Published in 1992

Eight stroke patients were examined serially in the acute phase and 1 week and 2-4 weeks after stroke with water-suppressed proton magnetic resonance spectroscopy. The time courses of lactate level and regional cerebral blood flow were studied. A high lactate level was found in the acute phase. The lactate content decreased to barely detectable levels during the following 3 weeks, while regional blood flow increased during this period. The inverse relationship between lactate level and cerebral blood flow suggests that lactate plays no substantial role in the vasodilatation underlying the hyperemia that follows reperfusion. The amount of lactate present in the acute phase reflects the severity of ischemia in the affected region. The lactate level was still above normal in the subacute phase with hyperemia, suggesting lactate production through aerobic glycolysis. Thus, the lactate level in the subacute phase probably does not reflect the degree of anaerobic glycolysis in hypoxic neuronal tissue.

Originalsprog Engelsk
Tidsskrift Journal of Magnetic Resonance Imaging
Udgivelsesdato 1 sep 1992
Vol/bind 2
Tidsskriftsnummer 5
Sider 511-517
Antal sider 7
ISSN 1053-1807
Status Udgivet

Consensus on fibromyalgia. Preliminary draft.

Kamper-Jørgensen, F., Jacobsen, S., Danneskiold-Samsøe, B. & Bartels, E. M. 1992 Consensus on fibromyalgia. Preliminary draft..

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Engelsk
Titel Consensus on fibromyalgia. Preliminary draft.
Publikationsdato 1992
Status Udgivet - 1992

Dynamic muscular endurance in primary fibromyalgia compared with chronic myofascial pain syndrome

Jacobsen, S. & Danneskiold-Samsøe, B. feb. 1992 I : Archives of Physical Medicine and Rehabilitation. 73, 2, s. 170-3 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The objective of the study was to quantify the voluntary dynamic muscular endurance (DME) in patients with primary fibromyalgia (PF) since easy fatigability of muscles is one of the major symptoms in this syndrome. Consecutive outpatients referred to a rheumatology clinic specializing in PF were investigated. Thirty-six patients with PF were compared with 18 patients with chronic myofascial pain (CMP) syndrome. Subjects were matched according to gender, age, height, weight, peak torque, and contractional work. The DME was defined as the number of repeated knee extensions necessary for the contractional work in two successive knee extensions to be equal to or below 70% of the initial value measured with an isokinetic dynamometer. A significantly lower DME was found in the PF group than in the CMP group: 11 (7-13) and 18 (11-25), respectively (median and quartiles), p less than .005. Patients with PF have a low voluntary muscular endurance compared to CMP patients.
Originalsprog Engelsk
Tidsskrift Archives of Physical Medicine and Rehabilitation
Vol/bind 73
Tidsskriftsnummer 2
Sider (fra-til) 170-3
Antal sider 4
ISSN 0003-9993
Status Udgivet - feb. 1992

BACKGROUND AND PURPOSE: The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy.

METHODS: Eight patients with acute stroke were studied serially in the acute phase, 1 week after, and 2-4 weeks after the onset of clinical symptoms. Ten healthy volunteers served as controls. A stimulated echo (STEAM) sequence was used for measurement of the brain metabolites in a volume of interest located within the infarcted area as visualized by magnetic resonance imaging. For quantification, the unsaturated water signal was used as the internal standard. Regional cerebral blood flow in the infarcted area was measured relative to a symmetrically located unaffected area by means of single-photon emission computed tomographic scanning, using 99mTc-labeled d,l-hexamethylenepropyleneamine oxime as the flow tracer.

RESULTS: Relative regional cerebral blood flow was considerably reduced in the infarcted area in the acute phase. After 1 week, hyperemia was seen in all but one patient. The N-acetylaspartate content was significantly reduced, with the loss appearing to occur between 6 and 24 hours after the stroke incident. The reduction in N-acetylaspartate content was greater in the central part than in the peripheral part of the infarcted area. Creatine and phosphocreatine were also reduced in the infarcted area, whereas no significant change was seen in the choline content.

CONCLUSIONS: Assuming that N-acetylaspartate content reflects neuronal survival or loss, our results may suggest that treatment procedures with restoration of blood flow to severely ischemic areas should be initiated within the first 6 hours after stroke onset.

