Published in 2011

Comparison of the manual and computer-aided techniques for evaluation of wrist synovitis using dynamic contrast-enhanced MRI on a dedicated scanner

Boesen, M., Kubassova, O., Parodi, M., Bliddal, H., Innocenti, S., Garlaschi, G. & Cimmino, M. A. 2011 I : European Journal of Radiology. 77, 2, s. 202-6 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Traditional methods for assessment of synovial inflammation in rheumatoid arthritis such as clinical examination, immunohistology of bioptic samples, scintigraphy, and radiography have several limitations, including lack of sensitivity, need of invasive techniques, and administration of radioactive material. MRI lacks on standardisation and the data are often analysed using laborious, relatively rigid scoring methods.
Originalsprog Engelsk
Tidsskrift European Journal of Radiology
Vol/bind 77
Tidsskriftsnummer 2
Sider (fra-til) 202-6
Antal sider 5
ISSN 0720-048X
DOI
Status Udgivet - 2011
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 70
Tidsskriftsnummer (Suppl. 3)
Sider (fra-til) 548-549
Antal sider 2
ISSN 0003-4967
Status Udgivet - 2011
Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatism
Vol/bind 63
Tidsskriftsnummer 10 (Suppl.)
Sider (fra-til) S370-S371
Antal sider 2
ISSN 0004-3591
Status Udgivet - 2011
The aim of this systematic review and meta-analysis was to summarize the evidence from observational studies assessing the association between intake of trans fatty acids (TFA) and the risk of coronary heart disease (CHD), with a specific emphasis on distinguishing between TFA of industrial and ruminant origin. By searching five bibliographic databases, analyses from six published and two unpublished prospective cohort studies, assessing the association of intake of TFA with fatal and/or non-fatal CHD, were identified. Four and three studies reported separate associations for intake of ruminant or industrial-TFA, respectively. The pooled relative risk estimates for comparison of extreme quintiles of total-TFA intake (corresponding to intake increments ranging from 2.8 to ∼10 g/day) were 1.22 (95% confidence interval: 1.08-1.38; P=0.002) for CHD events and 1.24 (1.07-1.43; P=0.003) for fatal CHD. Ruminant-TFA intake (increments ranging from 0.5 to 1.9 g/day) was not significantly associated with risk of CHD (risk ratio (RR)=0.92 (0.76-1.11); P=0.36), and neither was industrial-TFA intake, although there was a trend towards a positive association (RR=1.21 (0.97-1.50); P=0.09). In conclusion, our analysis suggests that industrial-TFA may be positively related to CHD, whereas ruminant-TFA is not, but the limited number of available studies prohibits any firm conclusions concerning whether the source of TFA is important. The null association of ruminant-TFA with CHD risk may be due to lower intake levels.
Originalsprog Engelsk
Tidsskrift European Journal of Clinical Nutrition
Vol/bind 65
Tidsskriftsnummer 7
Sider (fra-til) 773-83
Antal sider 11
ISSN 0954-3007
DOI
Status Udgivet - 1 jul. 2011

Developing a Construct to Evaluate Flares in Rheumatoid Arthritis: A Conceptual Report of the OMERACT RA Flare Definition Working Group

Alten, R., Choy, E. H., Christensen, R., Furst, D. E., Hewlett, S. E., Leong, A., May, J. E., Sanderson, T. C., Strand, V., Woodworth, T. G., Bingham, C. O. & The OMERACT RA Flare Definition Working Group 1 aug. 2011 I : Journal of Rheumatology. 38, 8, s. 1745-1750 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Rheumatoid arthritis (RA) patients and healthcare professionals (HCP) recognize that episodic worsening disease activity, often described as a "flare," is a common feature of RA that can contribute to impaired function and disability. However, there is no standard definition to enable measurement of its intensity and impact. The conceptual framework of the Outcome Measures in Rheumatology Clinical Trials (OMERACT) RA Flare Definition Working Group includes an anchoring statement, developed at OMERACT 9 in 2008: "flare in RA" is defined as worsening of signs and symptoms of sufficient intensity and duration to lead to change in therapy. Subsequently, domains characterizing flare have been identified by comprehensive literature review, patient focus groups, and patient/HCP Delphi exercises. This led to a consensus regarding preliminary domains and a research agenda at OMERACT 10 in May 2010. The conceptual framework of flare takes into account validated approaches to measurement in RA: (1) various disease activity indices (e.g., Disease Activity Score, Clinical Disease Activity Index, Simplified Disease Activity Index); (2) use of patient-reported outcomes (PRO); and (3) characterization of minimally clinically detectable and important differences (MCDD, MCID). The measurement of RA flare is composed of data collection assessing a range of unique domains describing key features of RA worsening at the time of patient self-report of flare, and then periodically for the duration of the flare. The components envisioned are: (1) Patient self-report using a "patient global question" with well characterized and validated anchors; (2) Patient assessment using a flare questionnaire and PRO available at the time of each self-report; (3) Physician/HCP assessment of disease activity status; and (4) Physician's determination whether to change treatment. In randomized controlled trials and observational studies, such a conceptual approach is intended to lead to a valid measure of this outcome/response, thus expanding an understanding of the true impact of a therapy to limit disease activity. Clinically, this approach is intended to enhance patient-HCP communication. This article describes the conceptual framework being used by the OMERACT RA Flare Definition Working Group in developing a standardized method for description and measurement of "flare in RA" to guide individual patient treatment.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 38
Tidsskriftsnummer 8
Sider (fra-til) 1745-1750
Antal sider 6
ISSN 0315-162X
DOI
Status Udgivet - 1 aug. 2011

