Published in 2011

Predictors of early and late case-fatality in a nationwide Danish study of 26,818 patients with first-ever ischemic stroke

Andersen, K. K., Andersen, Z. J. & Olsen, T. S., 2011, I : Stroke. 42, 10, s. 2806-12 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Predictors of early case-fatality (3-day, 7-day, and 30-day) in first-ever ischemic stroke were identified and compared with predictors of late case-fatality (90-day and 1-year).
Originalsprog Engelsk
Tidsskrift Stroke
Vol/bind 42
Udgave nummer 10
Sider (fra-til) 2806-12
Antal sider 7
ISSN 0039-2499
DOI
Status Udgivet - 2011
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 70
Udgave nummer 3 (Suppl.)
Sider (fra-til) 114
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2011
To study the predictive value of baseline radiographs and low-field (0.2T) MRI scans for the symptomatic outcome of clinically significant weight loss in obese patients with knee osteoarthritis.
Originalsprog Engelsk
Tidsskrift B M C Musculoskeletal Disorders
Vol/bind 12
Sider (fra-til) 56
ISSN 1471-2474
DOI
Status Udgivet - 1 jan. 2011

Rehabilitering

Wæhrens, E. E., Amris, K. & Lund, H., 2011, Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1. s. 373-381 9 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 9
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 373-381
Kapitel 24
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Rehabilitering af den reumatologiske patient

Amris, K. & Lund, H., 2011, Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1. s. 393-405 13 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 13
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 393-405
Kapitel 26
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients

Ge, H-Y., Wang, Y., Fernández-de-las-Peñas, C., Graven-Nielsen, T., Danneskiold-Samsøe, B. & Arendt-Nielsen, L., 2011, I : Arthritis Research & Therapy. 13, 2, s. R48

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

It has previously been reported that local and referred pain from active myofascial trigger points (MTPs) in the neck and shoulder region contribute to fibromyalgia (FM) pain and that the pain pattern induced from active MTPs can reproduce parts of the spontaneous clinical FM pain pattern. The current study investigated whether the overall spontaneous FM pain pattern can be reproduced by local and referred pain from active MTPs located in different muscles.
Originalsprog Engelsk
Tidsskrift Arthritis Research & Therapy
Vol/bind 13
Udgave nummer 2
Sider (fra-til) R48
ISSN 1478-6354
DOI
Status Udgivet - 2011
Originalsprog Engelsk
Tidsskrift Pain
Vol/bind 152
Udgave nummer 7
Sider (fra-til) 1685-1686
ISSN 0304-3959
DOI
Status Udgivet - 2011

Reumatoid artrit

Danneskiold-Samsøe, B. & Herlin, T., 2011, Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1. s. 135-172 38 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 38
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 135-172
Kapitel 11
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Rheumatoid factor and its interference with cytokine measurements: problems and solutions

Bartels, E. M., Falbe Wätjen, I., Littrup Andersen, E., Danneskiold-Samsøe, B., Bliddal, H. & Ribel-Madsen, S., 2011, I : Arthritis Today. 2011, s. 741071

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Use of cytokines as biomarkers for disease is getting more widespread. Cytokines are conveniently determined by immunoassay, but interference from present antibodies is known to cause problems. In rheumatoid arthritis (RA), interference of rheumatoid factor (RF) may be problematic. RF covers a group of autoantibodies from immunoglobulin subclasses and is present in 65-80% of RA patients. Partly removal of RF is possible by precipitation. This study aims at determining the effects of presence of RF in blood and synovial fluid on cytokine measurements in samples from RA patients and finding possible solutions for recognized problems. IL-1β, IL-4, IL-6, and IL-8 were determined with multiplex immunoassays (MIA) in samples from RA patients prior to and after polyethylene glycol (PEG 6000) precipitation. Presence of RF does interfere with MIA. PEG 6000 precipitation abolishes this RF interference. We recommend PEG precipitation for all immunoassay measurements of plasma samples from RA patients.
Originalsprog Engelsk
Tidsskrift Arthritis Today
Vol/bind 2011
Sider (fra-til) 741071
ISSN 0969-7039
DOI
Status Udgivet - 2011