Originalsprog Engelsk
Tidsskrift Stroke; a journal of cerebral circulation
Udgivelsesdato nov 1992
Vol/bind 23
Tidsskriftsnummer 11
Sider 1566-72
Antal sider 7
ISSN 0039-2499
Status Udgivet

BACKGROUND AND PURPOSE: The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy.

METHODS: Eight patients with acute stroke were studied serially in the acute phase, 1 week after, and 2-4 weeks after the onset of clinical symptoms. Ten healthy volunteers served as controls. A stimulated echo (STEAM) sequence was used for measurement of the brain metabolites in a volume of interest located within the infarcted area as visualized by magnetic resonance imaging. For quantification, the unsaturated water signal was used as the internal standard. Regional cerebral blood flow in the infarcted area was measured relative to a symmetrically located unaffected area by means of single-photon emission computed tomographic scanning, using 99mTc-labeled d,l-hexamethylenepropyleneamine oxime as the flow tracer.

RESULTS: Relative regional cerebral blood flow was considerably reduced in the infarcted area in the acute phase. After 1 week, hyperemia was seen in all but one patient. The N-acetylaspartate content was significantly reduced, with the loss appearing to occur between 6 and 24 hours after the stroke incident. The reduction in N-acetylaspartate content was greater in the central part than in the peripheral part of the infarcted area. Creatine and phosphocreatine were also reduced in the infarcted area, whereas no significant change was seen in the choline content.

CONCLUSIONS: Assuming that N-acetylaspartate content reflects neuronal survival or loss, our results may suggest that treatment procedures with restoration of blood flow to severely ischemic areas should be initiated within the first 6 hours after stroke onset.

Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato nov 1992
Vol/bind 23
Tidsskriftsnummer 11
Sider 1566-1572
Antal sider 7
ISSN 0039-2499
Status Udgivet

Fibromyalgia and magnesia

Prescott, E., Nørrgård, J., Rotbøl Pedersen, L. & Danneskiold-Samsøe, B. 1992 I : Scandinavian Journal of Rheumatology. 21, 4, s. 206

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 21
Tidsskriftsnummer 4
Sider (fra-til) 206
ISSN 0300-9742
Status Udgivet - 1992

Published in 1991

Isokinetic and isometric muscle strength combined with transcutaneous electrical muscle stimulation in primary fibromyalgia syndrome

Jacobsen, S., Wildschiødtz, G. & Danneskiold-Samsøe, B. sep. 1991 I : Journal of Rheumatology. 18, 9, s. 1390-3 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Twenty women with primary fibromyalgia syndrome and 20 age matched healthy women were investigated. The subjects performed maximum voluntary isokinetic contractions of the right quadriceps in an isokinetic dynamometer. Maximum voluntary isometric contractions of the right quadriceps were performed with superimposed transcutaneous electrical stimulation. The examination protocol was repeated after 1 h of resting. Isokinetic and isometric muscle strength was found to be, respectively, 45% (p = 0.0001) and 44% (p = 0.0001) lower in the patient group compared to the healthy subjects. The frequency of superimposed twitches was 65% in the patient group and 15% in the control group (p = 0.003). Patients with primary fibromyalgia have a lower maximum voluntary muscle strength than expected. The increased presence of superimposed electrically elicited twitches during maximum voluntary contraction indicates submaximal force application in primary fibromyalgia syndrome.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 18
Tidsskriftsnummer 9
Sider (fra-til) 1390-3
Antal sider 4
ISSN 0315-162X
Status Udgivet - sep. 1991

Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation

Jacobsen, S., Danneskiold-Samsøe, B. & Andersen, R. B. 1991 I : Scandinavian Journal of Rheumatology. 20, 4, s. 294-302 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

S-adenosylmethionine is a relatively new anti-inflammatory drug with analgesic and anti-depressant effects. Efficacy of 800 mg orally administered s-adenosylmethionine daily versus placebo for six weeks was investigated in 44 patients with primary fibromyalgia in double-blind settings. Tender point score, isokinetic muscle strength, disease activity, subjective symptoms (visual analog scale), mood parameters and side effects were evaluated. Improvements were seen for clinical disease activity (P = 0.04), pain experienced during the last week (P = 0.002), fatigue (P = 0.02), morning stiffness (P = 0.03) and mood evaluated by Face Scale (P = 0.006) in the actively treated group compared to placebo. The tender point score, isokinetic muscle strength, mood evaluated by Beck Depression Inventory and side effects did not differ in the two treatment groups. S-adenosylmethionine has some beneficial effects on primary fibromyalgia and could be an important option in the treatment hereof.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 20
Tidsskriftsnummer 4
Sider (fra-til) 294-302
Antal sider 9
ISSN 0300-9742
Status Udgivet - 1991