Different knee joint loading patterns in ACL deficient copers and non-copers during walking

Eriksen, T. A., Henriksen, M. & Simonsen, E. B. 1 apr. 2011 I : Knee Surgery, Sports Traumatology, Arthroscopy. 19, 4, s. 615-21 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Rupture of the anterior cruciate ligament (ACL) causes changes in the walking pattern. ACL deficient subjects classified as copers and non-copers have been observed to adopt different post-injury walking patterns. How these different patterns affect the knee compression and shear forces is unresolved. Thus, the aim of the present study was to investigate how different walking patterns observed between copers, non-copers, and controls affect the knee compression and shear forces during walking.
Originalsprog Engelsk
Tidsskrift Knee Surgery, Sports Traumatology, Arthroscopy
Vol/bind 19
Tidsskriftsnummer 4
Sider (fra-til) 615-21
Antal sider 7
ISSN 0942-2056
DOI
Status Udgivet - 1 apr. 2011
Dynamic contrast-enhanced MRI in inflammatory arthritis, especially in conjunction with computer-aided analysis using appropriate dedicated software, seems to be a highly sensitive tool for monitoring the early inflammatory treatment response in patients with rheumatoid arthritis. This paper gives a review of the current knowledge of the emerging technique. The potential of the technique is demonstrated and discussed in the context of a case report following the early effect of an intra-articular steroid injection in a patient with rheumatoid arthritis flare in the knee.
Originalsprog Engelsk
Tidsskrift Arthritis News
Vol/bind 2011
Tidsskriftsnummer Article ID 578252
Antal sider 8
ISSN 0144-6339
DOI
Status Udgivet - 2011

Effects of an intensive weight loss program on knee joint loading in obese adults with knee osteoarthritis

Aaboe, J., Bliddal, H., Messier, S. P., Eriksen, T. A. & Henriksen, M. 1 jul. 2011 I : Osteoarthritis and Cartilage. 19, 7, s. 822-8 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikel

To determine the effect of an intensive weight loss program on knee joint loads during walking in obese patients with knee osteoarthritis (OA).
Originalsprog Engelsk
Tidsskrift Osteoarthritis and Cartilage
Vol/bind 19
Tidsskriftsnummer 7
Sider (fra-til) 822-8
Antal sider 7
ISSN 1063-4584
DOI
Status Udgivet - 1 jul. 2011
To describe drug survival, disease activity and clinical response in patients with rheumatoid arthritis (RA) treated with abatacept or tocilizumab in routine care, based on prospectively registered observational data from the nationwide Danish DANBIO registry.
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 70
Tidsskriftsnummer 7
Sider (fra-til) 1216-22
Antal sider 7
ISSN 0003-4967
DOI
Status Udgivet - 2011

Evaluering af rehabilitering ved reumatiske sygdomme

Wæhrens, E. E., Bremander, A. & Christensen, R. D. K. 2011 Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1, s. 339-369 31 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologi

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 31
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 339-369
Kapitel 23
ISBN (Trykt) 9788762806726
Status Udgivet - 2011
Tendon-related injuries are a major problem, but the aetiology of tendinopathies is unknown. In tendinopathies as well as during unaccustomed loading, intra-tendinous flow can be detected indicating that extensive loading can provoke intra-tendinous flow. The aim of present study is to evaluate the vascular response as indicated by colour Doppler (CD) activity in both the Achilles and patella tendon after loading during high-level badminton matches. The Achilles tendon was subdivided into a mid-tendon, pre-insertional, and insertional region and the anterior knee tendons into a quadriceps-, patella- and tuberositas region. Intra-tendinous flow was measured using both a semi-quantitative grading system (CD grading) and a quantitative scoring system (CF) on colour Doppler. Intra-tendinous flow in the Achilles and anterior knee tendons was examined in fourteen single players before tournament and after 1st and 2nd match, respectively on both the dominant and non-dominant side. All players had abnormal intra-tendinous flow (Colour Doppler ≥ grade 2) in at least one tendon in at least one scan during the tournament. At baseline, only two of the 14 players had normal flow in all the tendons examined. After 1st match, tendencies to higher intra-tendinous flow were observed in both the dominant patella tendon and non-dominant quadriceps tendon (P-values n.s.). After 2nd match, intra-tendinous flow was significant increased in the dominant patella tendon (P = 0.009). In all other locations, there was a trend towards a stepwise increase in intra-tendinous flow. The preliminary results indicate that high amount of intra-tendinous flow was found in elite badminton players at baseline and was increased after repetitive loading, especially in the patella tendon (dominant leg). The colour Doppler measurement can be used to determine changes in intra-tendinous flow after repetitive loading.
Originalsprog Engelsk
Tidsskrift Knee Surgery, Sports Traumatology, Arthroscopy
Vol/bind 19
Tidsskriftsnummer 1
Sider (fra-til) 30-7
Antal sider 8
ISSN 0942-2056
DOI
Status Udgivet - 1 jan. 2011

Experimental knee pain reduces muscle strength

Henriksen, M., Mortensen, S. R., Aaboe, J., Nielsen, T. G. & Bliddal, H. 1 apr. 2011 I : Journal of Pain. 12, 4, s. 460-7 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Pain is the principal symptom in knee pathologies and reduced muscle strength is a common observation among knee patients. However, the relationship between knee joint pain and muscle strength remains to be clarified. This study aimed at investigating the changes in knee muscle strength following experimental knee pain in healthy volunteers, and if these changes were associated with the pain intensities. In a crossover study, 18 healthy subjects were tested on 2 different days. Using an isokinetic dynamometer, maximal muscle strength in knee extension and flexion was measured at angular velocities 0, 60, 120, and 180 degrees/second, before, during, and after experimental pain induced by injections of hypertonic saline into the infrapatellar fat pad. On a separate day, isotonic saline injections were used as control condition. The pain intensity was assessed on a 0- to 100-mm visual analogue scale. Knee pain reduced the muscle strength by 5 to 15% compared to the control conditions (P <.001) in both knee extension and flexion at all angular velocities. The reduction in muscle strength was positively correlated to the pain intensity. Experimental knee pain significantly reduced knee extension and flexion muscle strength indicating a generalized muscle inhibition augmented by higher pain intensities. PERSPECTIVE: This study showed that knee joint pain has a significant impact on muscle function. The findings provide evidence of a direct inhibition of muscle function by joint pain, implying that rehabilitative strengthening exercises may be antagonized by joint pain.
Originalsprog Engelsk
Tidsskrift Journal of Pain
Vol/bind 12
Tidsskriftsnummer 4
Sider (fra-til) 460-7
Antal sider 8
ISSN 1526-5900
DOI
Status Udgivet - 1 apr. 2011

Feasibility of a standardized ultrasound examination in patients with rheumatoid arthritis: Quality improvement among rheumatologists

Ellegaard, K., Torp-Pedersen, S. T., Christensen, R. D. K., Stoltenberg, M., Hansen, A., Lorenzen, T., Jensen, D., Juul, L., Lindegaard, H., Røgind, H., Bülow, P., Cheysider, S., Kowalski, M. R., Danneskiold-Samsøe, B. & Bliddal, H. 2011 I : Annals of the Rheumatic Diseases. 70, Suppl. 3, s. 544 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskrift

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 70
Tidsskriftsnummer Suppl. 3
Sider (fra-til) 544
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2011
Originalsprog Engelsk
Tidsskrift Baltic Journal of Comparative & Clinical Systems Biology
Vol/bind 1
Sider (fra-til) 35
Antal sider 44
Status Udgivet - 2011

FoxP3 mRNA splice forms in arthritis patients

Ryder, L. R. 2011 eget forlag.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandling

Originalsprog Engelsk
Udgivelses sted eget forlag
Status Udgivet - 2011

Generelle principper for vurdering af den reumatologiske patient i en rehabliteringskontekst

Amris, K. & Lund, H. 2011 Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1, s. 291-299 9 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologi

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 9
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 291-299
Kapitel 20
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Holistisk-neuropsykologisk genoptræning--dokumentationen mangler