Slidgigt (artrose, osteoartrose), Unrinsyregigt (artritis urica)

Bliddal, H., Christensen, R. D. K. & Christensen, P., 2011, Adipositas. Svendsen, O. L., Astrup, A. V. & Hansen, G. S. (red.). 1 udg. København, Bind 1. s. 78-82 5 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Adipositas
Redaktører Ole Lander Svendsen, Arne Vernon Astrup, Gitte Stage Hansen
Antal sider 5
Vol/bind 1
Udgivelses sted København
Publikationsdato 2011
Udgave 1
Sider 78-82
Kapitel 13
ISBN (Trykt) 9788762809666
Status Udgivet - 2011
ABSTRACT: BACKGROUND: To compare data based on touch screen to data based on traditional paper versions of questionnaires frequently used to examine patient reported outcomes in knee osteoarthritis patients and to examine the impact of patient characteristics on this comparison METHODS: Participants were recruited from an ongoing trial (ClinicalTrials.Gov Identifier: NCT00655941). 20 female participants, mean age 67 (SD 7), completed KOOS, VAS pain, function and patient global, SF-36, Physical Activity Scale, painDETECT, and the ADL Taxonomy. Patients were randomly assigned to one of two subgroups, completing either the paper or touch screen version first. Mean, mean differences (95% CI), median, median differences and Intraclass Correlation Coefficients (ICCs) were calculated for all questionnaires. RESULTS: ICCs between data based on computerized and paper versions ranged from 0.86 to 0.99. Analysis revealed a statistically significant difference between versions of the ADL Taxonomy, but not for the remaining questionnaires. Age, computer experience or education-level had no significant impact on the results. The computerized questionnaires were reported to be easier to use. CONCLUSION: The computerized questionnaires gave comparable results to answers given on paper. Patient characteristics did not influence results and implementation was feasible.
Originalsprog Engelsk
Tidsskrift B M C Musculoskeletal Disorders
Vol/bind 12
Udgave nummer 1
Sider (fra-til) 190
ISSN 1471-2474
DOI
Status Udgivet - 18 aug. 2011
Cross-sectional study.
Originalsprog Engelsk
Tidsskrift The Journal of orthopaedic and sports physical therapy
Vol/bind 41
Udgave nummer 8
Sider (fra-til) 592-9
Antal sider 8
DOI
Status Udgivet - 1 jan. 2011

The Copenhagen Hip and Groin Outcome Score (HAGOS): development and validation according to the COSMIN checklist

Thorborg, K., Hölmich, P., Christensen, R., Petersen, J. & Roos, E. M., 1 maj 2011, I : British Journal of Sports Medicine. 45, 6, s. 478-91 14 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Valid, reliable and responsive Patient-Reported Outcome (PRO) questionnaires for young to middle-aged, physically active individuals with hip and groin pain are lacking.
Originalsprog Engelsk
Tidsskrift British Journal of Sports Medicine
Vol/bind 45
Udgave nummer 6
Sider (fra-til) 478-91
Antal sider 14
ISSN 0306-3674
DOI
Status Udgivet - 1 maj 2011

The effects of rose hip (Rosa canina) on plasma antioxidative activity and C-reactive protein in patients with rheumatoid arthritis and normal controls: A prospective cohort study

Kirkeskov, B., Christensen, R., Bügel, S. G., Bliddal, H., Danneskiold-Samsøe, B., Christensen, L. P. & Andersen, J. R., 17 mar. 2011, I : Phytomedicine. 18, 11, s. 953-958