Radiologic manifestations of focal cerebral hyperemia in acute stroke

Olsen, T. S., Skriver, E. B. & Herning, M. mar. 1991 I : Acta Radiologica. 32, 2, s. 100-4 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In 16 acute stroke patients with focal cerebral hyperemia angiography and regional cerebral blood flow (rCBF) were studied 1 to 4 days post stroke. CT was performed twice with and without contrast enhancement 3 +/- 1 days and 16 +/- 4 days post stroke. Angiographic evidence of focal cerebral hyperemia was seen in 8 patients in the form of early filling veins. In 5 of these the hyperemic areas were located within infarcted areas and in 3 patients in areas which appeared normal on CT. In the remaining 8 patients the hyperemias were located perifocally around ischemic infarcts. Early filling veins were not seen in this type of hyperemia. The blood flow was higher and the transit time of the contrast medium was faster in the former type of hyperemia probably because of arteriovenous shunting. Contrast enhancement was not observed on the early CT but was typically seen in the infarcts on the late CT at a time when the hyperemic state is known to have vanished. It is concluded that focal cerebral hyperemia is not responsible for contrast enhancement on CT.

Originalsprog Engelsk
Tidsskrift Acta Radiologica
Vol/bind 32
Tidsskriftsnummer 2
Sider (fra-til) 100-4
Antal sider 5
ISSN 0284-1851
Status Udgivet - mar. 1991

Single cell morphology of muscle in patients with chronic muscle pain

Jacobsen, S., Bartels, E. M. & Danneskiold-Samsøe, B. 1991 I : Scandinavian Journal of Rheumatology. 20, 5, s. 336-43 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In 119 patients referred with suspected fibromyalgia, biopsies from the quadriceps muscle were analyzed for "rubber band" morphology, and isokinetic quadriceps strength was measured. Eighty-four fulfilled the criteria for fibromyalgia, 26 had chronic myofascial pain (CMP) and 9 had other diseases including 5 with concomitant fibromyalgia. Twenty-four CMP patients and 48 fibromyalgia patients were randomly selected to match with regard to sex, age, smoking and drinking habits. "Rubber band" morphology was blindly graded on a biopsy score scale from 0 to 2. A statistically significant difference in biopsy score was found between the two matched groups (P = 0.003); median biopsy score in fibromyalgia was 0.42 and 0.25 in CMP. A cut-off value at 0.33 gave a specificity of 71% and a sensitivity of 63%. Isokinetic muscle strength did not differ in the fibromyalgia and CMP groups and was not related to the biopsy score. "Rubber band" morphology is seen more often in fibromyalgia patients than in CMP patients. The exact genesis of this phenomenon is still unknown but theories connected with the possible pathogenesis of the syndrome are presented.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 20
Tidsskriftsnummer 5
Sider (fra-til) 336-43
Antal sider 8
ISSN 0300-9742
Status Udgivet - 1991

Published in 1990

Advances in Pain research and Therapy Volume 17

Andersen, R. B., Jacobsen, S., Danneskiold-Samsøe, B. & Bartels, E. M. 1990 Advances in Pain research and Therapy Volume 17. Bind 296-76

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

Originalsprog Engelsk
Titel Advances in Pain research and Therapy Volume 17
Vol/bind 296-76
Publikationsdato 1990
Status Udgivet - 1990

Migraeneauraen--karsygdom eller neuronsygdom?

Olsen, T. S., Friberg, L. & Lassen, N. A. 21 maj 1990 I : Ugeskrift for Laeger. 152, 21, s. 1507-9 3 s.

