. The rCBF measurements were performed in conjunction with cerebral angiography. During repeated rCBF measurements all 3 patients developed focal hypoperfusion originating in the frontal lobe, subsequently spreading posteriorly to involve the precentral and postcentral regions. In 2 cases focal hyperperfusion appeared to precede the hypoperfusion. In association with the rCBF changes the patients developed transient motor and/or sensory deficits and subsequently severe headache. No signs of arterial occlusion were found. In the over and underperfused regions blood flow fluctuated rapidly because of instability of cerebrovascular tone, defined as transient constriction of the smallest cerebral vessels (arterioles) alternating with a normal calibre for these vessels and/or short periods of vasodilatation. It is considered to be a primary pathological condition of the vessels. When vasoconstriction was present the blood flow decreased to values consistent with ischaemia, which was probably the cause of the neurological deficits. On the basis of these observations and previous work from our laboratory we conclude that instability of cerebrovascular tone may cause focal ischaemia during the course of attacks of classical and hemiplegic migraine.
Originalsprog Engelsk
Tidsskrift Brain
Udgivelsesdato aug 1987
Vol/bind 110 ( Pt 4)
Sider 917-34
Antal sider 18
ISSN 0006-8950
Status Udgivet
A common complaint among patients with fibrositis syndrome is exhaustion and fatique. It was therefore felt desirable to evaluate the muscle strength of these patients compared with normal subjects. Maximum isometric and isokinetic strength of knee extension was measured in 15 patients and 15 healthy matched subjects, using an isokinetic dynamometer (Cybex II). Maximum isometric strength at various knee extension angles (90 degrees, 60 degrees and 30 degrees degrees) was significantly (p less than 0.001) lower in the fibrositis group than in controls, a reduction of approximately 58-66%. Maximum isokinetic strength at various knee extension velocities (30-240 degrees per second) was also significantly (p less than 0.01) lower in the fibrositis group than in controls, the reduction being approximately 41-51%. In conclusion, isometric and isokinetic muscle strength is found to be lower in patients with fibrositis syndrome than in healthy subjects.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 16
Tidsskriftsnummer 1
Sider (fra-til) 61-5
Antal sider 5
ISSN 0300-9742
Status Udgivet - 1987

Published in 1985

Cerebral blood flow by xenon-133 washout: Tomographic/nontomographic metods compared

Kastrup, J., Olsen, T. S., Christensen, J., Sugiyama, H., Parving, H-H. & Lassen, N. A. 1985 I : Journal of Cerebral Blood Flow and Metabolism. s. 653-4 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Journal of Cerebral Blood Flow and Metabolism
Sider (fra-til) 653-4
Antal sider 2
ISSN 0271-678X
Status Udgivet - 1985

Focal increase of blood flow in the cerebral cortex of man during vestibular stimulation

Friberg, L., Olsen, T. S., Roland, P. E., Paulson, O. B. & Lassen, N. A. sep 1985 I : Brain. 108 ( Pt 3), s. 609-23 15 s.

Publikation: Forskning - peer reviewTidsskriftartikel

This study is an attempt to reveal projection areas for vestibular afferents to the human brain. Changes in regional cerebral blood flow (rCBF) were measured over 254 cortical regions during caloric vestibular stimulation with warm water (44 degrees C). rCBF was measured when the external auditory meatus was irrigated with water at body temperature as a control to vestibular stimulation. During vestibular stimulation there was only a single cortical area, located in the superior temporal region, which showed a consistent focal activation in the hemisphere contralateral to the stimulated side. On the rCBF display this area was located in the superior temporal region posterior to the auditory area, probably in the superior temporal gyrus. It is suggested that this area represents the primary projection area of the vestibular nerve and that it is the activation of this area during caloric stimulation that gives rise to the associated conscious vestibular sensation of vertigo.
Originalsprog Engelsk
Tidsskrift Brain
Udgivelsesdato sep 1985
Vol/bind 108 ( Pt 3)
Sider 609-23
Antal sider 15
ISSN 0006-8950
Status Udgivet

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