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVES: Rose hip (Rosa canina) has been used as an herbal remedy against a wide range of ailments including inflammatory disorders. The anti-inflammatory and antioxidant properties of rose hips have been evaluated in vitro and active constituents have been isolated. Rose hip contains antioxidant nutrients and an anti-inflammatory galactolipid. Rheumatoid arthritis (RA) is an inflammatory disease where activated cells release reactive oxygen substances. Thus it could be relevant to investigate if rose hip had an anti-inflammatory and/or antioxidant effect in this situation. METHODS: In this open case-control study 20 female patients with RA and 10 female controls were given 10.5g rose hip powder daily (Litozin(®)) for 28 days. Blood samples were analysed at baseline and follow-up for the capacity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase and the inflammatory marker C-reactive protein (CRP). The participants kept a food diary for the first 3 days and the last 3 days of the intervention period. The RA-patients completed The Stanford Health Assessment Questionnaire at baseline and follow-up. RESULTS: CRP-concentrations of both patients and healthy controls did not change. Nor was any effect found on the activity of antioxidant enzymes. There was no difference in food intake at baseline, but in the last week the RA-group reduced their energy intake. CONCLUSIONS: 10.5g Litozin(®) in 28 days had neither effect on clinical symptoms or laboratory measurements in patients with RA or healthy controls. This is in contrast to previous intervention studies with rose hip powder that found a reduction in the concentration of CRP. The results of the present study indicate that a daily amount of approximately 10g rose hip powder for one month has no anti-inflammatory and/or antioxidant effect.
Originalsprog Engelsk
Tidsskrift Phytomedicine
Vol/bind 18
Udgave nummer 11
Sider (fra-til) 953-958
ISSN 0944-7113
DOI
Status Udgivet - 17 mar. 2011

The Influence of Radiographic Severity on the Relationship between Muscle Strength and Joint Loading in Obese Knee Osteoarthritis Patients

Aaboe, J., Bliddal, H., Alkjaer, T., Boesen, M. & Henriksen, M., 2011, I : Arthritis Today. 2011, s. 571519

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Objective. To investigate the relationship between knee muscle strength and the external knee adduction moment during walking in obese knee osteoarthritis patients and whether disease severity influences this relationship. Methods. This cross-sectional study included 136 elderly obese (BMI > 30) adults with predominant medial knee osteoarthritis. Muscle strength, standing radiographic severity as measured by the Kellgren and Lawrence scale, and the peak external knee adduction moment were measured at self-selected walking speed. Results. According to radiographic severity, patients were classified as "less severe" (KL 1-2, N = 73) or "severe" (KL 3-4, N = 63). A significant positive association was demonstrated between the peak knee adduction moment and hamstring muscle strength in the whole cohort (P = .047). However, disease severity did not influence the relationship between muscle strength and dynamic medial knee joint loading. Severe patients had higher peak knee adduction moment and more varus malalignment (P <.001). Conclusion. Higher hamstring muscle strength relates to higher estimates of dynamic knee joint loading in the medial compartment. No such relationship existed for quadriceps muscle strength. Although cross sectional, the results suggest that hamstrings function should receive increased attention in future studies and treatments that aim at halting disease progression.
Originalsprog Engelsk
Tidsskrift Arthritis Today
Vol/bind 2011
Sider (fra-til) 571519
ISSN 0969-7039
DOI
Status Udgivet - 2011

The navicular position test - a reliable measure of the navicular bone position during rest and loading

Spörndly-Nees, S., Dåsberg, B., Nielsen, R. O., Boesen, M. I. & Jørgensen, H. L., 2011, I : International journal of sports physical therapy. 6, 3, s. 199-205 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Lower limb injuries are a large problem in athletes. However, there is a paucity of knowledge on the relationship between alignment of the medial longitudinal arch (MLA) of the foot and development of such injuries. A reliable and valid test to quantify foot type is needed to be able to investigate the relationship between arch type and injury likelihood. Feiss Line is a valid clinical measure of the MLA. However, no study has investigated the reliability of the test.
Originalsprog Engelsk
Tidsskrift International journal of sports physical therapy
Vol/bind 6
Udgave nummer 3
Sider (fra-til) 199-205
Antal sider 7
Status Udgivet - 2011

The number needed to treat for second-generation biologics when treating established rheumatoid arthritis: a systematic quantitative review of randomized controlled trials