Publikation: Forskning - peer reviewTidsskriftartikel

During the migraine-aura cerebral blood flow (CBF) is reduced in areas corresponding to the neurological deficits and symptoms. Whether this CBF reduction is the primary cause of the neurological deficits (the vascular theory) or a secondary result of primary neuronal dysfunction in particular "spreading depression" (SD) (the neurogenic theory) is still under discussion. The latter theory is supported by CBF investigations performed during attacks of migraine with aura (MA). The CBF reduction was found to be modest (20-35%) and not sufficient to cause ischemia which usually demands reduction of CBF by more than 50%. In addition the low-flow area appeared to "spreading" in the same manner as that seen in SD in the rat ("spreading oligemia"). Recent studies indicate, however, that the CBF reduction in most cases, after all, is sufficient to cause ischemia and that "spreading oligemia" might be an artifact caused by "scattered radiation". Persistent neurological deficits, EEG abnormalities and infarcts on CT-scans are seen after MA, thus further supporting the theory of vascular dysfunction (vasospasm) and ischemia as the cause of the migraine-aura.
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Udgivelsesdato 21 maj 1990
Vol/bind 152
Tidsskriftsnummer 21
Sider 1507-9
Antal sider 3
ISSN 0041-5782
Status Udgivet

Primary fibromyalgia: clinical parameters in relation to serum procollagen type III aminoterminal peptide

Jacobsen, S., Jensen, L. T., Foldager, M. V. & Danneskiold-Samsøe, B. jun. 1990 I : British Journal of Rheumatology. 29, 3, s. 174-7 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Serum concentrations of procollagen type III aminoterminal peptide have previously been reported to be low in some patients with primary fibromyalgia and the aim of this study was to determine if such patients differ clinically from primary fibromyalgia patients with normal levels of procollagen type III aminoterminal peptide. Subjective symptoms, tender points and dynamic muscle strength in 45 women with primary fibromyalgia were related to serum concentrations of procollagen type III aminoterminal peptide. Patients with low serum concentrations of procollagen type III aminoterminal peptide had more symptoms, a higher frequency of tender points and lesser quality of sleep compared to patients with normal serum concentrations of procollagen type III aminoterminal peptide (P less than 0.05). They also had a lower dynamic muscle strength (P less than 0.0005). We conclude that the serum concentrations of procollagen type III aminoterminal peptide of primary fibromyalgia patients are connected to the disease impact.
Originalsprog Engelsk
Tidsskrift British Journal of Rheumatology
Vol/bind 29
Tidsskriftsnummer 3
Sider (fra-til) 174-7
Antal sider 4
ISSN 0263-7103
Status Udgivet - jun. 1990

Screening for autoantibodies in patients with primary fibromyalgia syndrome and a matched control group

Jacobsen, S., Høyer-Madsen, M., Danneskiold-Samsøe, B. & Wiik, A. jul. 1990 I : APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 98, 7, s. 655-8 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Primary fibromyalgia syndrome (PFS) is a non-articular rheumatic condition characterized by chronic muscular pain. We have performed screening for autoantibodies in 20 women with PFS and in 19 age-matched healthy women. Fifty-five percent of the PFS patients had anti-smooth muscle antibodies and 40% had anti-striated muscle antibodies. None of the control subjects had any muscle antibodies. There was no significant difference in frequency of the remaining autoantibodies between the groups investigated. The present study indicates autoimmune responses in PFS against antigens of the diseased tissue itself, a finding which may be secondary to the disease or have relevance to the still obscure pathogenesis of the syndrome.
Originalsprog Engelsk
Tidsskrift APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Vol/bind 98
Tidsskriftsnummer 7
Sider (fra-til) 655-8
Antal sider 4
ISSN 0903-4641
Status Udgivet - jul. 1990

Severe non-occlusive ischemic stroke in young heroid addicts

Jensen, R., Olsen, T. S. & Winther, BB. 1990 I : Acta Neurologica Scandinavica. s. 354-7 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Dansk
Tidsskrift Acta Neurologica Scandinavica
Sider (fra-til) 354-7
Antal sider 4
ISSN 0001-6314
Status Udgivet - 1990