Olsen, T. S. 2011 I : Ugeskrift for Laeger. 173, 22, s. 1595

Publikation: Bidrag til tidsskriftTidsskriftartikel

Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 173
Tidsskriftsnummer 22
Sider (fra-til) 1595
ISSN 0041-5782
Status Udgivet - 2011

Identifying Preliminary Domains to Detect and Measure Rheumatoid Arthritis Flares: Report of the OMERACT 10 RA Flare Workshop

Bingham, C. O., Alten, R., Bartlett, S. J., Bykerk, V. P., Brooks, P. M., Choy, E., Christensen, R., Furst, D. E., Hewlett, S. E., Leong, A., May, J. E., Montie, P., Pohl, C., Sanderson, T. C., Strand, V., Woodworth, T. G. & for the OMERACT RA Flare Definition Working Group 1 aug. 2011 I : Journal of Rheumatology. 38, 8, s. 1751-1758 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Background. While disease flares in rheumatoid arthritis (RA) are a recognized aspect of the disease process, there is limited formative research to describe them. METHODS: The Outcome Measures in Rheumatology Clinical Trials (OMERACT) RA Flare Definition Working Group is conducting an international research project to understand the specific characteristics and impact of episodic disease worsening, or "flare," so that outcome measures can be developed or modified to reflect this uncommonly measured, but very real and sometimes disabling RA disease feature. Patient research partners provided critical insights into the multidimensional nature of flare. The perspectives of patients and healthcare and research professionals are being integrated to ensure that any outcome measurement to detect flares fulfills the first OMERACT criteria of Truth. Through an iterative data-driven Delphi process, a preliminary list of key domains has been identified to evaluate flare. RESULTS: At OMERACT 10, consensus was achieved identifying features of flare in addition to the existing core set for RA, including fatigue, stiffness, symptom persistence, systemic features, and participation. Patient self-report of flare was identified as a component of the research agenda needed to establish criterion validity for a flare definition; this can be used in prospective studies to further evaluate the Discrimination and Feasibility components of the OMERACT filter for a flare outcome measure. CONCLUSION: Our work to date has provided better understanding of key aspects of the RA disease process as episodic, potentially disabling disease worsening even when a patient is in low disease activity. It also highlights the importance of developing ways to enhance communication between patients and clinicians and improve the ability to achieve "tight control" of disease.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 38
Tidsskriftsnummer 8
Sider (fra-til) 1751-1758
Antal sider 8
ISSN 0315-162X
DOI
Status Udgivet - 1 aug. 2011

Introduction--microorganisms and the locomotor system

Wollheim, F. A. & Locht, H. 2011 I : Best Practice & Research: Clinical Rheumatology. 25, 3, s. 333-5 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Originalsprog Engelsk
Tidsskrift Best Practice & Research: Clinical Rheumatology
Vol/bind 25
Tidsskriftsnummer 3
Sider (fra-til) 333-5
Antal sider 3
ISSN 1521-6942
DOI
Status Udgivet - 2011

Is it possible to reduce the knee joint compression force during level walking with hiking poles?

Jensen, S. B., Henriksen, M., Aaboe, J., Hansen, L., Simonsen, E. B. & Alkjaer, T. 2011 I : Scandinavian Journal of Medicine & Science in Sports. 21, 6, s. E195-E200

Publikation: Bidrag til tidsskriftTidsskriftartikel

Walking with hiking poles has become a popular way of exercising. Walking with poles is advocated as a physical activity that significantly reduces the loading of the hip, knee and ankle joints. We have previously observed that pole walking does not lead to a reduction of the load on the knee joint. However, it is unclear whether an increased force transmitted through the poles can reduce the load on the knee joint. Thus, the purpose of the present study was to investigate if an increased load transmitted through the arms to the poles could reduce the knee joint compression force during level walking with poles. We hypothesized that an increased pole force would result in a reduction of the knee joint compression force. Gait analyses from 10 healthy subjects walking with poles were obtained. The pole force was measured simultaneously during the gait analyses. The knee joint compression forces were estimated by using a biomechanical knee joint model. The results showed that the subjects were able to increase the pole force by 2.4 times the normal pole force. However, this did not lead to a reduction in the knee joint compressive force and we rejected our hypothesis. In conclusion, the use of poles during level walking does not seem to reduce knee joint compressive loads. However, it is possible that the use of poles in other populations (e.g. osteoarthritis patients) and in terrain would unload the knee joint. This should be investigated in the future.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Medicine & Science in Sports
Vol/bind 21
Tidsskriftsnummer 6
Sider (fra-til) E195-E200
ISSN 0905-7188
DOI
Status Udgivet - 2011

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