Kristensen, L. E., Jakobsen, A. K., Bartels, E. M., Geborek, P., Bliddal, H., Saxne, T., Danneskiold-Samsøe, B. & Christensen, R., 2011, I : Scandinavian Journal of Rheumatology. 40, 1, s. 1-7 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To evaluate the number needed to treat (NNT) and the number needed to harm (NNH) of the second-generation biologics abatacept, certolizumab, golimumab, rituximab, and tocilizumab in patients with established rheumatoid arthritis (RA) taking concomitant methotrexate (MTX).
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 40
Udgave nummer 1
Sider (fra-til) 1-7
Antal sider 7
ISSN 0300-9742
DOI
Status Udgivet - 2011

The role of Campylobacter jejuni cytolethal distending toxin in gastroenteritis: toxin detection, antibody production, and clinical outcome

Mortensen, N. P., Schiellerup, P., Boisen, N., Klein, B. M., Locht, H., Abuoun, M., Newell, D. & Krogfelt, K. A. 2011 I : A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 119, 9, s. 626-34 9 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The role of Campylobacter jejuni cytolethal distending toxin (CDT) on clinical outcome after gastroenteritis was investigated. Clinical data, blood serum samples, and Campylobacter spp. isolated, from each of 30 patients were collected over a period of 6 months. The CDT encoding genes, cdtABC, characterized by PCR, revealed that all but one of the C. jejuni strains had the wild-type sequence. Sequencing of cdtABC from this strain showed two major deletions. From all of the strains, CDT titers were determined, and toxin neutralizing antibodies were documented using an in vitro assay. Three of the thirty clinical isolates, including the one with the mutant cdtABC coding genes, did not have a detectable CDT activity. Analyzing the relationship between CDT titer, serum neutralization of CDT, and the clinical outcome showed that campylobacteriosis caused by CDT-negative strains was clinically indistinguishable from that of patients infected with an isolate that produced high levels of CDT. These results suggest that CDT does not solely determine severity of infection and clinical outcome.
Originalsprog Engelsk
Tidsskrift A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
Udgivelsesdato 2011
Vol/bind 119
Tidsskriftsnummer 9
Sider 626-34
Antal sider 9
ISSN 0903-4641
DOI
Status Udgivet

Toward Development of a Fibromyalgia Responder Index and Disease Activity Score: OMERACT Module Update

Mease, P. J., Clauw, D. J., Christensen, R., Crofford, L. J., Gendreau, R. M., Martin, S. A., Simon, L. S., Strand, V., Williams, D. A., Arnold, L. M. & the OMERACT Fibromyalgia Working Group, 1 jul. 2011, I : Journal of Rheumatology. 38, 7, s. 1487-1495 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Following development of the core domain set for fibromyalgia (FM) in Outcome Measures in Rheumatology Clinical Trials (OMERACT) meetings 7 to 9, the FM working group has progressed toward the development of an FM responder index and a disease activity score based on these domains, utilizing outcome indices of these domains from archived randomized clinical trials in FM. Possible clinical domains that could be included in a responder index and disease activity score include pain, fatigue, sleep disturbance, cognitive dysfunction, mood disturbance, tenderness, stiffness, and functional impairment. Outcome measures for these domains demonstrate good to adequate psychometric properties, although measures of cognitive dysfunction need to be further developed. The approach used in the development of responder indices and disease activity scores for rheumatoid arthritis and ankylosing spondylitis represents heuristic models for our work, but FM is challenging in that there is no clear algorithm of treatment that defines disease activity based on treatment decisions, nor are there objective markers that define thresholds of severity or response to treatment. The process of developing candidate dichotomous responder definitions and continuous quantitative disease activity measures is described, along with participant discussions from OMERACT 10. Final results of this work will be published in a separate report pending completion of analyses.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 38
Udgave nummer 7
Sider (fra-til) 1487-1495
Antal sider 9
ISSN 0315-162X
DOI
Status Udgivet - 1 jul. 2011
To investigate disease activity, treatment response, and drug survival, and predictors thereof, among Danish patients with psoriatic arthritis (PsA) receiving their first treatment series with a tumor necrosis factor α (TNFα) inhibitor.
Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatism
Vol/bind 63
Udgave nummer 2
Sider (fra-til) 382-90
Antal sider 9
ISSN 0004-3591
DOI
Status Udgivet - 1 feb. 2011

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