Surecut 0.6 mm liver biopsy in the diagnosis of cirrhosis

Torp-Pedersen, S., Vyberg, M., Smith, E., Højgaard, L., Hansen, U., Stadeager, C., Schlichting, P., Juul, N. & Gluud, C. aug. 1990 I : Liver. 10, 4, s. 217-20 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Liver biopsy with the 0.6 mm (23 gauge) Surecut needle was compared to conventional Menghini biopsy in the diagnosis of cirrhosis. Seventy-seven consecutive patients (mainly alcoholics) with a clinical indication for liver biopsy had both biopsies performed simultaneously. In 71 patients sufficient material for a morphological diagnosis concerning liver architecture was obtained with both biopsy techniques (Surecut insufficient in 5 cases and Menghini insufficient in 2 cases). The biopsies were classified as cirrhosis or non-cirrhosis. There was agreement in 69 cases (97%, confidence limits 90-100%). Using the result of the Menghini biopsy as the final diagnosis, the predictive values for a positive and negative diagnosis for the Surecut needle were 96% and 98%, respectively. There were no complications to either of the biopsies. It is suggested that the 0.6 mm Surecut biopsy may be used in the diagnosis of cirrhosis in cases where conventional Menghini needle biopsy is contraindicated.
Originalsprog Engelsk
Tidsskrift Liver
Vol/bind 10
Tidsskriftsnummer 4
Sider (fra-til) 217-20
Antal sider 4
ISSN 0106-9543
Status Udgivet - aug. 1990
Originalsprog Engelsk
Tidsskrift Annals of Neurology
Udgivelsesdato 1990
Sider 791-8
Antal sider 8
ISSN 0364-5134
Status Udgivet
Ten years of study has resulted in considerable but fragmented knowledge about regional cerebral blood flow in migraine with aura (classic migraine). In the present study, the number of repeatedly studied patients (n = 63) was large enough to determine statistically significant sequences of events and statistically significant spatial relations. The first observable event was a decrease of regional cerebral blood flow posteriorly in one cerebral hemisphere. Further development of this pathological process was accompanied by the aura symptoms. Thereafter headache occurred while regional cerebral blood flow remained decreased. During the headache phase, regional cerebral blood flow gradually changed from abnormally low to abnormally high without apparent change in headache. In some patients headache disappeared while regional cerebral blood flow remained increased. Although regional cerebral blood flow reduction and aura symptoms in the great majority of patients were unilateral, one-third had bilateral headache. Unilateral headache usually localized to the side on which regional cerebral blood flow was reduced and from which the aura symptoms originated (i.e., aura symptoms were perceived to occur contralaterally but presumably originated in the hypoperfused hemisphere). Our results suggest a simple model for migraine attacks: A pathological disturbance in one cerebral hemisphere causes the aura symptoms and after a time delay, it also causes the headache by stimulating local vascular nociceptors. Bilateral headache caused by a unilateral cerebral disturbance may be explained by recent neuroanatomical and neurophysiological findings.
Originalsprog Engelsk
Tidsskrift Annals of Neurology
Udgivelsesdato dec 1990
Vol/bind 28
Tidsskriftsnummer 6
Sider 791-8
Antal sider 8
ISSN 0364-5134
DOI
Status Udgivet

Transperineal seed-implantation guided by biplanar transrectal ultrasound

Holm, H. H., Torp-Pedersen, S. & Myschetzky, P. 1990 I : Urology. 36, 3, s. 249-52 4 s.

Publikation: Forskning - peer reviewTidsskriftartikel

A new method for precise transperineal placement of therapeutic sources in prostatic cancer is described. The method is a modification of the technique described in 1983 by Holm and coworkers. Insertion of needles is monitored by transverse as well as longitudinal transrectal ultrasound.
Originalsprog Engelsk
Tidsskrift Urology
Udgivelsesdato 1990
Vol/bind 36
Tidsskriftsnummer 3
Sider 249-52
Antal sider 4
ISSN 0090-4295
Status Udgivet

Published in 1989

Patients with polymyositis show changes in muscle protein charges

Bartels, E. M., Jacobsen, S., Rasmussen, L. & Danneskiold-Samsøe, B. dec. 1989 I : Journal of Rheumatology. 16, 12, s. 1542-4 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Polymyositis (PM) appears with indolent proximal muscle weakness and is an inflammatory disease with breakdown of muscle cells. In our study the protein charge concentrations of the contractile proteins in the A and I bands were determined, applying a microelectrode technique. Patients with PM show a lower protein charge concentration than healthy control subjects which may be caused by the breakdown and removal of the proteins in the contractile filaments. A tool to judge the state of the disease as well as an aid in diagnosis may have been found in this method.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 16
Tidsskriftsnummer 12
Sider (fra-til) 1542-4
Antal sider 3
ISSN 0315-162X
Status Udgivet - dec. 1989

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